CoChat
Sign Up
Cited by 300Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsReproductive Biology and Fertility

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Restoration of Reproductive Potential by Lifestyle Modification in Obese Polycystic Ovary Syndrome: Role of Insulin Sensitivity and Luteinizing Hormone

Huber-Buchholz, M.-M.·1999·Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.84.4.1470
Open this paper in CoChat — free account

Abstract

Weight reduction and exercise have been shown to help with menstrual disturbance and infertility in obese women with polycystic ovary syndrome. We studied the relationship between insulin sensitivity and ovulation patterns in 18 infertile anovulatory obese polycystic ovary syndrome (PCOS) women (NO) with normal glucose tolerance, aged between 22–39 yr with a body mass index of 27–45 kg/m2, before and after a 6-month diet and exercise program. This program promotes healthy lifestyle factors, but does not lead to rapid weight loss. The anthropometric, metabolic, and endocrine factors of these subjects were compared to those of 10 age- and weight-matched PCOS women with regular monthly ovulation (RO). Before lifestyle modification, the anovulatory subjects had greater central obesity than regular ovulators, as assessed by percent central fat (NO, 45.7 ± 0.8%; RO, 42.2 ± 1.6%; P < 0.05), higher glucose increment after glucose challenge (NO, 10.1 ± 1.0 mmol/L; RO, 6.4 ± 1.1 mmol/L; P < 0.02), lower insulin sensitivity index (NO, 1.2 ± 0.2; RO, 2.8 ± 0.6 μmol/kg·min/pmol/L; P < 0.005), higher plasma LH (NO, 8.9 ± 0.9; RO, 4.6 ± 0.9 IU/L; P < 0.005), and lower plasma sex hormone-binding globulin (NO, 18.0 ± 2.5; RO, 27.8 ± 5.7 nmol/L; P < 0.05]. Anovulatory subjects were classified as responders (R) to the intervention if they regained ovulation during the study. As a result of intervention, R showed an 11% reduction in central fat, a 71% improvement in insulin sensitivity index, a 33% fall in fasting insulin levels, and a 39% reduction in LH levels. None of these parameters changed significantly in nonresponders (NR). At the end of the study, R had lower fasting insulin (R, 13.6 ± 1.7; NR, 23.0 ± 3.5 mU/L) and LH levels (R,5.0 ± 1.7; NR, 7.4± 1.4 IU/L), but similar androgen levels compared to NR. We conclude that lifestyle modification without rapid weight loss leads to a reduction of central fat and improved insulin sensitivity, which restores ovulation in overweight infertile women with PCOS. Lifestyle modification is the best initial management for obese women seeking to improve their reproductive function.

Overview

Integrity signals

Registry

Crossref · 10.1210/jc.84.4.1470

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

The publisher hasn’t deposited this paper’s reference list.

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Huber-Buchholz, M.-M.
Corresponding author
Huber-Buchholz, M.-M.
Venue
Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1999-04-01
Volume
84
Issue
4
Pages
1470-1474
ISSN
0021-972X (ISSN-L)
DOI
10.1210/jc.84.4.1470
OpenAlex
W4242137728
Cited by
269
References
0
Citations by year
2026: 1 · 2025: 5 · 2024: 9 · 2023: 5 · 2022: 8 · 2021: 12 · 2020: 9 · 2019: 6 · 2018: 6 · 2017: 10 · 2016: 6 · 2015: 11 · 2014: 3 · 2013: 8 · 2012: 6
FWCI
7.78
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords
polycystic ovary syndrome, obesity, insulin sensitivity, luteinizing hormone, lifestyle modification, diet and exercise, anovulation, ovulation induction, abdominal obesity, sex hormone-binding globulin, insulin resistance, infertility, weight loss, menstrual irregularity, insulin sensitivity index, fasting insulin, glucose tolerance, insulin resistance index

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review