Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale

DeRisi, Joseph L., Iyer, Vishwanath R., Brown, Patrick O.·1997·Science

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Abstract

DNA microarrays containing virtually every gene of Saccharomyces cerevisiae were used to carry out a comprehensive investigation of the temporal program of gene expression accompanying the metabolic shift from fermentation to respiration. The expression profiles observed for genes with known metabolic functions pointed to features of the metabolic reprogramming that occur during the diauxic shift, and the expression patterns of many previously uncharacterized genes provided clues to their possible functions. The same DNA microarrays were also used to identify genes whose expression was affected by deletion of the transcriptional co-repressor TUP1 or overexpression of the transcriptional activator YAP1 . These results demonstrate the feasibility and utility of this approach to genomewide exploration of gene expression patterns.

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Self-citation
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“Experimental design for genome expression analysis DNA microarray analyses (DeRisi, 1997 Daran-Lapujade et al., 2009) and RNA sequencing (Wang et al., 2009b; Ozsolak & Milos, 2011) enable the rapid, quantitative, and inclusive correlation of the yeast transcriptome to environmental or genetic…”
Method
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VisANT 3.0: new modules for pathway visualization, editing, prediction and construction
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Authors: DeRisi, J. L., Iyer, V. R., & Brown, P. O.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1997-10-24
Volume: 278
Issue: 5338
Pages: 680-686
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.278.5338.680
OpenAlex: W2165011536
Cited by: 4,456
References: 0
FWCI: 73.80
Type: journal article
Language: en
Open access: closed

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Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale

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