Cited by 877Diabetes, Cardiovascular Risks, and LipoproteinsAdipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

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Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

Perseghin, G, Scifo, P, De Cobelli, F, Pagliato, E, Battezzati, A, Arcelloni, C, Vanzulli, A, Testolin, G, Pozza, G, Del Maschio, A, Luzi, L·1999·Diabetes

DOI 10.2337/diabetes.48.8.1600

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Abstract

Insulin resistance is the best prediction factor for the clinical onset of type 2 diabetes. It was suggested that intramuscular triglyceride store may be a primary pathogenic factor for its development. To test this hypothesis, 14 young lean offspring of type 2 diabetic parents, a model of in vivo insulin resistance with increased risk to develop diabetes, and 14 healthy subjects matched for anthropomorphic parameters and life habits were studied with 1) euglycemic-hyperinsulinemic clamp to assess whole body insulin sensitivity, 2) localized 1H nuclear magnetic resonance (NMR) spectroscopy of the soleus (higher content of fiber type I, insulin sensitive) and tibialis anterior (higher content of fiber type IIb, less insulin sensitive) muscles to assess intramyocellular triglyceride content, 3) 13C NMR of the calf subcutaneous adipose tissue to assess composition in saturated/unsaturated carbons of triglyceride fatty acid chains, and 4) dual X-ray energy absorption to assess body composition. Offspring of diabetic parents, notwithstanding normal fat content and distribution, were characterized by insulin resistance and increased intramyocellular triglyceride content in the soleus (P < 0.01) but not in the tibialis anterior (P = 0.19), but showed a normal content of saturated/unsaturated carbons in the fatty acid chain of subcutaneous adipocytes. Stepwise regression analysis selected intramyocellular triglyceride soleus content and plasma free fatty acid levels as the main predictors of whole body insulin sensitivity. In conclusion, 1H and 13C NMR spectroscopy revealed intramyocellular abnormalities of lipid metabolism associated with whole body insulin resistance in subjects at high risk of developing diabetes, and might be useful tools for noninvasively monitoring these alterations in diabetes and prediabetic states.

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Authors: Perseghin, G., Scifo, P., De Cobelli, F., Pagliato, E., Battezzati, A., Arcelloni, C., Vanzulli, A., Testolin, G., Pozza, G., Del Maschio, A., & Luzi, L.
Affiliations: IRCCS Ospedale San Raffaele (IT)
Division of Internal Medicine, Istituto Scientifico H San Raffaele, Milan, Italy. perseghin.gianluca@hsr.it
ORCID: Perseghin, G
Scifo, P
Battezzati, A
Vanzulli, A
Luzi, L
Venue: Diabetes
Publisher: American Diabetes Association
Published: 1999-08-01
Volume: 48
Issue: 8
Pages: 1600-1606
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.48.8.1600
OpenAlex: W2148562280
Cited by: 877
References: 0
Citations by year: 2026: 5 · 2025: 8 · 2024: 4 · 2023: 12 · 2022: 6 · 2021: 13 · 2020: 26 · 2019: 30 · 2018: 30 · 2017: 22 · 2016: 25 · 2015: 35 · 2014: 27 · 2013: 27 · 2012: 38
FWCI: 19.58
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
BOA (University of Milano-Bicocca) (submittedVersion)
Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: intramyocellular triglyceride, insulin resistance, type 2 diabetes risk, soleus muscle, tibialis anterior, muscle fiber type, subcutaneous adipose tissue, plasma free fatty acids, whole-body insulin sensitivity, prediabetes
MeSH terms: Adult, Carbon Isotopes, Diabetes Mellitus, Type 2, Female, Humans, Hyperinsulinism, Insulin Resistance, Male, Middle Aged, Magnetic Resonance Spectroscopy, Sex Characteristics, Triglycerides, Tritium, Glucose Clamp Technique, Multivariate Analysis, Muscle, Skeletal

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Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

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