MicroRNAs in Common Human Diseases

Untitled work

Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714

The sequence of the human genome

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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

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Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets

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MicroRNA expression profiles classify human cancers

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Circulating microRNAs as stable blood-based markers for cancer detection

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Initial sequencing and comparative analysis of the mouse genome

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MicroRNAs: small RNAs with a big role in gene regulation

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Prediction of Mammalian MicroRNA Targets

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Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

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Identification of Novel Genes Coding for Small Expressed RNAs

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Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

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Combinatorial microRNA target predictions

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miRBase: tools for microRNA genomics

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NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses

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Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

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MicroRNA Gene Expression Deregulation in Human Breast Cancer

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miRBase: microRNA sequences, targets and gene nomenclature

Griffiths-Jones, S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj112 · Cited by 3,950

Mammalian microRNAs predominantly act to decrease target mRNA levels

Guo, H., Ingolia, N. T., Weissman, J. S., & Bartel, D. P. (2010) · Nature · doi:10.1038/nature09267 · Cited by 3,886

Human MicroRNA Targets

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RAS Is Regulated by the let-7 MicroRNA Family

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miRBase: integrating microRNA annotation and deep-sequencing data

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miR-15 and miR-16 induce apoptosis by targeting BCL2

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Identification of tissue-specific microRNAs from mouse

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An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

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Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

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Unique microRNA molecular profiles in lung cancer diagnosis and prognosis

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An Extensive Class of Small RNAs in Caenorhabditis elegans

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Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

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MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells

Chan, J. A., Krichevsky, A. M., & Kosik, K. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0137 · Cited by 2,557

MicroRNA biogenesis: coordinated cropping and dicing

Kim, V. N. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1644 · Cited by 2,546

Modulation of Hepatitis C Virus RNA Abundance by a Liver-Specific MicroRNA

Jopling, C. L., Yi, M., Lancaster, A. M., Lemon, S. M., & Sarnow, P. (2005) · Science · doi:10.1126/science.1113329 · Cited by 2,521

Genome sequence of the Brown Norway rat yields insights into mammalian evolution

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TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

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RNAhybrid: microRNA target prediction easy, fast and flexible

Kruger, J., & Rehmsmeier, M. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl243 · Cited by 1,941

Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps

Chi, S. W., Zang, J. B., Mele, A., & Darnell, R. B. (2009) · Nature · doi:10.1038/nature08170 · Cited by 1,791

Identification of Virus-Encoded MicroRNAs

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Human RISC Couples MicroRNA Biogenesis and Posttranscriptional Gene Silencing

Gregory, R. I., Chendrimada, T. P., Cooch, N., & Shiekhattar, R. (2005) · Cell · doi:10.1016/j.cell.2005.10.022 · Cited by 1,617

LNA-mediated microRNA silencing in non-human primates

Elmén, J., Lindow, M., Schütz, S., Lawrence, M., Petri, A., Obad, S., Lindholm, M., Hedtjärn, M., Hansen, H. F., Berger, U., et al. (2008) · Nature · doi:10.1038/nature06783 · Cited by 1,589 · cited 1×

Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection

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Evolutionary and biomedical insights from the rhesus macaque genome.

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A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons

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Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression

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Identification of microRNAs of the herpesvirus family

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MicroRNAs 103 and 107 regulate insulin sensitivity

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MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

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Modulation of microRNA processing and expression through RNA editing by ADAR deaminases

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Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes

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Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides

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Control of Peripheral Nerve Myelination by the ß-Secretase BACE1

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Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver

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Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression

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Cell-type-specific signatures of microRNAs on target mRNA expression

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SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells

Sullivan, C. S., Grundhoff, A. T., Tevethia, S., Pipas, J. M., & Ganem, D. (2005) · Nature · doi:10.1038/nature03576 · Cited by 623

MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47

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Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells

Cai, X., Lu, S., Zhang, Z., Gonzalez, C. M., Damania, B., & Cullen, B. R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408192102 · Cited by 586

A viral microRNA functions as an orthologue of cellular miR-155

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DIANA-microT web server: elucidating microRNA functions through target prediction

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Evidence that microRNA precursors, unlike other non-coding RNAs, have lower folding free energies than random sequences

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A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells

Png, K. J., Halberg, N., Yoshida, M., & Tavazoie, S. F. (2012) · Nature · doi:10.1038/nature10661 · Cited by 531

Cellular cofactors affecting hepatitis C virus infection and replication

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MicroRNAs: Potential biomarkers for cancer diagnosis, prognosis and targets for therapy

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MicroRNAs and cancer

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In vitro reconstitution of the human RISC-loading complex

MacRae, I. J., Ma, E., Zhou, M., Robinson, C. V., & Doudna, J. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710869105 · Cited by 434

MicroRNA 144 Impairs Insulin Signaling by Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus

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Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer

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MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinoma

Fang, Y., Xue, J.-L., Shen, Q., Chen, J., & Tian, L. (2012) · Hepatology · doi:10.1002/hep.25576 · Cited by 425

Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression

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Using expression profiling data to identify human microRNA targets

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A biochemical approach to identifying microRNA targets

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Multiple Sclerosis: MicroRNA Expression Profiles Accurately Differentiate Patients with Relapsing-Remitting Disease from Healthy Controls

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Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA

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A serum circulating miRNA diagnostic test to identify asymptomatic high‐risk individuals with early stage lung cancer

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Modulation of mismatch repair and genomic stability by miR-155

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The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma

Shimizu, S., Takehara, T., Hikita, H., Kodama, T., Miyagi, T., Hosui, A., Tatsumi, T., Ishida, H., Noda, T., Nagano, H., et al. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2009.12.024 · Cited by 343

Suppression of RNA Interference by Adenovirus Virus-Associated RNA

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Joint Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer's Disease Cortex Reveals Altered miRNA Regulation

Nunez-Iglesias, J., Liu, C.-C., Morgan, T. E., Finch, C. E., & Zhou, X. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008898 · Cited by 321

RNA editing of a miRNA precursor: FIGURE 1.

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MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression

Fang, J.-H., Zhou, H.-C., Zeng, C., Yang, J., Liu, Y., Huang, X., Zhang, J.-P., Guan, X.-Y., & Zhuang, S.-M. (2011) · Hepatology · doi:10.1002/hep.24577 · Cited by 307

Nuclear Outsourcing of RNA Interference Components to Human Mitochondria

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Hepatitis C virus-induced up-regulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling

Zhang, Y., Wei, W., Cheng, N., Wang, K., Li, B., Jiang, X., & Sun, S. (2012) · Hepatology · doi:10.1002/hep.25849 · Cited by 300

Serum MicroRNAs as Biomarkers for Hepatocellular Carcinoma in Chinese Patients with Chronic Hepatitis B Virus Infection

Qi, P., Cheng, S.-Q., Wang, H., Li, N., Chen, Y.-F., & Gao, C.-F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028486 · Cited by 290

Identification and Characterization of Human Cytomegalovirus-Encoded MicroRNAs

Grey, F., Antoniewicz, A., Allen, E., Saugstad, J., McShea, A., Carrington, J. C., & Nelson, J. (2005) · Journal of Virology · doi:10.1128/jvi.79.18.12095-12099.2005 · Cited by 271

A Functional Variant in MicroRNA-146a Promoter Modulates Its Expression and Confers Disease Risk for Systemic Lupus Erythematosus

Luo, X., Yang, W., Ye, D.-Q., Cui, H., Zhang, Y., Hirankarn, N., Qian, X., Tang, Y., Lau, Y. L., de Vries, N., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002128 · Cited by 262

HIV-1 nef suppression by virally encoded microRNA

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Epstein–Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-κB pathway

Gatto, G., Rossi, A., Rossi, D., Kroening, S., Bonatti, S., & Mallardo, M. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn666 · Cited by 254

Convergence of miRNA Expression Profiling, α-Synuclein Interacton and GWAS in Parkinson's Disease

Martins, M., Rosa, A., Guedes, L. C., Fonseca, B. V., Gotovac, K., Violante, S., Mestre, T., Coelho, M., Rosa, M. M., Martin, E. R., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025443 · Cited by 245

Induction of microRNA‐155 during Helicobacter pylori Infection and Its Negative Regulatory Role in the Inflammatory Response

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Identification of miRs-143 and -145 that Is Associated with Bone Metastasis of Prostate Cancer and Involved in the Regulation of EMT

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