Gut flora in health and disease

Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine

Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202

Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483

Functional food science and gastrointestinal physiology and function

Salminen, S., Bouley, C., Boutron, M.-C., Cummings, J. H., Franck, A., Gibson, G. R., Isolauri, E., Moreau, M.-C., Roberfroid, M., & Rowland, I. (1998) · British Journal of Nutrition · doi:10.1079/bjn19980108 · Cited by 1,398

Protective role of probiotics and prebiotics in colon cancer

Wollowski, I., Rechkemmer, G., & Pool-Zobel, B. L. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.451s · Cited by 560

Intestinal flora and endogenous vitamin synthesis

Hill, M. J. (1997) · European Journal of Cancer Prevention · doi:10.1097/00008469-199703001-00009 · Cited by 551

THE MICROBIAL CONTRIBUTION TO HUMAN FAECAL MASS

Stephen, A. M., & Cummings, J. H. (1980) · Journal of Medical Microbiology · doi:10.1099/00222615-13-1-45 · Cited by 545

Development and differences of intestinal flora in the neonatal period in breast-fed and bottle-fed infants

Yoshioka, H., Iseki, K.-I., & Fujita, K. (1983) · PEDIATRICS · doi:10.1542/peds.72.3.317 · Cited by 516

Bifidobacterium strains from resident infant human gastrointestinal microflora exert antimicrobial activity

Liévin, V, Peiffer, I., Hudault, S., Rochat, F., Brassart, D., Neeser, J.-R., & Servin, A. L. (2000) · Gut · doi:10.1136/gut.47.5.646 · Cited by 397

Microbiology of bacterial translocation in humans

O’Boyle, C. J., MacFie, J., Mitchell, C. J., Johnstone, D., Sagar, P. M., & Sedman, P. C. (1998) · Gut · doi:10.1136/gut.42.1.29 · Cited by 393

Carbohydrate fermentation decreases hepatic glucose output in healthy subjects

Thorburn, A., Muir, J., & Proietto, J. (1993) · Metabolism · doi:10.1016/0026-0495(93)90249-n · Cited by 178

The in vitro inhibition of Gram-negative pathogenic bacteria by Bifidobacteria is caused by the production of organic acids

Makras, L., & De Vuyst, L. (2006) · International Dairy Journal · doi:10.1016/j.idairyj.2005.09.006 · Cited by 147

Soy and Gut Microbiota: Interaction and Implication for Human Health

Huang, H., Krishnan, H. B., Pham, Q., Yu, L. L., & Wang, T. T. Y. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b03725 · Cited by 138

Breast-fed and bottle-fed infant rhesus macaques develop distinct gut microbiotas and immune systems

Ardeshir, A., Narayan, N. R., Méndez-Lagares, G., Lu, D., Rauch, M., Huang, Y., Van Rompay, K. K. A., Lynch, S. V., & Hartigan-O’Connor, D. J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008791 · Cited by 134

The microbiome and its potential as a cancer preventive intervention

Bultman, S. J. (2016) · Seminars in Oncology · doi:10.1053/j.seminoncol.2015.09.001 · Cited by 134

Effects of probiotic yogurt on fat distribution and gene expression of proinflammatory factors in peripheral blood mononuclear cells in overweight and obese people with or without weight-loss diet

Zarrati, M., Salehi, E., Nourijelyani, K., Mofid, V., Zadeh, M. J. H., Najafi, F., Ghaflati, Z., Bidad, K., Chamari, M., Karimi, M., et al. (2014) · Journal of the American College of Nutrition · doi:10.1080/07315724.2013.874937 · Cited by 130

The role of methane in intestinal diseases

Roccarina, D., Lauritano, E. C., Gabrielli, M., Franceschi, F., Ojetti, V., & Gasbarrini, A. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2009.744 · Cited by 117

Cross-Sectional and Longitudinal Comparisons of the Predominant Fecal Microbiota Compositions of a Group of Pediatric Patients with Cystic Fibrosis and Their Healthy Siblings

Duytschaever, G., Huys, G., Bekaert, M., Boulanger, L., De Boeck, K., & Vandamme, P. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.05933-11 · Cited by 114

Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice

Mendes, M. C. S., Paulino, D. S., Brambilla, S. R., Camargo, J. A., Persinoti, G. F., & Carvalheira, J. B. C. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i18.1995 · Cited by 116

A systems biology approach to studying the role of microbes in human health

Thiele, I., Heinken, A., & Fleming, R. M. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2012.10.001 · Cited by 114

Probiotics and Irritable Bowel Syndrome: Rationale, Putative Mechanisms, and Evidence of Clinical Efficacy

Camilleri, M. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200603000-00020 · Cited by 106

Well‐controlled proinflammatory cytokine responses of Peyer’s patch cells to probiotic Lactobacillus casei

Chiba, Y., Shida, K., Nagata, S., Wada, M., Bian, L., Wang, C., Shimizu, T., Yamashiro, Y., Kiyoshima‐Shibata, J., Nanno, M., et al. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03204.x · Cited by 102

Biorelevant dissolution testing of colon-specific delivery systems activated by colonic microflora

Yang, L. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.10.026 · Cited by 101

Screening of probiotic candidates in human oral bacteria for the prevention of dental disease

Terai, T., Okumura, T., Imai, S., Nakao, M., Yamaji, K., Ito, M., Nagata, T., Kaneko, K., Miyazaki, K., Okada, A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128657 · Cited by 99

Metabolomics and microbiomes as potential tools to evaluate the effects of the Mediterranean diet

Jin, Q., Black, A., Kales, S. N., Vattem, D., Ruiz-Canela, M., & Sotos-Prieto, M. (2019) · Nutrients · doi:10.3390/nu11010207 · Cited by 100

Intestinal barrier damage involved in intestinal microflora changes in fluoride-induced mice

Liu, J., Wang, H.-W., Lin, L., Miao, C.-Y., Zhang, Y., & Zhou, B.-H. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.06.080 · Cited by 100

Lactobacillus reuteri in children with functional abdominal pain (FAP)

Romano, C., Ferrau', V., Cavataio, F., Iacono, G., Spina, M., Lionetti, E., Comisi, F., Famiani, A., & Comito, D. (2014) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.2010.01797.x · Cited by 99

Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome

KAJANDER, K., KROGIUS‐KURIKKA, L., RINTTILÄ, T., KARJALAINEN, H., PALVA, A., & KORPELA, R. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03391.x · Cited by 95

Old drug new use - Amoxapine and its metabolites as potent bacterial β-glucuronidase inhibitors for alleviating cancer drug toxicity

Kong, R., Liu, T., Zhu, X., Ahmad, S., Williams, A. L., Phan, A. T., Zhao, H., Scott, J. E., Yeh, L.-A., & Wong, S. T. C. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0395 · Cited by 90

Efficacy and Safety of Probiotics for the Treatment of Alzheimer's Disease, Mild Cognitive Impairment, and Parkinson's Disease: A Systematic Review and Meta-Analysis

Xiang, S., Ji, J.-L., Li, S., Cao, X.-P., Xu, W., Tan, L., & Tan, C.-C. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.730036 · Cited by 89

Multiple Omics Uncovers Host–Gut Microbial Mutualism During Prebiotic Fructooligosaccharide Supplementation

Kato, T., Fukuda, S., Fujiwara, A., Suda, W., Hattori, M., Kikuchi, J., & Ohno, H. (2014) · DNA Research · doi:10.1093/dnares/dsu013 · Cited by 88

Characterization of bacterial isolates from the microbiota of mothers’ breast milk and their infants

Kozak, K., Charbonneau, D., Sanozky-Dawes, R., & Klaenhammer, T. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1103425 · Cited by 86

Giardia spp. and the Gut Microbiota: Dangerous Liaisons

Fekete, E., Allain, T., Siddiq, A., Sosnowski, O., & Buret, A. G. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.618106 · Cited by 86

Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism: A blinded case-control study

Rose, S., Bennuri, S. C., Murray, K. F., Buie, T., Winter, H., & Frye, R. E. (2017) · PLOS ONE · doi:10.1371/journal.pone.0186377 · Cited by 82

A Randomized, Double-Blind, Placebo-Controlled Trial: The Efficacy of Multispecies Probiotic Supplementation in Alleviating Symptoms of Irritable Bowel Syndrome Associated with Constipation

Mezzasalma, V., Manfrini, E., Ferri, E., Sandionigi, A., La Ferla, B., Schiano, I., Michelotti, A., Nobile, V., Labra, M., & Di Gennaro, P. (2016) · BioMed Research International · doi:10.1155/2016/4740907 · Cited by 81

An exploratory study on the influence of orange juice on gut microbiota using a dynamic colonic model

Duque, A. L. R. F., Monteiro, M., Adorno, M. A. T., Sakamoto, I. K., & Sivieri, K. (2016) · Food Research International · doi:10.1016/j.foodres.2016.03.028 · Cited by 81

Impact of antibiotics on arterial blood pressure in a patient with resistant hypertension — A case report

Qi, Y., Aranda, J. M., Rodriguez, V., Raizada, M. K., & Pepine, C. J. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.07.078 · Cited by 79

Transplantation of fecal microbiota from patients with alcoholism induces anxiety/depression behaviors and decreases brain mGluR1/PKC ε levels in mouse

Zhao, W., Hu, Y., Li, C., Li, N., Zhu, S., Tan, X., Li, M., Zhang, Y., Xu, Z., Ding, Z., et al. (2020) · BioFactors · doi:10.1002/biof.1567 · Cited by 75

Therapies Aimed at the Gut Microbiota and Inflammation: Antibiotics, Prebiotics, Probiotics, Synbiotics, Anti-inflammatory Therapies

Quigley, E. M. M. (2011) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2010.12.009 · Cited by 67

Manipulating Gut Microbiota Composition to Enhance the Therapeutic Effect of Cancer Immunotherapy

Yi, M., Jiao, D., Qin, S., Chu, Q., Li, A., & Wu, K. (2019) · Integrative Cancer Therapies · doi:10.1177/1534735419876351 · Cited by 69

Untitled work

(2022) · doi:10.1016/j.hsr.2021.100010 · Cited by 69

Crosstalk between gut microbiota and sepsis

Niu, M., & Chen, P. (2021) · Burns & Trauma · doi:10.1093/burnst/tkab036 · Cited by 69

Molecular Studies of Fecal Anaerobic Commensal Bacteria in Acute Diarrhea in Children

Balamurugan, R., Janardhan, H. P., George, S., Raghava, M. V., Muliyil, J., & Ramakrishna, B. S. (2008) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31815ce599 · Cited by 66

Gut hormones and gut microbiota: implications for kidney function and hypertension

Afsar, B., Vaziri, N. D., Aslan, G., Tarim, K., & Kanbay, M. (2016) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2016.10.007 · Cited by 63

Effect of probiotics on intestinal regrowth and bacterial translocation after massive small bowel resection in a rat

Mogilner, J. G., Srugo, I., Lurie, M., Shaoul, R., Coran, A. G., Shiloni, E., & Sukhotnik, I. (2007) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2007.03.035 · Cited by 62

Lactobacillus farciminis treatment attenuates stress‐induced overexpression of Fos protein in spinal and supraspinal sites after colorectal distension in rats

Ait‐belgnaoui, A., Eutamene, H., Houdeau, E., Bueno, L., Fioramonti, J., & Theodorou, V. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01280.x · Cited by 61

The gut microbiota ecology: a new opportunity for the treatment of metabolic diseases ?

Burcelin, R. (2009) · Frontiers in Bioscience · doi:10.2741/3589 · Cited by 55

Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment

Han, Y., Xiang, Y., Shi, Y., Tang, X., Pan, L., Gao, J., Bi, R., & Lai, X. (2021) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2021/9987097 · Cited by 51

Antigenotoxic Effect of Kefir and Ayran Supernatants on Fecal Water-Induced DNA Damage in Human Colon Cells

Grishina, A., Kulikova, I., Alieva, L., Dodson, A., Rowland, I., & Jin, J. (2011) · Nutrition and Cancer · doi:10.1080/01635581.2010.516873 · Cited by 48

A Possible Link of Gut Microbiota Alteration in Type 2 Diabetes and Alzheimer’s Disease Pathogenicity: An Update

Alam, M., Alam, Q., Kamal, M., Abuzenadah, A., & Haque, A. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660151 · Cited by 47

Estimation and Interpretation of Fermentation in the Gut: Coupling Results from a 24 h Batch in Vitro System with Fecal Measurements from a Human Intervention Feeding Study Using Fructo-oligosaccharides, Inulin, Gum Acacia, and Pea Fiber

Koecher, K. J., Noack, J. A., Timm, D. A., Klosterbuer, A. S., Thomas, W., & Slavin, J. L. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf404688n · Cited by 47

Immunomodulatory and ameliorative effects of Lactobacillus and Saccharomyces based probiotics on pathological effects of eimeriasis in broilers

Awais, M. M., Jamal, M. A., Akhtar, M., Hameed, M. R., Anwar, M. I., & Ullah, M. I. (2019) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.10.038 · Cited by 46

The Role of Fatty Acid Metabolites in Vaginal Health and Disease: Application to Candidiasis

Baldewijns, S., Sillen, M., Palmans, I., Vandecruys, P., Van Dijck, P., & Demuyser, L. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.705779 · Cited by 44

Safety and Immunomodulatory Effects of Three Probiotic Strains Isolated from the Feces of Breast-Fed Infants in Healthy Adults: SETOPROB Study

Plaza-Diaz, J., Gomez-Llorente, C., Campaña-Martin, L., Matencio, E., Ortuño, I., Martínez-Silla, R., Gomez-Gallego, C., Periago, M. J., Ros, G., Chenoll, E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078111 · Cited by 44

Helping patients make informed choices about probiotics: a need for research

Sharp, R. R., Achkar, J.-P., Brinich, M. A., & Farrell, R. M. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.68 · Cited by 43

Alteration of Local Microflora and α-defensins Hyper-production in Colonic Adenoma Mucosa

Pagnini, C., Corleto, V. D., Mangoni, M. L., Pilozzi, E., Torre, M. S., Marchese, R., Carnuccio, A., Giulio, E. D., & Fave, G. D. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31820abf29 · Cited by 43

Bosom Buddies: The Symbiotic Relationship Between Infants and Bifidobacterium longum ssp.longum and ssp.infantis. Genetic and Probiotic Features

Arboleya, S., Stanton, C., Ryan, C. A., Dempsey, E., & Ross, P. R. (2016) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-041715-033151 · Cited by 41

Probiotics in Children

Kligler, B., Hanaway, P., & Cohrssen, A. (2007) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2007.10.002 · Cited by 41

Untitled work

(2015) · PubMed · Cited by 35

The Short-Term Effects of Different Doses of Dexamethasone on the Numbers of some Bacteria in the Ileum

Ünsal, H., Balkaya, M., Ünsal, C., Bıyık, H., Başbülbül, G., & Poyrazoğlu, E. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-0089-6 · Cited by 31

Bacterial biofilms associated with food particles in the human large bowel

Van Wey, A. S., Cookson, A. L., Roy, N. C., McNabb, W. C., Soboleva, T. K., & Shorten, P. R. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000589 · Cited by 31

A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors

Ahmad, S., Hughes, M. A., Lane, K. T., Redinbo, M. R., Yeh, L.-A., & Scott, J. E. (2011) · Current Chemical Genomics · doi:10.2174/1875397301105010013 · Cited by 29

Unlocking the gut-liver axis: microbial contributions to the pathogenesis of metabolic-associated fatty liver disease

Buchynskyi, M., Kamyshna, I., Halabitska, I., Petakh, P., Kunduzova, O., Oksenych, V., & Kamyshnyi, O. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1577724 · Cited by 30

Breath test for differential diagnosis between small intestinal bacterial overgrowth and irritable bowel disease: An observation on non-absorbable antibiotics

Esposito, I. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.13.6016 · Cited by 28

Microbiome study of initial gut microbiota from newborn infants to children reveals that diet determines its compositional development

Ku, H.-J., Kim, Y.-T., & Lee, J.-H. (2020) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2002.02042 · Cited by 26

Bifidobacterial Diversity Determined by Culturing and by 16S rDNA Sequence Analysis in Feces and Mucosa from Ten Healthy Spanish Adults

Delgado, S., Suárez, A., & Mayo, B. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9293-z · Cited by 25

Cooperation and cheating as innovation: insights from cellular societies

Aktipis, A., & Maley, C. C. (2017) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0421 · Cited by 15

Diet supplementation with pomegranate peel extract altered odorants emission from fresh and incubated calves’ feces

Varma, V. S., Shabtay, A., Yishay, M., Mizrahi, I., Shterzer, N., Freilich, S., Medina, S., Agmon, R., & Laor, Y. (2018) · Frontiers in Sustainable Food Systems · doi:10.3389/fsufs.2018.00033 · Cited by 12

Influence of E. coli strain Nissle 1917 (EcN) on intestinal gas dynamics and abdominal sensation

Hernando-Harder, A. C., von Bünau, R., Nadarajah, M., Singer, M. V., & Harder, H. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-9892-3 · Cited by 6

The Gastrointestinal Tract and Its Microflora

Aimutis, W. R., & Polzin, K. (2010) · Nondigestible Carbohydrates and Digestive Health · doi:10.1002/9780470958186.ch2 · Cited by 1