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Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

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Energy metabolism in uncoupling protein 3 gene knockout mice

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Mitochondrial Uncoupling: Role of Uncoupling Protein Anion Carriers and Relationship to Thermogenesis and Weight Control “The Benefits of Losing Control”

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ROS function in redox signaling and oxidative stress

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Brown Adipose Tissue: Function and Physiological Significance

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ROS Are Good

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Physiological Roles of Mitochondrial Reactive Oxygen Species

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Obesity and the regulation of energy balance

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Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

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Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α (PGC-1α): Transcriptional Coactivator and Metabolic Regulator

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Tlr signalling augments macrophage bactericidal activity through mitochondrial ros

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Superoxide activates mitochondrial uncoupling proteins

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Mitochondria in innate immune responses

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Mitochondrial ROS Signaling in Organismal Homeostasis

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Role of Mitochondrial Dysfunction in Insulin Resistance

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Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins

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TNF and ROS crosstalk in inflammation

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Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction, and type 2 diabetes.

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Calorie restriction–the SIR2 connection

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Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3

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Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

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Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

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Thermogenic Mechanisms and Their Hormonal Regulation

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Mitochondrial uncoupling, ROS generation and cardioprotection

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Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma

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Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold

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UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation

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Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets

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Superoxide Activates Mitochondrial Uncoupling Protein 2 from the Matrix Side

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Mitochondria as a Cellular Hub in Infection and Inflammation

Andrieux, P., Chevillard, C., Cunha-Neto, E., & Nunes, J. P. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111338 · Cited by 346

Uncoupling Protein-2 Overexpression Inhibits Mitochondrial Death Pathway in Cardiomyocytes

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Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction

Krauss, S., Zhang, C.-Y., Scorrano, L., Dalgaard, L. T., St-Pierre, J., Grey, S. T., & Lowell, B. B. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319774 · Cited by 401

Mitochondria, oxygen free radicals, and apoptosis

Raha, S., & Robinson, B. H. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1398 · Cited by 306

Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity

Caldeira da Silva, C. C., Cerqueira, F. M., Barbosa, L. F., Medeiros, M. H. G., & Kowaltowski, A. J. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00407.x · Cited by 306

A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2

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AMPK, Mitochondrial Function, and Cardiovascular Disease

Wu, S., & Zou, M.-H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144987 · Cited by 286

Kinases mst1 and mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity

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Microglial UCP2 mediates inflammation and obesity induced by high-fat feeding

Kim, J. D., Yoon, N. A., Jin, S., & Diano, S. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.08.010 · Cited by 240

Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet

Joseph, J. W., Koshkin, V., Zhang, C.-Y., Wang, J., Lowell, B. B., Chan, C. B., & Wheeler, M. B. (2002) · Diabetes · doi:10.2337/diabetes.51.11.3211 · Cited by 220

Physiological Increases in Uncoupling Protein 3 Augment Fatty Acid Oxidation and Decrease Reactive Oxygen Species Production Without Uncoupling Respiration in Muscle Cells

MacLellan, J. D., Gerrits, M. F., Gowing, A., Smith, P. J. S., Wheeler, M. B., & Harper, M.-E. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2343 · Cited by 213

Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization

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UCP1 deficiency increases susceptibility to diet‐induced obesity with age

Kontani, Y., Wang, Y., Kimura, K., Inokuma, K. ‐., Saito, M., Suzuki‐Miura, T., Wang, Z., Sato, Y., Mori, N., & Yamashita, H. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00157.x · Cited by 207

Free Fatty Acid-induced β-Cell Defects Are Dependent on Uncoupling Protein 2 Expression

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NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: A bipartisan affair?

Bordt, E. A., & Polster, B. M. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.07.033 · Cited by 202

Uncoupling Protein-2 Is Critical for Nigral Dopamine Cell Survival in a Mouse Model of Parkinson's Disease

Andrews, Z. B., Horvath, B., Barnstable, C. J., Elseworth, J., Yang, L., Beal, M. F., Roth, R. H., Matthews, R. T., & Horvath, T. L. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4269-04.2005 · Cited by 199

Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3

BRAND, M. D., PAMPLONA, R., PORTERO-OTÍN, M., REQUENA, J. R., ROEBUCK, S. J., BUCKINGHAM, J. A., CLAPHAM, J. C., & CADENAS, S. (2002) · Biochemical Journal · doi:10.1042/bj20021077 · Cited by 184

The thermogenic effect of thyroid hormone and its clinical implications

Silva, J. E. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-3-200308050-00010 · Cited by 173

Vitamin A and the regulation of fat reserves

Bonet, M. L., Ribot, J., Felipe, F., & Palou, A. (2003) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-003-2290-x · Cited by 174

Mitochondrial uncoupling and lifespan

Mookerjee, S. A., Divakaruni, A. S., Jastroch, M., & Brand, M. D. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.03.010 · Cited by 169

Mitochondrial Proton Leak Plays a Critical Role in Pathogenesis of Cardiovascular Diseases

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Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic β-cell function.

Pi, J., Bai, Y., Daniel, K. W., Liu, D., Lyght, O., Edelstein, D., Brownlee, M., Corkey, B. E., & Collins, S. (2009) · Endocrinology · doi:10.1210/en.2008-1642 · Cited by 163

No Evidence for a Basal, Retinoic, or Superoxide-induced Uncoupling Activity of the Uncoupling Protein 2 Present in Spleen or Lung Mitochondria

Couplan, E., del Mar Gonzalez-Barroso, M., Alves-Guerra, M. C., Ricquier, D., Goubern, M., & Bouillaud, F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202535200 · Cited by 161

Expression modification of uncoupling proteins and MnSOD in retinal endothelial cells and pericytes induced by high glucose: The role of reactive oxygen species in diabetic retinopathy

Cui, Y., Xu, X., Bi, H., Zhu, Q., Wu, J., Xia, X., Ren, Q., & Ho, P. C. P. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2006.03.024 · Cited by 159

UCP2, not a physiologically relevant uncoupler but a glucose sparing switch impacting ROS production and glucose sensing

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The regulation and turnover of mitochondrial uncoupling proteins

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Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog

Masuda, Y., Haramizu, S., Oki, K., Ohnuki, K., Watanabe, T., Yazawa, S., Kawada, T., Hashizume, S.-I., & Fushiki, T. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00828.2002 · Cited by 143

β-Cell Uncoupling Protein 2 Regulates Reactive Oxygen Species Production, Which Influences Both Insulin and Glucagon Secretion

Robson-Doucette, C. A., Sultan, S., Allister, E. M., Wikstrom, J. D., Koshkin, V., Bhattacharjee, A., Prentice, K. J., Sereda, S. B., Shirihai, O. S., & Wheeler, M. B. (2011) · Diabetes · doi:10.2337/db11-0132 · Cited by 136

Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3

Talbot, D. A., Lambert, A. J., & Brand, M. D. (2004) · FEBS Letters · doi:10.1016/s0014-5793(03)01386-3 · Cited by 131

Decreased Mitochondrial Proton Leak and Reduced Expression of Uncoupling Protein 3 in Skeletal Muscle of Obese Diet-Resistant Women

Harper, M.-E., Dent, R., Monemdjou, S., Bézaire, V., Van Wyck, L., Wells, G., Kavaslar, G. N., Gauthier, A., Tesson, F., & McPherson, R. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2459 · Cited by 129

The efficiency of cellular energy transduction and its implications for obesity

Harper, M.-E., Green, K., & Brand, M. D. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155357 · Cited by 121

Timing of nutrient restriction and programming of fetal adipose tissue development

Symonds, M. E., Pearce, S., Bispham, J., Gardner, D. S., & Stephenson, T. (2004) · Proceedings of the Nutrition Society · doi:10.1079/pns2004366 · Cited by 121

The uncoupling protein 2 modulates the cytokine balance in innate immunity☆

ROUSSET, S., EMRE, Y., JOINLAMBERT, O., HURTAUD, C., RICQUIER, D., & CASSARDDOULCIER, A. (2006) · Cytokine · doi:10.1016/j.cyto.2006.07.012 · Cited by 114

Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels

De Bilbao, F., Arsenijevic, D., Vallet, P., Hjelle, O. P., Ottersen, O. P., Bouras, C., Raffin, Y., Abou, K., Langhans, W., Collins, S., et al. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02432.x · Cited by 108

Physiological Levels of Mammalian Uncoupling Protein 2 Do Not Uncouple Yeast Mitochondria

Stuart, J. A., Harper, J. A., Brindle, K. M., Jekabsons, M. B., & Brand, M. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011566200 · Cited by 99

Metformin induces oxidative stress in white adipocytes and raises uncoupling protein 2 levels

Anedda, A., Rial, E., & González-Barroso, M. M. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0278 · Cited by 98

Peroxisome proliferator-activated receptor δ promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage

Lee, C.-H., Kang, K., Mehl, I. R., Nofsinger, R., Alaynick, W. A., Chong, L.-W., Rosenfeld, J. M., & Evans, R. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510815103 · Cited by 98

Coenzyme Q10 Depletion in Medical and Neuropsychiatric Disorders: Potential Repercussions and Therapeutic Implications

Morris, G., Anderson, G., Berk, M., & Maes, M. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8477-8 · Cited by 96

Reactive oxygen species and uncoupling protein 2 in pancreatic β ‐cell function

Pi, J., & Collins, S. (2010) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01269.x · Cited by 91

Mitochondrial recoupling: a novel therapeutic strategy for cancer

Baffy, G., Derdak, Z., & Robson, S. C. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.245 · Cited by 88

Potassium channel openers are uncoupling protonophores: implication in cardioprotection

Holmuhamedov, E. L., Jahangir, A., Oberlin, A., Komarov, A., Colombini, M., & Terzic, A. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.05.031 · Cited by 90

Overexpression of plant uncoupling mitochondrial protein in transgenic tobacco increases tolerance to oxidative stress

Brandalise, M., Maia, I. G., Borecký, J., Vercesi, A. E., & Arruda, P. (2003) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1024603530043 · Cited by 76

Uncoupling Proteins: Role in Insulin Resistance and Insulin Insufficiency

B.Chan, C., & Harper, M.-E. (2006) · Current Diabetes Reviews · doi:10.2174/157339906777950660 · Cited by 71

Stanniocalcin-1 ameliorates lipopolysaccharide-induced pulmonary oxidative stress, inflammation, and apoptosis in mice

Tang, S.-E., Wu, C.-P., Wu, S.-Y., Peng, C.-K., Perng, W.-C., Kang, B.-H., Chu, S.-J., & Huang, K.-L. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.03.034 · Cited by 70

Mitochondrial ros potentiates indirect activation of the aim2 inflammasome

Crane, D. D., Bauler, T. J., Wehrly, T. D., & Bosio, C. M. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00438 · Cited by 63

Stable transfection of UCP1 confers resistance to hypoxia/reoxygenation in a heart-derived cell line

Bienengraeber, M. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00147-0 · Cited by 62

Respiratory uncoupling by UCP1 and UCP2 and superoxide generation in endothelial cell mitochondria

Fink, B. D., Reszka, K. J., Herlein, J. A., Mathahs, M. M., & Sivitz, W. I. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00332.2004 · Cited by 53

Expression of UCP3 in CHO cells does not cause uncoupling, but controls mitochondrial activity in the presence of glucose

Mozo, J., Ferry, G., Studeny, A., Pecqueur, C., Rodriguez, M., Boutin, J. A., & Bouillaud, F. (2006) · Biochemical Journal · doi:10.1042/bj20050494 · Cited by 52

The mtDNA nt7778 G/T polymorphism affects autoimmune diseases and reproductive performance in the mouse

Yu, X., Wester-Rosenlöf, L., Gimsa, U., Holzhueter, S.-A., Marques, A., Jonas, L., Hagenow, K., Kunz, M., Nizze, H., Tiedge, M., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp432 · Cited by 47

Mitochondrial Dysfunction in Aged Macrophages and Lung during Primary Streptococcus pneumoniae Infection is Improved with Pirfenidone

Plataki, M., Cho, S. J., Harris, R. M., Huang, H.-R., Yun, H. S., Schiffer, K. T., & Stout-Delgado, H. W. (2019) · Scientific Reports · doi:10.1038/s41598-018-37438-1 · Cited by 42

Impaired Expression of Uncoupling Protein 2 Causes Defective Postischemic Angiogenesis in Mice Deficient in AMP-Activated Protein Kinase α Subunits

Xu, M.-J., Song, P., Shirwany, N., Liang, B., Xing, J., Viollet, B., Wang, X., Zhu, Y., & Zou, M.-H. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.227991 · Cited by 39

The emerging neuroprotective role of mitochondrial uncoupling protein-2 in traumatic brain injury

Normoyle, K. P., Kim, M., Farahvar, A., Llano, D., Jackson, K., & Wang, H. (2015) · Translational Neuroscience · doi:10.1515/tnsci-2015-0019 · Cited by 36

Genetic variants in nuclear-encoded mitochondrial proteins are associated with oxidative stress in obsessive compulsive disorders

Orhan, N., Kucukali, C. I., Cakir, U., Seker, N., & Aydin, M. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.09.012 · Cited by 36

Uncoupling protein 2 in the glial response to stress: Implications for neuroprotection

Barnstable, C., & Hass, D. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.189159 · Cited by 33

The UCP2-866G/A Polymorphism Could be Considered as a Genetic Marker of Different Functional Prognosis in Ischemic Stroke after Recanalization

Díaz-Maroto Cicuéndez, I., Fernández-Díaz, E., García-García, J., Jordán, J., Fernández-Cadenas, I., Montaner, J., Serrano-Heras, G., & Segura, T. (2017) · NeuroMolecular Medicine · doi:10.1007/s12017-017-8470-x · Cited by 12