The DOI matches its Crossref record; 243 of the 243 references it cites were found in a registry or an index.
The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration
Abstract
Age-related macular degeneration (AMD) is the leading cause of blind registration in the developed world, and yet its pathogenesis remains poorly understood. Oxidative stress, which refers to cellular damage caused by reactive oxygen intermediates (ROI), has been implicated in many disease processes, especially age-related disorders. ROIs include free radicals, hydrogen peroxide, and singlet oxygen, and they are often the byproducts of oxygen metabolism. The retina is particularly susceptible to oxidative stress because of its high consumption of oxygen, its high proportion of polyunsaturated fatty acids, and its exposure to visible light. In vitro studies have consistently shown that photochemical retinal injury is attributable to oxidative stress and that the antioxidant vitamins A, C, and E protect against this type of injury. Furthermore, there is strong evidence suggesting that lipofuscin is derived, at least in part, from oxidatively damaged photoreceptor outer segments and that it is itself a photoreactive substance. However, the relationships between dietary and serum levels of the antioxidant vitamins and age-related macular disease are less clear, although a protective effect of high plasma concentrations of alpha-tocopherol has been convincingly demonstrated. Macular pigment is also believed to limit retinal oxidative damage by absorbing incoming blue light and/or quenching ROIs. Many putative risk-factors for AMD have been linked to a lack of macular pigment, including female gender, lens density, tobacco use, light iris color, and reduced visual sensitivity. Moreover, the Eye Disease Case-Control Study found that high plasma levels of lutein and zeaxanthin were associated with reduced risk of neovascular AMD. The concept that AMD can be attributed to cumulative oxidative stress is enticing, but remains unproven. With a view to reducing oxidative damage, the effect of nutritional antioxidant supplements on the onset and natural course of age-related macular disease is currently being evaluated.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Based on extensive biochemical, pathobiological, and genetic studies implicating oxidative stress and inflammation (12, 64, 165, 174), compromised energy and protein metabolism in aging retinal photoreceptors and RPE likely constitute one of the early steps in AMD pathogenesis (Figure 6).”
From Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration (2009) · cites this paper as [12]
In the citing paper
“Mitochondrial dysfunction and oxidative stress, including mitochondrial DNA damage, have been implicated in all three diseases—AD, PD, and AMD (12, 17, 98, 165).”
From Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration (2009) · cites this paper as [12]
Citations
Cites
[30] Microsomal lipid peroxidation
Buege, J. A., & Aust, S. D. (1978) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(78)52032-6 · Cited by 13,564
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952
Handbook of Sensory Physiology
Sanders, M. D. (1975) · British Journal of Ophthalmology · doi:10.1136/bjo.59.2.111-c · Cited by 7,166
Hydroperoxide metabolism in mammalian organs.
Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
The moulding of senescence by natural selection
Hamilton, W. D. O. (1966) · Journal of Theoretical Biology · doi:10.1016/0022-5193(66)90184-6 · Cited by 2,289
Final Report on the Aspirin Component of the Ongoing Physicians' Health Study
Steering Committee of the Physicians' Health Study Research Group (1989) · New England Journal of Medicine · doi:10.1056/nejm198907203210301 · Cited by 2,267
β-Carotene: an Unusual Type of Lipid Antioxidant
Burton, G. W., & Ingold, K. U. (1984) · Science · doi:10.1126/science.6710156 · Cited by 2,150
Bird, A. C., Bressler, N. M., Bressler, S. B., Chisholm, I. H., Coscas, G., Davis, M. D., de Jong, P. T. V. M., Klaver, C. C. W., Klein, B. E. K., Klein, R., et al. (1995) · Survey of Ophthalmology · doi:10.1016/s0039-6257(05)80092-x · Cited by 1,926
Harman, D. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.7124 · Cited by 1,915
Research works printed but not linked: 15
- 1993, The Eye Disease Case-Control Study Group, Arch Ophthalmol, 111, 104
- 1989, Steering Committee of the Physicians Health Study Research Group, N Engl J Med, 321, 129
- Ayebi, HE,. Wyss SR. Acatalasemia, in Stanbury JB, Wyngaarden JB, Frederickson DS (eds): The Metabolic Basis of Inherited Disease. New York, McGraw-Hill, 1978, pp 1792–1807
- Bazan, 1989, The metabolism of omega-3 polyunsaturated fatty acids in the eye, Prog Clin Biol Res, 312, 95
- Bone, 1988, Analysis of the macular pigment by HPLC, Invest Ophthalmol Vis Sci, 29, 843
- Buring, 1989, The Womens Health Study, J Myocardiol Ischaemia, 4, 27
- Chen, 1992, Inhibition of cytochrome c oxidase by blue light (404 nm). A factor that causes retinal injury?, Invest Ophthalmol Vis Sci, 33, 919
- Davies S, Boulton ME: The phototoxicity of lipofuscin in vitro. Exp Eye Res 102 (Suppl), Abstract 349.98. Proceedings of the XIII International Congress of Eye Research, Paris, 1998
- Eisner, 1987, Sensitivities in older eyes with good acuity, Invest Ophthalmol Vis Sci, 28, 1832
- Feeney-Burns, 1983, The fate of the phagosome, Trans Ophthalmol Soc UK, 103, 416
- Feeney-Burns, 1984, Aging human RPE, Invest Ophthalmol Vis Sci, 25, 195
- Gardes-Albert M, Ferradini C, Sekaki A, Droy-Lefaix MT: Oxygen-centred free radicals and their interactions with EGb 761 or CP 202, in Ferradini C, Droy-Lefaix MT, Christen Y (eds): Advances in Gingko Biloba Extract Research. Paris, Elsevier, 1993, pp 1–11
- Hammond, 1998, Preservation of visual sensitivity of older subjects, Invest Ophthalmol Vis Sci, 39, 397
- Oliveros, 1994, Quenching of singlet oxygen (1Δg) by carotenoid derivatives, New J Chem, 18, 535
- Seddon, 1994, Dietary fat intake and age-related macular degeneration (abstract), Invest Ophthalmol Vis Sci, 35, 2003
Cited by
Sorted by citations
Free Radicals, Antioxidants in Disease and Health
Department of Pharmacy, L. S. P. C. H., Pham-Huy, L. A., He, H., Department of Analytical Chemistry, C. P. U., Pham-Huyc, C., & Laboratory of Toxicology, F. O. P. (2008) · International Journal of Biomedical Science · doi:10.59566/ijbs.2008.4089 · Cited by 3,058
The Retinal Pigment Epithelium in Visual Function
Strauss, O. (2005) · Physiological Reviews · doi:10.1152/physrev.00021.2004 · Cited by 2,828
Potential Role of Carotenoids as Antioxidants in Human Health and Disease
Fiedor, J., & Burda, K. (2014) · Nutrients · doi:10.3390/nu6020466 · Cited by 1,420
Drusen proteome analysis: an approach to the etiology of age-related macular degeneration
Crabb, J. W., Miyagi, M., Gu, X., Shadrach, K., West, K. A., Sakaguchi, H., Kamei, M., Hasan, A., Yan, L., Rayborn, M. E., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222551899 · Cited by 1,208
Current concepts in the pathogenesis of age-related macular degeneration
Zarbin, M. A. (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.4.598 · Cited by 1,006
Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies
Ambati, J., Ambati, B. K., Yoo, S. H., Ianchulev, S., & Adamis, A. P. (2003) · Survey of Ophthalmology · doi:10.1016/s0039-6257(03)00030-4 · Cited by 959
Age-related macular degeneration
de Jong, P. T. V. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmra062326 · Cited by 787
B IOLOGIC M ECHANISMS OF THE P ROTECTIVE R OLE OF L UTEIN AND Z EAXANTHIN IN THE E YE
Krinsky, N. I., Landrum, J. T., & Bone, R. A. (2003) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.23.011702.073307 · Cited by 779
RPE lipofuscin and its role in retinal pathobiology
Sparrow, J. R., & Boulton, M. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.01.007 · Cited by 644
Self-citationThe dynamic nature of Bruch's membrane
Booij, J. C., Baas, D. C., Beisekeeva, J., Gorgels, T. G. M. F., & Bergen, A. A. B. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.08.003 · Cited by 581
Mitter, S. K., Song, C., Qi, X., Mao, H., Rao, H., Akin, D., Lewin, A., Grant, M., Dunn, W., Ding, J., et al. (2014) · Autophagy · doi:10.4161/auto.36184 · Cited by 449
Self-citationKanda, A., Chen, W., Othman, M., Branham, K. E. H., Brooks, M., Khanna, R., He, S., Lyons, R., Abecasis, G. R., & Swaroop, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703933104 · Cited by 441
Imamura, Y., Noda, S., Hashizume, K., Shinoda, K., Yamaguchi, M., Uchiyama, S., Shimizu, T., Mizushima, Y., Shirasawa, T., & Tsubota, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602131103 · Cited by 420
Deng, Y., Qiao, L., Du, M., Qu, C., Wan, L., Li, J., & Huang, L. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2021.02.009 · Cited by 411
Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration
Feher, J., Kovacs, I., Artico, M., Cavallotti, C., Papale, A., & Balacco Gabrieli, C. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.012 · Cited by 388
Dietary Antioxidants and the Long-term Incidence of Age-Related Macular Degeneration
Tan, J. S. L., Wang, J. J., Flood, V., Rochtchina, E., Smith, W., & Mitchell, P. (2008) · Ophthalmology · doi:10.1016/j.ophtha.2007.03.083 · Cited by 381
McBee, J. K., Palczewski, K., Baehr, W., & Pepperberg, D. R. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(01)00002-7 · Cited by 366
Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration
Golestaneh, N., Chu, Y., Xiao, Y.-Y., Stoleru, G. L., & Theos, A. C. (2017) · Cell Death & Disease · doi:10.1038/cddis.2016.453 · Cited by 357
Dietary intake of antioxidants and risk of age-related macular degeneration
van Leeuwen, R. (2005) · JAMA · doi:10.1001/jama.294.24.3101 · Cited by 345
Kaarniranta, K., Sinha, D., Blasiak, J., Kauppinen, A., Veréb, Z., Salminen, A., Boulton, M. E., & Petrovski, G. (2013) · Autophagy · doi:10.4161/auto.24546 · Cited by 326
Self-citationA2E, a byproduct of the visual cycle
Sparrow, J. R., Fishkin, N., Zhou, J., Cai, B., Jang, Y. P., Krane, S., Itagaki, Y., & Nakanishi, K. (2003) · Vision Research · doi:10.1016/s0042-6989(03)00475-9 · Cited by 318
Parallel findings in age-related macular degeneration and Alzheimer’s disease
Ohno-Matsui, K. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.02.004 · Cited by 280
Chong, E. W.-T. (2008) · Archives of Ophthalmology · doi:10.1001/archopht.126.6.826 · Cited by 279
Swaroop, A., Chew, E. Y., Bowes Rickman, C., & Abecasis, G. R. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164350 · Cited by 270
Cho, E. (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.6.883 · Cited by 266
Hahn, P. (2003) · Archives of Ophthalmology · doi:10.1001/archopht.121.8.1099 · Cited by 258
Iron homeostasis and toxicity in retinal degeneration
He, X., Hahn, P., Iacovelli, J., Wong, R., King, C., Bhisitkul, R., Massaro-Giordano, M., & Dunaief, J. L. (2007) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2007.07.004 · Cited by 260
Age-related macular degeneration (AMD): Alzheimer's disease in the eye?
Kaarniranta, K., Salminen, A., Haapasalo, A., Soininen, H., & Hiltunen, M. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101908 · Cited by 248
Cardiovascular Risk Factors and the Long-term Incidence of Age-Related Macular Degeneration
Tan, J. S. L., Mitchell, P., Smith, W., & Wang, J. J. (2007) · Ophthalmology · doi:10.1016/j.ophtha.2006.09.033 · Cited by 238
Meta-analysis of genome scans of age-related macular degeneration
Fisher, S. A., Abecasis, G. R., Yashar, B. M., Zareparsi, S., Swaroop, A., Iyengar, S. K., Klein, B. E. K., Klein, R., Lee, K. E., Majewski, J., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi230 · Cited by 239
SOD2 knockdown mouse model of early AMD
Justilien, V., Pang, J.-J., Renganathan, K., Zhan, X., Crabb, J. W., Kim, S. R., Sparrow, J. R., Hauswirth, W. W., & Lewin, A. S. (2007) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.07-0432 · Cited by 234
Thompson, C. S., & Hakim, A. M. (2009) · Stroke · doi:10.1161/strokeaha.108.542266 · Cited by 208
WIMMERS, S., KARL, M., & STRAUSS, O. (2007) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2006.12.002 · Cited by 207
Oxidation of glutathione and cysteine in human plasma associated with smoking
Moriarty, S. E., Shah, J. H., Lynn, M., Jiang, S., Openo, K., Jones, D. P., & Sternberg, P. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.09.006 · Cited by 193
Associations between Lutein, Zeaxanthin, and Age-Related Macular Degeneration: An Overview
Carpentier, S., Knaus, M., & Suh, M. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390802066979 · Cited by 182
Light‐induced Damage to the Retina: Role of Rhodopsin Chromophore Revisited
Różanowska, M., & Sarna, T. (2005) · Photochemistry and Photobiology · doi:10.1562/2004-11-13-ir-371 · Cited by 183
Swaroop, A., Branham, K. E., Chen, W., & Abecasis, G. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm212 · Cited by 173
Klein, M. L., Francis, P. J., Rosner, B., Reynolds, R., Hamon, S. C., Schultz, D. W., Ott, J., & Seddon, J. M. (2008) · Ophthalmology · doi:10.1016/j.ophtha.2008.01.036 · Cited by 172
How does the macula protect itself from oxidative stress?
Handa, J. T. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.03.006 · Cited by 154
Conley, Y. P., Thalamuthu, A., Jakobsdottir, J., Weeks, D. E., Mah, T., Ferrell, R. E., & Gorin, M. B. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi204 · Cited by 158
Radu, R. A., Hu, J., Yuan, Q., Welch, D. L., Makshanoff, J., Lloyd, M., McMullen, S., Travis, G. H., & Bok, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.191866 · Cited by 157
V. Skulachev, M., N. Antonenko, Y., N. Anisimov, V., V. Chernyak, B., A. Cherepanov, D., A. Chistyakov, V., V. Egorov, M., G. Kolosova, N., A. Korshunova, G., G. Lyamzaev, K., et al. (2011) · Current Drug Targets · doi:10.2174/138945011795528859 · Cited by 156
McKay, G. J., Patterson, C. C., Chakravarthy, U., Dasari, S., Klaver, C. C., Vingerling, J. R., Ho, L., de Jong, P. T. V. M., Fletcher, A. E., Young, I. S., et al. (2011) · Human Mutation · doi:10.1002/humu.21577 · Cited by 151
Shaw, P. X., Zhang, L., Zhang, M., Du, H., Zhao, L., Lee, C., Grob, S., Lim, S. L., Hughes, G., Lee, J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121309109 · Cited by 148
Zou, M., Ke, Q., Nie, Q., Qi, R., Zhu, X., Liu, W., Hu, X., Sun, Q., Fu, J.-L., Tang, X., et al. (2022) · Cell Death & Differentiation · doi:10.1038/s41418-022-00967-4 · Cited by 138
Complement in removal of the dead – balancing inflammation
Martin, M., & Blom, A. M. (2016) · Immunological Reviews · doi:10.1111/imr.12462 · Cited by 130
Receptor for advanced glycation end products and age-related macular degeneration
Howes, K. A., Liu, Y., Dunaief, J. L., Milam, A., Frederick, J. M., Marks, A., & Baehr, W. (2004) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.04-0404 · Cited by 131
IRON TOXICITY AS A POTENTIAL FACTOR IN AMD
WONG, R. W., RICHA, D. C., HAHN, P., GREEN, W. R., & DUNAIEF, J. L. (2007) · Retina · doi:10.1097/iae.0b013e318074c290 · Cited by 131
Grishanova, A. Y., & Perepechaeva, M. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126719 · Cited by 130
Ebrahem, Q., Renganathan, K., Sears, J., Vasanji, A., Gu, X., Lu, L., Salomon, R. G., Crabb, J. W., & Anand-Apte, B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601552103 · Cited by 117
Tuo, J., Ning, B., Bojanowski, C. M., Lin, Z.-N., Ross, R. J., Reed, G. F., Shen, D., Jiao, X., Zhou, M., Chew, E. Y., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603485103 · Cited by 114
Lipids, oxidized lipids, oxidation-specific epitopes, and Age-related macular degeneration.
Handa, J. T., Cano, M., Wang, L., Datta, S., & Liu, T. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.07.013 · Cited by 112
MAP kinase pathways in UV-induced apoptosis of retinal pigment epithelium ARPE19 cells
Roduit, R., & Schorderet, D. F. (2008) · Apoptosis · doi:10.1007/s10495-008-0179-8 · Cited by 110
Canter, J. A., Olson, L. M., Spencer, K., Schnetz-Boutaud, N., Anderson, B., Hauser, M. A., Schmidt, S., Postel, E. A., Agarwal, A., Pericak-Vance, M. A., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002091 · Cited by 110
Song, C., Mitter, S. K., Qi, X., Beli, E., Rao, H. V., Ding, J., Ip, C. S., Gu, H., Akin, D., Dunn, W. A., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171940 · Cited by 100
Self-citationGlotin, A.-L., Calipel, A., Brossas, J.-Y., Faussat, A.-M., Tre´ton, J., & Mascarelli, F. (2006) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.06-0297 · Cited by 99
Ultrastructure of the human retina in aging and various pathological states
Nag, T. C., & Wadhwa, S. (2012) · Micron · doi:10.1016/j.micron.2012.01.011 · Cited by 88
Retinal carotenoids can attenuate formation of A2E in the retinal pigment epithelium
Bhosale, P., Serban, B., & Bernstein, P. S. (2009) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.09.012 · Cited by 85
Kyosseva, S. V., Chen, L., Seal, S., & McGinnis, J. F. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.08.003 · Cited by 82
Targeting MAPK Signaling in Age-Related Macular Degeneration
Kyosseva, S. V. (2016) · Ophthalmology and Eye Diseases · doi:10.4137/oed.s32200 · Cited by 74
Loss of chromatic sensitivity in AMD and diabetes: a comparative study
O’Neill‐Biba, M., Sivaprasad, S., Rodriguez‐Carmona, M., Wolf, J. E., & Barbur, J. L. (2010) · Ophthalmic and Physiological Optics · doi:10.1111/j.1475-1313.2010.00775.x · Cited by 74
miRNAs as potential therapeutic targets for age-related macular degeneration
Wang, S., Koster, K. M., He, Y., & Zhou, Q. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.11.176 · Cited by 67
Sorsby fundus dystrophy—A review of pathology and disease mechanisms
Christensen, D. R. G., Brown, F. E., Cree, A. J., Ratnayaka, J. A., & Lotery, A. J. (2017) · Experimental Eye Research · doi:10.1016/j.exer.2017.08.014 · Cited by 60
Frost, L. S., Lopes, V. S., Bragin, A., Reyes-Reveles, J., Brancato, J., Cohen, A., Mitchell, C. H., Williams, D. S., & Boesze-Battaglia, K. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-8920-5 · Cited by 63
Jiang, Q. (2011) · Molecular Medicine Reports · doi:10.3892/mmr.2011.582 · Cited by 59
Dow, C. T., & Harley, C. (2016) · Clinical Ophthalmology · doi:10.2147/opth.s100042 · Cited by 56
Seo, S.-J., Krebs, M. P., Mao, H., Jones, K., Conners, M., & Lewin, A. S. (2012) · Experimental Eye Research · doi:10.1016/j.exer.2012.05.013 · Cited by 51
Peroxisome proliferator-activated receptor and age-related macular degeneration
Herzlich, A. A., Tuo, J., & Chan, C.-C. (2008) · PPAR Research · doi:10.1155/2008/389507 · Cited by 43
Retinal pigment epithelium, age-related macular degeneration and neurotrophic keratouveitis
BIANCHI, E., SCARINCI, F., RIPANDELLI, G., FEHER, J., PACELLA, E., MAGLIULO, G., GABRIELI, C. B., PLATEROTI, R., PLATEROTI, P., MIGNINI, F., et al. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2012.1164 · Cited by 40
Hypoxia-regulated retinal glial cell-specific promoter for potential gene therapy in disease
Prentice, H. M., Biswal, M. R., Dorey, C. K., & Blanks, J. C. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-6835 · Cited by 35
Voloboueva, L. A., Killilea, D. W., Atamna, H., & Ames, B. N. (2007) · The FASEB Journal · doi:10.1096/fj.07-8396com · Cited by 33
Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration
Chen, J., Connor, K. M., & Smith, L. E. H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci33513 · Cited by 29
de Smet, M. D., Lynch, J. L., Dejneka, N. S., Keane, M., & Khan, I. J. (2018) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.17-22233 · Cited by 23
Olchawa, M. M., Herrnreiter, A. M., Skumatz, C. M. B., Zareba, M., Sarna, T. J., & Burke, J. M. (2013) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.12-11154 · Cited by 23
Qin, T., & Gao, S. (2018) · Journal of Ophthalmology · doi:10.1155/2018/5392432 · Cited by 13
Metadata
- Authors
- Beatty, S., Koh, H.-H., Phil, M., Henson, D., & Boulton, M.
- Affiliations
- Manchester Royal Eye Hospital (GB)
- University of Manchester (GB)
- Cardiff University (GB)
- Venue
- Survey of Ophthalmology
- Publisher
- Elsevier BV
- Published
- 2000-09
- Volume
- 45
- Issue
- 2
- Pages
- 115-134
- ISSN
- 0039-6257 (ISSN-L)
- OpenAlex
- W2144839999
- Cited by
- 2,051
- References
- 243
- Citations by year
- 2026: 51 · 2025: 52 · 2024: 65 · 2023: 80 · 2022: 79 · 2021: 109 · 2020: 68 · 2019: 106 · 2018: 86 · 2017: 92 · 2016: 83 · 2015: 87 · 2014: 104 · 2013: 104 · 2012: 119
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Survey of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Keywords
- age-related macular degeneration, oxidative stress, reactive oxygen species, photoreceptor outer segments, lipofuscin, macular pigment, lutein, zeaxanthin, alpha-tocopherol, antioxidant vitamins, macular pigment optical density, neovascular AMD, dietary antioxidants, risk factors
- MeSH terms
- Aging, Antioxidants, Ascorbic Acid, Humans, Macular Degeneration, Prognosis, Retina, Vitamin A, Vitamin E, Reactive Oxygen Species, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
