p53, the Cellular Gatekeeper for Growth and Division

WAF1, a potential mediator of p53 tumor suppression

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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p53 is required for radiation-induced apoptosis in mouse thymocytes

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Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

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p53: puzzle and paradigm.Preprint

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

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Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain

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The hallmarks of cancer

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Surfing the p53 network

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In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

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Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage

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Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

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A model for p53-induced apoptosis

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PUMA, a Novel Proapoptotic Gene, Is Induced by p53

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TP53 mutations in human cancers: origins, consequences, and clinical use.

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

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Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

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Transcriptional control of human p53-regulated genes

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Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

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The RB and p53 pathways in cancer

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Modes of p53 regulation.

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2’s inhibition of p53

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p53 mutant mice that display early ageing-associated phenotypes

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Crosstalk between apoptosis.; necrosis and autophagy

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Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

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p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

Budanov, A. V., & Karin, M. (2008) · Cell · doi:10.1016/j.cell.2008.06.028 · Cited by 1,326

Is a p53-Regulated Inhibitor of G2/M Progression

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The coordinate regulation of the p53 and mTOR pathways in cells

Feng, Z., Zhang, H., Levine, A. J., & Jin, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502857102 · Cited by 1,235

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

Mayo, L. D., & Donner, D. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181181198 · Cited by 1,230

DNA damage activates p53 through a phosphorylation–acetylation cascade

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Tumor suppressors and cell metabolism: a recipe for cancer growth

Jones, R. G., & Thompson, C. B. (2009) · Genes & Development · doi:10.1101/gad.1756509 · Cited by 1,085

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound

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Disruption of p53 in human cancer cells alters the responses to therapeutic agents.

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p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

Chin, L., Artandi, S. E., Shen, Q., Tam, A., Lee, S.-L., Gottlieb, G. J., Greider, C. W., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80762-x · Cited by 979

Regulation of p53 in response to DNA damage

Lakin, N. D., & Jackson, S. P. (1999) · Oncogene · doi:10.1038/sj.onc.1203015 · Cited by 987

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

Shieh, S.-Y., Ahn, J., Tamai, K., Taya, Y., & Prives, C. (2000) · Genes & Development · doi:10.1101/gad.14.3.289 · Cited by 972

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

Ravi, R., Mookerjee, B., Bhujwalla, Z. M., Sutter, C. H., Artemov, D., Zeng, Q., Dillehay, L. E., Madan, A., Semenza, G. L., & Bedi, A. (2000) · Genes & Development · doi:10.1101/gad.14.1.34 · Cited by 967

Rules for Making Human Tumor Cells

Hahn, W. C., & Weinberg, R. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmra021902 · Cited by 951

p53 ubiquitination: Mdm2 and beyond

Brooks, C. L., & Gu, W. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.020 · Cited by 924

Human Telomerase and Its Regulation

Cong, Y.-S., Wright, W. E., & Shay, J. W. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.3.407-425.2002 · Cited by 898

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

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TP53 mutations in human cancers: Functional selection and impact on cancer prognosis and outcomes

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p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

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Chk2/hCds1 functions as a DNA damage checkpoint in G1by stabilizing p53

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Rapid Destruction of Human Cdc25A in Response to DNA Damage

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p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

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Acetylation of the p53 DNA-binding domain regulates apoptosis induction.

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A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

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Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

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The Evolution of Iron Chelators for the Treatment of Iron Overload Disease and Cancer

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Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

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Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

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Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction

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Signal Transduction and the Control of Gene Expression

Brivanlou, A. H., & Darnell, J. E. (2002) · Science · doi:10.1126/science.1066355 · Cited by 699

Metal-induced oxidative stress and signal transduction

Leonard, S. S., Harris, G. K., & Shi, X. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.09.010 · Cited by 663

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

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The ARF/p53 pathway.

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MDM2 — master regulator of the p53 tumor suppressor protein

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GADD45 induction of a G 2 /M cell cycle checkpoint

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Akt Enhances Mdm2-mediated Ubiquitination and Degradation of p53

Ogawara, Y., Kishishita, S., Obata, T., Isazawa, Y., Suzuki, T., Tanaka, K., Masuyama, N., & Gotoh, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109745200 · Cited by 617

Transcriptional Cross Talk between NF-κB and p53

Webster, G. A., & Perkins, N. D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3485 · Cited by 598

Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development

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Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

Hwang, B. J., Ford, J. M., Hanawalt, P. C., & Chu, G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.424 · Cited by 581

Life on a planet of its own: Regulation of RNA polymerase I transcription in the nucleolus

Grummt, I. (2003) · Genes & Development · doi:10.1101/gad.1098503r · Cited by 540

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation

Alt, J. R., Cleveland, J. L., Hannink, M., & Diehl, J. A. (2000) · Genes & Development · doi:10.1101/gad.854900 · Cited by 535

The INK4A/ARF locus and its two gene products.

Sharpless, N. E., & DePinho, R. A. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80004-5 · Cited by 533

MDM2 inhibitors for cancer therapy

Vassilev, L. T. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.11.002 · Cited by 532

DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis

Bernstein, C. (2002) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(02)00009-1 · Cited by 527

Zinc deficiency, DNA damage and cancer risk

Ho, E. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.07.005 · Cited by 518

H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation

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Extracellular Matrix Survival Signals Transduced by Focal Adhesion Kinase Suppress p53-mediated Apoptosis

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A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

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Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

Khosravi, R., Maya, R., Gottlieb, T., Oren, M., Shiloh, Y., & Shkedy, D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14973 · Cited by 461

Regulation of p53 function and stability by phosphorylation.

Ashcroft, M., Kubbutat, M. H. G., & Vousden, K. H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.1751 · Cited by 452

Serine 15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2

Dumaz, N., & Meek, D. W. (1999) · The EMBO Journal · doi:10.1093/emboj/18.24.7002 · Cited by 455

Regulating tumor suppressor genes: post-translational modifications

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E3 ubiquitin ligases: styles, structures and functions

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Drugging the undruggables: exploring the ubiquitin system for drug development

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DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

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Structural Basis of DNA Recognition by p53 Tetramers

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p300/MDM2 complexes participate in MDM2-mediated p53 degradation

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Discovery of RG7112: a small-molecule MDM2 inhibitor in clinical development

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A p53 Amino-Terminal Nuclear Export Signal Inhibited by DNA Damage-Induced Phosphorylation

Zhang, Y., & Xiong, Y. (2001) · Science · doi:10.1126/science.1058637 · Cited by 378

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo

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Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

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The MDM2 RING-finger domain is required to promote p53 nuclear export

Geyer, R. K., Yu, Z. K., & Maki, C. G. (2000) · Nature Cell Biology · doi:10.1038/35023507 · Cited by 361

The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53

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PTEN Protects p53 from Mdm2 and Sensitizes Cancer Cells to Chemotherapy

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The molecular basis of asbestos induced lung injury

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