The DOI matches its Crossref record.
Cluster analysis and display of genome-wide expression patterns
Open accessAbstract
A system of cluster analysis for genome-wide expression data from DNA microarray hybridization is described that uses standard statistical algorithms to arrange genes according to similarity in pattern of gene expression. The output is displayed graphically, conveying the clustering and the underlying expression data simultaneously in a form intuitive for biologists. We have found in the budding yeast Saccharomyces cerevisiae that clustering gene expression data groups together efficiently genes of known similar function, and we find a similar tendency in human data. Thus patterns seen in genome-wide expression experiments can be interpreted as indications of the status of cellular processes. Also, coexpression of genes of known function with poorly characterized or novel genes may provide a simple means of gaining leads to the functions of many genes for which information is not available currently.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Hierarchical clustering based on the average linkage of Pearson Correlation (Eisen et al., 1998) of miRNA profiles revealed non-random partition of the samples into two major branches, one containing all five individual neuron types and the other containing the two tissue types (Figure 3).”
From Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain (2012) · cites this paper as Eisen et al., 1998
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 16
- 10.1126/science.270.5235.467 · DOI · Paper page
- 10.1126/science.270.5235.484 · DOI
- 10.1038/nbt1296-1675 · DOI
- 10.1007/978-3-642-97966-8 · DOI
- R R Sokal, C D Michener Univ Kans Sci Bull 38, 1409–1438 (1958).
- 10.1073/pnas.93.20.10614 · DOI
- 10.1101/gr.6.7.639 · DOI
- 10.1126/science.278.5338.680 · DOI
- Spellman P. T. Sherlock G. Iyer V. R. Zhang M. Anders K. Eisen M. B. Brown P. O. Botstein D. & Futcher B. (1998). Mol. Biol. Cell in press.
- 10.1126/science.282.5389.699 · DOI
- Iyer V. R. Eisen M. B. Ross D. R. Schuler G. Moore T. Lee J. C. F. Trent J. M. Hudson J. Boguski M. Lashkari D. et al. (1998) Science in press.
- 10.1038/387s067 · DOI
- 10.1128/mcb.1.11.1007-1015.1981 · DOI
- 10.1007/BF00281618 · DOI
- 10.1242/jeb.201.8.1177 · DOI
- 10.1016/0092-8674(81)90326-3 · DOI
Cited by
Sorted by citations
Items 101–200 of 325
Hypoxia-induced gene expression profiling in the euryoxic fish Gillichthys mirabilis
Gracey, A. Y., Troll, J. V., & Somero, G. N. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1993 · Cited by 561
Coordination of Growth Rate, Cell Cycle, Stress Response, and Metabolic Activity in Yeast
Brauer, M. J., Huttenhower, C., Airoldi, E. M., Rosenstein, R., Matese, J. C., Gresham, D., Boer, V. M., Troyanskaya, O. G., & Botstein, D. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-08-0779 · Cited by 558
Self-citationGasch, A. P., Huang, M., Metzner, S., Botstein, D., Elledge, S. J., & Brown, P. O. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.10.2987 · Cited by 542
Self-citationvan de Mortel, J. E., Almar Villanueva, L., Schat, H., Kwekkeboom, J., Coughlan, S., Moerland, P. D., Ver Loren van Themaat, E., Koornneef, M., & Aarts, M. G. M. (2006) · Plant Physiology · doi:10.1104/pp.106.082073 · Cited by 547
'Gene shaving' as a method for identifying distinct sets of genes with similar expression patterns
Hastie, T., Tibshirani, R., Eisen, M. B., Alizadeh, A., Levy, R., Staudt, L., Chan, W. C., Botstein, D., & Brown, P. (2000) · Genome Biology · doi:10.1186/gb-2000-1-2-research0003 · Cited by 547
Self-citationGreer, E. L., Maures, T. J., Hauswirth, A. G., Green, E. M., Leeman, D. S., Maro, G. S., Han, S., Banko, M. R., Gozani, O., & Brunet, A. (2010) · Nature · doi:10.1038/nature09195 · Cited by 543
CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons
Tian, R., Gachechiladze, M. A., Ludwig, C. H., Laurie, M. T., Hong, J. Y., Nathaniel, D., Prabhu, A. V., Fernandopulle, M. S., Patel, R., Abshari, M., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.014 · Cited by 543
A motif-based profile scanning approach for genome-wide prediction of signaling pathways
Yaffe, M. B., Leparc, G. G., Lai, J., Obata, T., Volinia, S., & Cantley, L. C. (2001) · Nature Biotechnology · doi:10.1038/86737 · Cited by 517
Coppé, J.-P., Rodier, F., Patil, C. K., Freund, A., Desprez, P.-Y., & Campisi, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.257071 · Cited by 506
Large-Scale Delineation of Secreted Protein Biomarkers Overexpressed in Cancer Tissue and Serum
Welsh, J. B., Sapinoso, L. M., Kern, S. G., Brown, D. A., Liu, T., Bauskin, A. R., Ward, R. L., Hawkins, N. J., Quinn, D. I., Russell, P. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530278100 · Cited by 503
Kislinger, T., Cox, B., Kannan, A., Chung, C., Hu, P., Ignatchenko, A., Scott, M. S., Gramolini, A. O., Morris, Q., Hallett, M. T., et al. (2006) · Cell · doi:10.1016/j.cell.2006.01.044 · Cited by 482
Yauch, R. L., Januario, T., Eberhard, D. A., Cavet, G., Zhu, W., Fu, L., Pham, T. Q., Soriano, R., Stinson, J., Seshagiri, S., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1492 · Cited by 495
Elevated gene expression levels distinguish human from non-human primate brains
Cáceres, M., Lachuer, J., Zapala, M. A., Redmond, J. C., Kudo, L., Geschwind, D. H., Lockhart, D. J., Preuss, T. M., & Barlow, C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135499100 · Cited by 491
Bootstrapping cluster analysis: Assessing the reliability of conclusions from microarray experiments
Kerr, M. K., & Churchill, G. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161273698 · Cited by 474
TMPRSS2:ETV4 Gene Fusions Define a Third Molecular Subtype of Prostate Cancer
Tomlins, S. A., Mehra, R., Rhodes, D. R., Smith, L. R., Roulston, D., Helgeson, B. E., Cao, X., Wei, J. T., Rubin, M. A., Shah, R. B., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0168 · Cited by 469
Comparison of co-expression measures: mutual information, correlation, and model based indices
Song, L., Langfelder, P., & Horvath, S. (2012) · BMC Bioinformatics · doi:10.1186/1471-2105-13-328 · Cited by 460
Fradin, C., De Groot, P., MacCallum, D., Schaller, M., Klis, F., Odds, F. C., & Hube, B. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04557.x · Cited by 455
Gene expression patterns in human placenta
Sood, R., Zehnder, J. L., Druzin, M. L., & Brown, P. O. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508035103 · Cited by 454
Self-citationUnderstanding network concepts in modules
Dong, J., & Horvath, S. (2007) · BMC Systems Biology · doi:10.1186/1752-0509-1-24 · Cited by 455
Coppé, J.-P., Patil, C. K., Rodier, F., Krtolica, A., Beauséjour, C. M., Parrinello, S., Hodgson, J. G., Chin, K., Desprez, P.-Y., & Campisi, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009188 · Cited by 455
Ma, C., Fan, R., Ahmad, H., Shi, Q., Comin-Anduix, B., Chodon, T., Koya, R. C., Liu, C.-C., Kwong, G. A., Radu, C. G., et al. (2011) · Nature Medicine · doi:10.1038/nm.2375 · Cited by 441
A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas
Dahia, P. L. M., Ross, K. N., Wright, M. E., Hayashida, C. Y., Santagata, S., Barontini, M., Kung, A. L., Sanso, G., Powers, J. F., Tischler, A. S., et al. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010008 · Cited by 443
Telomerase modulates expression of growth-controlling genes and enhances cell proliferation
Smith, L. L., Coller, H. A., & Roberts, J. M. (2003) · Nature Cell Biology · doi:10.1038/ncb985 · Cited by 438
Salcedo, R., Worschech, A., Cardone, M., Jones, Y., Gyulai, Z., Dai, R.-M., Wang, E., Ma, W., Haines, D., O'hUigin, C., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100199 · Cited by 429
AGEMAP: A Gene Expression Database for Aging in Mice
Zahn, J. M., Poosala, S., Owen, A. B., Ingram, D. K., Lustig, A., Carter, A., Weeraratna, A. T., Taub, D. D., Gorospe, M., Mazan-Mamczarz, K., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030201 · Cited by 431
Wolfe, C. J., Kohane, I. S., & Butte, A. J. (2005) · BMC Bioinformatics · doi:10.1186/1471-2105-6-227 · Cited by 422
Concordant Regulation of Translation and mRNA Abundance for Hundreds of Targets of a Human microRNA
Hendrickson, D. G., Hogan, D. J., McCullough, H. L., Myers, J. W., Herschlag, D., Ferrell, J. E., & Brown, P. O. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000238 · Cited by 418
Self-citationBrash, D. E. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12377 · Cited by 401
Beg, Q. K., Vazquez, A., Ernst, J., de Menezes, M. A., Bar-Joseph, Z., Barabási, A.-L., & Oltvai, Z. N. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609845104 · Cited by 368
Nucleus alignment and cell signaling in fibroblasts: response to a micro-grooved topography
Dalby, M. J., Riehle, M. O., Yarwood, S. J., Wilkinson, C. D. W., & Curtis, A. S. G. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00053-8 · Cited by 408
Yoshimoto, H., Saltsman, K., Gasch, A. P., Li, H. X., Ogawa, N., Botstein, D., Brown, P. O., & Cyert, M. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202718200 · Cited by 404
Self-citationHumphries, J. D., Byron, A., Bass, M. D., Craig, S. E., Pinney, J. W., Knight, D., & Humphries, M. J. (2009) · Science Signaling · doi:10.1126/scisignal.2000396 · Cited by 404
Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling
Giordano, T. J., Kuick, R., Else, T., Gauger, P. G., Vinco, M., Bauersfeld, J., Sanders, D., Thomas, D. G., Doherty, G., & Hammer, G. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1067 · Cited by 401
Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence
Chicas, A., Wang, X., Zhang, C., McCurrach, M., Zhao, Z., Mert, O., Dickins, R. A., Narita, M., Zhang, M., & Lowe, S. W. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.01.023 · Cited by 388
Johannes, G., Carter, M. S., Eisen, M. B., Brown, P. O., & Sarnow, P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13118 · Cited by 394
Self-citationA Pilot Study of Circulating miRNAs as Potential Biomarkers of Early Stage Breast Cancer
Zhao, H., Shen, J., Medico, L., Wang, D., Ambrosone, C. B., & Liu, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013735 · Cited by 398
Callahan, B. J., DiGiulio, D. B., Goltsman, D. S. A., Sun, C. L., Costello, E. K., Jeganathan, P., Biggio, J. R., Wong, R. J., Druzin, M. L., Shaw, G. M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705899114 · Cited by 391
Automatic speech emotion recognition using modulation spectral features
Wu, S., Falk, T. H., & Chan, W.-Y. (2011) · Speech Communication · doi:10.1016/j.specom.2010.08.013 · Cited by 389
Genome-wide responses to mitochondrial dysfunction
Epstein, C. B., Waddle, J. A., Hale, W., Davé, V., Thornton, J., Macatee, T. L., Garner, H. R., & Butow, R. A. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.2.297 · Cited by 389
Corcoran, R. B., Cheng, K. A., Hata, A. N., Faber, A. C., Ebi, H., Coffee, E. M., Greninger, P., Brown, R. D., Godfrey, J. T., Cohoon, T. J., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2012.11.007 · Cited by 377
The expression of adipogenic genes is decreased in obesity and diabetes mellitus
Nadler, S. T., Stoehr, J. P., Schueler, K. L., Tanimoto, G., Yandell, B. S., & Attie, A. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11371 · Cited by 386
Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis
Giordano, T. J., Thomas, D. G., Kuick, R., Lizyness, M., Misek, D. E., Smith, A. L., Sanders, D., Aljundi, R. T., Gauger, P. G., Thompson, N. W., et al. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63846-1 · Cited by 383
Gene expression analysis identifies global gene dosage sensitivity in cancer
Fehrmann, R. S. N., Karjalainen, J. M., Krajewska, M., Westra, H.-J., Maloney, D., Simeonov, A., Pers, T. H., Hirschhorn, J. N., Jansen, R. C., Schultes, E. A., et al. (2015) · Nature Genetics · doi:10.1038/ng.3173 · Cited by 347
Transcription Profiling of Candida albicans Cells Undergoing the Yeast-to-Hyphal Transition
Nantel, A., Dignard, D., Bachewich, C., Harcus, D., Marcil, A., Bouin, A.-P., Sensen, C. W., Hogues, H., van het Hoog, M., Gordon, P., et al. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-05-0272 · Cited by 378
Rae, J. M., Creighton, C. J., Meck, J. M., Haddad, B. R., & Johnson, M. D. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-006-9392-8 · Cited by 374
A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility
Bassik, M. C., Kampmann, M., Lebbink, R. J., Wang, S., Hein, M. Y., Poser, I., Weibezahn, J., Horlbeck, M. A., Chen, S., Mann, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.01.030 · Cited by 365
The Fungal Pathogen Candida albicans Autoinduces Hyphal Morphogenesis by Raising Extracellular pH
Vylkova, S., Carman, A. J., Danhof, H. A., Collette, J. R., Zhou, H., & Lorenz, M. C. (2011) · mBio · doi:10.1128/mbio.00055-11 · Cited by 365
Rajski, M., Zanetti-Dällenbach, R., Vogel, B., Herrmann, R., Rochlitz, C., & Buess, M. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-1 · Cited by 355
Transcriptional profiling of aging in human muscle reveals a common aging signature
Zahn, J. M., Sonu, R., Vogel, H., Crane, E., Mazan-Mamczarz, K., Rabkin, R., Davis, R. W., Becker, K. G., Owen, A. B., & Kim, S. K. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020115 · Cited by 351
Integrating regulatory motif discovery and genome-wide expression analysis
Conlon, E. M., Liu, X. S., Lieb, J. D., & Liu, J. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630591100 · Cited by 343
García, R., Bermejo, C., Grau, C., Pérez, R., Rodríguez-Peña, J. M., Francois, J., Nombela, C., & Arroyo, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312954200 · Cited by 338
Jelinsky, S. A., Estep, P., Church, G. M., & Samson, L. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.21.8157-8167.2000 · Cited by 335
Bone marrow mesenchymal stem cells are abnormal in multiple myeloma
Corre, J., Mahtouk, K., Attal, M., Gadelorge, M., Huynh, A., Fleury-Cappellesso, S., Danho, C., Laharrague, P., Klein, B., Rème, T., et al. (2007) · Leukemia · doi:10.1038/sj.leu.2404621 · Cited by 328
Comparative Metabolic Flux Profiling of Melanoma Cell Lines
Scott, D. A., Richardson, A. D., Filipp, F. V., Knutzen, C. A., Chiang, G. G., Ronai, Z. A., Osterman, A. L., & Smith, J. W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.282046 · Cited by 328
VAN DE MORTEL, J. E., SCHAT, H., MOERLAND, P. D., VAN THEMAAT, E. V. L., VAN DER ENT, S., BLANKESTIJN, H., GHANDILYAN, A., TSIATSIANI, S., & AARTS, M. G. M. (2008) · Plant, Cell & Environment · doi:10.1111/j.1365-3040.2007.01764.x · Cited by 326
Stress-activated Genomic Expression Changes Serve a Preparative Role for Impending Stress in Yeast
Berry, D. B., & Gasch, A. P. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-07-0680 · Cited by 326
Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae
Reguly, T., Breitkreutz, A., Boucher, L., Breitkreutz, B.-J., Hon, G. C., Myers, C. L., Parsons, A., Friesen, H., Oughtred, R., Tong, A., et al. (2006) · Journal of Biology · doi:10.1186/jbiol36 · Cited by 326
Self-citationMoore, M. J., Scheel, T. K. H., Luna, J. M., Park, C. Y., Fak, J. J., Nishiuchi, E., Rice, C. M., & Darnell, R. B. (2015) · Nature Communications · doi:10.1038/ncomms9864 · Cited by 326
When is hub gene selection better than standard meta-analysis?
Langfelder, P., Mischel, P. S., & Horvath, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061505 · Cited by 313
Subtypes of Preeclampsia: Recognition and Determining Clinical Usefulness
Roberts, J. M., Rich-Edwards, J. W., McElrath, T. F., Garmire, L., Myatt, L., & for the Global Pregnancy Collaboration (2021) · Hypertension · doi:10.1161/hypertensionaha.120.14781 · Cited by 311
Auxin-related gene families in abiotic stress response in Sorghum bicolor
Wang, S., Bai, Y., Shen, C., Wu, Y., Zhang, S., Jiang, D., Guilfoyle, T. J., Chen, M., & Qi, Y. (2010) · Functional & Integrative Genomics · doi:10.1007/s10142-010-0174-3 · Cited by 297
Diverse and Specific Gene Expression Responses to Stresses in Cultured Human Cells
Murray, J. I., Whitfield, M. L., Trinklein, N. D., Myers, R. M., Brown, P. O., & Botstein, D. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-11-0799 · Cited by 300
Self-citationPTEN negatively regulates neural stem cell self-renewal by modulating G 0 -G 1 cell cycle entry
Groszer, M., Erickson, R., Scripture-Adams, D. D., Dougherty, J. D., Le Belle, J., Zack, J. A., Geschwind, D. H., Liu, X., Kornblum, H. I., & Wu, H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509939103 · Cited by 306
Kabir, M., Skurnik, G., Naour, N., Pechtner, V., Meugnier, E., Rome, S., Quignard-Boulangé, A., Vidal, H., Slama, G., Clément, K., et al. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1670 · Cited by 316
Mizuki, M., Schwäble, J., Steur, C., Choudhary, C., Agrawal, S., Sargin, B., Steffen, B., Matsumura, I., Kanakura, Y., Böhmer, F. D., et al. (2003) · Blood · doi:10.1182/blood-2002-06-1677 · Cited by 298
Early-branching gut fungi possess a large, comprehensive array of biomass-degrading enzymes
Solomon, K. V., Haitjema, C. H., Henske, J. K., Gilmore, S. P., Borges-Rivera, D., Lipzen, A., Brewer, H. M., Purvine, S. O., Wright, A. T., Theodorou, M. K., et al. (2016) · Science · doi:10.1126/science.aad1431 · Cited by 302
Longitudinal Study of Postconcussion Syndrome: Not Everyone Recovers
Hiploylee, C., Dufort, P. A., Davis, H. S., Wennberg, R. A., Tartaglia, M. C., Mikulis, D., Hazrati, L.-N., & Tator, C. H. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2016.4677 · Cited by 293
Ploran, E. J., Nelson, S. M., Velanova, K., Donaldson, D. I., Petersen, S. E., & Wheeler, M. E. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3522-07.2007 · Cited by 282
“As a means of accommodating more diverse patterns of data, UPGMA was developed (Eisen et al., 1998).”
MethodLipoprotein lipase links dietary fat to solid tumor cell proliferation
Kuemmerle, N. B., Rysman, E., Lombardo, P. S., Flanagan, A. J., Lipe, B. C., Wells, W. A., Pettus, J. R., Froehlich, H. M., Memoli, V. A., Morganelli, P. M., et al. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-0802 · Cited by 286
Segman, R. H., Shefi, N., Goltser-Dubner, T., Friedman, N., Kaminski, N., & Shalev, A. Y. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001636 · Cited by 281
Kemmeren, P., Sameith, K., van de Pasch, L. A. L., Benschop, J. J., Lenstra, T. L., Margaritis, T., O’Duibhir, E., Apweiler, E., van Wageningen, S., Ko, C. W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.02.054 · Cited by 277
Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain
He, M., Liu, Y., Wang, X., Zhang, M. Q., Hannon, G. J., & Huang, Z. J. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.010 · Cited by 277
Greenfield, A., Madar, A., Ostrer, H., & Bonneau, R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013397 · Cited by 255
Li, J. Z., Vawter, M. P., Walsh, D. M., Tomita, H., Evans, S. J., Choudary, P. V., Lopez, J. F., Avelar, A., Shokoohi, V., Chung, T., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh065 · Cited by 261
eSGA: E. coli synthetic genetic array analysis
Butland, G., Babu, M., Díaz-Mejía, J. J., Bohdana, F., Phanse, S., Gold, B., Yang, W., Li, J., Gagarinova, A. G., Pogoutse, O., et al. (2008) · Nature Methods · doi:10.1038/nmeth.1239 · Cited by 256
de Fraipont, F., El Atifi, M., Cherradi, N., Le Moigne, G., Defaye, G., Houlgatte, R., Bertherat, J., Bertagna, X., Plouin, P.-F., Baudin, E., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1075 · Cited by 261
Time- and exercise-dependent gene regulation in human skeletal muscle
Zambon, A. C., McDearmon, E. L., Salomonis, N., Vranizan, K. M., Johansen, K. L., Adey, D., Takahashi, J. S., Schambelan, M., & Conklin, B. R. (2003) · Genome Biology · doi:10.1186/gb-2003-4-10-r61 · Cited by 254
Elliot, M. A., Karoonuthaisiri, N., Huang, J., Bibb, M. J., Cohen, S. N., Kao, C. M., & Buttner, M. J. (2003) · Genes & Development · doi:10.1101/gad.264403 · Cited by 246
Meyer, M., Ronald, J., Vernuccio, F., Nelson, R. C., Ramirez-Giraldo, J. C., Solomon, J., Patel, B. N., Samei, E., & Marin, D. (2019) · Radiology · doi:10.1148/radiol.2019190928 · Cited by 258
Genome-wide Analysis of the Response to Cell Wall Mutations in the Yeast Saccharomyces cerevisiae
Lagorce, A., Hauser, N. C., Labourdette, D., Rodriguez, C., Martin-Yken, H., Arroyo, J., Hoheisel, J. D., & François, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211604200 · Cited by 254
Cloutier, N., Tan, S., Boudreau, L. H., Cramb, C., Subbaiah, R., Lahey, L., Albert, A., Shnayder, R., Gobezie, R., Nigrovic, P. A., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201201846 · Cited by 254
Guidance for RNA-seq co-expression network construction and analysis: safety in numbers
Ballouz, S., Verleyen, W., & Gillis, J. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv118 · Cited by 215
Gotea, V., Visel, A., Westlund, J. M., Nobrega, M. A., Pennacchio, L. A., & Ovcharenko, I. (2010) · Genome Research · doi:10.1101/gr.104471.109 · Cited by 248
Molecular aging in human prefrontal cortex is selective and continuous throughout adult life
Erraji-Benchekroun, L., Underwood, M. D., Arango, V., Galfalvy, H., Pavlidis, P., Smyrniotopoulos, P., Mann, J. J., & Sibille, E. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.034 · Cited by 236
Gene expression profiling of cutaneous wound healing
Deonarine, K., Panelli, M. C., Stashower, M. E., Jin, P., Smith, K., Slade, H. B., Norwood, C., Wang, E., Marincola, F. M., & Stroncek, D. F. (2007) · Journal of Translational Medicine · doi:10.1186/1479-5876-5-11 · Cited by 229
Devarajan, P., Mishra, J., Supavekin, S., Patterson, L. T., & Steven Potter, S. (2003) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2003.09.012 · Cited by 229
LoCascio, R. G., Desai, P., Sela, D. A., Weimer, B., & Mills, D. A. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.00675-10 · Cited by 229
Li, Y., Su, Z., Zhao, W., Zhang, X., Momin, N., Zhang, C., Wittrup, K. D., Dong, Y., Irvine, D. J., & Weiss, R. (2020) · Nature Cancer · doi:10.1038/s43018-020-0095-6 · Cited by 233
A global view of protein expression in human cells, tissues, and organs
Pontén, F., Gry, M., Fagerberg, L., Lundberg, E., Asplund, A., Berglund, L., Oksvold, P., Björling, E., Hober, S., Kampf, C., et al. (2009) · Molecular Systems Biology · doi:10.1038/msb.2009.93 · Cited by 222
Hansson, A., Hance, N., Dufour, E., Rantanen, A., Hultenby, K., Clayton, D. A., Wibom, R., & Larsson, N.-G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308710100 · Cited by 220
Lane, S., Birse, C., Zhou, S., Matson, R., & Liu, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104484200 · Cited by 220
De Backer, M. D., Ilyina, T., Ma, X.-J., Vandoninck, S., Luyten, W. H. M. L., & Vanden Bossche, H. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.6.1660-1670.2001 · Cited by 211
Integrating physical and genetic maps: from genomes to interaction networks
Beyer, A., Bandyopadhyay, S., & Ideker, T. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2144 · Cited by 207
Comparative genomics of the environmental stress response in ascomycete fungi
Gasch, A. P. (2007) · Yeast · doi:10.1002/yea.1512 · Cited by 210
Kassen, S. C., Ramanan, V., Montgomery, J. E., T. Burket, C., Liu, C., Vihtelic, T. S., & Hyde, D. R. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20362 · Cited by 203
Gaussian mixture clustering and imputation of microarray data
Ouyang, M., Welsh, W. J., & Georgopoulos, P. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth007 · Cited by 202
“Clustering methods usually fall into two categories: hierarchical methods (Eisen et al., 1998) and relocational methods.”
Britschgi, M., Olin, C. E., Johns, H. T., Takeda-Uchimura, Y., LeMieux, M. C., Rufibach, K., Rajadas, J., Zhang, H., Tomooka, B., Robinson, W. H., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904866106 · Cited by 201
Insights into TREM2 biology by network analysis of human brain gene expression data
Forabosco, P., Ramasamy, A., Trabzuni, D., Walker, R., Smith, C., Bras, J., Levine, A. P., Hardy, J., Pocock, J. M., Guerreiro, R., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.05.001 · Cited by 180
Bargehr, J., Ong, L. P., Colzani, M., Davaapil, H., Hofsteen, P., Bhandari, S., Gambardella, L., Le Novère, N., Iyer, D., Sampaziotis, F., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0197-9 · Cited by 195
Boisvert, F.-M., Lam, Y. W., Lamont, D., & Lamond, A. I. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900429-mcp200 · Cited by 185
Metadata
- Authors
- Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Botstein, David
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1998-12-08
- Volume
- 95
- Issue
- 25
- Pages
- 14863-14868
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC24541
- OpenAlex
- W2150926065
- Cited by
- 16,184
- References
- 0
- Citations by year
- 2026: 115 · 2025: 129 · 2024: 164 · 2023: 251 · 2022: 230 · 2021: 264 · 2020: 318 · 2019: 366 · 2018: 408 · 2017: 428 · 2016: 538 · 2015: 588 · 2014: 665 · 2013: 692 · 2012: 763
- FWCI
- 73.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Alfred P. Sloan Foundation
- National Institutes of Health
- National Human Genome Research Institute (R01HG000983)
- National Eye Institute
- National Cancer Institute (CA46406, R01CA077097)
- National Institute of General Medical Sciences (R37GM046406, R01GM046406)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- gene expression clustering, microarray hybridization, gene co-expression, Saccharomyces cerevisiae, human gene expression, gene function prediction, gene function similarity
- MeSH terms
- Multigene Family, Humans, Saccharomyces cerevisiae, Gene Expression, Genome, Human, Cluster Analysis, Genome, Fungal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review