Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

Positional cloning of the mouse obese gene and its human homologue

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Obesity is associated with macrophage accumulation in adipose tissue

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The metabolic syndrome—a new worldwide definition

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

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The gut microbiota as an environmental factor that regulates fat storage

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Adipose Tissue as an Endocrine Organ

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Increased oxidative stress in obesity and its impact on metabolic syndrome

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Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity

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Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

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Inflammation and insulin resistance

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

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A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

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TLR4 links innate immunity and fatty acid-induced insulin resistance

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A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

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Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

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Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

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MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

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Mechanisms underlying the resistance to diet-induced obesity in germ-free mice

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Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

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Dynamics of fat cell turnover in humans

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Novel Modulator for Endothelial Adhesion Molecules

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Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

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Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

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cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 (AdiposeMost Abundant Gene Transcript 1)

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Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

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Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1

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From endoplasmic-reticulum stress to the inflammatory response

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Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

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High body mass index for age among US children and adolescents, 2003-2006.

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Obesity, Inflammation, and Insulin Resistance

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Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid

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Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-κB Signaling Through a cAMP-Dependent Pathway

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Variation in FTO contributes to childhood obesity and severe adult obesity

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Absence of Monocyte Chemoattractant Protein-1 Reduces Atherosclerosis in Low Density Lipoprotein Receptor–Deficient Mice

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CCR2 modulates inflammatory and metabolic effects of high-fat feeding

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Recombinant Leptin for Weight Loss in Obese and Lean Adults: A Randomized, Controlled, Dose-Escalation Trial

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Visceral fat adipokine secretion is associated with systemic inflammation in obese humans

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Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

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Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

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Relationship of Childhood Obesity to Coronary Heart Disease Risk Factors in Adulthood: The Bogalusa Heart Study

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Common variants near MC4R are associated with fat mass, weight and risk of obesity

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Relationship between Adipocyte Size and Adipokine Expression and Secretion

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Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages

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Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation

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Leptin-Replacement Therapy for Lipodystrophy

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Monocyte chemoattractant protein 1 in obesity and insulin resistance

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Reduction of Macrophage Infiltration and Chemoattractant Gene Expression Changes in White Adipose Tissue of Morbidly Obese Subjects After Surgery-Induced Weight Loss

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Disruption of adiponectin causes insulin resistance and neointimal formation

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Adiponectin and protection against type 2 diabetes mellitus

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Adiponectin and development of type 2 diabetes in the Pima Indian population

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Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes

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Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes

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Nutrient sensing and inflammation in metabolic diseases

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A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways

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Cloning and Characterization of the cDNA Encoding a Novel Human pre-B-Cell Colony-enhancing Factor

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Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

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Beyond insulin resistance in NASH: TNF-α or adiponectin?

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Nampt/PBEF/Visfatin Regulates Insulin Secretion in β Cells as a Systemic NAD Biosynthetic Enzyme

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Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis

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Adiponectin as an anti-inflammatory factor

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Apelin, a Newly Identified Adipokine Up-Regulated by Insulin and Obesity

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HIF-1 and human disease: one highly involved factor

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The Metabolic Syndrome: A Global Public Health Problem and A New Definition

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Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

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Adipose tissue mass can be regulated through the vasculature

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Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

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Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob / ob and dietary obese mice

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TNF‐α and adipocyte biology

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Adiponectin acts in the brain to decrease body weight

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Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

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Reduced Adipose Tissue Oxygenation in Human Obesity

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Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans

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Adipocytokines and the Metabolic Complications of Obesity

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Plasma Visfatin Concentrations and Fat Depot–Specific mRNA Expression in Humans

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Obesity prevalence from a European perspective: a systematic review

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Acute stimulation of glucose metabolism in mice by leptin treatment

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Adipocyte-Derived Plasma Protein Adiponectin Acts as a Platelet-Derived Growth Factor-BB–Binding Protein and Regulates Growth Factor–Induced Common Postreceptor Signal in Vascular Smooth Muscle Cell

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T-lymphocyte Infiltration in Visceral Adipose Tissue: A Primary Event in Adipose Tissue Inflammation and the Development of Obesity-Mediated Insulin Resistance

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APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function

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The National Cholesterol Education Program–Adult Treatment Panel III, International Diabetes Federation, and World Health Organization Definitions of the Metabolic Syndrome as Predictors of Incident Cardiovascular Disease and Diabetes

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Tumor Necrosis Factor-α Induces Skeletal Muscle Insulin Resistance in Healthy Human Subjects via Inhibition of Akt Substrate 160 Phosphorylation

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Leptin Regulates Striatal Regions and Human Eating Behavior

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Energy intake is associated with endotoxemia in apparently healthy men

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