The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

Grakoui, Arash, Bromley, Shannon K., Sumen, Cenk, Davis, Mark M., Shaw, Andrey S., Allen, Paul M., Dustin, Michael L.·1999·Science

DOI 10.1126/science.285.5425.221

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Abstract

The specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring of adhesion molecules. Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands. Initially, T cell receptor ligands were engaged in an outermost ring of the nascent synapse. Transport of these complexes into the central cluster was dependent on T cell receptor–ligand interaction kinetics. Finally, formation of a stable central cluster at the heart of the synapse was a determinative event for T cell proliferation.

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Untitled work
Kalina (2002) · doi:10.1002/1521-4141(200209)32:9<2635::aid-immu2635>3.0.co;2-n

Authors: Grakoui, A., Bromley, S. K., Sumen, C., Davis, M. M., Shaw, A. S., Allen, P. M., & Dustin, M. L.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1999-07-09
Volume: 285
Issue: 5425
Pages: 221-227
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.285.5425.221
OpenAlex: W2096234619
Cited by: 3,102
References: 0
FWCI: 50.20
Type: journal article
Language: en
Open access: closed

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The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

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