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Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

Goldgaber, Dmitry, Lerman, Michael I., McBride, O. Wesley, Saffiotti, Umberto, Gajdusek, D. Carleton·1987·Science

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Abstract

Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the β peptide of brain amyloid from Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids, including the known amino acid sequence of this polypeptide. The 3.5-kilobase messenger RNA was detected in mammalian brains and human thymus. The gene is highly conserved in evolution and has been mapped to human chromosome 21.

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Authors: Goldgaber, D., Lerman, M. I., McBride, O. W., Saffiotti, U., & Gajdusek, D. C.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1987-02-20
Volume: 235
Issue: 4791
Pages: 877-880
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.3810169
OpenAlex: W2091505182
Cited by: 1,333
References: 1
FWCI: 107.78
Type: journal article
Language: en
Open access: closed

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Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

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