Cited by 985Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 357 of the 359 references it cites were found in a registry or an index.

Cortico-Basal Ganglia Reward Network: Microcircuitry

Open access

Sesack, Susan R, Grace, Anthony A·2010·Neuropsychopharmacology

DOI 10.1038/npp.2009.93PMC PMC2879005

Open this paper in CoChat — free account Open PDF

Abstract

Many of the brain's reward systems converge on the nucleus accumbens, a region richly innervated by excitatory, inhibitory, and modulatory afferents representing the circuitry necessary for selecting adaptive motivated behaviors. The ventral subiculum of the hippocampus provides contextual and spatial information, the basolateral amygdala conveys affective influence, and the prefrontal cortex provides an integrative impact on goal-directed behavior. The balance of these afferents is under the modulatory influence of dopamine neurons in the ventral tegmental area. This midbrain region receives its own complex mix of excitatory and inhibitory inputs, some of which have only recently been identified. Such afferent regulation positions the dopamine system to bias goal-directed behavior based on internal drives and environmental contingencies. Conditions that result in reward promote phasic dopamine release, which serves to maintain ongoing behavior by selectively potentiating ventral subicular drive to the accumbens. Behaviors that fail to produce an expected reward decrease dopamine transmission, which favors prefrontal cortical-driven switching to new behavioral strategies. As such, the limbic reward system is designed to optimize action plans for maximizing reward outcomes. This system can be commandeered by drugs of abuse or psychiatric disorders, resulting in inappropriate behaviors that sustain failed reward strategies. A fuller appreciation of the circuitry interconnecting the nucleus accumbens and ventral tegmental area should serve to advance discovery of new treatment options for these conditions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/npp.2009.93

Cites

357 of 357 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Emotion circuits in the brain
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466
Dopamine, learning and motivation.
Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379 · cited 8×
“The DA projection to the NAc also contributes to the rewards associated with drugs of abuse (Koob, 1992; Wise, 2004; Ikemoto, 2007), and plasticity in this system is strongly implicated in addictive disorders that involve compulsive drug-seeking (Wolf et al, 2004; Zweifel et al, 2008).”
Influential
Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229
D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons
Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., & Sibley, D. R. (1990) · Science · doi:10.1126/science.2147780 · Cited by 2,967
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647
THE BASAL GANGLIA: FOCUSED SELECTION AND INHIBITION OF COMPETING MOTOR PROGRAMS
Mink, J. W. (1996) · Progress in Neurobiology · doi:10.1016/s0301-0082(96)00042-1 · Cited by 2,478
Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions.
Alexander, G. E., Crutcher, M. D., & DeLong, M. R. (1990) · PubMed · Cited by 2,422
From motivation to action: Functional interface between the limbic system and the motor system
MOGENSON, G., JONES, D., & YIM, C. (1980) · Progress in Neurobiology · doi:10.1016/0301-0082(80)90018-0 · Cited by 2,331
Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity.
Kalivas, P., & Stewart, J. (1991) · Brain research. Brain research reviews · doi:10.1016/0165-0173(91)90007-u · Cited by 2,087
Drugs of abuse: anatomy, pharmacology and function of reward pathways
Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070
The hippocampal-VTA loop: controlling the entry of information into long-term memory
Lisman, J. E., & Grace, A. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.002 · Cited by 1,983
Self-citation
Brain Dopamine and Reward
Wise, R. A., & Rompre, P.-P. (1989) · Annual Review of Psychology · doi:10.1146/annurev.ps.40.020189.001203 · Cited by 1,968
Chapter 6 Basal ganglia-thalamocortical circuits: Parallel substrates for motor, oculomotor, “prefrontal” and “limbic” functions
(1991) · Progress in Brain Research · doi:10.1016/s0079-6123(08)62678-3 · Cited by 1,961
Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia
Grace, A. A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90196-u · Cited by 1,831
Self-citation
Dopamine neuron systems in the brain: An update
Björklund, A., & Dunnett, S. B. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.006 · Cited by 1,777
The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718 · cited 10×
“Although they are often referred to as interneurons, the predominant evidence indicates that these cells issue long-range projections that parallel those of DA neurons (Figure 1; Swanson, 1982; Van Bockstaele and Pickel, 1995; Steffensen et al, 1998; Carr and Sesack, 2000a).”
Influential
Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum
Haber, S. N., Fudge, J. L., & McFarland, N. R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02369.2000 · Cited by 1,610
Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract‐tracing study with Phaseolus vulgaris leucoagglutinin
Sesack, S. R., Deutch, A. Y., Roth, R. H., & Bunney, B. S. (1989) · Journal of Comparative Neurology · doi:10.1002/cne.902900205 · Cited by 1,568
Self-citation
Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477
The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine‐ B ‐hydroxylase as a marker
Swanson, L. W., & Hartman, B. K. (1975) · The Journal of Comparative Neurology · doi:10.1002/cne.901630406 · Cited by 1,475
Neuronal signalling of fear memory
Maren, S., & Quirk, G. J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1535 · Cited by 1,428
Neuronal Coding of Prediction Errors
Schultz, W., & Dickinson, A. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.473 · Cited by 1,427
The control of firing pattern in nigral dopamine neurons: burst firing
Grace, A., & Bunney, B. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-11-02877.1984 · Cited by 1,346
Self-citation
A role for lateral hypothalamic orexin neurons in reward seeking
Harris, G. C., Wimmer, M., & Aston-Jones, G. (2005) · Nature · doi:10.1038/nature04071 · Cited by 1,311
Efferent connections of the substantia nigra and ventral tegmental area in the rat
Beckstead, R. M., Domesick, V. B., & Nauta, W. J. H. (1979) · Brain Research · doi:10.1016/0006-8993(79)91001-1 · Cited by 1,293
Lateral habenula as a source of negative reward signals in dopamine neurons
Matsumoto, M., & Hikosaka, O. (2007) · Nature · doi:10.1038/nature05860 · Cited by 1,292
Specificity in the projection patterns of accumbal core and shell in the rat
Heimer, L., Zahm, D. S., Churchill, L., Kalivas, P. W., & Wohltmann, C. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90202-y · Cited by 1,219
New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: The striatopallidal, amygdaloid, and corticopetal components of substantia innominata
Alheid, G. F., & Heimer, L. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90217-5 · Cited by 1,217
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons
Surmeier, D. J., Ding, J., Day, M., Wang, Z., & Shen, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.008 · Cited by 1,203
The basal ganglia: a vertebrate solution to the selection problem?
Redgrave, P., Prescott, T. J., & Gurney, K. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00319-4 · Cited by 1,199
Striatal interneurones: chemical, physiological and morphological characterization
Kawaguchi, Y., Wilson, C. J., Augood, S. J., & Emson, P. C. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)98374-8 · Cited by 1,197
Catecholamine innervation of the basal forebrain IV. Topography of the dopamine projection to the basal forebrain and neostriatum
Fallon, J. H., & Moore, R. Y. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901800310 · Cited by 1,190
Dopamine neurons report an error in the temporal prediction of reward during learning
Hollerman, J. R., & Schultz, W. (1998) · Nature Neuroscience · doi:10.1038/1124 · Cited by 1,161
Structural plasticity associated with exposure to drugs of abuse
Robinson, T. E., & Kolb, B. E. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.025 · Cited by 1,130
Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons
Ungless, M. A., Whistler, J. L., Malenka, R. C., & Bonci, A. (2001) · Nature · doi:10.1038/35079077 · Cited by 1,106
Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission
Floresco, S. B., West, A. R., Ash, B., Moore, H., & Grace, A. A. (2003) · Nature Neuroscience · doi:10.1038/nn1103 · Cited by 1,106
Self-citation
The patterns of afferent innervation of the core and shell in the “Accumbens” part of the rat ventral striatum: Immunohistochemical detection of retrogradely transported fluoro‐gold
Brog, J. S., Salyapongse, A., Deutch, A. Y., & Zahm, D. S. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903380209 · Cited by 1,102
The melanin‐concentrating hormone system of the rat brain: An immuno‐ and hybridization histochemical characterization
Bittencourt, J. C., Presse, F., Arias, C. M., Peto, C. A., Vaughan, J. M., Nahon, J., Vale, W., & Sawchenko, P. E. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903190204 · Cited by 1,075
On the significance of subterritories in the “accumbens” part of the rat ventral striatum
Zahm, D. S., & Brog, J. S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90202-d · Cited by 1,040
Regulation of firing of dopaminergic neurons and control of goal-directed behaviors
Grace, A. A., Floresco, S. B., Goto, Y., & Lodge, D. J. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.003 · Cited by 1,034
Self-citation
Behavioral dopamine signals.
Schultz, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.007 · Cited by 1,028
The neostriatal mosaic: multiple levels of compartmental organization in the basal ganglia
Gerfen, C. R. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.001441 · Cited by 1,004
Reciprocal Connections between the Amygdala and the Hippocampal Formation, Perirhinal Cortex, and Postrhinal Cortex in Rat: A Review
Pitkänen, A., Pikkarainen, M., Nurminen, N., & Ylinen, A. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06738.x · Cited by 1,001
Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system
Lammel, S., Hetzel, A., Häckel, O., Jones, I., Liss, B., & Roeper, J. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.022 · Cited by 976
Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction
Everitt, B. J., Belin, D., Economidou, D., Pelloux, Y., Dalley, J. W., & Robbins, T. W. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0089 · Cited by 974
Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events
Horvitz, J. C. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00019-1 · Cited by 967
Computational roles for dopamine in behavioural control
Montague, P. R., Hyman, S. E., & Cohen, J. D. (2004) · Nature · doi:10.1038/nature03015 · Cited by 966
Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization
Grace, A. A., & Bunney, B. S. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90135-5 · Cited by 937
Self-citation
The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants
Wolf, M. E. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00090-7 · Cited by 934
Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens
Nicola, S. M., Surmeier, D. J., & Malenka, R. C. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.185 · Cited by 931
The amygdalostriatal projection in the rat—an anatomical study by anterograde and retrograde tracing methods
Kelley, A. E., Domesick, V. B., & Nauta, W. J. H. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90067-7 · Cited by 888
Projections from the Rat Prefrontal Cortex to the Ventral Tegmental Area: Target Specificity in the Synaptic Associations with Mesoaccumbens and Mesocortical Neurons
Carr, D. B., & Sesack, S. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03864.2000 · Cited by 880
Self-citation
Efferent connections and nigral afferents of the nucleus accumbens septi in the rat
Nauta, W. J. H., Smith, G. P., Faull, R. L. M., & Domesick, V. B. (1978) · Neuroscience · doi:10.1016/0306-4522(78)90041-6 · Cited by 876
Organization of the projections from the subiculum to the ventral striatum in the rat. A study using anterograde transport of Phaseolus vulgaris leucoagglutinin
Groenewegen, H. J., Vermeulen‐Vanderzee, E., Kortschot, A. T., & Witter, M. P. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90275-2 · Cited by 867
The control of firing pattern in nigral dopamine neurons: single spike firing
Grace, A., & Bunney, B. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-11-02866.1984 · Cited by 862
Self-citation
Efferent connections of the habenular nuclei in the rat
Herkenham, M. A., & Nauta, W. J. H. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901870103 · Cited by 855
Topographical organization and relationship with ventral striatal compartments of prefrontal corticostriatal projections in the rat
Berendse, H. W., Graaf, Y. G.-D., & Groenewegen, H. J. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903160305 · Cited by 847
Neocortical modulation of the amygdala response to fearful stimuli
Hariri, A. R., Mattay, V. S., Tessitore, A., Fera, F., & Weinberger, D. R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01786-9 · Cited by 828
Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area
Sesack, S. R., & Pickel, V. M. (1992) · Journal of Comparative Neurology · doi:10.1002/cne.903200202 · Cited by 820
Self-citation
The nucleus accumbens as a complex of functionally distinct neuronal ensembles: An integration of behavioural, electrophysiological and anatomical data
Pennartz, C. M. A., Groenewegen, H. J., & LOPESDASILVA, F. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90025-6 · Cited by 809
Contextual control of the extinction of conditioned fear: Tests for the associative value of the context.
Bouton, M. E., & King, D. A. (1983) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.9.3.248 · Cited by 796
An autoradiographic examination of corticocortical and subcortical projections of the mediodorsal‐projection (prefrontal) cortex in the rat
Beckstead, R. M. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901840104 · Cited by 792
Uniform Inhibition of Dopamine Neurons in the Ventral Tegmental Area by Aversive Stimuli
Ungless, M. A., Magill, P. J., & Bolam, J. P. (2004) · Science · doi:10.1126/science.1093360 · Cited by 782
Coordinated Expression of Dopamine Receptors in Neostriatal Medium Spiny Neurons
Surmeier, D. J., Song, W., & Yan, Z. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-20-06579.1996 · Cited by 762
Synaptic interactions among excitatory afferents to nucleus accumbens neurons: hippocampal gating of prefrontal cortical input
O’Donnell, P., & Grace, A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03622.1995 · Cited by 760
Self-citation
Contextual fear, gestalt memories, and the hippocampus
Fanselow, M. S. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00186-2 · Cited by 752
The distribution of the projection from the hippocampal formation to the nucleus accumbens in the rat: An anterograde and retrograde-horseradish peroxidase study
Kelley, A. E., & Domesick, V. B. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90198-1 · Cited by 746
Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models
Day, M., Wang, Z., Ding, J., An, X., Ingham, C. A., Shering, A. F., Wokosin, D., Ilijic, E., Sun, Z., Sampson, A. R., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1632 · Cited by 745 · cited 1×
“…dendrites provides a potential substrate for enabling local plasticity of glutamate transmission based on synaptic experience (Flores et al, 2005; Day et al, 2006; Surmeier et al, 2007) or chronic exposure to psychostimulants that enhance DA levels (Robinson and Kolb, 2004; Wolf et al, 2004; Lee…”
Self-citation
Organization of the afferent connections of the mediodorsal thalamic nucleus in the rat, related to the mediodorsal-prefrontal topography
Groenewegen, H. J. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90339-9 · Cited by 732
Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro
Grace, A., & Onn, S. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-10-03463.1989 · Cited by 720
Self-citation
Orexin A in the VTA Is Critical for the Induction of Synaptic Plasticity and Behavioral Sensitization to Cocaine
Borgland, S. L., Taha, S. A., Sarti, F., Fields, H. L., & Bonci, A. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.016 · Cited by 718
An autoradiographic study of the projections of the central nucleus of the monkey amygdala
Price, J. L., & Amaral, D. (1981) · Journal of Neuroscience · doi:10.1523/jneurosci.01-11-01242.1981 · Cited by 709
The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses.
Jhou, T. C., Fields, H. L., Baxter, M. G., Saper, C. B., & Holland, P. C. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.001 · Cited by 696
Convergence and segregation of ventral striatal inputs and outputs
GROENEWEGEN, H. J., WRIGHT, C. I., BEIJER, A. V. J., & VOORN, P. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09260.x · Cited by 684
Two types of neurone in the rat ventral tegmental area and their synaptic inputs.
Johnson, S. W., & NORTH, R. A. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019136 · Cited by 672
Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission
Kalivas, P. W., Volkow, N., & Seamans, J. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.005 · Cited by 657
Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat
Nair‐Roberts, R. G., Chatelain-Badie, S. D., Benson, E. M., White‐Cooper, H., Bolam, J. P., & Ungless, M. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.046 · Cited by 635
Ventral Tegmental Area Neurons in Learned Appetitive Behavior and Positive Reinforcement
Fields, H. L., Hjelmstad, G. O., Margolis, E. B., & Nicola, S. M. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094341 · Cited by 632
The Existence of a Second Vesicular Glutamate Transporter Specifies Subpopulations of Glutamatergic Neurons
Herzog, É., Bellenchi, G. C., Gras, C., Bernard, V., Ravassard, P., Bedet, C., Gasnier, B., Bruno Giros, A., & Mestikawy, S. E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-22-j0001.2001 · Cited by 625
Brain circuitry and the reinstatement of cocaine-seeking behavior
Kalivas, P., & McFarland, K. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1393-2 · Cited by 613
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
Segal, D. S., & Mandell, A. J. (1974) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(74)90060-4 · Cited by 604
Organization of the thalamostriatal projections in the rat, with special emphasis on the ventral striatum
Berendse, H. W., & Groenewegen, H. J. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902990206 · Cited by 598
The thalamostriatal system: a highly specific network of the basal ganglia circuitry
Smith, Y., Raju, D. V., Paré, J., & Sidibé, M. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.07.004 · Cited by 595
Excitation of Ventral Tegmental Area Dopaminergic and Nondopaminergic Neurons by Orexins/Hypocretins
Korotkova, T. M., Sergeeva, O. A., Eriksson, K. S., Haas, H. L., & Brown, R. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00007.2003 · Cited by 583
D1 and D2 dopamine receptor gene expression in the rat striatum: Sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAS in distinct neuronal populations of the dorsal and ventral striatum
Moine, C. L., & Bloch, B. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903550308 · Cited by 576
Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior
Goto, Y., & Grace, A. A. (2005) · Nature Neuroscience · doi:10.1038/nn1471 · Cited by 576
Self-citation
Biological substrates of reward and aversion: A nucleus accumbens activity hypothesis
Carlezon, W. A., & Thomas, M. J. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.075 · Cited by 561
Neuromodulatory actions of dopamine in the neostriatum are dependent upon the excitatory amino acid receptor subtypes activated.
Cepeda, C., Buchwald, N. A., & Levine, M. S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9576 · Cited by 559
Glutamatergic Afferents from the Hippocampus to the Nucleus Accumbens Regulate Activity of Ventral Tegmental Area Dopamine Neurons
Floresco, S., Todd, C. L., & Grace, A. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04915.2001 · Cited by 556
Self-citation
Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity
Bunney, B. S., & Grace, A. A. (1978) · Life Sciences · doi:10.1016/0024-3205(78)90471-x · Cited by 553
Self-citation
Afferent projections to the ventral tegmental area of Tsai and interfascicular nucleus: A horseradish peroxidase study in the rat
Phillipson, O. T. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901870108 · Cited by 553
Basolateral Amygdala Neurons Facilitate Reward-Seeking Behavior by Exciting Nucleus Accumbens Neurons
Ambroggi, F., Ishikawa, A., Fields, H. L., & Nicola, S. M. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.004 · Cited by 523
Dopaminergic Control of Corticostriatal Long-Term Synaptic Depression in Medium Spiny Neurons Is Mediated by Cholinergic Interneurons
Wang, Z., Li, K., Day, M., Ronesi, J. A., Yin, H. H., Ding, J., Tkatch, T., Lovinger, D. M., & Surmeier, D. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.010 · Cited by 513
Neural systems and cue-induced cocaine craving
Bonson, K. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00371-2 · Cited by 507 · cited 1×
“Thus, the initial reinforcement of appetitive and drug stimuli activates ventral striatal structures (Bonson et al, 2002; Yin et al, 2008); however, with repetitive exposure, activation of more dorsal striatal structures will predominate (Robbins and Everitt, 2002; Yin et al, 2008).”
Anatomical substrates of orexin–dopamine interactions: lateral hypothalamic projections to the ventral tegmental area
Fadel, J. R., & Deutch, A. Y. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00017-9 · Cited by 503
The mesopontine rostromedial tegmental nucleus: A structure targeted by the lateral habenula that projects to the ventral tegmental area of tsai and substantia nigra compacta
Jhou, T. C., Geisler, S., Marinelli, M., Degarmo, B. A., & Zahm, D. S. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.21891 · Cited by 503
An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens
Zahm, D. S. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00065-2 · Cited by 487
Glutamatergic Afferents of the Ventral Tegmental Area in the Rat
Geisler, S., Derst, C., Veh, R. W., & Zahm, D. S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0012-07.2007 · Cited by 486
Electron microscopic analysis of D1 and D2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents
Hersch, S. M., Ciliax, B. J., Gutekunst, C., Rees, H., Heilman, C. J., Yung, K. K. L., Bolam, J. P., Ince, E., Yi, H. L., & Levey, A. I. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-07-05222.1995 · Cited by 483
Role of conditioned contextual stimuli in reinstatement of extinguished fear.
Bouton, M. E., & Bolles, R. C. (1979) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037//0097-7403.5.4.368 · Cited by 481
Widespread origin of the primate mesofrontal dopamine system
Williams, S. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.4.321 · Cited by 479
Pedunculopontine and laterodorsal tegmental nuclei contain distinct populations of cholinergic, glutamatergic and GABAergic neurons in the rat
Wang, H., & Morales, M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06576.x · Cited by 478
Chemical and structural analysis of the relation between cortical inputs and tyrosine hydroxylase-containing terminals in rat neostriatum
Bouyer, J. J., Park, D. H., JOH, T. H., & Pickel, V. M. (1984) · Brain Research · doi:10.1016/0006-8993(84)90239-7 · Cited by 472
Drug Addiction and the Memory Systems of the Brain
Robbins, T. W., Ersche, K. D., & Everitt, B. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1441.020 · Cited by 467
Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue
Ito, R., Dalley, J. W., Robbins, T. W., & Everitt, B. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-14-06247.2002 · Cited by 463
Organization of the output of the ventral striatopallidal system in the rat: ventral pallidal efferents
Groenewegen, H. J., Berendse, H. W., & Haber, S. N. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90115-v · Cited by 456
Input from the frontal cortex and the parafascicular nucleus to cholinergic interneurons in the dorsal striatum of the rat
Lapper, S. R., & Bolam, J. P. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90293-b · Cited by 451
Organization of the efferent projections of the nucleus accumbens to pallidal, hypothalamic, and mesencephalic structures: A tracing and immunohistochemical study in the cat
Groenewegen, H. J., & Russchen, F. T. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902230303 · Cited by 447
The isodendritic core of the brain stem
Ramón‐Moliner, E., & Nauta, W. J. H. (1966) · Journal of Comparative Neurology · doi:10.1002/cne.901260301 · Cited by 442
Increasing effects of repetitive cocaine administration in the rat
Post, R. M., & Rose, H. H. R. M. (1976) · Nature · doi:10.1038/260731a0 · Cited by 442
In the rat medial nucleus accumbens, hippocampal and catecholaminergic terminals converge on spiny neurons and are in apposition to each other
Sesack, S. R., & Pickel, V. M. (1990) · Brain Research · doi:10.1016/0006-8993(90)91146-8 · Cited by 439
Self-citation
Dopamine receptor subtypes colocalize in rat striatonigral neurons.
Surmeier, D. J., Eberwine, J. H., Wilson, C. J., Cao, Y., Stefani, A., & Kitai, S. T. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10178 · Cited by 433
Habenula: crossroad between the basal ganglia and the limbic system
Hikosaka, O., Sesack, S. R., Lecourtier, L., & Shepard, P. D. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3463-08.2008 · Cited by 432
Self-citation
Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression
Bellone, C., & Lüscher, C. (2006) · Nature Neuroscience · doi:10.1038/nn1682 · Cited by 429
Cellular Mechanisms of Infralimbic and Prelimbic Prefrontal Cortical Inhibition and Dopaminergic Modulation of Basolateral Amygdala Neurons In Vivo
Rosenkranz, J., & Grace, A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00324.2002 · Cited by 422
Self-citation
Reward-guided learning beyond dopamine in the nucleus accumbens: the integrative functions of cortico-basal ganglia networks
Yin, H. H., Ostlund, S. B., & Balleine, B. W. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06422.x · Cited by 416
Two transpallidal pathways originating in the rat nucleus accumbens
Zahm, D. S., & Heimer, L. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903020302 · Cited by 406
Distribution of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area
Oakman, S., Faris, P. L., Kerr, P., Cozzari, C., & Hartman, B. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-09-05859.1995 · Cited by 392
Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons
Grace, A. A., & Bunney, B. S. (1979) · European Journal of Pharmacology · doi:10.1016/0014-2999(79)90283-8 · Cited by 392
Self-citation
Lateral Habenula Stimulation Inhibits Rat Midbrain Dopamine Neurons through a GABAA Receptor-Mediated Mechanism
Ji, H., & Shepard, P. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0958-07.2007 · Cited by 388
Electrophysiological Characterization of GABAergic Neurons in the Ventral Tegmental Area
Steffensen, S. C., Svingos, A. L., Pickel, V. M., & Henriksen, S. J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-08003.1998 · Cited by 388
Specificity in the efferent projections of the nucleus accumbens in the rat: Comparison of the rostral pole projection patterns with those of the core and shell
Zahm, D. S., & Heimer, L. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903270205 · Cited by 385
Feedforward Inhibition of Projection Neurons by Fast-Spiking GABA Interneurons in the Rat StriatumIn Vivo
Mallet, N. P., Moine, C. L., Charpier, S., & Gonon, F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5027-04.2005 · Cited by 380
Afferents of the ventral tegmental area in the rat-anatomical substratum for integrative functions
Geisler, S., & Zahm, D. S. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20668 · Cited by 379
Limbic-Striatal Memory Systems and Drug Addiction
Robbins, T. W. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2002.4103 · Cited by 379
Role of conditioned contextual stimuli in reinstatement of extinguished fear.
Bouton, M. E., & Bolles, R. C. (1979) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.5.4.368 · Cited by 376
Topographical organization of amygdaloid projections to the caudatoputamen, nucleus accumbens, and related striatal-like areas of the rat brain
Mcdonald, A. J. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90248-m · Cited by 372
Serotonin axon terminals in the ventral tegmental area of the rat: fine structure and synaptic input to dopaminergic neurons
Hervé, D., Pickel, V. M., JOH, T. H., & Beaudet, A. (1987) · Brain Research · doi:10.1016/0006-8993(87)91588-5 · Cited by 372
Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens
Lee, K.-W., Kim, Y. D., Kim, A. M., Helmin, K. A., Nairn, A. C., & Greengard, P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511244103 · Cited by 369
Glutamatergic neurons are present in the rat ventral tegmental area
Yamaguchi, T., Sheen, W., & Morales, M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05263.x · Cited by 367
Compartmental organization of the ventral striatum of the rat: Immunohistochemical distribution of enkephalin, substance P, dopamine, and calcium‐binding protein
Voorn, P., Gerfen, C. R., & Groenewegen, H. J. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902890202 · Cited by 362
Amygdaloid projections to the frontal cortex and the striatum in the rat
Kita, H., & Kitai, S. T. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902980104 · Cited by 351
Cocaine but Not Natural Reward Self-Administration nor Passive Cocaine Infusion Produces Persistent LTP in the VTA
Chen, B. T., Bowers, M. S., Martín, M., Hopf, F. W., Guillory, A. M., Carelli, R. M., Chou, J., & Bonci, A. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.024 · Cited by 350
The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons
Lodge, D. J., & Grace, A. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510715103 · Cited by 349
Self-citation
Afferents to the GABAergic tail of the ventral tegmental area in the rat
Kaufling, J., Veinante, P., Pawlowski, S. A., Freund‐Mercier, M., & Barrot, M. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.21983 · Cited by 347
Chapter 29 The nucleus accumbens: gateway for limbic structures to reach the motor system?
Groenewegen, H. J., Wright, C. I., & Beijer, A. V. J. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)61883-x · Cited by 344
Tonic Activation of NMDA Receptors Causes Spontaneous Burst Discharge of Rat Midbrain Dopamine Neurons In Vivo
Chergui, K., Charléty, P. J., Akaoka, H., Saunier, C. F., Brunet, J.-L., Buda, M., Svensson, T. H., & Chouvet, G. (1993) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1993.tb00479.x · Cited by 343
Anatomical evidence for direct projections from the entorhinal area to the entire cortical mantle in the rat
Swanson, L. W., & Köhler, C. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-10-03010.1986 · Cited by 340
Properties and opioid inhibition of mesolimbic dopamine neurons vary according to target location
Ford, C. P., Mark, G. P., & Williams, J. T. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4331-05.2006 · Cited by 339
Dopamine Attenuates Prefrontal Cortical Suppression of Sensory Inputs to the Basolateral Amygdala of Rats
Rosenkranz, J. A., & Grace, A. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-04090.2001 · Cited by 339
Self-citation
Identification of synaptic terminals of thalamic or cortical origin in contact with distinct medium‐size spiny neurons in the rat neostriatum
Dubé, L., Smith, A. D., & Bolam, J. P. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902670402 · Cited by 333
Limbic and cortical information processing in the nucleus accumbens
Goto, Y., & Grace, A. A. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.08.002 · Cited by 332
Self-citation
GABA-containing neurons in the ventral tegmental area project to the nucleus accumbens in rat brain
Bockstaele, E. J. V., & Pickel, V. M. (1995) · Brain Research · doi:10.1016/0006-8993(95)00334-m · Cited by 329
The Primate Thalamus Is a Key Target for Brain Dopamine
García‐Cabezas, M. Á., García‐Cabezas, M. Á., Rico, B., & Cavada, C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0968-05.2005 · Cited by 323
Expression of D1 receptor, D2 receptor, substance P and enkephalin messenger RNAs in the neurons projecting from the nucleus accumbens
Lu, X.-Y., Ghasemzadeh, M. B., & Kalivas, P. W. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00327-8 · Cited by 321
The dopaminergic innervation of the ventral striatum in the rat: A light‐ and electron‐microscopical study with antibodies against dopamine
Voorn, P., Jorritsma‐Byham, B., Dijk, C. V., & Buijs, R. M. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902510106 · Cited by 318
Synaptic relationships between dopaminergic afferents and cortical or thalamic input in the sensorimotor territory of the striatum in monkey
Smith, Y., Bennett, B. D., Bolam, J. P., Parent, A., & Sadikot, A. F. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903440102 · Cited by 312
Increased Occupancy of Dopamine Receptors in Human Striatum during Cue-Elicited Cocaine Craving
Wong, D. F., Kuwabara, H., Schretlen, D. J., Bonson, K. R., Zhou, Y., Nandi, A., Brašić, J. R., Kimes, A. S., Maris, M. A., Kumar, A., et al. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301194 · Cited by 311
Self-citation
Basal amygdaloid complex afferents to the rat nucleus accumbens are compartmentally organized
Wright, C., Beijer, A. V. J., & Groenewegen, H. J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-05-01877.1996 · Cited by 307
Origin of the dopaminergic innervation of the central extended amygdala and accumbens shell: A combined retrograde tracing and immunohistochemical study in the rat
Hasue, R. H., & Shammah‐Lagnado, S. J. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10420 · Cited by 306
Vglut2 afferents to the medial prefrontal and primary somatosensory cortices: A combined retrograde tracing in situ hybridization
Hur, E. E., & Záborszky, L. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20444 · Cited by 305
A direct projection from superior colliculus to substantia nigra for detecting salient visual events
Comoli, E., Coizet, V., Boyes, J., Bolam, J. P., Canteras, N. S., Quirk, R. H., Overton, P. G., & Redgrave, P. (2003) · Nature Neuroscience · doi:10.1038/nn1113 · Cited by 295
Topographic organization of the ventral striatal efferent projections in the rhesus monkey: An anterograde tracing study
Haber, S. N., Lynd‐Balta, E., Klein, C. M., & Groenewegen, H. J. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902930210 · Cited by 291
Acute and Chronic Cocaine-Induced Potentiation of Synaptic Strength in the Ventral Tegmental Area: Electrophysiological and Behavioral Correlates in Individual Rats
Borgland, S. L., Malenka, R. C., & Bonci, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1312-04.2004 · Cited by 289
Psychomotor stimulants and neuronal plasticity
Wolf, M. E., Sun, X., Mangiavacchi, S., & Chao, S. Z. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.006 · Cited by 288
Activation of Ventral Tegmental Area Cells by the Bed Nucleus of the Stria Terminalis: A Novel Excitatory Amino Acid Input to Midbrain Dopamine Neurons
Georges, F. E., & Aston‐Jones, G. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-12-05173.2002 · Cited by 287
How visual stimuli activate dopaminergic neurons at short latency
Dommett, E., Coizet, V., Blaha, C. D., Martindale, J., Lefebvre, V., Walton, N., Mayhew, J. E. W., Overton, P. G., & Redgrave, P. (2005) · Science · doi:10.1126/science.1107026 · Cited by 285
The subiculum: what it does, what it might do, and what neuroanatomy has yet to tell us
O'Mara, S. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00446.x · Cited by 285
Dopaminergic Modulation of NMDA-Induced Whole Cell Currents in Neostriatal Neurons in Slices: Contribution of Calcium Conductances
Cepeda, C., Colwell, C. S., Itri, J. N., Chandler, S. H., & Levine, M. S. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.1.82 · Cited by 283
The Hippocampus Modulates Dopamine Neuron Responsivity by Regulating the Intensity of Phasic Neuron Activation
Lodge, D. J., & Grace, A. A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300963 · Cited by 280
Self-citation
Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity
Grace, A. A., & Bunney, B. S. (1985) · Brain Research · doi:10.1016/0006-8993(85)91581-1 · Cited by 280
Self-citation
Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains
Porrino, L. J., Lyons, D., Smith, H. R., Daunais, J. B., & Nader, M. A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5578-03.2004 · Cited by 276
Limbic Corticostriatal Systems and Delayed Reinforcement
Cardinal, R. N., Winstanley, C. A., Robbins, T. W., & Everitt, B. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1308.004 · Cited by 273
Organization of CA1 projections to the subiculum: A PHA‐L analysis in the rat
Amaral, D. G., Dolorfo, C. L., & Alvarez‐Royo, P. (1991) · Hippocampus · doi:10.1002/hipo.450010410 · Cited by 272
Laterodorsal tegmental stimulation elicits dopamine efflux in the rat nucleus accumbens by activation of acetylcholine and glutamate receptors in the ventral tegmental area
Forster, G. L., & Blaha, C. D. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00250.x · Cited by 271
Origin of noradrenergic afferents to the shell subregion of the nucleus accumbens: anterograde and retrograde tract-tracing studies in the rat
Delfs, J. M., Zhu, Y., Druhan, J. P., & Aston‐Jones, G. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00672-6 · Cited by 267
Convergence of hippocampal and dopaminergic input onto identified neurons in the nucleus accumbens of the rat.
Totterdell, S., & Smith, A. D. (1989) · PubMed · Cited by 266
Synaptic input and output of parvalbumin-immunoreactive neurons in the neostriatum of the rat
Bennett, B. D., & Bolam, J. P. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90471-5 · Cited by 262
What does the hippocampus really do?
Jarrard, L. E. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00034-8 · Cited by 261
What is reinforced by phasic dopamine signals?
Redgrave, P., GURNEY, K. N., & Reynolds, J. N. J. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.10.007 · Cited by 261
The regulation of forebrain dopamine transmission: relevance to the pathophysiology and psychopathology of schizophrenia.
Moore, H., West, A. R., & Grace, A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00078-5 · Cited by 257
Self-citation
Laterodorsal tegmental projections to identified cell populations in the rat ventral tegmental area
Omelchenko, N., & Sesack, S. R. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20417 · Cited by 257
Self-citation
Corticotropin‐releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C‐dependent enhancement of Ih
Wanat, M. J., Hopf, F. W., Stuber, G. D., Phillips, P. E. M., & Bonci, A. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.150078 · Cited by 256
Dopamine gating of forebrain neural ensembles
O’Donnell, P. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02463.x · Cited by 253
Opposite Influences of Endogenous Dopamine D1and D2Receptor Activation on Activity States and Electrophysiological Properties of Striatal Neurons: Studies CombiningIn VivoIntracellular Recordings and Reverse Microdialysis
West, A. R., & Grace, A. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00294.2002 · Cited by 252
Self-citation
Efferent projections of the nucleus accumbens in the rat with special reference to subdivision of the nucleus: biotinylated dextran amine study
Usuda, I., Tanaka, K., & Chiba, T. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00359-x · Cited by 248
Firing properties of substantia nigra dopaminergic neurons in freely moving rats
Freeman, A. S., Meltzer, L. T., & Bunney, B. S. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90448-5 · Cited by 240
Glutamatergic and cholinergic inputs from the pedunculopontine tegmental nucleus to dopamine neurons in the substantia nigra pars compacta
Futami, T., Takakusaki, K., & Kitai, S. T. (1995) · Neuroscience Research · doi:10.1016/0168-0102(94)00869-h · Cited by 239
Specificity in the Projections of Prefrontal and Insular Cortex to Ventral Striatopallidum and the Extended Amygdala
Reynolds, S. M., & Zahm, D. S. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3432-05.2005 · Cited by 239
Midbrain Dopamine Neurons: Projection Target Determines Action Potential Duration and Dopamine D 2 Receptor Inhibition
Margolis, E. B., Mitchell, J., Ishikawa, J., Hjelmstad, G. O., & Fields, H. L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1526-08.2008 · Cited by 239
Segregation of Amphetamine Reward and Locomotor Stimulation between Nucleus Accumbens Medial Shell and Core
Sellings, L. H. L., & Clarke, P. B. S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06295.2003 · Cited by 238
Selective prefrontal cortex inputs to dopamine cells: implications for schizophrenia
Sesack, S. R., & CARR, D. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00931-9 · Cited by 238
Self-citation
Electrophysiological responses of neurones in the nucleus accumbens to hippocampal stimulation and the attenuation of the excitatory responses by the mesolimbic dopaminergic system
Yang, C. R., & Mogenson, G. J. (1984) · Brain Research · doi:10.1016/0006-8993(84)90623-1 · Cited by 235
Role of the ventral subiculum in stress integration
Herman, J. P., & Mueller, N. K. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.05.035 · Cited by 235
Pedunculopontine nucleus in the squirrel monkey: Cholinergic and glutamatergic projections to the substantia nigra
Lavoie, B. A., & Parent, A. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903440205 · Cited by 235
A Subpopulation of Neurons in the Medial Prefrontal Cortex Encodes Emotional Learning with Burst and Frequency Codes through a Dopamine D4Receptor-Dependent Basolateral Amygdala Input
Laviolette, S. R., Lipski, W. J., & Grace, A. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1168-05.2005 · Cited by 235
Self-citation
Mesocortical Dopamine Neurons Operate in Distinct Temporal Domains Using Multimodal Signaling
Lavin, A., Nogueira, L., Lapish, C. C., Wightman, R. M., Phillips, P. E. M., & Seamans, J. K. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0557-05.2005 · Cited by 233
Morphological differences between projection neurons of the core and shell in the nucleus accumbens of the rat
Meredith, G. E., Agolia, R., Arts, M. P. M., Groenewegen, H. J., & Zahm, D. S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90389-j · Cited by 231
Functional Interaction between the Hippocampus and Nucleus Accumbens Shell Is Necessary for the Acquisition of Appetitive Spatial Context Conditioning
Ito, R., Robbins, T. W., Pennartz, C. M. A., & Everitt, B. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1615-08.2008 · Cited by 230
Particular subpopulations of midbrain and hypothalamic dopamine neurons express vesicular glutamate transporter 2 in the rat brain
Kawano, M., Kawasaki, A., Sakata‐Haga, H., Fukui, Y., Kawano, H., Nogami, H., & Hisano, S. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21054 · Cited by 230
Dopamine Neurons Mediate a Fast Excitatory Signal via Their Glutamatergic Synapses
Chuhma, N., Zhang, H., Masson, J., Zhuang, X., Sulzer, D. L., Hen, R., & Rayport, S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4317-03.2004 · Cited by 228
Immunohistochemical Characterization of the Shell and Core Territories of the Nucleus Accumbens in the Rat
Jongen‐Rêlo, A. L., Voorn, P., & Groenewegen, H. J. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00315.x · Cited by 227
Expression of the d3 dopamine receptor in peptidergic neurons of the nucleus accumbens: Comparison with the D1 and D2 dopamine receptors
Moine, C. L., & Bloch, B. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00029-2 · Cited by 225
Modulation of dopamine efflux in the nucleus accumbens after cholinergic stimulation of the ventral tegmental area in intact, pedunculopontine tegmental nucleus-lesioned, and laterodorsal tegmental nucleus-lesioned rats
Blaha, C. D., Allen, L., Das, S., Inglis, W. L., LATIMER, M. L., Vincent, S., & Winn, P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-02-00714.1996 · Cited by 223
Alterations in dendritic morphology of prefrontal cortical and nucleus accumbens neurons in post-pubertal rats after neonatal excitotoxic lesions of the ventral hippocampus
Flores, G., Alquicer, G., Gómez, A. B. S., Zaldivar, G. A., Stewart, J., Quirion, R., & Srivastava, L. K. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.02.021 · Cited by 223
The Synaptic Framework for Chemical Signaling in Nucleus Accumbens
Meredith, G. E. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09266.x · Cited by 215
Cholinergic synaptic input to different parts of spiny striatonigral neurons in the rat
Izzo, P. N., & Bolam, J. P. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902690207 · Cited by 213

Research works printed but not linked: 8

Bell RL, Omelchenko N, Sesack SR (2007). Lateral habenula projections to the ventral tegmental area in the rat synapse onto dopamine and GABA neurons. Soc Neurosc Abstr 33: 780.9.
Dobi A, Morales M (2007). Dopaminergic neurons in the rat ventral tegmental area (VTA) receive glutamatergic inputs from local glutamatergic neurons. Soc Neurosci Abstr 916: 8.
Jhou TC, Gallagher M (2007). Paramedian raphe neurons that project to midbrain dopamine neurons are activated by aversive stimuli. Soc Neurosci Abstr 425: 5.
Lewis DA, Sesack SR (1997). Dopamine systems in the primate brain. In: Bloom FE, Björklund A, Hökfelt T (eds). Handbook of Chemical Neuroanatomy, The Primate Nervous System, Part I. Elsevier: Amsterdam. pp 261–373.
Lipski WJ, Grace AA (2008). Neurons in the ventral subiculum are activated by noxious stimuli and are modulated by noradrenergic afferents. Soc Neurosci Abstr 195: 1.
Mugnaini E, Oertel WH (1985). An atlas of the distribution of GABAergic neurons and terminals in the rat CNS as revealed by GAD immunocytochemistry. In: Björklund A, Hökfelt T (eds). Handbook of Chemical Neuroanatomy. Vol 4: GABA and Neuropeptides in the CNS, Part I. Elsevier BV: Amsterdam. pp 436–608.
Smith Y, Charara A, Parent A (1996). Synaptic innervation of midbrain dopaminergic neurons by glutamate-enriched terminals in the squirrel monkey. J Comp Neurol 364: 231–253. · DOI
Zahm DS, Williams E, Wohltmann C (1996). Ventral striatopallidothalamic projection: IV. Relative involvements of neurochemically distinct subterritories in the ventral pallidum and adjacent parts of the rostroventral forebrain. J Comp Neurol 364: 340–362. · DOI

Sorted by citations

The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870
Rethinking the Emotional Brain
LeDoux, J. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.004 · Cited by 1,594
“…1980; Balleine and Killcross, 1994; Killcross and Robbins, 1993; Everitt et al., 1999; Cardinal et al., 2002; Ikemoto and Panksepp, 1999; Parkinson et al., 1999; Koob, 2009; Sesack and Grace, 2010; Berridge, 2007, 2009; Berridge and Robinson, 1998; Hyman et al., 2006; Nestler, 2004; Kelley, 2004).”
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579
The brain on drugs: from reward to addiction
Volkow, N. D., & Morales, M. (2015) · Cell · doi:10.1016/j.cell.2015.07.046 · Cited by 1,306
Input-specific control of reward and aversion in the ventral tegmental area
Lammel, S., Lim, B. K., Ran, C., Huang, K. W., Betley, M. J., Tye, K. M., Deisseroth, K., & Malenka, R. C. (2012) · Nature · doi:10.1038/nature11527 · Cited by 1,300

See all 985

Authors: Sesack, S. R., & Grace, A. A.
Affiliations: University of Pittsburgh (US)
Corresponding author: Sesack, Susan R
Grace, Anthony A
ORCID: Sesack, Susan R
Grace, Anthony A
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2009-08-12
Volume: 35
Issue: 1
Pages: 27-47
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/npp.2009.93
PMC: PMC2879005
OpenAlex: W1971690948
Cited by: 985
References: 359
Citations by year: 2026: 33 · 2025: 40 · 2024: 48 · 2023: 37 · 2022: 46 · 2021: 59 · 2020: 51 · 2019: 57 · 2018: 58 · 2017: 69 · 2016: 87 · 2015: 78 · 2014: 85 · 2013: 86 · 2012: 76
FWCI: 4.32
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (R37MH057440)
National Institute on Drug Abuse (R01DA015408)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: reward systems, nucleus accumbens, ventral tegmental area, dopamine, ventral subiculum, basolateral amygdala, prefrontal cortex, hippocampus, microcircuitry, goal-directed behavior, phasic dopamine release, drug addiction, mental illness, afferent input
MeSH terms: Animals, Basal Ganglia, Cerebral Cortex, Humans, Models, Neurological, Neural Pathways, Nucleus Accumbens, Reward, Ventral Tegmental Area

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cortico-Basal Ganglia Reward Network: Microcircuitry

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks