Cited by 16,184Gene expression and cancer classificationBioinformatics and Genomic NetworksFungal and yeast genetics research

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Cluster analysis and display of genome-wide expression patterns

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Eisen, Michael B., Spellman, Paul T., Brown, Patrick O., Botstein, David·1998·Proceedings of the National Academy of Sciences

Abstract

A system of cluster analysis for genome-wide expression data from DNA microarray hybridization is described that uses standard statistical algorithms to arrange genes according to similarity in pattern of gene expression. The output is displayed graphically, conveying the clustering and the underlying expression data simultaneously in a form intuitive for biologists. We have found in the budding yeast Saccharomyces cerevisiae that clustering gene expression data groups together efficiently genes of known similar function, and we find a similar tendency in human data. Thus patterns seen in genome-wide expression experiments can be interpreted as indications of the status of cellular processes. Also, coexpression of genes of known function with poorly characterized or novel genes may provide a simple means of gaining leads to the functions of many genes for which information is not available currently.

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Research works printed but not linked: 16

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Metadata

Authors
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Botstein, David
Venue
Proceedings of the National Academy of Sciences
Published
1998-12-08
Volume
95
Issue
25
Pages
14863-14868
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2150926065
Cited by
16,184
References
0
Citations by year
2026: 115 · 2025: 129 · 2024: 164 · 2023: 251 · 2022: 230 · 2021: 264 · 2020: 318 · 2019: 366 · 2018: 408 · 2017: 428 · 2016: 538 · 2015: 588 · 2014: 665 · 2013: 692 · 2012: 763
FWCI
73.93
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Howard Hughes Medical Institute
  • Alfred P. Sloan Foundation
  • National Institutes of Health
  • National Human Genome Research Institute (R01HG000983)
  • National Eye Institute
  • National Cancer Institute (CA46406, R01CA077097)
  • National Institute of General Medical Sciences (R37GM046406, R01GM046406)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
gene expression clustering, microarray hybridization, gene co-expression, Saccharomyces cerevisiae, human gene expression, gene function prediction, gene function similarity
MeSH terms
Multigene Family, Humans, Saccharomyces cerevisiae, Gene Expression, Genome, Human, Cluster Analysis, Genome, Fungal

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