Dopamine receptors –IUPHAR R eview 13

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Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

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Cell Signaling by Receptor Tyrosine Kinases

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Dopamine receptors: from structure to function

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The physiology, signaling, and pharmacology of dopamine receptors

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Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

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GSK3 takes centre stage more than 20 years after its discovery

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SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity

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Molecular cloning and expression of glycogen synthase kinase‐3/factor A.

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β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

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Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

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Molecular biology of dopamine receptors

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An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior

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Distinct roles for direct and indirect pathway striatal neurons in reinforcement

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Convergent evidence for impaired AKT1-GSK3β signaling in schizophrenia

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Trace amines: Identification of a family of mammalian G protein-coupled receptors

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DESENSITIZATION OF G PROTEIN–COUPLED RECEPTORS AND NEURONAL FUNCTIONS

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The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

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Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds

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Adenosine–dopamine receptor–receptor interactions as an integrative mechanism in the basal ganglia

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Structure and function of dopamine receptors

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Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade

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Inositol trisphosphate and calcium signalling mechanisms

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DARPP-32: An Integrator of Neurotransmission

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RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation

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Molecular Diversity of the Dopamine Receptors

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Opposing Patterns of Signaling Activation in Dopamine D1and D2Receptor-Expressing Striatal Neurons in Response to Cocaine and Haloperidol

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PKB/AKT: functional insights from genetic models

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THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels

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Mitogen inactivation of glycogen synthase kinase-3 β in intact cells via serine 9 phosphorylation

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Illuminating insights into protein-protein interactions using bioluminescence resonance energy transfer (BRET)

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Calcium-dependent Epidermal Growth Factor Receptor Transactivation Mediates the Angiotensin II-induced Mitogen-activated Protein Kinase Activation in Vascular Smooth Muscle Cells

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The Concise Guide to PHARMACOLOGY 2013/14: G Protein‐Coupled Receptors

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Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

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Stimulation of high-affinity adenosine A2 receptors decreases the affinity of dopamine D2 receptors in rat striatal membranes.

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D1/D5 receptor agonists induce a protein synthesis-dependent late potentiation in the CA1 region of the hippocampus.

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Dual Regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine d1 receptor

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Transient and Selective Overexpression of Dopamine D2 Receptors in the Striatum Causes Persistent Abnormalities in Prefrontal Cortex Functioning

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Neuronal autoantigens—pathogenesis, associated disorders and antibody testing

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The IGF-1/Akt Pathway Is Neuroprotective in Huntington's Disease and Involves Huntingtin Phosphorylation by Akt

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Coaggregation, Cointernalization, and Codesensitization of Adenosine A2A Receptors and Dopamine D2Receptors

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D1–D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of G q /11 in the striatum

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GSK-3: Functional Insights from Cell Biology and Animal Models

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A Possible Role for the Striatum in the Pathogenesis of the Cognitive Symptoms of Schizophrenia

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Dopamine D1 and D2 Receptor Co-activation Generates a Novel Phospholipase C-mediated Calcium Signal

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Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells

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Dopamine D 1 and adenosine A 1 receptors form functionally interacting heteromeric complexes

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D2Dopamine Receptors in Striatal Medium Spiny Neurons Reduce L-Type Ca2+Currents and Excitability via a Novel PLCβ1–IP3–Calcineurin-Signaling Cascade

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Adenosine A2A-Dopamine D2 Receptor-Receptor Heteromerization

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An updated view on the role of dopamine in myopia

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The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

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Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.

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The Akt–GSK-3 signaling cascade in the actions of dopamine

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Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

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The β2-Adrenergic Receptor Mediates Extracellular Signal-regulated Kinase Activation via Assembly of a Multi-receptor Complex with the Epidermal Growth Factor Receptor

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Control of Basal Ganglia Output by Direct and Indirect Pathway Projection Neurons

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Metabolic side effects of antipsychotic drug treatment – pharmacological mechanisms

Reynolds, G. P., & Kirk, S. L. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.10.010 · Cited by 401

Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor

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Antibodies to surface dopamine-2 receptor in autoimmune movement and psychiatric disorders

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Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors

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TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity

Revel, F. G., Moreau, J.-L., Gainetdinov, R. R., Bradaia, A., Sotnikova, T. D., Mory, R., Durkin, S., Zbinden, K. G., Norcross, R., Meyer, C. A., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103029108 · Cited by 364

A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior

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Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices

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Discovery of β-Arrestin–Biased Dopamine D 2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy

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Trace Amine-Associated Receptor 1 Modulates Dopaminergic Activity

Lindemann, L., Meyer, C. A., Jeanneau, K., Bradaia, A., Ozmen, L., Bluethmann, H., Bettler, B., Wettstein, J. G., Borroni, E., Moreau, J.-L., et al. (2008) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.132647 · Cited by 348

Transgenic Mice Overexpressing Glycogen Synthase Kinase 3β: A Putative Model of Hyperactivity and Mania

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Time-resolved FRET between GPCR ligands reveals oligomers in native tissues

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Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation

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Dopamine D2 receptors form higher order oligomers at physiological expression levels

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G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins

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Antagonism of dopamine D2 receptor/β-arrestin 2 interaction is a common property of clinically effective antipsychotics

Masri, B., Salahpour, A., Didriksen, M., Ghisi, V., Beaulieu, J.-M., Gainetdinov, R. R., & Caron, M. G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803522105 · Cited by 320

Apo-Ghrelin Receptor Forms Heteromers with DRD2 in Hypothalamic Neurons and Is Essential for Anorexigenic Effects of DRD2 Agonism

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AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test

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Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use

Bock, R., Shin, J. H., Kaplan, A. R., Dobi, A., Markey, E., Kramer, P. F., Gremel, C. M., Christensen, C. H., Adrover, M. F., & Alvarez, V. A. (2013) · Nature Neuroscience · doi:10.1038/nn.3369 · Cited by 307

Fluorescence/Bioluminescence Resonance Energy Transfer Techniques to Study G-Protein-Coupled Receptor Activation and Signaling

Lohse, M. J., Nuber, S., & Hoffmann, C. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.004309 · Cited by 307

Gene Expression Profiling of Facilitated L-LTP in VP16-CREB Mice Reveals that BDNF Is Critical for the Maintenance of LTP and Its Synaptic Capture

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Targeting the dopamine D2receptor in schizophrenia

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Parsing Molecular and Behavioral Effects of Cocaine in Mitogen- and Stress-Activated Protein Kinase-1-Deficient Mice

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G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins

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A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight

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Retinal Dopamine Mediates Multiple Dimensions of Light-Adapted Vision

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Calcium signaling cascade links dopamine D1–D2 receptor heteromer to striatal BDNF production and neuronal growth

Hasbi, A., Fan, T., Alijaniaram, M., Nguyen, T., Perreault, M. L., O'Dowd, B. F., & George, S. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903676106 · Cited by 273

Regulation of Akt Signaling by D2and D3Dopamine Receptors In Vivo

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