On the origin of cancer cells

Warburg, Otto·1956·Science

Cited by (296)

Items 101–200 of 296

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  5. A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors
    Raez, Luis E., Papadopoulos, Kyriakos, Ricart, Alejandro D., Chiorean, E. Gabriella, DiPaola, Robert S., Stein, Mark N., Rocha Lima, Caio M., Schlesselman, James J., Tolba, Khaled, Langmuir, Virginia K. et al. · 2013 · Cancer Chemotherapy and Pharmacology
  6. Increased demand for NAD(+) relative to ATP drives aerobic glycolysis
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  7. ATP citrate lyase is an important component of cell growth and transformation
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  8. PKM2, cancer metabolism, and the road ahead
    Dayton, Talya L, Jacks, Tyler, Vander Heiden, Matthew G · 2016 · The EMBO Reports
  9. Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells
    Everts, Bart, Amiel, Eyal, van der Windt, Gerritje J. W., Freitas, Tori C., Chott, Robert, Yarasheski, Kevin E., Pearce, Erika L., Pearce, Edward J. · 2012 · Blood
  10. Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells
    Xie, Han, Hanai, Jun-ichi, Ren, Jian-Guo, Kats, Lev, Burgess, Kerri, Bhargava, Parul, Signoretti, Sabina, Billiard, Julia, Duffy, Kevin J., Grant, Aaron et al. · 2014 · Cell Metabolism
  11. Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis
    Kettner, Nicole M., Voicu, Horatio, Finegold, Milton J., Coarfa, Cristian, Sreekumar, Arun, Putluri, Nagireddy, Katchy, Chinenye A., Lee, Choogon, Moore, David D., Fu, Loning · 2016 · Cancer Cell
  12. A history of exploring cancer in context
    Maman, Shelly, Witz, Isaac P. · 2018 · Nature Reviews Cancer
  13. Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor
    Hung, Yin Pun, Albeck, John G., Tantama, Mathew, Yellen, Gary · 2011 · Cell Metabolism
  14. Oncogenic K‐Ras decouples glucose and glutamine metabolism to support cancer cell growth
    Gaglio, Daniela, Metallo, Christian M, Gameiro, Paulo A, Hiller, Karsten, Danna, Lara Sala, Balestrieri, Chiara, Alberghina, Lilia, Stephanopoulos, Gregory, Chiaradonna, Ferdinando · 2011 · Molecular Systems Biology
  15. Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation
    Sellers, Katherine, Fox, Matthew P., Bousamra, Michael, Slone, Stephen P., Higashi, Richard M., Miller, Donald M., Wang, Yali, Yan, Jun, Yuneva, Mariia O., Deshpande, Rahul et al. · 2015 · Journal of Clinical Investigation
  16. Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals
    Nisoli, Enzo, Falcone, Sestina, Tonello, Cristina, Cozzi, Valeria, Palomba, Letizia, Fiorani, Mara, Pisconti, Addolorata, Brunelli, Silvia, Cardile, Annalisa, Francolini, Maura et al. · 2004 · Proceedings of the National Academy of Sciences
  17. Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target
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  18. Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging
    Terman, Alexei, Kurz, Tino, Navratil, Marian, Arriaga, Edgar A., Brunk, Ulf T. · 2010 · Antioxidants & Redox Signaling
  19. MOLECULAR GENETIC ASPECTS OF HUMAN MITOCHONDRIAL DISORDERS
    Larsson, Nils-Göran, Clayton, David A. · 1995 · Annual Review of Genetics
  20. Cancer-associated adipocytes: key players in breast cancer progression
    Wu, Qi, Li, Bei, Li, Zhiyu, Li, Juanjuan, Sun, Si, Sun, Shengrong · 2019 · Journal of Hematology & Oncology
  21. Glutaminolysis as a target for cancer therapy
    Jin, L, Alesi, G N, Kang, S · 2016 · Oncogene
  22. The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression
    Diaz-Ruiz, Rodrigo, Rigoulet, Michel, Devin, Anne · 2011 · Biochimica et Biophysica Acta (BBA) - Bioenergetics
  23. From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular Senescence
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  24. Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer
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  25. Tumour-associated mutant p53 drives the Warburg effect
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  26. Glutamine‐driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia
    Fan, Jing, Kamphorst, Jurre J, Mathew, Robin, Chung, Michelle K, White, Eileen, Shlomi, Tomer, Rabinowitz, Joshua D · 2013 · Molecular Systems Biology
  27. Engineering of a Nanosized Biocatalyst for Combined Tumor Starvation and Low-Temperature Photothermal Therapy
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  28. <scp>mTOR</scp> , metabolism, and the regulation of T‐cell differentiation and function
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  29. Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth
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  30. ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer
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  31. mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc
    Masui, Kenta, Tanaka, Kazuhiro, Akhavan, David, Babic, Ivan, Gini, Beatrice, Matsutani, Tomoo, Iwanami, Akio, Liu, Feng, Villa, Genaro R., Gu, Yuchao et al. · 2013 · Cell Metabolism
  32. Regulation of cancer cell metabolism: Oncogenic MYC in the driver’s seat
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  33. SDH mutations in cancer
    Bardella, Chiara, Pollard, Patrick J., Tomlinson, Ian · 2011 · Biochimica et Biophysica Acta (BBA) - Bioenergetics
  34. Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species <sup>1</sup>
    Brand, Karl A., Hermfisse, Ulrich · 1997 · The FASEB Journal
  35. Glucose Conjugation for the Specific Targeting and Treatment of Cancer
    Calvaresi, Emilia C., Hergenrother, Paul J. · 2013 · Chemical Science
  36. Mitochondria as biosynthetic factories for cancer proliferation
    Ahn, Christopher S, Metallo, Christian M · 2015 · Cancer &amp; Metabolism
  37. Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition
    Jacque, Nathalie, Ronchetti, Anne Marie, Larrue, Clément, Meunier, Godelieve, Birsen, Rudy, Willems, Lise, Saland, Estelle, Decroocq, Justine, Maciel, Thiago Trovati, Lambert, Mireille et al. · 2015 · Blood
  38. 3D microtumors in vitro supported by perfused vascular networks
    Sobrino, Agua, Phan, Duc T. T., Datta, Rupsa, Wang, Xiaolin, Hachey, Stephanie J., Romero-López, Mónica, Gratton, Enrico, Lee, Abraham P., George, Steven C., Hughes, Christopher C. W. · 2016 · Scientific Reports
  39. Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays
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  40. Role of monocarboxylate transporters in human cancers: state of the art
    Pinheiro, Céline, Longatto-Filho, Adhemar, Azevedo-Silva, João, Casal, Margarida, Schmitt, Fernando C., Baltazar, Fátima · 2012 · Journal of Bioenergetics and Biomembranes
  41. The molecular determinants of de novo nucleotide biosynthesis in cancer cells
    Tong, Xuemei, Zhao, Fangping, Thompson, Craig B · 2009 · Current Opinion in Genetics &amp; Development
  42. Manganese Superoxide Dismutase: Guardian of the Powerhouse
    Holley, Aaron K., Bakthavatchalu, Vasudevan, Velez-Roman, Joyce M., St. Clair, Daret K. · 2011 · International Journal of Molecular Sciences
  43. Modulation of inflammation by autophagy: Consequences for human disease
    Netea-Maier, Romana T., Plantinga, Theo S., van de Veerdonk, Frank L., Smit, Johannes W., Netea, Mihai G. · 2016 · Autophagy
  44. Metabolism of [U‐ <sup>13</sup> C]glucose in human brain tumors <i>in vivo</i>
    Maher, Elizabeth A., Marin‐Valencia, Isaac, Bachoo, Robert M., Mashimo, Tomoyuki, Raisanen, Jack, Hatanpaa, Kimmo J., Jindal, Ashish, Jeffrey, F. Mark, Choi, Changho, Madden, Christopher et al. · 2012 · NMR in Biomedicine
  45. Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells
    Yang, Zhen, Fujii, Hiroshi, Mohan, Shalini V., Goronzy, Jorg J., Weyand, Cornelia M. · 2013 · Journal of Experimental Medicine
  46. Mitochondria in lung disease
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  47. An evolutionary perspective on the Crabtree effect
    Pfeiffer, Thomas, Morley, Annabel · 2014 · Frontiers in Molecular Biosciences
  48. Metabolism in T cell activation and differentiation
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  49. The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling
    Sullivan, Lucas B., Martinez-Garcia, Eva, Nguyen, Hien, Mullen, Andrew R., Dufour, Eric, Sudarshan, Sunil, Licht, Jonathan D., Deberardinis, Ralph J., Chandel, Navdeep S. · 2013 · Molecular Cell
  50. Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex
    Fan, Jun, Shan, Changliang, Kang, Hee-Bum, Elf, Shannon, Xie, Jianxin, Tucker, Meghan, Gu, Ting-Lei, Aguiar, Mike, Lonning, Scott, Chen, Huaibin et al. · 2014 · Molecular Cell
  51. Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy
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  52. Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production.
    Greiner, E F, Guppy, M, Brand, K · 1994 · Journal of Biological Chemistry
  53. Mitochondrial DNA variation and cancer
    Kopinski, Piotr K., Singh, Larry N., Zhang, Shiping, Lott, Marie T., Wallace, Douglas C. · 2021 · Nature reviews. Cancer
  54. Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY‐876
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  55. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling
    Lin, Ruiting, Elf, Shannon, Shan, Changliang, Kang, Hee-Bum, Ji, Quanjiang, Zhou, Lu, Hitosugi, Taro, Zhang, Liang, Zhang, Shuai, Seo, Jae Ho et al. · 2015 · Nature Cell Biology
  56. Isotope tracing of human clear cell renal cell carcinomas demonstrates suppressed glucose oxidation in vivo
    Courtney, Kevin D., Bezwada, Divya, Mashimo, Tomoyuki, Pichumani, Kumar, Vemireddy, Vamsidhara, Funk, Alexander M., Wimberly, Jennifer, McNeil, Sarah S., Kapur, Payal, Lotan, Yair et al. · 2018 · Cell Metabolism
  57. Aberrant succination of proteins in fumarate hydratase‐deficient mice and HLRCC patients is a robust biomarker of mutation status
    Bardella, Chiara, El‐Bahrawy, Mona, Frizzell, Norma, Adam, Julie, Ternette, Nicola, Hatipoglu, Emine, Howarth, Kimberley, O'Flaherty, Linda, Roberts, Ian, Turner, Gareth et al. · 2011 · The Journal of Pathology
  58. The Influence of Metabolism on Drug Response in Cancer
    Zaal, Esther A., Berkers, Celia R. · 2018 · Frontiers in Oncology
  59. Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism
    Ros, Susana, Schulze, Almut · 2013 · Cancer &amp; Metabolism
  60. Hyaluronidases in cancer biology
    Stern, Robert · 2008 · Seminars in Cancer Biology
  61. Ecdysone and Mediator Change Energy Metabolism to Terminate Proliferation in Drosophila Neural Stem Cells
    Homem, Catarina C.F., Steinmann, Victoria, Burkard, Thomas R., Jais, Alexander, Esterbauer, Harald, Knoblich, Juergen A. · 2014 · Cell
  62. The circadian clock in cancer development and therapy
    Fu, Loning, Kettner, Nicole M. · 2013 · Progress in Molecular Biology and Translational Science
  63. Transketolase counteracts oxidative stress to drive cancer development
    Xu, Iris Ming-Jing, Lai, Robin Kit-Ho, Lin, Shu-Hai, Tse, Aki Pui-Wah, Chiu, David Kung-Chun, Koh, Hui-Yu, Law, Cheuk-Ting, Wong, Chun-Ming, Cai, Zongwei, Wong, Carmen Chak-Lui et al. · 2016 · Proceedings of the National Academy of Sciences
  64. Oncogene-induced senescence: the bright and dark side of the response
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  65. The malate-aspartate shuttle (Borst cycle): how it started and developed into a major metabolic pathway
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  66. Genome-Scale Metabolic Modeling Elucidates the Role of Proliferative Adaptation in Causing the Warburg Effect
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  67. Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer
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  68. Hypoxia-Inducible Factor-1α and the Glycolytic Phenotype in Tumors
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  69. Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment
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  70. Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression
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  71. RETRACTED ARTICLE: Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression
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  73. Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates
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  74. Cancer metabolism at a glance
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  75. Pluronics and MDR reversal: an update
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  77. 100 years of the Warburg effect: A cancer metabolism endeavor
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  78. Pyruvate Dehydrogenase and Pyruvate Dehydrogenase Kinase Expression in Non Small Cell Lung Cancer and Tumor-Associated Stroma
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  79. Tumor hypoxia: From basic knowledge to therapeutic implications
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  80. mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging
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  81. Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species
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  82. Succinate dehydrogenase (SDH) and mitochondrial driven neoplasia
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  83. Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment
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  86. The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels
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  95. The emerging role of fumarate as an oncometabolite
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  100. Sodium-glucose transporter 2 is a diagnostic and therapeutic target for early-stage lung adenocarcinoma
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