The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Time Trends and the Influence of Age and Gender on Serum Concentrations of Perfluorinated Compounds in Archived Human Samples
Abstract
Fifty-seven pooled archived human serum samples were analyzed to assess the time trends as well as influence of age and gender on selected perfluorinated compounds (PFCs) in Norwegian residents. The study comprised determinations of 19 PFCs in serum samples pooled according to year of collection from 28 years in the period 1976 to 2007. A 9-fold increase in the serum concentrations of perfluorooctyl sulfonate, perfluorooctanoic acid, and perfluoroheptyl sulfonate was measured for men (40-50 years) from 1977 to the mid 1990s where the concentrations reached a plateau before starting to decrease around year 2000. A similar trend was also seen for perfluorohexyl sulfonate, perfluorononanoic acid, perfluorodecanoic acid, and perfluoroundecanoic acid, but no clear decline was observed for these PFCs in the recent years. No statistically significant difference was observed between the PFC levels in the male and female serum pools, though the statistical power is low due to few data points. For most PFCs, the concentrations in the human serum samples were found to increase with age in the pools from 2007, while the results for 1976, 1987, and 1998 were more varying. Several PFCs were significantly intercorrelated.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings
Lau, C., Anitole, K., Hodes, C., Lai, D., Pfahles-Hutchens, A., & Seed, J. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm128 · Cited by 2,620
Olsen, G. W., Burris, J. M., Ehresman, D. J., Froehlich, J. W., Seacat, A. M., Butenhoff, J. L., & Zobel, L. R. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10009 · Cited by 2,049
Calafat, A. M., Wong, L.-Y., Kuklenyik, Z., Reidy, J. A., & Needham, L. L. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10598 · Cited by 1,247
Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries
Kannan, K., Corsolini, S., Falandysz, J., Fillmann, G., Kumar, K. S., Loganathan, B. G., Mohd, M. A., Olivero, J., Wouwe, N. V., Yang, J. H., et al. (2004) · Environmental Science & Technology · doi:10.1021/es0493446 · Cited by 1,056
Estimating Consumer Exposure to PFOS and PFOA
Trudel, D., Horowitz, L., Wormuth, M., Scheringer, M., Cousins, I. T., & Hungerbühler, K. (2008) · Risk Analysis · doi:10.1111/j.1539-6924.2008.01017.x · Cited by 514
Olsen, G. W., Mair, D. C., Church, T. R., Ellefson, M. E., Reagen, W. K., Boyd, T. M., Herron, R. M., Medhdizadehkashi, Z., Nobiletti, J. B., Rios, J. A., et al. (2008) · Environmental Science & Technology · doi:10.1021/es800071x · Cited by 244
Cited by
Sunderland, E. M., Hu, X. C., Dassuncao, C., Tokranov, A. K., Wagner, C. C., & Allen, J. G. (2019) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-018-0094-1 · Cited by 2,786
Polyfluorinated Compounds: Past, Present, and Future
Lindstrom, A. B., Strynar, M. J., & Libelo, E. L. (2011) · Environmental Science & Technology · doi:10.1021/es2011622 · Cited by 1,628
Risk to human health related to the presence of perfluoroalkyl substances in food
Panel), E. P. O. C. I. T. F. C. (. C., Schrenk, D., Bignami, M., Bodin, L., Chipman, J. K., del Mazo, J., Grasl‐Kraupp, B., Hogstrand, C., Hoogenboom, L. (., Leblanc, J., et al. (2020) · EFSA Journal · doi:10.2903/j.efsa.2020.6223 · Cited by 989
Self-citationTrends in Exposure to Polyfluoroalkyl Chemicals in the U.S. Population: 1999−2008
Kato, K., Wong, L.-Y., Jia, L. T., Kuklenyik, Z., & Calafat, A. M. (2011) · Environmental Science & Technology · doi:10.1021/es1043613 · Cited by 777
Accumulation of perfluoroalkyl substances in human tissues
Pérez, F., Nadal, M., Navarro-Ortega, A., Fàbrega, F., Domingo, J. L., Barceló, D., & Farré, M. (2013) · Environment International · doi:10.1016/j.envint.2013.06.004 · Cited by 730
Post, G. B., Cohn, P. D., & Cooper, K. R. (2012) · Environmental Research · doi:10.1016/j.envres.2012.03.007 · Cited by 639
Glynn, A., Berger, U., Bignert, A., Ullah, S., Aune, M., Lignell, S., & Darnerud, P. O. (2012) · Environmental Science & Technology · doi:10.1021/es301168c · Cited by 417
Haug, L. S., Huber, S., Becher, G., & Thomsen, C. (2011) · Environment International · doi:10.1016/j.envint.2011.01.011 · Cited by 391
Self-citationBrase, R. A., Mullin, E. J., & Spink, D. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22030995 · Cited by 374
Halldorsson, T. I., Rytter, D., Haug, L. S., Bech, B. H., Danielsen, I., Becher, G., Henriksen, T. B., & Olsen, S. F. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104034 · Cited by 353
Self-citationGranum, B., Haug, L. S., Namork, E., Stølevik, S. B., Thomsen, C., Aaberge, I. S., van Loveren, H., Løvik, M., & Nygaard, U. C. (2013) · Journal of Immunotoxicology · doi:10.3109/1547691x.2012.755580 · Cited by 339
Self-citationMartin, J. W., Asher, B. J., Beesoon, S., Benskin, J. P., & Ross, M. S. (2010) · Journal of Environmental Monitoring · doi:10.1039/c0em00295j · Cited by 311
Per- and polyfluorinated substances (PFASs): Environmental challenges
Krafft, M. P., & Riess, J. G. (2015) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2015.07.004 · Cited by 294
Blake, B. E., Pinney, S. M., Hines, E. P., Fenton, S. E., & Ferguson, K. K. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.07.042 · Cited by 236
Land, M., de Wit, C. A., Bignert, A., Cousins, I. T., Herzke, D., Johansson, J. H., & Martin, J. W. (2018) · Environmental Evidence · doi:10.1186/s13750-017-0114-y · Cited by 219
“The two datasets showing an increasing trend prior to the change point were also the datasets with the oldest archived samples; showing an increasing trend in adult male serum from Norway between 1978 and 1993 [92] and in primiparous female serum from Stockholm, Sweden between 1972 and 1988 [137].”
InfluentialWong, F., MacLeod, M., Mueller, J. F., & Cousins, I. T. (2014) · Environmental Science & Technology · doi:10.1021/es500796y · Cited by 220
Vierke, L., Staude, C., Biegel-Engler, A., Drost, W., & Schulte, C. (2012) · Environmental Sciences Europe · doi:10.1186/2190-4715-24-16 · Cited by 222
Dietary exposure to perfluoroalkyl acids for the Swedish population in 1999, 2005 and 2010
Vestergren, R., Berger, U., Glynn, A., & Cousins, I. T. (2012) · Environment International · doi:10.1016/j.envint.2012.08.016 · Cited by 213
Neurotoxic Effects of Perfluoroalkylated Compounds: Mechanisms of Action and Environmental Relevance
Mariussen, E. (2012) · Archives of Toxicology · doi:10.1007/s00204-012-0822-6 · Cited by 204
D’eon, J. C., & Mabury, S. A. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1002409 · Cited by 193
Dietary Habits Related to Food Packaging and Population Exposure to PFASs
Susmann, H. P., Schaider, L. A., Rodgers, K. M., & Rudel, R. A. (2019) · Environmental Health Perspectives · doi:10.1289/ehp4092 · Cited by 165
Fujii, Y., Harada, K. H., & Koizumi, A. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.06.049 · Cited by 162
Eriksson, U., & Kärrman, A. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b00679 · Cited by 159
Global transport of perfluoroalkyl acids via sea spray aerosol
Johansson, J. H., Salter, M. E., Acosta Navarro, J. C., Leck, C., Nilsson, E. D., & Cousins, I. T. (2019) · Environmental Science: Processes & Impacts · doi:10.1039/c8em00525g · Cited by 158
Borg, D., Lund, B.-O., Lindquist, N.-G., & Håkansson, H. (2013) · Environment International · doi:10.1016/j.envint.2013.05.009 · Cited by 155
Lee, H., & Mabury, S. A. (2011) · Environmental Science & Technology · doi:10.1021/es200167q · Cited by 153
Early life exposure to per- and polyfluoroalkyl substances (PFASs): a critical review
Winkens, K., Vestergren, R., Berger, U., & Cousins, I. T. (2017) · Emerging Contaminants · doi:10.1016/j.emcon.2017.05.001 · Cited by 145
Distribution and desorption of perfluorinated compounds in fractionated sediments
Zhao, L., Zhu, L., Yang, L., Liu, Z., & Zhang, Y. (2012) · Chemosphere · doi:10.1016/j.chemosphere.2012.05.062 · Cited by 118
Dassuncao, C., Hu, X. C., Nielsen, F., Weihe, P., Grandjean, P., & Sunderland, E. M. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.7b06044 · Cited by 110
Loi, E. I. H., Yeung, L. W. Y., Mabury, S. A., & Lam, P. K. S. (2013) · Environmental Science & Technology · doi:10.1021/es303805k · Cited by 108
Are humans exposed to increasing amounts of unidentified organofluorine?
Yeung, L. W. Y., & Mabury, S. A. (2016) · Environmental Chemistry · doi:10.1071/en15041 · Cited by 107
Chen, N., Li, J., Li, D., Yang, Y., & He, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113453 · Cited by 105
Yeung, L. W. Y., Robinson, S. J., Koschorreck, J., & Mabury, S. A. (2013) · Environmental Science & Technology · doi:10.1021/es4004153 · Cited by 102
Spulber, S., Kilian, P., Wan Ibrahim, W. N., Onishchenko, N., Ulhaq, M., Norrgren, L., Negri, S., Di Tuccio, M., & Ceccatelli, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094227 · Cited by 98
Eryasa, B., Grandjean, P., Nielsen, F., Valvi, D., Zmirou-Navier, D., Sunderland, E., Weihe, P., & Oulhote, Y. (2019) · Environment International · doi:10.1016/j.envint.2019.05.068 · Cited by 98
Chou, W.-C., & Lin, Z. (2019) · Environment International · doi:10.1016/j.envint.2019.03.058 · Cited by 98
Rand, A. A., & Mabury, S. A. (2017) · Toxicology · doi:10.1016/j.tox.2016.11.011 · Cited by 92
Zhou, W., Zhao, S., Tong, C., Chen, L., Yu, X., Yuan, T., Aimuzi, R., Luo, F., Tian, Y., & Zhang, J. (2019) · Environment International · doi:10.1016/j.envint.2019.03.075 · Cited by 92
Case–control study on perfluorinated alkyl acids (PFAAs) and the risk of prostate cancer
Hardell, E., Kärrman, A., van Bavel, B., Bao, J., Carlberg, M., & Hardell, L. (2014) · Environment International · doi:10.1016/j.envint.2013.10.005 · Cited by 80
Harada, K. H., Hitomi, T., Niisoe, T., Takanaka, K., Kamiyama, S., Watanabe, T., Moon, C.-S., Yang, H.-R., Hung, N. N., & Koizumi, A. (2011) · Environment International · doi:10.1016/j.envint.2011.04.011 · Cited by 78
Borg, D., Bogdanska, J., Sundström, M., Nobel, S., Håkansson, H., Bergman, Å., DePierre, J. W., Halldin, K., & Bergström, U. (2010) · Reproductive Toxicology · doi:10.1016/j.reprotox.2010.07.004 · Cited by 76
Liu, X., Guo, Z., Krebs, K. A., Pope, R. H., & Roache, N. F. (2014) · Chemosphere · doi:10.1016/j.chemosphere.2013.10.001 · Cited by 71
Inconsistencies in the EU regulatory risk assessment of PFAS call for readjustment
Reinikainen, J., Bouhoulle, E., & Sorvari, J. (2024) · Environment International · doi:10.1016/j.envint.2024.108614 · Cited by 72
Ames, J. L., Sharma, V., & Lyall, K. (2025) · Current Environmental Health Reports · doi:10.1007/s40572-024-00464-5 · Cited by 68
Rand, A. A., Rooney, J. P., Butt, C. M., Meyer, J. N., & Mabury, S. A. (2014) · Chemical Research in Toxicology · doi:10.1021/tx400317p · Cited by 64
Gao, K., Fu, J., Xue, Q., Li, Y., Liang, Y., Pan, Y., Zhang, A., & Jiang, G. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.10.038 · Cited by 53
Zhu, Y., Pan, X., Jia, Y., Yang, X., Song, X., Ding, J., Zhong, W., Feng, J., & Zhu, L. (2023) · Environmental Health Perspectives · doi:10.1289/ehp11969 · Cited by 49
An automated high-throughput SPE micro-elution method for perfluoroalkyl substances in human serum
Huber, S., & Brox, J. (2015) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-015-8601-x · Cited by 46
Liu, Y., Pereira, A. S., Beesoon, S., Vestergren, R., Berger, U., Olsen, G. W., Glynn, A., & Martin, J. W. (2015) · Environment International · doi:10.1016/j.envint.2014.11.014 · Cited by 45
Gribble, M. O., Bartell, S. M., Kannan, K., Wu, Q., Fair, P. A., & Kamen, D. L. (2015) · Environmental Research · doi:10.1016/j.envres.2015.03.012 · Cited by 43
Minet, L., Wang, Z., Shalin, A., Bruton, T. A., Blum, A., Peaslee, G. F., Schwartz-Narbonne, H., Venier, M., Whitehead, H., Wu, Y., et al. (2022) · Environmental Science: Processes & Impacts · doi:10.1039/d2em00166g · Cited by 43
Fang, X., Gao, G., Xue, H., Zhang, X., & Wang, H. (2012) · Toxicology · doi:10.1016/j.tox.2012.02.008 · Cited by 43
Rand, A. A., & Mabury, S. A. (2013) · Environmental Science & Technology · doi:10.1021/es303760u · Cited by 34
Berg, V., Sandanger, T. M., Hanssen, L., Rylander, C., & Nøst, T. H. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-13809-6 · Cited by 29
“Overall, the observed PFAS concentrations in our study sample are in line with the concentration ranges of PFASs in the period 1986–2007 reported for both women and men by other studies from overlapping sampling periods (Berg et al. 2014; Eriksson et al. 2017; Haug et al. 2009; Jain 2018; Kato et al. 2011; Nøst et al.…”
BackgroundResultInfluentialForthun, I. H., Roelants, M., Haug, L. S., Knutsen, H. K., Schell, L. M., Jugessur, A., Bjerknes, R., Sabaredzovic, A., Bruserud, I. S., & Juliusson, P. B. (2023) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2023.114199 · Cited by 26
Self-citationRatier, A., Casas, M., Grazuleviciene, R., Slama, R., Småstuen Haug, L., Thomsen, C., Vafeiadi, M., Wright, J., Zeman, F. A., Vrijheid, M., et al. (2024) · Environment International · doi:10.1016/j.envint.2024.108621 · Cited by 16
Self-citation
Metadata
- Authors
- Haug, L. S., Thomsen, C., & Becher, G.
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-02-06
- Volume
- 43
- Issue
- 6
- Pages
- 2131-2136
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W2091501679
- Cited by
- 301
- References
- 6
- FWCI
- 22.05
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
