The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence?
Abstract
Converging evidence indicates that a profound reorganization of human brain function takes place during adolescence: the amount of deep sleep and the rate of brain metabolism fall sharply; the latency of certain event-related potentials declines; the capacity to recover function after brain injury diminishes; and adult problem-solving "power" appears. A reduction in cortical synaptic density has recently been observed and might account for all of these changes. Such synaptic "pruning" may be analogous to the programmed elimination of neural elements in very early development. A defect in this maturational process may underlie those cases of schizophrenia that emerge during adolescence.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Both Apoe and C1q are also biologically associated with synaptic function; C1q is a component of the complement pathway that accumulates at synapses to promote selective synaptic pruning during brain development (Huttenlocher 1979, Feinberg 1982) and mediates pathological elimination of synapses where microglia engulf or “prune” synapses (Hong, Beja-Glasser et al. 2016).”
From SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain (2026) · cites this paper as Feinberg 1982
In the citing paper
“this reduced synaptic connectivity stems from disturbances of key events of brain development during late adolescence and early adulthood, including myelogenesis (Bartzokis, 2002; Bartzokis et al., 2003; Benes, 1989) and synaptic pruning (Feinberg, 1982; Keshavan et al., 1994; McGlashan and Hoffman, 2000)”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Feinberg, 1982
In the citing paper
“In light of the fact that PNNs are known to play a role in regulating developmental synaptic pruning in the cerebral cortex and that synaptic pruning deficit has long been speculated to contribute to the onset of schizophrenia (McGlashan and Hoffman, 2000; Feinberg, 1982; Keshavan et al., 1994)”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Feinberg, 1982
In the citing paper
“some recent studies have inferred changes in the activity of dopaminergic neurons on the basis of variations in the blood oxygen level-dependent signal in midbrain nuclei, 82,83”
From Schizophrenia, myelination, and delayed corollary discharges: a hypothesis (2012) · cites this paper as [83]
In the citing paper
“Interestingly, exaggerated pruning of synapses 92 and dysconnectivity of neural networks, 93 are longstanding neurobiological models of schizophrenia, and convergent evidence points to synaptic pathways being integral to conferring schizophrenia risk.”
From Towards an Integrative Account of Potential Mechanisms Mediating the Path From Sleep Dysfunction to Hallucinations (2025) · cites this paper as [92]
Citations
Cites
Quantitative growth and development of human brain
Dobbing, J., & Sands, J. (1973) · Archives of Disease in Childhood · doi:10.1136/adc.48.10.757 · Cited by 1,442
Sleep deprivation: effect on sleep stages and EEG power density in man
Borbély, A. A., Baumann, F., Brandeis, D., Strauch, I., & Lehmann, D. (1981) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(81)90225-x · Cited by 1,013
Growth and Reshaping of Axons in the Establishment of Visual Callosal Connections
Innocenti, G. M. (1981) · Science · doi:10.1126/science.7221566 · Cited by 597
Ontogenetic changes in the projections of neocortical neurons
Ivy, G., & Killackey, H. (1982) · The Journal of Neuroscience · doi:10.1523/jneurosci.02-06-00735.1982 · Cited by 271
Research works printed but not linked: 33
- Borbely, 1982, Sleep/wake-dependent and circadian aspects of sleep regulation, Paper presented at the Sixth European Congress on Sleep Research, Zurich, Switzerland
- Changeux, 1976, Selective stabilization of developing synapses as a mechanism for the specification of neuronal networks, Nature, 264, 705, 10.1038/264705a0 · DOI · Paper page
- Chaudhari, 1983, Genetic expression in the developing brain, Science, 220, 924, 10.1126/science.6189184 · DOI
- Courchesne, 1977, Event-related brain potentials: comparison between children and adults, Science, 197, 589, 10.1126/science.877575 · DOI · Paper page
- Cragg, 1975, The density of synapses and neurons in normal, mentally defective and ageing human brains, Brain, 98, 81, 10.1093/brain/98.1.81 · DOI
- Dreyfus-Brusac, 1958, L'electroencephalogramme de l'enfant normal de moins de 3 ans, Etudes neonatal, 7, 143
- Elul, 1972, The genesis of the EEG, Vol. 15, 228
- Evarts, 1971, Feedback and corollary discharge: a merging of the concepts, Neurosci. Res. Prog. Bull., 9, 86
- Feinberg, 1974, Changes in sleep cycle patterns with age, J. psychiat. Res., 10, 283, 10.1016/0022-3956(74)90011-9 · DOI
- Feinberg, 1978, Efference copy and corollary discharge: implications for thinking and its disorders, Schizophrenia Bull., 4, 636, 10.1093/schbul/4.4.636 · DOI · Paper page
- Feinberg, 1982, Schizophrenia and late maturational brain changes in man, Psychopharmac. Bull., 18, 29
- Feinberg, 1968, Sleep variables as a function of age in man, Archs gen. Psychiat., 18, 239, 10.1001/archpsyc.1968.01740020111014 · DOI
- Feinberg, 1969, Changing concepts of the function of sleep: discovery of intense brain activity during sleep calls for revision of hypotheses as to its function, Biol. Psychiat., 1, 331
- Feinberg, 1982, The regulation of human sleep: clues from its phenomenology, Hum. Neurobiol., 1, 185
- Feinberg, 1978, Sleep patterns in schizophrenia: a selective review, 205
- Feinberg, 1967, EEG sleep patterns as a function of normal and pathological aging in man, J. psychiat. Res., 5, 107, 10.1016/0022-3956(67)90027-1 · DOI
- Feinberg, 1964, Child devel., 35, 547, 10.2307/1126718 · DOI
- Freyhan, 1951, J. nerv. ment. Dis., 113, 449
- Goodin, 1978, Age-related variations in evoked potentials to auditory stimuli in normal human subjects, Electroenceph. clin. neurophysiol., 44, 447, 10.1016/0013-4694(78)90029-9 · DOI
- Hamburger, 1982, Naturally occuring neuronal death in vertebrates, Neurosci. Commentaries, 1, 39
- Hökfelt, 1980, Nature, 284, 515, 10.1038/284515a0 · DOI
- Huttenlocher, 1979, Brain Res., 163, 195, 10.1016/0006-8993(79)90349-4 · DOI · Paper page
- Huttenlocher, 1982, Neurosci. Lett., 33, 247, 10.1016/0304-3940(82)90379-2 · DOI · Paper page
- Kasamatsu, 1976, Depletion of brain catecholamines: failure of ocular dominance shift after monocular occlusion in kittens, Science, 194, 206, 10.1126/science.959850 · DOI
- Kety, 1956, Human cerebral blood flow and oxygen consumption as related to aging, Assoc. Res. nerv. ment. Dis., 35, 31
- Kety, 1948, The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure and normal values, J. clin. Invest., 27, 476, 10.1172/JCI101994 · DOI
- Lassen, 1960, Bilateral studies of cerebral oxygen uptake in young and aged normal subjects and in patients with organic dementia, J. clin. Invest., 39, 491, 10.1172/JCI104063 · DOI
- May, 1931, The dementia praecox—schizophrenia problem, Am. J. Psychiat., 88, 401, 10.1176/ajp.88.3.401 · DOI
- O'Leary, 1981, Devl Brain Res., 1, 607, 10.1016/0165-3806(81)90012-2 · DOI · Paper page
- Pettigrew, 1978, Nature, 271, 761, 10.1038/271761a0 · DOI
- Purves, 1980, Neuronal competition, Nature, 287, 585, 10.1038/287585a0 · DOI
- Purves, 1980, Science, 210, 153, 10.1126/science.7414326 · DOI · Paper page
- Truman, 1982, Insect systems for the study of programmed neuronal death, Neurosci. Commentaries, 1, 66
Cited by
Sorted by citations
Why do many psychiatric disorders emerge during adolescence?
Paus, T., Keshavan, M., & Giedd, J. N. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2513 · Cited by 3,123
Schizophrenia risk from complex variation of complement component 4
Sekar, A., Bialas, A. R., de Rivera, H., Davis, A., Hammond, T. R., Kamitaki, N., Tooley, K., Presumey, J., Baum, M., Van Doren, V., et al. (2016) · Nature · doi:10.1038/nature16549 · Cited by 2,394
A review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346
Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151
Abnormal neural oscillations and synchrony in schizophrenia
Uhlhaas, P. J., & Singer, W. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2774 · Cited by 2,120
Insel, T. R. (2010) · Nature · doi:10.1038/nature09552 · Cited by 1,783
Microglia emerge as central players in brain disease
Salter, M. W., & Stevens, B. (2017) · Nature Medicine · doi:10.1038/nm.4397 · Cited by 1,767
Chambers, R. A., Taylor, J. R., & Potenza, M. N. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.6.1041 · Cited by 1,719
The neuropathology of schizophrenia
Harrison, P. J. (1999) · Brain · doi:10.1093/brain/122.4.593 · Cited by 1,677
De novo mutations in schizophrenia implicate synaptic networks
Fromer, M., Pocklington, A. J., Kavanagh, D. H., Williams, H. J., Dwyer, S., Gormley, P., Georgieva, L., Rees, E., Palta, P., Ruderfer, D. M., et al. (2014) · Nature · doi:10.1038/nature12929 · Cited by 1,617
Trajectories of brain development: point of vulnerability or window of opportunity?
Andersen, S. L. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00005-8 · Cited by 1,503
Normal development of brain circuits
Tau, G. Z., & Peterson, B. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.115 · Cited by 1,391
Sleep and synaptic homeostasis: a hypothesis
Tononi, G., & Cirelli, C. (2003) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2003.09.004 · Cited by 1,217
Schizophrenia as a Disorder of Neurodevelopment
Lewis, D. A., & Levitt, P. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142754 · Cited by 1,163
The neural basis of puberty and adolescence
Sisk, C. L., & Foster, D. L. (2004) · Nature Neuroscience · doi:10.1038/nn1326 · Cited by 1,085
The neurodevelopmental model of schizophrenia: update 2005
Rapoport, J. L., Addington, A. M., Frangou, S., & Psych, M. R. C. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001642 · Cited by 993
The reduced neuropil hypothesis: a circuit based model of schizophrenia
Selemon, L. D., & Goldman-Rakic, P. S. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00281-9 · Cited by 909
Mueser, K. T., & McGurk, S. R. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16458-1 · Cited by 876
Regionally Localized Thinning of the Cerebral Cortex in Schizophrenia
Kuperberg, G. R., Broome, M. R., McGuire, P. K., David, A. S., Eddy, M., Ozawa, F., Goff, D., West, W. C., Williams, S. C. R., van der Kouwe, A. J. W., et al. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.9.878 · Cited by 843
Thompson, P. M., Vidal, C., Giedd, J. N., Gochman, P., Blumenthal, J., Nicolson, R., Toga, A. W., & Rapoport, J. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201243998 · Cited by 812
Regulation of adolescent sleep: Implications for behavior
CARSKADON, M. A., ACEBO, C., & JENNI, O. G. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1308.032 · Cited by 792
Sex Differences in Brain Maturation during Childhood and Adolescence
De Bellis, M. D. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.6.552 · Cited by 728
Astill, R. G., Van der Heijden, K. B., Van IJzendoorn, M. H., & Van Someren, E. J. W. (2012) · Psychological Bulletin · doi:10.1037/a0028204 · Cited by 707
Clark, L. A., Cuthbert, B., Lewis-Fernández, R., Narrow, W. E., & Reed, G. M. (2017) · Psychological Science in the Public Interest · doi:10.1177/1529100617727266 · Cited by 688
Functional and Anatomical Aspects of Prefrontal Pathology in Schizophrenia
Goldman-Rakic, P. S., & Selemon, L. D. (1997) · Schizophrenia Bulletin · doi:10.1093/schbul/23.3.437 · Cited by 668
The environment and susceptibility to schizophrenia
Brown, A. S. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.09.003 · Cited by 664
Stability and Course of Neuropsychological Deficits in Schizophrenia
Heaton, R. K., Gladsjo, J. A., Palmer, B. W., Kuck, J., Marcotte, T. D., & Jeste, D. V. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.1.24 · Cited by 618
Cannon, T. D., Chung, Y., He, G., Sun, D., Jacobson, A., van Erp, T. G. M., McEwen, S., Addington, J., Bearden, C. E., Cadenhead, K., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.05.023 · Cited by 599
Development of Anterior Cingulate Functional Connectivity from Late Childhood to Early Adulthood
Kelly, A. M. C., Di Martino, A., Uddin, L. Q., Shehzad, Z., Gee, D. G., Reiss, P. T., Margulies, D. S., Castellanos, F. X., & Milham, M. P. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn117 · Cited by 572
Dendritic spine pathology in schizophrenia
Glausier, J. R., & Lewis, D. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.044 · Cited by 581
Pantelis, C. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbi034 · Cited by 573
Synaptic development of the cerebral cortex: implications for learning, memory and mental illness
(1994) · Progress in Brain Research · doi:10.1016/s0079-6123(08)60543-9 · Cited by 565
Keshavan, M. S., Anderson, S., & Pettergrew, J. W. (1994) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)90009-4 · Cited by 525
Teicher, M. H., Andersen, S. L., & Hostetter, J. C. (1995) · Developmental Brain Research · doi:10.1016/0165-3806(95)00109-q · Cited by 505
Emerging principles of altered neural circuitry in schizophrenia
Benes, F. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00041-7 · Cited by 513
Public health implications of altered puberty timing
Golub, M. S., Collman, G. W., Foster, P. M. D., Kimmel, C. A., Rajpert-De Meyts, E., Reiter, E. O., Sharpe, R. M., Skakkebaek, N. E., & Toppari, J. (2008) · PEDIATRICS · doi:10.1542/peds.2007-1813g · Cited by 497
Alexander-Bloch, A. F., Gogtay, N., Meunier, D., Birn, R., Clasen, L., Lalonde, F., Lenroot, R., Giedd, J., & Bullmore, E. T. (2010) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2010.00147 · Cited by 480
MATURATION OF HUMAN CEREBRUM OBSERVED IN VIVO DURING ADOLESCENCE
JERNIGAN, T. L., TRAUNER, D. A., HESSELINK, J. R., & TALLAL, P. A. (1991) · Brain · doi:10.1093/brain/114.5.2037 · Cited by 444
Psychobiology of Altered States of Consciousness.
Vaitl, D., Birbaumer, N., Gruzelier, J., Jamieson, G. A., Kotchoubey, B., Kübler, A., Lehmann, D., Miltner, W. H. R., Ott, U., Pütz, P., et al. (2005) · Psychological Bulletin · doi:10.1037/0033-2909.131.1.98 · Cited by 448
Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia
Mirnics, K., Middleton, F. A., Stanwood, G. D., Lewis, D. A., & Levitt, P. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000866 · Cited by 446
Disrupted axonal fiber connectivity in schizophrenia
Zalesky, A., Fornito, A., Seal, M. L., Cocchi, L., Westin, C.-F., Bullmore, E. T., Egan, G. F., & Pantelis, C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.022 · Cited by 439
The stress cascade and schizophrenia: Etiology and onset
Corcoran, C., Walker, E., Huot, R., Mittal, V., Tessner, K., Kestler, L., & Malaspina, D. (2003) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007038 · Cited by 439
Brain maturation in adolescence: concurrent changes in neuroanatomy and neurophysiology
Whitford, T. J., Rennie, C. J., Grieve, S. M., Clark, C. R., Gordon, E., & Williams, L. M. (2007) · Human Brain Mapping · doi:10.1002/hbm.20273 · Cited by 391
Kurth, S., Ringli, M., Geiger, A., LeBourgeois, M., Jenni, O. G., & Huber, R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2532-10.2010 · Cited by 373
Lewis, D. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00277-1 · Cited by 388
Do glia drive synaptic and cognitive impairment in disease?
Chung, W.-S., Welsh, C. A., Barres, B. A., & Stevens, B. (2015) · Nature Neuroscience · doi:10.1038/nn.4142 · Cited by 385
Cortical Abnormalities in Schizophrenia Identified by Structural Magnetic Resonance Imaging
Goldstein, J. M. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.6.537 · Cited by 369
Toward a Neurodevelopmental Model of Obsessive–Compulsive Disorder
Rosenberg, D. R., & Keshavan, M. S. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00443-5 · Cited by 355
Cannabis and adolescent brain development.
Lubman, D. I., Cheetham, A., & Yücel, M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.11.009 · Cited by 360
Schizophrenia: a tale of two critical periods for prefrontal cortical development
Selemon, L. D., & Zecevic, N. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.115 · Cited by 336
Bayer, T. A., Falkai, P., & Maier, W. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00039-4 · Cited by 346
Yilmaz, M., Yalcin, E., Presumey, J., Aw, E., Ma, M., Whelan, C. W., Stevens, B., McCarroll, S. A., & Carroll, M. C. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00763-8 · Cited by 321
Neuron-glia signaling in synapse elimination
Wilton, D. K., Dissing-Olesen, L., & Stevens, B. (2019) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070918-050306 · Cited by 332
Age-related Volumetric Changes of Brain Gray and White Matter in Healthy Infants and Children
Matsuzawa, J. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.4.335 · Cited by 315
Rosenberg, D. R., & Lewis, D. A. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903580306 · Cited by 319
Reduced Dendritic Spine Density in Auditory Cortex of Subjects with Schizophrenia
Sweet, R. A., Henteleff, R. A., Zhang, W., Sampson, A. R., & Lewis, D. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.67 · Cited by 290
Microglia and the brain: Complementary partners in development and disease
Hammond, T. R., Robinton, D., & Stevens, B. (2018) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100616-060509 · Cited by 288
Sleep EEG changes during adolescence: An index of a fundamental brain reorganization
Feinberg, I., & Campbell, I. G. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.09.008 · Cited by 280
Self-citationCampbell, I. G., & Feinberg, I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812947106 · Cited by 280
Self-citationThe negative symptoms of schizophrenia: A cognitive perspective
Rector, N. A., Beck, A. T., & Stolar, N. (2005) · The Canadian Journal of Psychiatry · doi:10.1177/070674370505000503 · Cited by 268
Glantz, L. A., Gilmore, J. H., Hamer, R. M., Lieberman, J. A., & Jarskog, L. F. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.06.036 · Cited by 270
Pfefferbaum, A., Rohlfing, T., Rosenbloom, M. J., Chu, W., Colrain, I. M., & Sullivan, E. V. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2012.10.008 · Cited by 256
Kolluri, N., Sun, Z., Sampson, A. R., & Lewis, D. A. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.6.1200 · Cited by 241
Anderson, S. A., Classey, J. D., Condé, F., Lund, J. S., & Lewis, D. A. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00051-j · Cited by 245
Synaptic and plasticity-associated proteins in anterior frontal cortex in severe mental illness
Honer, W. G., Falkai, P., Chen, C., Arango, V., Mann, J. J., & Dwork, A. J. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00679-4 · Cited by 244
Onwordi, E. C., Halff, E. F., Whitehurst, T., Mansur, A., Cotel, M.-C., Wells, L., Creeney, H., Bonsall, D., Rogdaki, M., Shatalina, E., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14122-0 · Cited by 243
Gender Differences in Human Brain: A Review
Zaidi, Z. F. (2010) · The Open Anatomy Journal · doi:10.2174/1877609401002010037 · Cited by 229
Rethinking schizophrenia in the context of normal neurodevelopment
Catts, V. S., Fung, S. J., Long, L. E., Joshi, D., Vercammen, A., Allen, K. M., Fillman, S. G., Rothmond, D. A., Sinclair, D., Tiwari, Y., et al. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00060 · Cited by 206
Characteristics of sleep slow waves in children and adolescents
Kurth, S., Jenni, O. G., Riedner, B. A., Tononi, G., Carskadon, M. A., & Huber, R. (2010) · Sleep · doi:10.1093/sleep/33.4.475 · Cited by 156
Peripubertal refinement of the intrinsic and associational circuitry in monkey prefrontal cortex
Woo, T.-U., Pucak, M. L., Kye, C. H., Matus, C. V., & Lewis, D. A. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00059-6 · Cited by 157
Pubertal changes in gonadal hormones do not underlie adolescent dopamine receptor overproduction
Andersen, S. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00069-5 · Cited by 152
Adolescent Neurodevelopment and Vulnerability to Psychosis
Patel, P. K., Leathem, L. D., Currin, D. L., & Karlsgodt, K. H. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.06.028 · Cited by 152
Schizophrenia, myelination, and delayed corollary discharges: a hypothesis
Whitford, T. J., Ford, J. M., Mathalon, D. H., Kubicki, M., & Shenton, M. E. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq105 · Cited by 140
The natural history and pathophysiology of treatment resistant schizophrenia
Sheitman, B. B., & Lieberman, J. A. (1998) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(97)00052-6 · Cited by 140
Semaphorins in Adult Nervous System Plasticity and Disease
Carulli, D., de Winter, F., & Verhaagen, J. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.672891 · Cited by 137
Factors Influencing Sleep Patterns of Adolescents
Carskadon, M. A. (2001) · Adolescent Sleep Patterns · doi:10.1017/cbo9780511499999.005 · Cited by 136
Brain Neuroplasticity in Healthy, Hyperactive and Psychotic Children: Insights from Neuroimaging
Rapoport, J. L., & Gogtay, N. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301553 · Cited by 132
Nondementia Nonpraecox Dementia Praecox?: Late-Onset Schizophrenia
Jeste, D. V., Symonds, L. L., Harris, M. J., Paulsen, J. S., Palmer, B. W., & Heaton, R. K. (1997) · The American Journal of Geriatric Psychiatry · doi:10.1097/00019442-199700540-00005 · Cited by 125
Gogtay, N., Lu, A., Leow, A. D., Klunder, A. D., Lee, A. D., Chavez, A., Greenstein, D., Giedd, J. N., Toga, A. W., Rapoport, J. L., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806485105 · Cited by 125
Gogtay, N. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm103 · Cited by 124
Cruz, D. A., Eggan, S. M., & Lewis, D. A. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10833 · Cited by 118
Developmental Differences Between Schizophrenia and Bipolar Disorder
Parellada, M., Gomez-Vallejo, S., Burdeus, M., & Arango, C. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx126 · Cited by 114
de Bartolomeis, A., Barone, A., Vellucci, L., Mazza, B., Austin, M. C., Iasevoli, F., & Ciccarelli, M. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02976-3 · Cited by 113
Tracing the development of psychosis and its prevention: what can be learned from animal models
Piontkewitz, Y., Arad, M., & Weiner, I. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.04.019 · Cited by 108
Maturation of the human striatal dopamine system revealed by PET and quantitative MRI
Larsen, B., Olafsson, V., Calabro, F., Laymon, C., Tervo-Clemmens, B., Campbell, E., Minhas, D., Montez, D., Price, J., & Luna, B. (2020) · Nature Communications · doi:10.1038/s41467-020-14693-3 · Cited by 107
Liu, C. H., Keshavan, M. S., Tronick, E., & Seidman, L. J. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv047 · Cited by 104
Abnormal synaptic pruning during adolescence underlying the development of psychotic disorders
Germann, M., Brederoo, S. G., & Sommer, I. E. C. (2021) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000696 · Cited by 102
Prenatal Expression Patterns of Genes Associated With Neuropsychiatric Disorders
Birnbaum, R., Jaffe, A. E., Hyde, T. M., Kleinman, J. E., & Weinberger, D. R. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.13111452 · Cited by 97
Gamma oscillation deficits and the onset and early progression of schizophrenia
Woo, T.-U. W., Spencer, K., & McCarley, R. W. (2010) · Harvard Review of Psychiatry · doi:10.3109/10673221003747609 · Cited by 96
Perineuronal nets and schizophrenia: The importance of neuronal coatings
Bitanihirwe, B. K. Y., & Woo, T.-U. W. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.018 · Cited by 95
Campbell, I. G., & Feinberg, I. (2016) · Sleep · doi:10.5665/sleep.5346 · Cited by 64
Self-citationBenson, K. L. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2014.11.001 · Cited by 70
Jucaite, A., Forssberg, H., Karlsson, P., Halldin, C., & Farde, L. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.01.034 · Cited by 67
Onwordi, E. C., Whitehurst, T., Mansur, A., Statton, B., Berry, A., Quinlan, M., O’Regan, D. P., Rogdaki, M., Marques, T. R., Rabiner, E. A., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01515-3 · Cited by 55
Hui, C. W., Vecchiarelli, H. A., Gervais, É., Luo, X., Michaud, F., Scheefhals, L., Bisht, K., Sharma, K., Topolnik, L., & Tremblay, M.-È. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.558181 · Cited by 64
Isolating the delay component of impulsive choice in adolescent rats
McClure, J., Podos, J., & Richardson, H. N. (2014) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2014.00003 · Cited by 62
Slow wave sleep deficits as a trait marker in patients with schizophrenia
Sarkar, S., Katshu, M. Z. U. H., Nizamie, S. H., & Praharaj, S. K. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.08.013 · Cited by 59
Antidepressants and the adolescent brain
Cousins, L., & Goodyer, I. M. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115573542 · Cited by 61
Fung, S. J., Sivagnanasundaram, S., & Weickert, C. S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.036 · Cited by 54
The neuroanatomy of schizophrenia: circuitry and neurotransmitter systems
Fallon, J. H., Opole, I. O., & Potkin, S. G. (2003) · Clinical Neuroscience Research · doi:10.1016/s1566-2772(03)00022-7 · Cited by 53
Metadata
- Authors
- Feinberg, I.
- Affiliations
- San Francisco VA Medical Center (US)
- Corresponding author
- Feinberg, I.
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 1982-01
- Volume
- 17
- Issue
- 4
- Pages
- 319-334
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2025011978
- Cited by
- 1,395
- References
- 4
- Citations by year
- 2026: 29 · 2025: 33 · 2024: 60 · 2023: 49 · 2022: 52 · 2021: 55 · 2020: 44 · 2019: 72 · 2018: 30 · 2017: 38 · 2016: 36 · 2015: 42 · 2014: 38 · 2013: 46 · 2012: 31
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- schizophrenia, synaptic pruning, adolescence, brain maturation, slow-wave sleep, brain metabolism, event-related potentials, brain injury recovery
- MeSH terms
- Adolescent, Cell Count, Cerebral Cortex, Cognition, Dopamine, Electroencephalography, Energy Metabolism, Evoked Potentials, Frontal Lobe, Humans, Models, Neurological, Nerve Degeneration, Neuronal Plasticity, Neurons, Reaction Time, Schizophrenia, Sleep Stages, Synapses
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
