Cited by 143Gut microbiota and healthTryptophan and brain disordersProbiotics and Fermented Foods

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Role of the Intestinal Microbiome, Intestinal Barrier and Psychobiotics in Depression

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Trzeciak, Paulina, Herbet, Mariola·2021·Nutrients

DOI 10.3390/nu13030927PMC PMC8000572

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Abstract

The intestinal microbiota plays an important role in the pathophysiology of depression. As determined, the microbiota influences the shaping and modulation of the functioning of the gut–brain axis. The intestinal microbiota has a significant impact on processes related to neurotransmitter synthesis, the myelination of neurons in the prefrontal cortex, and is also involved in the development of the amygdala and hippocampus. Intestinal bacteria are also a source of vitamins, the deficiency of which is believed to be related to the response to antidepressant therapy and may lead to exacerbation of depressive symptoms. Additionally, it is known that, in periods of excessive activation of stress reactions, the immune system also plays an important role, negatively affecting the tightness of the intestinal barrier and intestinal microflora. In this review, we have summarized the role of the gut microbiota, its metabolites, and diet in susceptibility to depression. We also describe abnormalities in the functioning of the intestinal barrier caused by increased activity of the immune system in response to stressors. Moreover, the presented study discusses the role of psychobiotics in the prevention and treatment of depression through their influence on the intestinal barrier, immune processes, and functioning of the nervous system.

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Authors: Trzeciak, P., & Herbet, M.
Affiliations: Medical University of Lublin (PL)
Corresponding author: Herbet, Mariola
ORCID: Trzeciak, Paulina
Herbet, Mariola
Venue: Nutrients
Publisher: MDPI AG
Published: 2021-03-12
Volume: 13
Issue: 3
Pages: 927
ISSN: 2072-6643 (ISSN-L)
DOI: 10.3390/nu13030927
PMC: PMC8000572
OpenAlex: W3136512166
Cited by: 139
References: 209
Citations by year: 2026: 15 · 2025: 30 · 2024: 38 · 2023: 33 · 2022: 17 · 2021: 6
FWCI: 2.47
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Nutrients (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: gut microbiota, depression, gut-brain axis, intestinal barrier, psychobiotics, neurotransmitter synthesis, myelination, prefrontal cortex, amygdala, hippocampus, vitamin deficiency, antidepressant response, stress response, immune system, gut microbiota metabolites, diet, depression vulnerability
MeSH terms: Gastrointestinal Microbiome, Animals, Depression, Diet, Humans, Intestinal Mucosa, Probiotics

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Role of the Intestinal Microbiome, Intestinal Barrier and Psychobiotics in Depression

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