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Mesenchymal stem cells
Abstract
Bone and cartilage formation in the embryo and repair and turnover in the adult involve the progeny of a small number of cells called mesenchymal stem cells. These cells divide, and their progeny become committed to a specific and distinctive phenotypic pathway, a lineage with discrete steps and, finally, end‐stage cells involved with fabrication of a unique tissue type, e.g., cartilage or bone. Local cuing (extrinsic factors) and the genomic potential (intrinsic factors) interact at each lineage step to control the rate and characteristic phenotype of the cells in the emerging tissue. The study of these mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair. The isolation, mitotic expansion, and site‐directed delivery of autologous stem cells can govern the rapid and specific repair of skeletal tissues.
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Bak, E. J., Park, H. G., Kim, J. M., Kim, J. M., Yoo, Y.-J., & Cha, J.-H. (2010) · International Journal of Obesity · doi:10.1038/ijo.2009.223 · Cited by 54
Metadata
- Authors
- Caplan, A. I.
- Venue
- Journal of Orthopaedic Research
- Publisher
- Wiley
- Published
- 1991-09
- Volume
- 9
- Issue
- 5
- Pages
- 641-650
- ISSN
- 0736-0266 (ISSN-L)
- 1554-527X
- OpenAlex
- W2144268541
- Cited by
- 6,548
- References
- 2
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
