Cited by 3,736Historical and modern epidemiology studiesStatistical Methods in EpidemiologyHealth, Environment, Cognitive Aging

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Sick individuals and sick populations

Rose, Geoffrey·2001·International Journal of Epidemiology

DOI 10.1093/ije/30.3.427

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Rose G (Department of Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK). Sick individuals and sick populations. International Journal of Epidemiology 1985;14:32--38. Aetiology confronts two distinct issues: the determinants of individual cases, and the determinants of incidence rate. If exposure to a necessary agent is homogeneous within a population, then case/control and cohort methods will fail to detect it: they will only identify markers of susceptibility. The corresponding strategies in control are the 'high-risk' approach, which seeks to protect susceptible individuals, and the population approach, which seeks to control the causes of incidence. The two approaches are not usually in competition, but the prior concern should always be to discover and control the causes of incidence.

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Authors: Rose, G.
Affiliations: London School of Hygiene & Tropical Medicine (GB)
Corresponding author: Rose, Geoffrey
Venue: International Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 2001-06
Volume: 30
Issue: 3
Pages: 427-432
ISSN: 0300-5771 (ISSN-L)
1464-3685
DOI: 10.1093/ije/30.3.427
OpenAlex: W1907953089
Cited by: 3,736
References: 7
Citations by year: 2026: 84 · 2025: 108 · 2024: 113 · 2023: 157 · 2022: 137 · 2021: 184 · 2020: 168 · 2019: 182 · 2018: 162 · 2017: 153 · 2016: 154 · 2015: 192 · 2014: 184 · 2013: 174 · 2012: 177
FWCI: 374.79
Type: journal article
Language: en
Open access: closed
Locations: International Journal of Epidemiology (publishedVersion)
PubMed (publishedVersion)
LSHTM Research Online (London School of Hygiene and Tropical Medicine) (submittedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Historical and modern epidemiology studies
Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Keywords: etiology, incidence rates, case-control study, cohort studies, susceptibility markers, high-risk approach, population approach, disease control
MeSH terms: Cardiovascular Diseases, Disease Susceptibility, Epidemiologic Methods, Humans, Population Surveillance, Risk, Causality, Incidence

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