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Inflammatory Cytokine Alterations in Schizophrenia: A Systematic Quantitative Review

Potvin, Stéphane, Stip, Emmanuel, Sepehry, Amir A., Gendron, Alain, Bah, Ramatoulaye, Kouassi, Edouard·2008·Biological Psychiatry
DOI 10.1016/j.biopsych.2007.09.024
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Abstract

Background Cytokines play an important role in infection and inflammation and are crucial mediators of the cross-talk between the brain and the immune system. Schizophrenia would be associated with an imbalance in inflammatory cytokines, leading to a decrease in Th1 and an increase in Th2 cytokine secretion. However, data published so far have been inconsistent. The primary objective of the present meta-analysis was to verify whether the cytokine imbalance hypothesis of schizophrenia is substantiated by evidence. Methods Cross-sectional studies were included if they assessed in vivo plasma or serum cytokine concentrations and/or in vitro secretion of cytokines by peripheral blood leukocytes from schizophrenia patients and healthy volunteers. Results Data from 62 studies involving a total sample size of 2298 schizophrenia patients and 1858 healthy volunteers remained for analysis. Ten cytokines were assessed, including the prototypic Th1 and Th2 cytokines gamma interferon (IFN-gamma) and interleukin 4 (IL-4) as well as IL-2, soluble IL-2 receptor (sIL-2R), IL-1beta, IL-1 receptor antagonist (IL-1RA), tumor necrosis factor-alpha (TNF-alpha), IL-6, soluble IL-6 receptor (sIL-6R), and IL-10. The results show that an increase occurs in in vivo IL-1RA, sIL-2R, and IL-6 and a decrease occurs in in vitro IL-2 in schizophrenia. No significant effect sizes were obtained for the other cytokines. Conclusions These findings provide the first evidence of establishment of an inflammatory sy…

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Authors
Potvin, S., Stip, E., Sepehry, A. A., Gendron, A., Bah, R., & Kouassi, E.
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2008-04
Volume
63
Issue
8
Pages
801-808
ISSN
0006-3223
DOI
10.1016/j.biopsych.2007.09.024
Cited by
858
References
10
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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