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The blood–brain barrier in health and disease: Important unanswered questions

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Profaci, Caterina P., Munji, Roeben N., Pulido, Robert S., Daneman, Richard·2020·Journal of Experimental Medicine
DOI 10.1084/jem.20190062
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Abstract

The blood vessels vascularizing the central nervous system exhibit a series of distinct properties that tightly control the movement of ions, molecules, and cells between the blood and the parenchyma. This “blood–brain barrier” is initiated during angiogenesis via signals from the surrounding neural environment, and its integrity remains vital for homeostasis and neural protection throughout life. Blood–brain barrier dysfunction contributes to pathology in a range of neurological conditions including multiple sclerosis, stroke, and epilepsy, and has also been implicated in neurodegenerative diseases such as Alzheimer’s disease. This review will discuss current knowledge and key unanswered questions regarding the blood–brain barrier in health and disease.

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Cited by

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Metadata

Authors
Profaci, C. P., Munji, R. N., Pulido, R. S., & Daneman, R.
Venue
Journal of Experimental Medicine
Publisher
Rockefeller University Press
Published
2020-03-25
Volume
217
Issue
4
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.20190062
OpenAlex
W3013784088
Cited by
761
References
69
FWCI
29.66
Type
journal article
Language
en
Open access
hybrid
Licence

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