The extracellular matrix as a multitasking player in disease

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

Kessenbrock, K., Plaks, V., & Werb, Z. (2010) · Cell · doi:10.1016/j.cell.2010.03.015 · Cited by 5,151

Tumour exosome integrins determine organotropic metastasis

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The extracellular matrix at a glance

Frantz, C., Stewart, K. M., & Weaver, V. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.023820 · Cited by 4,334

Extracellular matrix structure

Theocharis, A. D., Skandalis, S. S., Gialeli, C., & Karamanos, N. K. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.001 · Cited by 2,598

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

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Collagen reorganization at the tumor-stromal interface facilitates local invasion

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Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting

Gialeli, C., Theocharis, A. D., & Karamanos, N. K. (2011) · The FEBS Journal · doi:10.1111/j.1742-4658.2010.07919.x · Cited by 1,607

Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

Gaggioli, C., Hooper, S., Hidalgo-Carcedo, C., Grosse, R., Marshall, J. F., Harrington, K., & Sahai, E. (2007) · Nature Cell Biology · doi:10.1038/ncb1658 · Cited by 1,589

Every step of the way: integrins in cancer progression and metastasis

Hamidi, H., & Ivaska, J. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0038-z · Cited by 1,493

Fibrosis–a common pathway to organ injury and failure

Rockey, D. C., Bell, P. D., & Hill, J. A. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1300575 · Cited by 1,428

Targeted Disruption of Decorin Leads to Abnormal Collagen Fibril Morphology and Skin Fragility

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Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

Wipff, P.-J., Rifkin, D. B., Meister, J.-J., & Hinz, B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704042 · Cited by 1,346

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

Conklin, M. W., Eickhoff, J. C., Riching, K. M., Pehlke, C. A., Eliceiri, K. W., Provenzano, P. P., Friedl, A., & Keely, P. J. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2010.11.076 · Cited by 1,285

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

Iozzo, R. V., & Schaefer, L. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.02.003 · Cited by 1,263

The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

Sorushanova, A., Delgado, L. M., Wu, Z., Shologu, N., Kshirsagar, A., Raghunath, R., Mullen, A. M., Bayon, Y., Pandit, A., Raghunath, M., et al. (2019) · Advanced Materials · doi:10.1002/adma.201801651 · Cited by 1,151

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

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Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

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The Fibronectin Domain ED-A Is Crucial for Myofibroblastic Phenotype Induction by Transforming Growth Factor-β1

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Osteogenesis imperfecta

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Collagens at a glance

Kadler, K. E., Baldock, C., Bella, J., & Boot-Handford, R. P. (2007) · Journal of Cell Science · doi:10.1242/jcs.03453 · Cited by 823

A Stem Cell–Based Approach to Cartilage Repair

Johnson, K., Zhu, S., Tremblay, M. S., Payette, J. N., Wang, J., Bouchez, L. C., Meeusen, S., Althage, A., Cho, C. Y., Wu, X., et al. (2012) · Science · doi:10.1126/science.1215157 · Cited by 796

Extracellular control of TGFβ signalling in vascular development and disease

ten Dijke, P., & Arthur, H. M. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2262 · Cited by 778

Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators

Kadler, K. E., Hill, A., & Canty-Laird, E. G. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.06.008 · Cited by 756

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

Labernadie, A., Kato, T., Brugués, A., Serra-Picamal, X., Derzsi, S., Arwert, E., Weston, A., González-Tarragó, V., Elosegui-Artola, A., Albertazzi, L., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3478 · Cited by 747

Lumican regulates collagen fibril assembly: skin fragility and corneal opacity in the absence of lumican

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The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1

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Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans

Zuo, F., Kaminski, N., Eugui, E., Allard, J., Yakhini, Z., Ben-Dor, A., Lollini, L., Morris, D., Kim, Y., DeLustro, B., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092134099 · Cited by 620

Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development

Liu, X., Wu, H., Byrne, M., Krane, S., & Jaenisch, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.1852 · Cited by 614

Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice

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The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship

Hinz, B. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.05.006 · Cited by 608

Role of COL4A1 in Small-Vessel Disease and Hemorrhagic Stroke

Gould, D. B., Phalan, F. C., van Mil, S. E., Sundberg, J. P., Vahedi, K., Massin, P., Bousser, M. G., Heutink, P., Miner, J. H., Tournier-Lasserve, E., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa053727 · Cited by 581

The nature and biology of basement membranes

Pozzi, A., Yurchenco, P. D., & Iozzo, R. V. (2017) · Matrix Biology · doi:10.1016/j.matbio.2016.12.009 · Cited by 575

Glycosaminoglycans: key players in cancer cell biology and treatment

Afratis, N., Gialeli, C., Nikitovic, D., Tsegenidis, T., Karousou, E., Theocharis, A. D., Pavão, M. S., Tzanakakis, G. N., & Karamanos, N. K. (2012) · The FEBS Journal · doi:10.1111/j.1742-4658.2012.08529.x · Cited by 554

Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin

Erdogan, B., Ao, M., White, L. M., Means, A. L., Brewer, B. M., Yang, L., Washington, M. K., Shi, C., Franco, O. E., Weaver, A. M., et al. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201704053 · Cited by 552

Fibrotic extracellular matrix activates a profibrotic positive feedback loop

Parker, M. W., Rossi, D., Peterson, M., Smith, K., Sikström, K., White, E. S., Connett, J. E., Henke, C. A., Larsson, O., & Bitterman, P. B. (2014) · Journal of Clinical Investigation · doi:10.1172/jci71386 · Cited by 548

Mutations in Col4a1 Cause Perinatal Cerebral Hemorrhage and Porencephaly

Gould, D. B., Phalan, F. C., Breedveld, G. J., van Mil, S. E., Smith, R. S., Schimenti, J. C., Aguglia, U., van der Knaap, M. S., Heutink, P., & John, S. W. M. (2005) · Science · doi:10.1126/science.1109418 · Cited by 541

The good and the bad collagens of fibrosis – Their role in signaling and organ function

Karsdal, M. A., Nielsen, S. H., Leeming, D. J., Langholm, L. L., Nielsen, M. J., Manon-Jensen, T., Siebuhr, A., Gudmann, N. S., Rønnow, S., Sand, J. M., et al. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.014 · Cited by 509

Laminins

Durbeej, M. (2010) · Cell and Tissue Research · doi:10.1007/s00441-009-0838-2 · Cited by 500

Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney

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Scar-Associated Macrophages Are a Major Source of Hepatic Matrix Metalloproteinase-13 and Facilitate the Resolution of Murine Hepatic Fibrosis

Fallowfield, J. A., Mizuno, M., Kendall, T. J., Constandinou, C. M., Benyon, R. C., Duffield, J. S., & Iredale, J. P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5288 · Cited by 479

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

Babelova, A., Moreth, K., Tsalastra-Greul, W., Zeng-Brouwers, J., Eickelberg, O., Young, M. F., Bruckner, P., Pfeilschifter, J., Schaefer, R. M., Gröne, H.-J., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.014266 · Cited by 474

Glypican-3 Promotes the Growth of Hepatocellular Carcinoma by Stimulating Canonical Wnt Signaling

Capurro, M. I., Xiang, Y.-Y., Lobe, C., & Filmus, J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4244 · Cited by 469

Phenotypic Effects of Biglycan Deficiency Are Linked to Collagen Fibril Abnormalities, Are Synergized by Decorin Deficiency, and Mimic Ehlers-Danlos-Like Changes in Bone and Other Connective Tissues

Corsi, A., Xu, T., Chen, X.-D., Boyde, A., Liang, J., Mankani, M., Sommer, B., Iozzo, R. V., Eichstetter, I., Robey, P. G., et al. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.7.1180 · Cited by 465

Cartilage diseases

Krishnan, Y., & Grodzinsky, A. J. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.05.005 · Cited by 443

Keloids: The paradigm of skin fibrosis — Pathomechanisms and treatment

Andrews, J. P., Marttala, J., Macarak, E., Rosenbloom, J., & Uitto, J. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.01.013 · Cited by 433

Glypican-3 as a Serum Marker for Hepatocellular Carcinoma

Capurro, M., & Filmus, J. (2005) · Cancer Research · doi:10.1158/0008-5472.372.65.1 · Cited by 432

The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain.

Sandy, J. D., Flannery, C. R., Neame, P. J., & Lohmander, L. S. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115742 · Cited by 411

Matrix remodeling by MMPs during wound repair

Rohani, M. G., & Parks, W. C. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.03.002 · Cited by 407

Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting

Theocharis, A. D., Skandalis, S. S., Tzanakakis, G. N., & Karamanos, N. K. (2010) · The FEBS Journal · doi:10.1111/j.1742-4658.2010.07800.x · Cited by 403

Tenascin‐C and SF/HGF produced by myofibroblasts in vitro provide convergent proinvasive signals to human colon cancer cells through RhoA and Rac

De Wever, O., Nguyen, Q., Van Hoorde, L., Bracke, M., Bruyneel, E., Gespach, C., & Mareel, M. (2004) · The FASEB Journal · doi:10.1096/fj.03-1110fje · Cited by 402

TGF-β Modulates Ovarian Cancer Invasion by Upregulating CAF-Derived Versican in the Tumor Microenvironment

Yeung, T.-L., Leung, C. S., Wong, K.-K., Samimi, G., Thompson, M. S., Liu, J., Zaid, T. M., Ghosh, S., Birrer, M. J., & Mok, S. C. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0023 · Cited by 394

Revisiting the matricellular concept

Murphy-Ullrich, J. E., & Sage, E. H. (2014) · Matrix Biology · doi:10.1016/j.matbio.2014.07.005 · Cited by 392

Fibronectin, the extracellular glue

Zollinger, A. J., & Smith, M. L. (2017) · Matrix Biology · doi:10.1016/j.matbio.2016.07.011 · Cited by 383

The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer.

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Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics

Karamanos, N. K., Piperigkou, Z., Theocharis, A. D., Watanabe, H., Franchi, M., Baud, S., Brézillon, S., Götte, M., Passi, A., Vigetti, D., et al. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00354 · Cited by 367

Glypican-3 Inhibits Hedgehog Signaling during Development by Competing with Patched for Hedgehog Binding

Capurro, M. I., Xu, P., Shi, W., Li, F., Jia, A., & Filmus, J. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.03.006 · Cited by 364

Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

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Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix

Kubow, K. E., Vukmirovic, R., Zhe, L., Klotzsch, E., Smith, M. L., Gourdon, D., Luna, S., & Vogel, V. (2015) · Nature Communications · doi:10.1038/ncomms9026 · Cited by 344

FBN1: The disease-causing gene for Marfan syndrome and other genetic disorders

Sakai, L. Y., Keene, D. R., Renard, M., & De Backer, J. (2016) · Gene · doi:10.1016/j.gene.2016.07.033 · Cited by 342

Cancer-associated fibroblasts lead tumor invasion through integrin-β3–dependent fibronectin assembly

Attieh, Y., Clark, A. G., Grass, C., Richon, S., Pocard, M., Mariani, P., Elkhatib, N., Betz, T., Gurchenkov, B., & Vignjevic, D. M. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201702033 · Cited by 338

Matrilysin (Matrix Metalloproteinase-7) Mediates E-Cadherin Ectodomain Shedding in Injured Lung Epithelium

McGuire, J. K., Li, Q., & Parks, W. C. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64318-0 · Cited by 322

Myeloid Progenitor Cells in the Premetastatic Lung Promote Metastases by Inducing Mesenchymal to Epithelial Transition

Gao, D., Joshi, N., Choi, H., Ryu, S., Hahn, M., Catena, R., Sadik, H., Argani, P., Wagner, P., Vahdat, L. T., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2905 · Cited by 307

Targeting renal fibrosis: Mechanisms and drug delivery systems

Nastase, M. V., Zeng-Brouwers, J., Wygrecka, M., & Schaefer, L. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.12.019 · Cited by 302

Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease.

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Extracellular matrix networks in bone remodeling

Alford, A. I., Kozloff, K. M., & Hankenson, K. D. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.05.008 · Cited by 300

Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal

Ikenaga, N., Peng, Z.-W., Vaid, K. A., Liu, S. B., Yoshida, S., Sverdlov, D. Y., Mikels-Vigdal, A., Smith, V., Schuppan, D., & Popov, Y. V. (2017) · Gut · doi:10.1136/gutjnl-2016-312473 · Cited by 295

New developments in osteoarthritis: Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options

Lotz, M. K. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3046 · Cited by 294

Aggrecan Protects Cartilage Collagen from Proteolytic Cleavage

Pratta, M. A., Yao, W., Decicco, C., Tortorella, M. D., Liu, R.-Q., Copeland, R. A., Magolda, R., Newton, R. C., Trzaskos, J. M., & Arner, E. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303737200 · Cited by 292

Tenascin-C drives persistence of organ fibrosis

Bhattacharyya, S., Wang, W., Morales-Nebreda, L., Feng, G., Wu, M., Zhou, X., Lafyatis, R., Lee, J., Hinchcliff, M., Feghali-Bostwick, C., et al. (2016) · Nature Communications · doi:10.1038/ncomms11703 · Cited by 292

ADAMTS and ADAM metalloproteinases in osteoarthritis – looking beyond the ‘usual suspects’

Yang, C.-Y., Chanalaris, A., & Troeberg, L. (2017) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2017.02.791 · Cited by 291

Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cells.

Matsuda, K., Maruyama, H., Guo, F., Kleeff, J. H., Itakura, J., Matsumoto, Y., Lander, A. D., & Korc, M. (2001) · PubMed · Cited by 289

Syndecans – key regulators of cell signaling and biological functions

Afratis, N. A., Nikitovic, D., Multhaupt, H. A. B., Theocharis, A. D., Couchman, J. R., & Karamanos, N. K. (2017) · The FEBS Journal · doi:10.1111/febs.13940 · Cited by 283

ADAMTS proteins in human disorders

Mead, T. J., & Apte, S. S. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.06.002 · Cited by 279

Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma

Derksen, P. W. B., Keehnen, R. M. J., Evers, L. M., van Oers, M. H. J., Spaargaren, M., & Pals, S. T. (2002) · Blood · doi:10.1182/blood.v99.4.1405 · Cited by 274

Biological interplay between proteoglycans and their innate immune receptors in inflammation

Frey, H., Schroeder, N., Manon‐Jensen, T., Iozzo, R. V., & Schaefer, L. (2013) · The FEBS Journal · doi:10.1111/febs.12145 · Cited by 274

Complexes of Matrilin-1 and Biglycan or Decorin Connect Collagen VI Microfibrils to Both Collagen II and Aggrecan

Wiberg, C., Klatt, A. R., Wagener, R., Paulsson, M., Bateman, J. F., Heinegård, D., & Mörgelin, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304638200 · Cited by 267

Collagen I–mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1

Shintani, Y., Fukumoto, Y., Chaika, N., Svoboda, R., Wheelock, M. J., & Johnson, K. R. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708137 · Cited by 267

Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat

Iimuro, Y., Nishio, T., Morimoto, T., Nitta, T., Stefanovic, B., Choi, S. K., Brenner, D. A., & Yamaoka, Y. (2003) · Gastroenterology · doi:10.1053/gast.2003.50063 · Cited by 263

A type X collagen mutation causes Schmid metaphyseal chondrodysplasia

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The Ehlers–Danlos syndromes, rare types

Brady, A. F., Demirdas, S., Fournel‐Gigleux, S., Ghali, N., Giunta, C., Kapferer‐Seebacher, I., Kosho, T., Mendoza‐Londono, R., Pope, M. F., Rohrbach, M., et al. (2017) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31550 · Cited by 258

Diminished Type III Collagen Promotes Myofibroblast Differentiation and Increases Scar Deposition in Cutaneous Wound Healing

Volk, S. W., Wang, Y., Mauldin, E. A., Liechty, K. W., & Adams, S. L. (2011) · Cells Tissues Organs · doi:10.1159/000322399 · Cited by 257

Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases

Karamanos, N. K., Theocharis, A. D., Neill, T., & Iozzo, R. V. (2019) · Matrix Biology · doi:10.1016/j.matbio.2018.08.007 · Cited by 254

Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin

Bix, G., Fu, J., Gonzalez, E. M., Macro, L., Barker, A., Campbell, S., Zutter, M. M., Santoro, S. A., Kim, J. K., Höök, M., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200401150 · Cited by 252

Matrix Metalloproteinase 3 Is a Mediator of Pulmonary Fibrosis

Yamashita, C. M., Dolgonos, L., Zemans, R. L., Young, S. K., Robertson, J., Briones, N., Suzuki, T., Campbell, M. N., Gauldie, J., Radisky, D. C., et al. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.06.041 · Cited by 247

Sites of Aggrecan Cleavage by Recombinant Human Aggrecanase-1 (ADAMTS-4)

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Osteopontin Expression Is Required for Myofibroblast Differentiation

Lenga, Y., Koh, A., Perera, A. S., McCulloch, C. A., Sodek, J., & Zohar, R. (2008) · Circulation Research · doi:10.1161/circresaha.107.160408 · Cited by 241

Reduced expression of the small leucine-rich proteoglycans, lumican, and decorin is associated with poor outcome in node-negative invasive breast cancer.

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Extracellular matrix: The driving force of mammalian diseases

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