Protein Oxidation and Aging

Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

Benedetti, A., Comporti, M., & Esterbauer, H. (1980) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(80)90209-x · Cited by 1,085

Metal-catalyzed oxidation of proteins. Physiological consequences

Stadtman, E. R., & Oliver, C. N. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52199-2 · Cited by 862

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413

Free radicals, metals and antioxidants in oxidative stress-induced cancer

Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680

Oxidants, antioxidants, and the degenerative diseases of aging.

Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958

The Free Radical Theory of Aging Matures

BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879

The molecular pathology of Alzheimer's disease

Selkoe, D. J. (1991) · Neuron · doi:10.1016/0896-6273(91)90052-2 · Cited by 2,708

Oxidative damage and mitochondrial decay in aging.

Shigenaga, M. K., Hagen, T. M., & Ames, B. N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.10771 · Cited by 2,055

Gene expression profile of aging and its retardation by caloric restriction

Lee, C.-K., Klopp, R. G., Weindruch, R., & Prolla, T. A. (1999) · Science · doi:10.1126/science.285.5432.1390 · Cited by 1,473

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8098 · Cited by 1,363

4-Hydroxy-2-nonenal: a product and mediator of oxidative stress

Uchida, K. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00014-6 · Cited by 1,164

Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide

Butterfield, D. A., Drake, J., Pocernich, C., & Castegna, A. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02173-6 · Cited by 1,114

The role of mitochondria in aging

Bratic, A., & Larsson, N.-G. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64125 · Cited by 1,087

Molecular Mechanisms of Dermal Aging and Antiaging Approaches

Shin, J.-W., Kwon, S.-H., Choi, J.-Y., Na, J.-I., Huh, C.-H., Choi, H.-R., & Park, K.-C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092126 · Cited by 875

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

Morimoto, R. I. (2008) · Genes & Development · doi:10.1101/gad.1657108 · Cited by 872

Reactive oxygen species, aging and antioxidative nutraceuticals

Lee, J., Koo, N., & Min, D. B. (2004) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2004.tb00058.x · Cited by 864

3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.

Hazen, S. L., & Heinecke, J. W. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119379 · Cited by 842

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

Sohal, R. S., Ku, H.-H., Agarwal, S., Forster, M. J., & Lal, H. (1994) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)90104-x · Cited by 788

Does oxidative damage to DNA increase with age?

Hamilton, M. L., Van Remmen, H., Drake, J. A., Yang, H., Guo, Z. M., Kewitt, K., Walter, C. A., & Richardson, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171202698 · Cited by 768

Oxidative Stress Resistance in Deinococcus radiodurans

Slade, D., & Radman, M. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00015-10 · Cited by 761

Review: Alzheimer's Amyloid β-Peptide-Associated Free Radical Oxidative Stress and Neurotoxicity

Varadarajan, S., Yatin, S., Aksenova, M., & Butterfield, D. A. (2000) · Journal of Structural Biology · doi:10.1006/jsbi.2000.4274 · Cited by 735

Stress, Glucocorticoids, and Damage to the Nervous System: The Current State of Confusion

Sapolsky, R. M. (1996) · Stress · doi:10.3109/10253899609001092 · Cited by 738

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

Hartleben, B., Gödel, M., Meyer-Schwesinger, C., Liu, S., Ulrich, T., Köbler, S., Wiech, T., Grahammer, F., Arnold, S. J., Lindenmeyer, M. T., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39492 · Cited by 721

Oxidative DNA damage and senescence of human diploid fibroblast cells.

Chen, Q., Fischer, A., Reagan, J. D., Yan, L. J., & Ames, B. N. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4337 · Cited by 720

Molecular characterization of a copper transport protein in S. cerevisiae: An unexpected role for copper in iron transport

Dancis, A., Yuan, D. S., Haile, D., Askwith, C., Eide, D., Moehle, C., Kaplan, J., & Klausner, R. D. (1994) · Cell · doi:10.1016/0092-8674(94)90345-x · Cited by 659

Role of mitochondria in oxidative stress and ageing

Lenaz, G. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00120-0 · Cited by 650

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

Ben-Zvi, A., Miller, E. A., & Morimoto, R. I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902882106 · Cited by 649

Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

Chen, Q., & Ames, B. N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4130 · Cited by 641

Molecular mechanisms of seed dormancy

GRAEBER, K., NAKABAYASHI, K., MIATTON, E., LEUBNER‐METZGER, G., & SOPPE, W. J. J. (2012) · Plant, Cell & Environment · doi:10.1111/j.1365-3040.2012.02542.x · Cited by 640

Insulin resistance as a predictor of age-related diseases

Facchini, F. S., Hua, N., Abbasi, F., & Reaven, G. M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7763 · Cited by 594

Circulating Glycotoxins and Dietary Advanced Glycation Endproducts: Two Links to Inflammatory Response, Oxidative Stress, and Aging

Uribarri, J., Cai, W., Peppa, M., Goodman, S., Ferrucci, L., Striker, G., & Vlassara, H. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.4.427 · Cited by 570

Cutaneous photodamage, oxidative stress, and topical antioxidant protection

Pinnell, S. R. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.16 · Cited by 544

Oxidative stress in Huntington’s disease

Browne, S. E., Ferrante, R. J., & Beal, M. F. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00216.x · Cited by 508

Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin

Fisher, G. J., Quan, T., Purohit, T., Shao, Y., Cho, M. K., He, T., Varani, J., Kang, S., & Voorhees, J. J. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080599 · Cited by 487

The redox stress hypothesis of aging

Sohal, R. S., & Orr, W. C. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.445 · Cited by 473

Stable markers of oxidant damage to proteins and their application in the study of human disease

Davies, M. J., Fu, S., Wang, H., & Dean, R. T. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00206-3 · Cited by 461

The antioxidants α‐lipoic acid and N ‐acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice

Farr, S. A., Poon, H. F., Dogrukol‐Ak, D., Drake, J., Banks, W. A., Eyerman, E., Butterfield, D. A., & Morley, J. E. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01580.x · Cited by 459

Mannitol Protects against Oxidation by Hydroxyl Radicals

Shen, B., Jensen, R. G., & Bohnert, H. J. (1997) · Plant Physiology · doi:10.1104/pp.115.2.527 · Cited by 422

Lipofuscin: Formation, Distribution, and Metabolic Consequences

JUNG, T., BADER, N., & GRUNE, T. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1404.008 · Cited by 415

Mitochondrial adenine nucleotide translocase is modified oxidatively during aging

Yan, L.-J., & Sohal, R. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.12896 · Cited by 414

Chapter 7 Protein Oxidation Processes in Aging Brain

Butterfield, D. A., & Stadtman, E. R. (1997) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(08)60057-7 · Cited by 390

Peroxiredoxin III, a Mitochondrion-specific Peroxidase, Regulates Apoptotic Signaling by Mitochondria

Chang, T.-S., Cho, C.-S., Park, S., Yu, S., Kang, S. W., & Rhee, S. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407707200 · Cited by 388

Regulation of cell function by methionine oxidation and reduction

Hoshi, T., & Heinemann, S. H. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0001j.x · Cited by 384

Proposal: Trauma as the Cause of the Peyronie's Lesion

Devine, C. J. J., Somers, K. D., Jordan, G. H., & Schlossberg, S. M. (1997) · Journal of Urology · doi:10.1016/s0022-5347(01)65361-8 · Cited by 381

Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: Insights into the development of Alzheimer's disease

Butterfield, D. A., Poon, H. F., St. Clair, D., Keller, J. N., Pierce, W. M., Klein, J. B., & Markesbery, W. R. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.11.002 · Cited by 377

Tyrosyl radical generated by myeloperoxidase catalyzes the oxidative cross-linking of proteins.

Heinecke, J. W., Li, W., Francis, G. A., & Goldstein, J. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116531 · Cited by 354

Targeting iron metabolism in drug discovery and delivery

Crielaard, B. J., Lammers, T., & Rivella, S. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.248 · Cited by 352

Decline with age of the respiratory chain activity in human skeletal muscle

Boffoli, D., Scacco, S. C., Vergari, R., Solarino, G., Santacroce, G., & Papa, S. (1994) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(94)90061-2 · Cited by 341

Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder

Kuloglu, M., Ustundag, B., Atmaca, M., Canatan, H., Tezcan, A. E., & Cinkilinc, N. (2002) · Cell Biochemistry and Function · doi:10.1002/cbf.940 · Cited by 321

eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans

Syntichaki, P., Troulinaki, K., & Tavernarakis, N. (2007) · Nature · doi:10.1038/nature05603 · Cited by 319

Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Formation of cross-linked protein that inhibits the multicatalytic protease.

Friguet, B., Stadtman, E. R., & Szweda, L. I. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31853-7 · Cited by 311

Revenge of the “Sit”: How lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity

Vaynman, S., & Gomez‐Pinilla, F. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20979 · Cited by 299

Reactive oxygen species in human health and disease

Castro, L., & Freeman, B. A. (2001) · Nutrition · doi:10.1016/s0899-9007(00)00570-0 · Cited by 296

Determination of protein carbonyls in plasma, cell extracts, tissue homogenates, isolated proteins: Focus on sample preparation and derivatization conditions

Weber, D., Davies, M. J., & Grune, T. (2015) · Redox Biology · doi:10.1016/j.redox.2015.06.005 · Cited by 295

Iron–sulfur proteins with nonredox functions

Flint, D. H., & Allen, R. M. (1996) · Chemical Reviews · doi:10.1021/cr950041r · Cited by 280

Oxidative stress associated with exercise, psychological stress and life-style factors

Møller, P., Wallin, H., & Knudsen, L. E. (1996) · Chemico-Biological Interactions · doi:10.1016/0009-2797(96)03729-5 · Cited by 270

Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent

Ogryzko, V. V., Hirai, T. H., Russanova, V. R., Barbie, D. A., & Howard, B. H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.5210 · Cited by 268

Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle

Radák, Z., Naito, H., Kaneko, T., Tahara, S., Nakamoto, H., Takahashi, R., Cardozo-Pelaez, F., & Goto, S. (2002) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s00424-002-0918-6 · Cited by 269

Zinc Oxide Nanoparticle Induced Autophagic Cell Death and Mitochondrial Damage via Reactive Oxygen Species Generation

Yu, K.-N., Yoon, T.-J., Minai-Tehrani, A., Kim, J.-E., Park, S. J., Jeong, M. S., Ha, S.-W., Lee, J.-K., Kim, J. S., & Cho, M.-H. (2013) · Toxicology in Vitro · doi:10.1016/j.tiv.2013.02.010 · Cited by 268

Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity

Calabrese, V., Scapagnini, G., Giuffrida Stella, A. M., Bates, T. E., & Clark, J. B. (2001) · Neurochemical Research · doi:10.1023/a:1010955807739 · Cited by 263

Skin antioxidants: Their role in aging and in oxidative stress — New approaches for their evaluation

Kohen, R. (1999) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(99)80087-0 · Cited by 260

Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis

Kapadia, G. J., Azuine, M. A., Tokuda, H., Takasaki, M., Mukainaka, T., Konoshima, T., & Nishino, H. (2002) · Pharmacological Research · doi:10.1006/phrs.2002.0992 · Cited by 238

Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

Chen, L., Xu, B., Liu, L., Luo, Y., Yin, J., Zhou, H., Chen, W., Shen, T., Han, X., & Huang, S. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.36 · Cited by 236

Plasma chain-breaking antioxidants in Alzheimer's disease, vascular dementia and Parkinson's disease

Foy, C. J. (1999) · QJM · doi:10.1093/qjmed/92.1.39 · Cited by 235

Fifty years of skin aging

Yaar, M., Eller, M. S., & Gilchrest, B. A. (2002) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1046/j.1523-1747.2002.19636.x · Cited by 233

Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-κB signaling in in vivo SKH-1 hairless mice

Sharma, S. D., Meeran, S. M., & Katiyar, S. K. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0661 · Cited by 219

Oxidative Damage to Specific Proteins in Replicative and Chronological-aged Saccharomyces cerevisiae

Reverter-Branchat, G., Cabiscol, E., Tamarit, J., & Ros, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404849200 · Cited by 218

Proteomic identification of 3-nitrotyrosine-containing rat cardiac proteins: effects of biological aging

Kanski, J., Behring, A., Pelling, J., & Schöneich, C. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01030.2003 · Cited by 217

Endogenous oxidative stress: relationship to aging, longevity and caloric restriction

Barja, G. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00008-9 · Cited by 215

Involvement of Hydrogen Peroxide in Collagen Cross-linking by High Glucose in Vitro and in Vivo

Elgawish, A., Glomb, M., Friedlander, M., & Monnier, V. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.12964 · Cited by 201

Sources and implications of NADH/NAD+ redox imbalance in diabetes and its complications

Yan, L.-J., Wu, J., Jin, Z., & Zheng, H. (2016) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s106087 · Cited by 198

Proteostasis collapse is a driver of cell aging and death

Santra, M., Dill, K. A., & de Graff, A. M. R. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1906592116 · Cited by 175

Excitatory Amino Acids and Multiple Sclerosis: Evidence From Cerebrospinal Fluid

Sarchielli, P., Greco, L., Floridi, A., Floridi, A., & Gallai, V. (2003) · Archives of Neurology · doi:10.1001/archneur.60.8.1082 · Cited by 168

Hypothesis: Ataxia‐telangiectasia: Is ATM a sensor of oxidative damage and stress?

Rotman, G., & Shiloh, Y. (1997) · BioEssays · doi:10.1002/bies.950191011 · Cited by 160

Mitochondrial ATP-synthase in the entorhinal cortex is a target of oxidative stress at stages I/II of Alzheimer’s disease pathology

Terni, B., Boada, J., Portero‐Otin, M., Pamplona, R., & Ferrer, I. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00266.x · Cited by 159

Effects of reactive oxygen species on brain synaptic plasma membrane Ca2+-ATPase

Zaidi, A., & Michaelis, M. L. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00128-8 · Cited by 154

Heavy Metal Induced Oxidative Damage in Terrestrial Plants

Shaw, B. P., Sahu, S. K., & Mishra, R. K. (2004) · Heavy Metal Stress in Plants · doi:10.1007/978-3-662-07743-6_4 · Cited by 153

2‐Oxo‐histidine as a novel biological marker for oxidatively modified proteins

Uchida, K., & Kawakishi, S. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80632-5 · Cited by 146

Age-related alterations in the activation of heat shock transcription factor 1 in rat hepatocytes

Heydari, A. R., You, S., Takahashi, R., Gutsmann-Conrad, A., Sarge, K. D., & Richardson, A. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4808 · Cited by 125

Bacopa monniera prevents from aluminium neurotoxicity in the cerebral cortex of rat brain

Jyoti, A., Sethi, P., & Sharma, D. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.10.037 · Cited by 119

Mechanisms of metal-catalyzed oxidation of histidine to 2-oxo-histidine in peptides and proteins

Schöneich, C. (2000) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(99)00182-x · Cited by 118

Oxidative Targets in the Stratum corneum

Thiele, J. J. (2001) · Skin Pharmacology and Physiology · doi:10.1159/000056395 · Cited by 117

Melatonin Reduces Oxidative Damage of Neural Lipids and Proteins in Senescence-Accelerated Mouse

Okatani, Y., Wakatsuki, A., Reiter, R. J., & Miyahara, Y. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00005-2 · Cited by 112

The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis‐resistance to non‐thermal plasma therapy

Toyokuni, S. (2016) · Pathology International · doi:10.1111/pin.12396 · Cited by 111

Aconitase and ATP synthase are targets of malondialdehyde modification and undergo an age-related decrease in activity in mouse heart mitochondria

Yarian, C. S., Rebrin, I., & Sohal, R. S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.135 · Cited by 111

The role of mitochondria in aging of skeletal muscle

Figueiredo, P. A., Mota, M. P., Appell, H. J., & Duarte, J. A. (2008) · Biogerontology · doi:10.1007/s10522-007-9121-7 · Cited by 109

Progeric Effects of Catalase Inactivation in Human Cells

Koepke, J. I., Wood, C. S., Terlecky, L. J., Walton, P. A., & Terlecky, S. R. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.06.004 · Cited by 101

Aging impairs skeletal muscle mitochondrial bioenergetic function

Figueiredo, P. A., Powers, S. K., Ferreira, R. M., Appell, H. J., & Duarte, J. A. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/gln048 · Cited by 102

Plasmalogen phospholipids protect internodal myelin from oxidative damage

Luoma, A. M., Kuo, F., Cakici, O., Crowther, M. N., Denninger, A. R., Avila, R. L., Brites, P., & Kirschner, D. A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.012 · Cited by 97

Age-Related Oxidative Stress Compromises Endosomal Proteostasis

Cannizzo, E. S., Clement, C. C., Morozova, K., Valdor, R., Kaushik, S., Almeida, L. N., Follo, C., Sahu, R., Cuervo, A. M., Macian, F., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.06.005 · Cited by 95

Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway

Dehghan, E., Zhang, Y., Saremi, B., Yadavali, S., Hakimi, A., Dehghani, M., Goodarzi, M., Tu, X., Robertson, S., Lin, R., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02394-3 · Cited by 92

Assessment of mitochondrial biogenesis and mTORC1 signaling during chronic rapamycin feeding in male and female mice

Drake, J. C., Peelor, F. F., Biela, L. M., Watkins, M. K., Miller, R. A., Hamilton, K. L., & Miller, B. F. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt047 · Cited by 87

Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila

Bayne, A.-C. V., Mockett, R. J., Orr, W. C., & Sohal, R. S. (2005) · Biochemical Journal · doi:10.1042/bj20041872 · Cited by 84

Developmental and physiological challenges of octopus (Octopus vulgaris) early life stages under ocean warming

Repolho, T., Baptista, M., Pimentel, M. S., Dionísio, G., Trübenbach, K., Lopes, V. M., Lopes, A. R., Calado, R., Diniz, M., & Rosa, R. (2014) · Journal of Comparative Physiology B · doi:10.1007/s00360-013-0783-y · Cited by 85

Antioxidant enzyme and malondialdehyde values in social phobia before and after citalopram treatment

Atmaca, M., Tezcan, E., Kuloglu, M., Ustundag, B., & Tunckol, H. (2004) · European Archives of Psychiatry and Clinical Neurosciences · doi:10.1007/s00406-004-0484-3 · Cited by 75

Dose-Dependent Increase of Oxidative Damage in the Testes of Rats Subjected to Acute Iron Overload

Lucesoli, F., Caligiuri, M., Roberti, M. F., Perazzo, J. C., & Fraga, C. G. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1476 · Cited by 75

Impacts of transcriptional regulation on aging and senescence

Roy, A. K., Oh, T., Rivera, O., Mubiru, J., Song, C. S., & Chatterjee, B. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00006-5 · Cited by 72

Proteasomal degradation of glutamine synthetase regulates schwann cell differentiation

Saitoh, F., & Araki, T. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3591-09.2010 · Cited by 70

Premature aging in mice with error-prone protein synthesis

Shcherbakov, D., Nigri, M., Akbergenov, R., Brilkova, M., Mantovani, M., Petit, P. I., Grimm, A., Karol, A. A., Teo, Y., Sanchón, A. C., et al. (2022) · Science Advances · doi:10.1126/sciadv.abl9051 · Cited by 68

Age and sex-related changes in rat brain mitochondrial oxidative status

Guevara, R., Gianotti, M., Oliver, J., & Roca, P. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.08.003 · Cited by 63

Formation of Nɛ-(succinyl)lysine in vivo: a novel marker for docosahexaenoic acid-derived protein modification

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