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Cited by 1,727

The DOI matches its Crossref record; 595 of the 595 references it cites were found in a registry or an index.

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

Open access
Ravikumar, Brinda, Sarkar, Sovan, Davies, Janet E., Futter, Marie, Garcia-Arencibia, Moises, Green-Thompson, Zeyn W., Jimenez-Sanchez, Maria, Korolchuk, Viktor I., Lichtenberg, Maike, Luo, Shouqing, Massey, Dunecan C. O., Menzies, Fiona M., Moreau, Kevin, Narayanan, Usha, Renna, Maurizio, Siddiqi, Farah H., Underwood, Benjamin R., Winslow, Ashley R., Rubinsztein, David C.·2010·Physiological Reviews
DOI 10.1152/physrev.00030.2009
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Abstract

(Macro)autophagy is a bulk degradation process that mediates the clearance of long-lived proteins and organelles. Autophagy is initiated by double-membraned structures, which engulf portions of cytoplasm. The resulting autophagosomes ultimately fuse with lysosomes, where their contents are degraded. Although the term autophagy was first used in 1963, the field has witnessed dramatic growth in the last 5 years, partly as a consequence of the discovery of key components of its cellular machinery. In this review we focus on mammalian autophagy, and we give an overview of the understanding of its machinery and the signaling cascades that regulate it. As recent studies have also shown that autophagy is critical in a range of normal human physiological processes, and defective autophagy is associated with diverse diseases, including neurodegeneration, lysosomal storage diseases, cancers, and Crohn's disease, we discuss the roles of autophagy in health and disease, while trying to critically evaluate if the coincidence between autophagy and these conditions is causal or an epiphenomenon. Finally, we consider the possibility of autophagy upregulation as a therapeutic approach for various conditions.

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Crossref · 10.1152/physrev.00030.2009

Cites

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Citations

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Metadata

Authors
Ravikumar, B., Sarkar, S., Davies, J. E., Futter, M., Garcia-Arencibia, M., Green-Thompson, Z. W., Jimenez-Sanchez, M., Korolchuk, V. I., Lichtenberg, M., Luo, S., Massey, D. C. O., Menzies, F. M., Moreau, K., Narayanan, U., Renna, M., Siddiqi, F. H., Underwood, B. R., Winslow, A. R., & Rubinsztein, D. C.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2010-10
Volume
90
Issue
4
Pages
1383-1435
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00030.2009
OpenAlex
W2046250764
Cited by
1,727
References
595
FWCI
11.32
Type
journal article
Language
en
Open access
green

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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