On the origin of cancer cells

Warburg, Otto·1956·Science

Cited by (296)

Items 201–296 of 296

  1. Molecular Consequences of Silencing Mutant K-<i>ras</i> in Pancreatic Cancer Cells: Justification for K-<i>ras</i>–Directed Therapy
    Fleming, Jason B., Shen, Guo-Liang, Holloway, Shane E., Davis, Mishel, Brekken, Rolf A. · 2005 · Molecular Cancer Research
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    Meiser, Johannes, Tumanov, Sergey, Maddocks, Oliver, Labuschagne, Christiaan Fred, Athineos, Dimitris, Van Den Broek, Niels, Mackay, Gillian M., Gottlieb, Eyal, Blyth, Karen, Vousden, Karen et al. · 2016 · Science Advances
  3. Metabolic changes in cancer: beyond the Warburg effect
    Wu, Weihua, Zhao, Shimin · 2013 · Acta Biochimica et Biophysica Sinica
  4. The SIRT1/HIF2α Axis Drives Reductive Glutamine Metabolism under Chronic Acidosis and Alters Tumor Response to Therapy
    Corbet, Cyril, Draoui, Nihed, Polet, Florence, Pinto, Adan, Drozak, Xavier, Riant, Olivier, Feron, Olivier · 2014 · Cancer Research
  5. Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment
    Fan, Tengjiao, Sun, Guohui, Sun, Xiaodong, Zhao, Lijiao, Zhong, Rugang, Peng, Yongzhen · 2019 · Cancers
  6. Succinate inhibition of α-ketoglutarate-dependent enzymes in a yeast model of paraganglioma
    Smith, Emily H., Janknecht, Ralf, Maher, L. James · 2007 · Human Molecular Genetics
  7. Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth
    Schöckel, Laura, Glasauer, Andrea, Basit, Farhan, Bitschar, Katharina, Truong, Hoa, Erdmann, Gerrit, Algire, Carolyn, Hägebarth, Andrea, Willems, Peter HGM, Kopitz, Charlotte et al. · 2015 · Cancer &amp; Metabolism
  8. The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation
    Samudio, Ismael, Fiegl, Michael, McQueen, Teresa, Clise-Dwyer, Karen, Andreeff, Michael · 2008 · Cancer Research
  9. E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation
    Almeida, Angeles, Bolaños, Juan P., Moncada, Salvador · 2010 · Proceedings of the National Academy of Sciences
  10. One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy
    Shuvalov, Oleg, Petukhov, Alexey, Daks, Alexandra, Fedorova, Olga, Vasileva, Elena, Barlev, Nickolai A. · 2017 · Oncotarget
  11. Glutamine deprivation induces abortive s-phase rescued by deoxyribonucleotides in k-ras transformed fibroblasts
    Gaglio, Daniela, Soldati, Chiara, Vanoni, Marco, Alberghina, Lilia, Chiaradonna, Ferdinando · 2009 · PLoS ONE
  12. Starvation, Stress Resistance, and Cancer
    Buono, Roberta, Longo, Valter D. · 2018 · Trends in Endocrinology &amp; Metabolism
  13. Circadian gene variants in cancer
    Kettner, Nicole M., Katchy, Chinenye A., Fu, Loning · 2014 · Annals of Medicine
  14. M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth
    Cortés-Cros, Marta, Hemmerlin, Christelle, Ferretti, Stephane, Zhang, Juan, Gounarides, John S., Yin, Hong, Muller, Alban, Haberkorn, Anne, Chene, Patrick, Sellers, William R. et al. · 2013 · Proceedings of the National Academy of Sciences
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    Bao, Xingting, Zhang, Jinhua, Huang, Guomin, Yan, Junfang, Xu, Caipeng, Dou, Zhihui, Sun, Chao, Zhang, Hong · 2021 · Cell Death &amp; Disease
  17. High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells
    Poulain, L, Sujobert, P, Zylbersztejn, F, Barreau, S, Stuani, L, Lambert, M, Palama, T L, Chesnais, V, Birsen, R, Vergez, F et al. · 2017 · Leukemia
  18. Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity
    Wang, Qian, Liberti, Maria V., Liu, Pei, Deng, Xiaobing, Liu, Ying, Locasale, Jason W., Lai, Luhua · 2017 · Cell Chemical Biology
  19. The metabolic landscape of lung cancer: New insights in a disturbed glucose metabolism
    Vanhove, Karolien, Graulus, Geert-Jan, Mesotten, Liesbet, Thomeer, Michiel, Derveaux, Elien, Noben, Jean-Paul, Guedens, Wanda, Adriaensens, Peter · 2019 · Frontiers in Oncology
  20. Ovarian Cancer Relies on Glucose Transporter 1 to Fuel Glycolysis and Growth: Anti-Tumor Activity of BAY-876
    Ma, Yibao, Wang, Wei, Idowu, Michael O., Oh, Unsong, Wang, Xiang-Yang, Temkin, Sarah M., Fang, Xianjun · 2018 · Cancers
  21. Oligomycin-induced bioenergetic adaptation in cancer cells with heterogeneous bioenergetic organization
    Hao, Wenshan, Chang, Chao-Pei Betty, Tsao, Cheng-Chung, Xu, Jun · 2010 · Journal of Biological Chemistry
  22. Germline BAP1 mutations induce a Warburg effect
    Bononi, Angela, Yang, Haining, Giorgi, Carlotta, Patergnani, Simone, Pellegrini, Laura, Su, Mingming, Xie, Guoxiang, Signorato, Valentina, Pastorino, Sandra, Morris, Paul et al. · 2017 · Cell Death &amp; Differentiation
  23. New dimensions in tumor immunology: what does 3D culture reveal?
    Feder-Mengus, Chantal, Ghosh, Sourabh, Reschner, Anca, Martin, Ivan, Spagnoli, Giulio C. · 2008 · Trends in Molecular Medicine
  24. Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance
    Li, Jincai, Wong, Chun Loong, Vijayasankaran, Natarajan, Hudson, Terry, Amanullah, Ashraf · 2012 · Biotechnology and Bioengineering
  25. Glucose metabolism in mammalian cell culture: new insights for tweaking vintage pathways
    Mulukutla, Bhanu Chandra, Khan, Salmaan, Lange, Alex, Hu, Wei-Shou · 2010 · Trends in biotechnology
  26. Altered energy metabolism in cancer: A unique opportunity for therapeutic intervention
    Zhang, Yi, Yang, Jin-Ming · 2013 · Cancer Biology &amp; Therapy
  27. LncRNA IDH1-AS1 links the functions of c-Myc and HIF1α via IDH1 to regulate the Warburg effect
    Xiang, Shaoxun, Gu, Hao, Jin, Lei, Thorne, Rick F., Zhang, Xu Dong, Wu, Mian · 2018 · Proceedings of the National Academy of Sciences
  28. Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells
    Rasola, Andrea, Neckers, Len, Picard, Didier · 2014 · Trends in Cell Biology
  29. The role of hypoxia-inducible factor-2 in digestive system cancers
    Zhao, J, Du, F, Shen, G, Zheng, F, Xu, B · 2015 · Cell Death &amp; Disease
  30. Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice
    Thierbach, René, Schulz, Tim J., Isken, Frank, Voigt, Anja, Mietzner, Brun, Drewes, Gunnar, von Kleist-Retzow, Jürgen-Christoph, Wiesner, Rudolf J., Magnuson, Mark A., Puccio, Hélène et al. · 2005 · Human Molecular Genetics
  31. Hypoxia-Inducible Factor-1α Promotes Nonhypoxia-Mediated Proliferation in Colon Cancer Cells and Xenografts
    Dang, Duyen T., Chen, Fang, Gardner, Lawrence B., Cummins, Jordan M., Rago, Carlo, Bunz, Fred, Kantsevoy, Sergey V., Dang, Long H. · 2006 · Cancer Research
  32. Glucose Promotes Breast Cancer Aggression and Reduces Metformin Efficacy
    Wahdan-Alaswad, Reema, Fan, Zeying, Edgerton, Susan M, Liu, Bolin, Deng, Xin-Sheng, Arnadottir, Sigrid Salling, Richer, Jennifer K, Anderson, Steven M, Thor, Ann D · 2013 · Cell Cycle
  33. Recapitulating the human tumor microenvironment: Colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth
    Romero-López, Mónica, Trinh, Andrew L., Sobrino, Agua, Hatch, Michaela M.S., Keating, Mark T., Fimbres, Cristhian, Lewis, David E., Gershon, Paul D., Botvinick, Elliot L., Digman, Michelle et al. · 2017 · Biomaterials
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    Policastro, Lucia Laura, Ibañez, Irene Laura, Notcovich, Cintia, Duran, Hebe Alicia, Podhajcer, Osvaldo Luis · 2013 · Antioxidants &amp; Redox Signaling
  35. The regulation of cancer cell death and metabolism by extracellular matrix attachment
    Buchheit, Cassandra L., Rayavarapu, Raju R., Schafer, Zachary T. · 2012 · Seminars in Cell &amp; Developmental Biology
  36. Hypoxia signaling in cancer: Implications for therapeutic interventions
    Zhuang, Yan, Liu, Kua, He, Qinyu, Gu, Xiaosong, Jiang, Chunping, Wu, Junhua · 2023 · MedComm
  37. Oncogene-induced senescence: From biology to therapy
    Zhu, Haoran, Blake, Shaun, Kusuma, Frances K, Pearson, Richard B, Kang, Jian, Chan, Keefe T · 2020 · Mechanisms of Ageing and Development
  38. Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1α and HIF-2α target genes
    Chun, Sang Y, Johnson, Craig, Washburn, Joseph G, Cruz-Correa, Marcia R, Dang, Duyen T, Dang, Long H · 2010 · Molecular Cancer
  39. Current and future perspectives of functional metabolomics in disease studies–A review
    Yan, Min, Xu, Guowang · 2018 · Analytica Chimica Acta
  40. Aerobic glycolysis in the primate brain: Reconsidering the implications for growth and maintenance
    Bauernfeind, Amy L., Barks, Sarah K., Duka, Tetyana, Grossman, Lawrence I., Hof, Patrick R., Sherwood, Chet C. · 2014 · Brain Structure and Function
  41. Metabolic dysregulation in monogenic disorders and cancer — finding method in madness
    Erez, Ayelet, DeBerardinis, Ralph J. · 2015 · Nature Reviews Cancer
  42. The role of ultraviolet radiation in melanomagenesis
    Von Thaler, Anna‐Katharina, Kamenisch, York, Berneburg, Mark · 2010 · Experimental Dermatology
  43. A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia
    Adam, Julie, Yang, Ming, Bauerschmidt, Christina, Kitagawa, Mitsuhiro, O’Flaherty, Linda, Maheswaran, Pratheesh, Özkan, Gizem, Sahgal, Natasha, Baban, Dilair, Kato, Keiko et al. · 2013 · Cell Reports
  44. Metabolomics of B to plasma cell differentiation
    Garcia-Manteiga, Jose Manuel, Mari, Silvia, Godejohann, Markus, Spraul, Manfred, Napoli, Claudia, Cenci, Simone, Musco, Giovanna, Sitia, Roberto · 2011 · Journal of Proteome Research
  45. Therapeutic m <sup>6</sup> A Eraser ALKBH5 mRNA-Loaded Exosome–Liposome Hybrid Nanoparticles Inhibit Progression of Colorectal Cancer in Preclinical Tumor Models
    Wu, Shenshen, Yun, Jun, Tang, Weiyan, Familiari, Giuseppe, Relucenti, Michela, Wu, Jiong, Li, Xiaobo, Chen, Hanqing, Chen, Rui · 2023 · ACS Nano
  46. Glycolysis for Microbiome Generation
    Wolfe, Alan J. · 2015 · Microbiology Spectrum
  47. Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene‐induced senescent cells
    Takebayashi, Shin‐ichiro, Tanaka, Hiroshi, Hino, Shinjiro, Nakatsu, Yuko, Igata, Tomoka, Sakamoto, Akihisa, Narita, Masashi, Nakao, Mitsuyoshi · 2015 · Aging Cell
  48. Diabetes medications and risk of HCC
    Plaz Torres, Maria Corina, Jaffe, Ariel, Perry, Rachel, Marabotto, Elisa, Strazzabosco, Mario, Giannini, Edoardo G. · 2022 · Hepatology
  49. Metabolic regulation of glucose transport
    Ismail-Beigi, Faramarz · 1993 · The Journal of Membrane Biology
  50. Mouse Genetics Suggests Cell-Context Dependency for Myc-Regulated Metabolic Enzymes during Tumorigenesis
    Nilsson, Lisa M., Plym Forshell, Tacha Zi, Rimpi, Sara, Kreutzer, Christiane, Pretsch, Walter, Bornkamm, Georg W., Nilsson, Jonas A. · 2012 · PLoS Genetics
  51. Identification of and molecular basis for sirt6 loss-of-function point mutations in cancer
    Kugel, Sita, Feldman, Jessica L., Klein, Mark A., Silberman, Dafne M., Sebastián, Carlos, Mermel, Craig, Dobersch, Stephanie, Clark, Abbe R., Getz, Gad, Denu, John M. et al. · 2015 · Cell Reports
  52. Targeted Cancer Therapy with a 2-Deoxyglucose-Based Adriamycin Complex
    Cao, Jie, Cui, Sisi, Li, Siwen, Du, Changli, Tian, Junmei, Wan, Shunan, Qian, Zhiyu, Gu, Yueqing, Chen, Wei R., Wang, Guangji · 2013 · Cancer Research
  53. Interactions between epigenetics and metabolism in cancers
    Yun, Jihye, Johnson, Jared L., Hanigan, Christin L., Locasale, Jason W. · 2012 · Frontiers in Oncology
  54. Exploring the Potential of Nanotherapeutics in Targeting Tumor Microenvironment for Cancer Therapy
    Muntimadugu, Eameema, Kommineni, Nagavendra, Khan, Wahid · 2017 · Pharmacological Research
  55. Multiplicity of Steady States in Glycolysis and Shift of Metabolic State in Cultured Mammalian Cells
    Mulukutla, Bhanu Chandra, Yongky, Andrew, Grimm, Simon, Daoutidis, Prodromos, Hu, Wei-Shou · 2015 · PLOS ONE
  56. The Warburg Effect is the result of faster ATP production by glycolysis than respiration
    Kukurugya, Matthew A., Rosset, Saharon, Titov, Denis V. · 2024 · Proceedings of the National Academy of Sciences
  57. PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia
    Pin, Fabrizio, Novinger, Leah J., Huot, Joshua R., Harris, Robert A., Couch, Marion E., O'Connell, Thomas M., Bonetto, Andrea · 2019 · The FASEB Journal
  58. Expression of serine/glycine metabolism-related proteins is different according to the thyroid cancer subtype
    Sun, Woo Young, Kim, Hye Min, Jung, Woo-Hee, Koo, Ja Seung · 2016 · Journal of Translational Medicine
  59. Respiratory complex III dysfunction in humans and the use of yeast as a model organism to study mitochondrial myopathy and associated diseases
    Meunier, B., Fisher, N., Ransac, S., Mazat, J.-P., Brasseur, G. · 2013 · Biochimica et Biophysica Acta (BBA) - Bioenergetics
  60. Knockdown of creatine kinase B inhibits ovarian cancer progression by decreasing glycolysis
    Li, Xu-Hui, Chen, Xiang-Jun, Ou, Wen-Bin, Zhang, Qian, Lv, Zhi-Rong, Zhan, Yi, Ma, Long, Huang, Tao, Yan, Yong-Bin, Zhou, Hai-Meng · 2013 · The International Journal of Biochemistry &amp; Cell Biology
  61. Molecular Crowding Defines a Common Origin for the Warburg Effect in Proliferating Cells and the Lactate Threshold in Muscle Physiology
    Vazquez, Alexei, Oltvai, Zoltán N. · 2011 · PLoS ONE
  62. Changes in Global Gene Expression Associated with 3D Structure of Tumors: An Ex Vivo Matrix-Free Mesothelioma Spheroid Model
    Kim, Heungnam, Phung, Yen, Ho, Mitchell · 2012 · PLoS ONE
  63. The unfolded protein response and cancer: A brighter future unfolding?
    Scriven, Peter, Brown, Nicola J., Pockley, A. Graham, Wyld, Lynda · 2007 · Journal of Molecular Medicine
  64. Sirtuins at the Service of Healthy Longevity
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  65. Targeted killing of a mammalian cell based upon its specialized metabolic state
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  66. COX6B2 drives metabolic reprogramming toward oxidative phosphorylation to promote metastasis in pancreatic ductal cancer cells
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  67. Hypoxia-inducible factors as key regulators of tumor inflammation
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  68. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor α (ERRα)
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  69. Metabolism of short‐chain fatty acid propionate induces surface expression of NKG2D ligands on cancer cells
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  70. Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells
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  71. Metabolic cooperation between co-cultured lung cancer cells and lung fibroblasts
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  72. In vivo <sup>13</sup>C and <sup>1</sup>H‐[<sup>13</sup>C] MRS studies of neuroenergetics and neurotransmitter cycling, applications to neurological and psychiatric disease and brain cancer
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  73. Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeast
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  74. Tumor Hypoxia Imaging
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  76. Inhibition of mitochondrial glutaminase activity reverses acquired erlotinib resistance in non-small cell lung cancer
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