Cited by 137Seed and Plant BiochemistryFood Science and Nutritional StudiesPhytochemicals and Antioxidant Activities

The DOI matches its Crossref record; 153 of the 155 references it cites were found in a registry or an index; 1 of the 133 sources its claims cite were checked for support.

Nutritional and Functional New Perspectives and Potential Health Benefits of Quinoa and Chia Seeds

Open access

Abstract

Quinoa (Chenopodium quinoa Willd) and chia (Salvia hispanica) are essential traditional crops with excellent nutritional properties. Quinoa is known for its high and good quality protein content and nine essential amino acids vital for an individual’s development and growth, whereas chia seeds contain high dietary fiber content, calories, lipids, minerals (calcium, magnesium, iron, phosphorus, and zinc), and vitamins (A and B complex). Chia seeds are also known for their presence of a high amount of omega-3 fatty acids. Both quinoa and chia seeds are gluten-free and provide medicinal properties due to bioactive compounds, which help combat various chronic diseases such as diabetes, obesity, cardiovascular diseases, and metabolic diseases such as cancer. Quinoa seeds possess phenolic compounds, particularly kaempferol, which can help prevent cancer. Many food products can be developed by fortifying quinoa and chia seeds in different concentrations to enhance their nutritional profile, such as extruded snacks, meat products, etc. Furthermore, it highlights the value-added products that can be developed by including quinoa and chia seeds, alone and in combination. This review focused on the recent development in quinoa and chia seeds nutritional, bioactive properties, and processing for potential human health and therapeutic applications.

Overview

AI snapshot

Written from the paper’s full text.

TL;DR

Quinoa and chia are gluten-free traditional crops rich in protein, fiber, omega-3 fatty acids, minerals, vitamins, and bioactive compounds with antioxidant, antidiabetic, anticancer, and cardiovascular-related potential. The review synthesizes their nutritional profiles, bioactive properties, processing effects, and use in value-added foods, while calling for more human studies.

Key findings

  • Quinoa protein content is 13.8–16.5% (average 15%) and contains all nine essential amino acids; chia contains 15–23% protein, 30–34 g/100 g dietary fiber, and 25–40% fat, of which 83% is PUFAs, including omega-3 α-linolenic acid (64%) and omega-6 α-linolenic acid (20%). Table 1 reports per 100 g: quinoa protein 14.1 g, fat 6.10 g, fiber 7.00 g; chia protein 24.2 g, fat 40.2 g, fiber 34.4 g.
  • Quinoa bioactives include phenolics at 0.46–1.84 mg/g dry weight, phytosterols at 118 mg/100 g, and phytoecdysteroids at 138–570 µg/g; kaempferol is highlighted for anticancer potential via Nrf2/Keap1 pathways. Chia has ~98 mg total phenols (GAE/100 g), rosmarinic acid at 0.93 mg/g, and phytosterols at ~0.02%.
  • Both seeds are linked to health benefits such as antioxidant, antidiabetic, anticancer, antihypertensive, anti-inflammatory, and hypocholesterolemic effects; chia is especially noted as a plant source of omega-3 fatty acids.
  • Food applications include quinoa-fortified bread with 2% higher protein and 1% higher oil and fiber, pasta with 7.5% chia flour, a ready-to-eat porridge with 15% replacement of rice flour by a 1:1 quinoa:chia mix, cookies with 20% chia mucilage, and yogurt with 6% chia seeds plus 12% strawberry.

Methods

  • Narrative review of recent literature on quinoa and chia seeds, covering nutritional composition, bioactive compounds, processing, health benefits, and value-added food products.
  • Data are drawn from cited studies and nutrient composition tables, including Table 1 with per-100 g nutrient values for quinoa and chia.
  • Main analysis is qualitative synthesis; no systematic search strategy, inclusion criteria, meta-analysis, or primary experimental study is reported.

Limitations

  • The paper states that further studies are needed to reveal benefits to a larger population and to investigate effects on human health, and that challenges in including quinoa and chia in food products need study.
  • The paper notes that antioxidant properties of polyphenols have been widely demonstrated mainly in vitro, while in vivo biological relevance is questionable, especially for cardiovascular effects, due to low blood concentrations and extensive metabolism after ingestion.
  • Evident from the text: as a narrative review, it does not provide a systematic protocol or quantitative synthesis, and many health claims rely on cited animal, in vitro, or small human studies rather than large clinical trials.

Model-written summary. Check it against the paper before relying on it.

Integrity signals

Registry

Crossref · 10.3390/antiox12071413

Cites

153 of 153 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Figures

Figure 1 Functional properties of quinoa (Chenopodium quinoa Willd).
Figure 1 Functional properties of quinoa (Chenopodium quinoa Willd).CC BY · PubMed Central
Figure 2 Mechanism of cholesterol reduction in human body by phytosterols in quinoa (Chenopodium quinoa Willd).
Figure 2 Mechanism of cholesterol reduction in human body by phytosterols in quinoa (Chenopodium quinoa Willd).CC BY · PubMed Central
Figure 3 Antioxidant activity and mode of action of kaempferol in preventing cancer.
Figure 3 Antioxidant activity and mode of action of kaempferol in preventing cancer.CC BY · PubMed Central
Figure 4 Different forms of chia (Salvia hispanica) seeds are used in food products.
Figure 4 Different forms of chia (Salvia hispanica) seeds are used in food products.CC BY · PubMed Central
Figure 5 Functional properties of chia (Salvia hispanica) seeds.
Figure 5 Functional properties of chia (Salvia hispanica) seeds.CC BY · PubMed Central

Verification

Claims the paper makes

98 Not checked yet · 6 Own interpretation · 1 Supported

Verify all 132 references — free account

Show all 62 claims

  • It may state two separate claims as one. 42
  • Probably not a substantial claim. 2
43 of 43
  • The paper relies on this without support.

    Chia seed germination is an effective and inexpensive method that can provide functional chia seed flour by increasing phenolic compounds, antioxidant activity, and GABA.

    “In addition, chia seeds germination is an effective and inexpensive method that can help provide functional chia seed flour by increasing the phenolic compounds, antioxidant activity, and γ-aminobutyric acid (GABA).”
  • The paper relies on this without support.

    Chia is a strong contender for controlling diabetes because it contains dietary fiber (18–30%) and α-linolenic fatty acids.

    “Additionally, chia is a strong contender for controlling diabetes since it contains dietary fiber (18–30%), and α-linolenic fatty acids.”
  • The paper relies on this without support.

    Chia seeds have a high caloric value of 486 kcal and contain about 2.3-, 8.3-, and 9.8-fold higher fiber per 100 g than oats, corn, and rice.

    “Chia seeds have a high caloric value of 486 kcal and contain ~2.3-, 8.3-, and 9.8-fold higher fiber per 100 g than oats, corn, and rice.”
3 of 3

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Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Each contradiction between two passages listed here was confirmed by an independent check.

4 of 4

Citations

Cites

Show all 155 references

Research works printed but not linked: 3

  1. Goyat, 2017, Quinoa (Chenopodium quinoa Willd.)—The unforgotten golden grain, IJFANS Int. J. Food Nutr. Sci., 7, 1
  2. Sharma, 2015, Quinoa (Chenopodium quinoa Willd.): A nutritional healthy grain, Int. J. Adv. Res., 3, 725
  3. Puri, 2020, Evaluation of the nutritional value of snacks prepared by fortification of gram flour with chia seeds, Int. J. Home Sci., 6, 35

Cited by

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Metadata

Authors
Agarwal, A., Rizwana, Tripathi, A. D., Kumar, T., Sharma, K. P., & Patel, S. K. S.
Affiliations
  • University of Delhi (IN)
  • Department of Food Technology, Bhaskaracharya College of Applied Sciences, Sector-2, Dwarka, New Delhi 110075, India
  • Banaras Hindu University (IN)
  • Maharaja Sayajirao University of Baroda (IN)
  • Central University of Haryana (IN)
  • Konkuk University (KR)
Corresponding author
Patel, Sanjay Kumar Singh
Venue
Antioxidants
Publisher
MDPI AG
Published
2023-07-12
Volume
12
Issue
7
Pages
1413
ISSN
2076-3921 (ISSN-L)
OpenAlex
W4384202525
Cited by
135
References
155
Citations by year
2026: 42 · 2025: 48 · 2024: 38 · 2023: 7
FWCI
3.12
Type
journal article
Language
en
Open access
Locations
  • Antioxidants (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Seed and Plant Biochemistry
  • Health Sciences › Nursing › Nutrition and Dietetics › Food Science and Nutritional Studies
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords
quinoa, Salvia hispanica, nutritional properties, functional foods, bioactive compounds, kaempferol, phenolic compounds, omega-3 fatty acids, gluten-free foods, food fortification, value-added food products, chronic disease prevention, cancer prevention, extrusion

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