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Targeting agr- and agr-Like Quorum Sensing Systems for Development of Common Therapeutics to Treat Multiple Gram-Positive Bacterial Infections

Gray, Brian, Hall, Pamela, Gresham, Hattie·2013·Sensors
DOI 10.3390/s130405130
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Abstract

Invasive infection by the Gram-positive pathogen Staphylococcus aureus is controlled by a four gene operon, agr that encodes a quorum sensing system for the regulation of virulence. While agr has been well studied in S. aureus, the contribution of agr homologues and analogues in other Gram-positive pathogens is just beginning to be understood. Intriguingly, other significant human pathogens, including Clostridium perfringens, Listeria monocytogenes, and Enterococcus faecalis contain agr or analogues linked to virulence. Moreover, other significant human Gram-positive pathogens use peptide based quorum sensing systems to establish or maintain infection. The potential for commonality in aspects of these signaling systems across different species raises the prospect of identifying therapeutics that could target multiple pathogens. Here, we review the status of research into these agr homologues, analogues, and other peptide based quorum sensing systems in Gram-positive pathogens as well as the potential for identifying common pathways and signaling mechanisms for therapeutic discovery.

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Metadata

Authors
Gray, B., Hall, P., & Gresham, H.
Venue
Sensors
Publisher
MDPI AG
Published
2013-04-18
Volume
13
Issue
4
Pages
5130-5166
ISSN
1424-8220
DOI
10.3390/s130405130
Cited by
128
References
9
Language
en
Licence
creativecommons.org/licenses/by/3.0/ (vor)

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CoChat. (2026). Citation check: Targeting agr- and agr-Like Quorum Sensing Systems for Development of Common Therapeutics to Treat Multiple Gram-Positive Bacterial Infections. https://app.cochat.ai/papers/10.3390/s130405130
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Gray, B., Hall, P., & Gresham, H. (2013). Targeting agr- and agr-Like Quorum Sensing Systems for Development of Common Therapeutics to Treat Multiple Gram-Positive Bacterial Infections. Sensors. https://doi.org/10.3390/s130405130

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