Cellular Motility Driven by Assembly and Disassembly of Actin Filaments

Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck

Eden, S., Rohatgi, R., Podtelejnikov, A. V., Mann, M., & Kirschner, M. W. (2002) · Nature · doi:10.1038/nature00859 · Cited by 835

Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex

Machesky, L. M., Mullins, R. D., Higgs, H. N., Kaiser, D. A., Blanchoin, L., May, R. C., Hall, M. E., & Pollard, T. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3739 · Cited by 773

Activation of Arp2/3 complex-mediated actin polymerization by cortactin

Uruno, T., Liu, J., Zhang, P., Fan, Y.-X., Egile, C., Li, R., Mueller, S. C., & Zhan, X. (2001) · Nature Cell Biology · doi:10.1038/35060051 · Cited by 568

Microscopic analysis of polymerization dynamics with individual actin filaments

Fujiwara, I., Takahashi, S., Tadakuma, H., Funatsu, T., & Ishiwata, S. (2002) · Nature Cell Biology · doi:10.1038/ncb841 · Cited by 420

Control of actin dynamics in cell motility

Carlier, M.-F., & Pantaloni, D. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1062 · Cited by 351

Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex

Marchand, J.-B., Kaiser, D. A., Pollard, T. D., & Higgs, H. N. (2001) · Nature Cell Biology · doi:10.1038/35050590 · Cited by 331

Structure of Arp2/3 Complex in Its Activated State and in Actin Filament Branch Junctions

Volkmann, N., Amann, K. J., Stoilova-McPhie, S., Egile, C., Winter, D. C., Hazelwood, L., Heuser, J. E., Li, R., Pollard, T. D., & Hanein, D. (2001) · Science · doi:10.1126/science.1063025 · Cited by 258

RHO GTPASES: Biochemistry and Biology

Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009

Phosphoinositides in cell regulation and membrane dynamics

Di Paolo, G., & De Camilli, P. (2006) · Nature · doi:10.1038/nature05185 · Cited by 2,790

Mechanisms of clathrin-mediated endocytosis

Kaksonen, M., & Roux, A. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.132 · Cited by 1,698

Complex archaea that bridge the gap between prokaryotes and eukaryotes

Spang, A., Saw, J. H., Jørgensen, S. L., Zaremba-Niedzwiedzka, K., Martijn, J., Lind, A. E., van Eijk, R., Schleper, C., Guy, L., & Ettema, T. J. G. (2015) · Nature · doi:10.1038/nature14447 · Cited by 1,324

Actin structure and function

Dominguez, R., & Holmes, K. C. (2011) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-042910-155359 · Cited by 1,211

Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses

Zhou, Q., Homma, K. J., & Poo, M.-M. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.011 · Cited by 1,025

The WASP-WAVE protein network: Connecting the membrane to the cytoskeleton.

Takenawa, T., & Suetsugu, S. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2069 · Cited by 947

Structure-stability-function relationships of dendritic spines

Kasai, H., Matsuzaki, M., Noguchi, J., Yasumatsu, N., & Nakahara, H. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00162-0 · Cited by 847

Structural dynamics of dendritic spines in memory and cognition

Kasai, H., Fukuda, M., Watanabe, S., Hayashi-Takagi, A., & Noguchi, J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.01.001 · Cited by 804

Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy.

Cingolani, L. A., & Goda, Y. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2373 · Cited by 831

Actin in dendritic spines: connecting dynamics to function

Hotulainen, P., & Hoogenraad, C. C. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201003008 · Cited by 815

Appreciating force and shape—the rise of mechanotransduction in cell biology

Iskratsch, T., Wolfenson, H., & Sheetz, M. P. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3903 · Cited by 798

The actin cytoskeleton and actin-based motility

Svitkina, T. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018267 · Cited by 761

Harnessing actin dynamics for clathrin-mediated endocytosis

Kaksonen, M., Toret, C. P., & Drubin, D. G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1940 · Cited by 706

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

Wiel, C., Le Gal, K., Ibrahim, M. X., Jahangir, C. A., Kashif, M., Yao, H., Ziegler, D. V., Xu, X., Ghosh, T., Mondal, T., et al. (2019) · Cell · doi:10.1016/j.cell.2019.06.005 · Cited by 579

A FAM21-Containing WASH Complex Regulates Retromer-Dependent Sorting

Gomez, T. S., & Billadeau, D. D. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.09.009 · Cited by 521

The Subspine Organization of Actin Fibers Regulates the Structure and Plasticity of Dendritic Spines

Honkura, N., Matsuzaki, M., Noguchi, J., Ellis-Davies, G. C. R., & Kasai, H. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.013 · Cited by 490

Hypoxia: an alarm signal during intestinal inflammation

Colgan, S. P., & Taylor, C. T. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.39 · Cited by 461

The actin cytoskeleton: integrating form and function at the synapse

Dillon, C., & Goda, Y. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135757 · Cited by 447

Lamellipodial Versus Filopodial Mode of the Actin Nanomachinery

Mejillano, M. R., Kojima, S.-I., Applewhite, D. A., Gertler, F. B., Svitkina, T. M., & Borisy, G. G. (2004) · Cell · doi:10.1016/j.cell.2004.07.019 · Cited by 420

Molecular Architecture of Synaptic Actin Cytoskeleton in Hippocampal Neurons Reveals a Mechanism of Dendritic Spine Morphogenesis

Korobova, F., & Svitkina, T. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-07-0596 · Cited by 399

Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation

Mizuno, K. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2012.11.001 · Cited by 396

HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination

Boyault, C., Sadoul, K., Pabion, M., & Khochbin, S. (2007) · Oncogene · doi:10.1038/sj.onc.1210614 · Cited by 397

Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis

Hotulainen, P., Llano, O., Smirnov, S., Tanhuanpää, K., Faix, J., Rivera, C., & Lappalainen, P. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200809046 · Cited by 360

Endocytosis and signaling: Cell logistics shape the eukaryotic cell plan

Sigismund, S., Confalonieri, S., Ciliberto, A., Polo, S., Scita, G., & Di Fiore, P. P. (2012) · Physiological Reviews · doi:10.1152/physrev.00005.2011 · Cited by 338

Abi, Sra1, and Kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions

Kunda, P., Craig, G., Dominguez, V., & Baum, B. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.005 · Cited by 341

The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration

Suraneni, P., Rubinstein, B., Unruh, J. R., Durnin, M., Hanein, D., & Li, R. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201112113 · Cited by 337

Ins and outs of ADF/cofilin activity and regulation

Van Troys, M., Huyck, L., Leyman, S., Dhaese, S., Vandekerkhove, J., & Ampe, C. (2008) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2008.04.001 · Cited by 329

Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells

Walter, M., Liang, S., Ghosh, S., Hornsby, P. J., & Li, R. (2009) · Oncogene · doi:10.1038/onc.2009.130 · Cited by 312

mTORC2 controls actin polymerization required for consolidation of long-term memory

Huang, W., Zhu, P. J., Zhang, S., Zhou, H., Stoica, L., Galiano, M., Krnjević, K., Roman, G., & Costa-Mattioli, M. (2013) · Nature Neuroscience · doi:10.1038/nn.3351 · Cited by 307

Regulation of actin dynamics by WASP and WAVE family proteins

Stradal, T. E. B., Rottner, K., Disanza, A., Confalonieri, S., Innocenti, M., & Scita, G. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.04.007 · Cited by 286

Endocytic Internalization in Budding Yeast Requires Coordinated Actin Nucleation and Myosin Motor Activity

Sun, Y., Martin, A. C., & Drubin, D. G. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.05.008 · Cited by 255

Actin-binding proteins – a unifying hypothesis

Dominguez, R. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.09.004 · Cited by 242

The Exocyst at a Glance

Wu, B., & Guo, W. (2015) · Journal of Cell Science · doi:10.1242/jcs.156398 · Cited by 240

PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia

Oikawa, T., Yamaguchi, H., Itoh, T., Kato, M., Ijuin, T., Yamazaki, D., Suetsugu, S., & Takenawa, T. (2004) · Nature Cell Biology · doi:10.1038/ncb1125 · Cited by 224

Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3

Chai, X., Förster, E., Zhao, S., Bock, H. H., & Frotscher, M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2934-08.2009 · Cited by 202

WASH and the Arp2/3 complex regulate endosome shape and trafficking

Duleh, S. N., & Welch, M. D. (2010) · Cytoskeleton · doi:10.1002/cm.20437 · Cited by 207

Diverse functional roles of lipocalin-2 in the central nervous system

Jha, M. K., Lee, S., Park, D. H., Kook, H., Park, K.-G., Lee, I.-K., & Suk, K. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.006 · Cited by 195

Smooth Muscle α Actin (Acta2) and Myofibroblast Function during Hepatic Wound Healing

Rockey, D. C., Weymouth, N., & Shi, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077166 · Cited by 188

Integrins control motile strategy through a Rho–cofilin pathway

Danen, E. H. J., van Rheenen, J., Franken, W., Huveneers, S., Sonneveld, P., Jalink, K., & Sonnenberg, A. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412081 · Cited by 185

Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration

Jayatilaka, H., Tyle, P., Chen, J. J., Kwak, M., Ju, J., Kim, H. J., Lee, J. S. H., Wu, P.-H., Gilkes, D. M., Fan, R., et al. (2017) · Nature Communications · doi:10.1038/ncomms15584 · Cited by 177

Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATPchannel activation

Mirshamsi, S., Laidlaw, H. A., Ning, K., Anderson, E., Burgess, L. A., Gray, A., Sutherland, C., & Ashford, M. L. (2004) · BMC Neuroscience · doi:10.1186/1471-2202-5-54 · Cited by 173

Cofilin promotes stimulus-induced lamellipodium formation by generating an abundant supply of actin monomers

Kiuchi, T., Ohashi, K., Kurita, S., & Mizuno, K. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200610005 · Cited by 172

Organization of Actin Networks in Intact Filopodia

Medalia, O., Beck, M., Ecke, M., Weber, I., Neujahr, R., Baumeister, W., & Gerisch, G. (2007) · Current Biology · doi:10.1016/j.cub.2006.11.022 · Cited by 170

Genetics of primary sclerosing cholangitis and pathophysiological implications

Jiang, X., & Karlsen, T. H. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.154 · Cited by 155

Mechanisms of nuclear actin in chromatin-remodeling complexes

Kapoor, P., & Shen, X. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.10.007 · Cited by 137

Actin mediates the nanoscale membrane organization of the clustered membrane protein influenza hemagglutinin

Gudheti, M. V., Curthoys, N. M., Gould, T. J., Kim, D., Gunewardene, M. S., Gabor, K. A., Gosse, J. A., Kim, C. H., Zimmerberg, J., & Hess, S. T. (2013) · Biophysical Journal · doi:10.1016/j.bpj.2013.03.054 · Cited by 106

MEDYAN: mechanochemical simulations of contraction and polarity alignment in actomyosin networks

Popov, K., Komianos, J., & Papoian, G. A. (2016) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1004877 · Cited by 104

The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer

Khan, M. W., Saadalla, A., Ewida, A. H., Al-Katranji, K., Al-Saoudi, G., Giaccone, Z. T., Gounari, F., Zhang, M., Frank, D. A., & Khazaie, K. (2018) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-017-2057-0 · Cited by 103

Regulation of N-WASP and the Arp2/3 Complex by Abp1 Controls Neuronal Morphology

Pinyol, R., Haeckel, A., Ritter, A., Qualmann, B., & Kessels, M. M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000400 · Cited by 96

Origin, Organization, Dynamics, and Function of Actin and Actomyosin Networks at the T Cell Immunological Synapse

Hammer, J. A., Wang, J. C., Saeed, M., & Pedrosa, A. T. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041341 · Cited by 96

Lymphocyte Chemotaxis Is Regulated by Histone Deacetylase 6, Independently of Its Deacetylase Activity

Cabrero, J. R., Serrador, J. M., Barreiro, O., Mittelbrunn, M., Naranjo-Suárez, S., Martín-Cófreces, N., Vicente-Manzanares, M., Mazitschek, R., Bradner, J. E., Ávila, J., et al. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-01-0008 · Cited by 95

Rapid Signaling of Estrogen to WAVE1 and Moesin Controls Neuronal Spine Formation via the Actin Cytoskeleton

Sanchez, A. M., Flamini, M. I., Fu, X.-D., Mannella, P., Giretti, M. S., Goglia, L., Genazzani, A. R., & Simoncini, T. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0408 · Cited by 86

Correlation between liver metastasis of the colocalization of actin–related protein 2 and 3 complex and WAVE2 in colorectal carcinoma

Iwaya, K., Oikawa, K., Semba, S., Tsuchiya, B., Mukai, Y., Otsubo, T., Nagao, T., Izumi, M., Kuroda, M., Domoto, H., et al. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00488.x · Cited by 82

Arp2/3 complex inhibition radically alters lamellipodial actin architecture, suspended cell shape, and the cell spreading process

Henson, J. H., Yeterian, M., Weeks, R. M., Medrano, A. E., Brown, B. L., Geist, H. L., Pais, M. D., Oldenbourg, R., & Shuster, C. B. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-07-1244 · Cited by 81

RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration

Goldfinger, L. E., Ptak, C., Jeffery, E. D., Shabanowitz, J., Hunt, D. F., & Ginsberg, M. H. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200603111 · Cited by 78

Creatine kinase-mediated ATP supply fuels actin-based events in phagocytosis

Kuiper, J. W. P., Pluk, H., Oerlemans, F., van Leeuwen, F. N., de Lange, F., Fransen, J., & Wieringa, B. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060051 · Cited by 75

MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression

Kpetemey, M., Dasgupta, S., Rajendiran, S., Das, S., Gibbs, L. D., Shetty, P., Gryczynski, Z., & Vishwanatha, J. K. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0428-8 · Cited by 68

Spatial coordination of actin polymerization and ILK–Akt2 activity during endothelial cell migration.

Fan, Y., Gong, Y., Ghosh, P. K., Graham, L. M., & Fox, P. L. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.03.009 · Cited by 68

Essential role for Abi1 in embryonic survival and WAVE2 complex integrity

Dubielecka, P. M., Ladwein, K. I., Xiong, X., Migeotte, I., Chorzalska, A., Anderson, K. V., Sawicki, J. A., Rottner, K., Stradal, T. E., & Kotula, L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016811108 · Cited by 66

Study on Invadopodia Formation for Lung Carcinoma Invasion with a Microfluidic 3D Culture Device

Wang, S., Li, E., Gao, Y., Wang, Y., Guo, Z., He, J., Zhang, J., Gao, Z., & Wang, Q. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056448 · Cited by 65

Dock4 regulates dendritic development in hippocampal neurons.

Ueda, S., Fujimoto, S., Hiramoto, K., Negishi, M., & Katoh, H. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21763 · Cited by 61

When Actin is Not Actin’ Like It Should: A New Category of Distinct Primary Immunodeficiency Disorders

Sprenkeler, E. G. G., Webbers, S. D. S., & Kuijpers, T. W. (2021) · Journal of Innate Immunity · doi:10.1159/000509717 · Cited by 54

Perspectives in Lipocalin-2: Emerging Biomarker for Medical Diagnosis and Prognosis for Alzheimer's Disease

Song, J., & Kim, O. Y. (2018) · Clinical Nutrition Research · doi:10.7762/cnr.2018.7.1.1 · Cited by 53

Dynamic Microenvironment Induces Phenotypic Plasticity of Esophageal Cancer Cells Under Flow

Calibasi Kocal, G., Güven, S., Foygel, K., Goldman, A., Chen, P., Sengupta, S., Paulmurugan, R., Baskin, Y., & Demirci, U. (2016) · Scientific Reports · doi:10.1038/srep38221 · Cited by 52

Neuropeptides as neuroprotective agents: oxytocin a forefront developmental player in the mammalian brain

Vargas-Martínez, F., Uvnäs-Moberg, K., Petersson, M., Olausson, H. A., & Jiménez-Estrada, I. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.10.001 · Cited by 51

Effect of WAVE2 Phosphorylation on Activation of the Arp2/3 Complex

Nakanishi, O., Suetsugu, S., Yamazaki, D., & Takenawa, T. (2006) · Journal of Biochemistry · doi:10.1093/jb/mvm034 · Cited by 50

AMPA-receptor activation regulates the diffusion of a membrane marker in parallel with dendritic spine motility in the mouse hippocampus

Richards, D. A., De Paola, V., Caroni, P., Gähwiler, B. H., & McKinney, R. A. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.062091 · Cited by 49

Phagocyte meets prey: Uptake, internalization, and killing of bacteria by Dictyostelium amoebae

Clarke, M., & Maddera, L. (2006) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2006.05.004 · Cited by 48

Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies

Sarowar, T., & Grabrucker, A. M. (2016) · Neural Plasticity · doi:10.1155/2016/8051861 · Cited by 46

Proteomic identification of specifically carbonylated brain proteins in APPNLh/APPNLh×PS-1P264L/PS-1P264L human double mutant knock-in mice model of Alzheimer disease as a function of age

Sultana, R., Robinson, R. A. S., Di Domenico, F., Abdul, H. M., Clair, D. K. S., Markesbery, W. R., Cai, J., Pierce, W. M., & Butterfield, D. A. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.06.015 · Cited by 41

Denbinobin, a Phenanthrene from Dendrobium nobile, Impairs Prostate Cancer Migration by Inhibiting Rac1 Activity

Lu, T.-L., Han, C.-K., Chang, Y.-S., Lu, T.-J., Huang, H.-C., Bao, B.-Y., Wu, H.-Y., Huang, C.-H., Li, C.-Y., & Wu, T.-S. (2014) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x14500967 · Cited by 37

Role of Cofilin in Alzheimer’s Disease

Wang, Q., Yuan, W., Yang, X., Wang, Y., Li, Y., & Qiao, H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.584898 · Cited by 35

The Uncoupling of the Effects of Formins on the Local and Global Dynamics of Actin Filaments

Kupi, T., Gróf, P., Nyitrai, M., & Belágyi, J. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.11.058 · Cited by 19

RhoA/Rock2/Limk1/cofilin1 pathway is involved in attenuation of neuronal dendritic spine loss by paeonol in the frontal cortex of D-galactose and aluminum-induced Alzheimer’s disease-like rat model

Han, F., Xu, H., Shen, J.-X., Pan, C., Yu, Z.-H., Chen, J.-J., Zhu, X.-L., Cai, Y.-F., & Lu, Y.-P. (2020) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2020-021 · Cited by 18

Intellectual Disability and Behavioral Deficits Linked to CYFIP1 Missense Variants Disrupting Actin Polymerization

Mariano, V., Kanellopoulos, A. K., Ricci, C., Di Marino, D., Borrie, S. C., Dupraz, S., Bradke, F., Achsel, T., Legius, E., Odent, S., et al. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.08.027 · Cited by 14