The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index; 6 of the 149 sources its claims cite were checked for support.
Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases
Open accessAbstract
The term sarcopenia refers to the loss of muscle mass that occurs with ageing. On the basis of study results showing that muscle mass is only moderately related to functional outcomes, international working groups have proposed that loss of muscle strength or physical function should also be included in the definition. Irrespective of how sarcopenia is defined, both low muscle mass and poor muscle strength are clearly highly prevalent and important risk factors for disability and potentially mortality in individuals as they age. Many chronic diseases, in addition to ageing, could also accelerate decrease of muscle mass and strength, and this effect could be a main underlying mechanism by which chronic diseases cause physical disability. In this Review, we address both age-related and disease-related muscle loss, with a focus on diabetes and obesity but including other disease states, and potential common mechanisms and treatments. Development of treatments for age-related and disease-related muscle loss might improve active life expectancy in older people, and lead to substantial health-care savings and improved quality of life.
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Claims the paper makes
123 Not checked yet · 11 Own interpretation · 5 No basis given · 2 Supported · 2 Supported so far · 2 Partly supported · accuracy not yet measured
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In the paper
“Fat infiltration of muscle (both intramuscular and intermuscular) is further related to poor lower extremity physical performance.63”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Obesity
What the sources say
- Partly supportedcites [63] Tuttle, 2012, Intermuscular adipose tissue is muscle specific and associated with poor functional performance, J Aging Res sourceExperimental — accuracy not yet measured
The Results report that greater calf intermuscular adipose tissue (IMAT) was associated with poorer six-minute walk and physical performance test scores. The Assessments section describes IMAT measurement as including fat within and between muscles, but the paper does not report a separate association for intramuscular fat. Thus the claim is supported for the combined measure, not for both types independently. (LLM, conf=0.84)
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Partly supported
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In the paper
“Chronic or intermittent hypoxaemia could also affect mitochondrial function in a similar way to age-related muscle loss, leading to oxidative stress, reduced energy availability, and decreased protein synthesis.”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Muscle loss in other disease states
What the sources say
- Partly supportedcites [109] Buford, 2010, Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy, Ageing Res Rev sourceExperimental — accuracy not yet measured
Section 5.2 says chronic or intermittent hypoxia can suppress protein synthesis and reports mitochondrial dysfunction and oxidative damage in patients with peripheral arterial disease. It does not establish that hypoxia causes the mitochondrial dysfunction or that this pathway reduces energy availability; the authors explicitly say the causal link for mitochondrial dysfunction remains uncertain. Page numbers are unavailable in our copy. (LLM, conf=0.85)
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- Partly supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“After exercise, the ability of insulin to stimulate GLUT4-mediated glucose transport is substantially improved.132”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Treatments for age-related and disease-related muscle loss > Exercise
What the sources say
- Supportedcites [132] Frøsig, 2009, Improved insulin sensitivity after exercise: focus on insulin signaling, Obesity (Silver Spring) source
The 'Improved Insulin Action after Acute Exercise' section says insulin-stimulated glucose uptake was markedly increased after exercise. The 'Summary and Perspectives' section identifies increased GLUT4 translocation to the muscle membrane as the primary explanation for improved insulin action, supporting the paraphrase. The effect is described in previously active muscle. (LLM, conf=0.91)
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- Supported
None of the sources cited for this claim have been checked yet.
In the paper
“Age-related muscle loss is a strong risk factor for disability, hospitalisation, and death in older adults.10,13”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Introduction
What the sources say
- Not checked yetcites [10] Fielding, 2011, Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia, J Am Med Dir Assoc source
- Not checked yetcites [13] Visser, 2005, Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons, J Gerontol A Biol Sci Med Sci source
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None of the sources cited for this claim have been checked yet.
In the paper
“However, it has become clear that decreases in muscle strength exceed what is expected on the basis of the decline in muscle mass during ageing,18 especially after the age of 60–70 years.19”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Age-related muscle loss
What the sources say
- Not checked yetcites [18] Goodpaster, 2006, The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study, J Gerontol A Biol Sci Med Sci source
- Not checked yetcites [19] Baum, 2009, Comparison of skeletal muscle strength between cardiac patients and age-matched healthy controls, Int J Med Sci source
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None of the sources cited for this claim have been checked yet.
In the paper
“Sarcopenia might affect up to half of people aged 80 years and older, but, without a standard definition, no real estimates of prevalence and incidence are possible.11,12”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Introduction
What the sources say
- Not checked yetcites [11] von Haehling, 2010, An overview of sarcopenia: facts and numbers on prevalence and clinical impact, J Cachexia Sarcopenia Muscle source
- Not checked yetcites [12] Volpato, 2013, Prevalence and clinical correlates of sarcopenia in community-dwelling older people: application of the EWGSOP definition and diagnostic algorithm, J Gerontol A Biol Sci Med Sci
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“the cross-sectional area of the vastus lateralis (quadriceps) muscle decreases by up to 40% between the ages of 20 and 80 years.16”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Age-related muscle loss
What the sources say
- Not checked yetcites [16] Lexell, 1995, Human aging, muscle mass, and fiber type composition, J Gerontol A Biol Sci Med Sci
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Increased expression of these E3 enzymes in insulin resistant individuals contributes to muscle protein degradation, a mechanism not shared by age-related sarcopenia.47”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Diabetes
What the sources say
- Not checked yetcites [47] Wang, 2006, Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling, Endocrinology source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“The progressive mismatch between mass and strength probably occurs because of a deterioration of muscle quality.20”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Age-related muscle loss
What the sources say
- Not checked yetcites [20] Moore, 2014, Difference in Muscle Quality over the Adult Life Span and Biological Correlates in the Baltimore Longitudinal Study of Aging, J Am Geriatr Soc source
hedgedconditional- Asserted: passes — The authors put it forward as true.
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In the paper
“Low mitochondrial size correlates with low glucose disposal rate and insulin sensitivity.48,49”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Diabetes
What the sources say
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- It may state two separate claims as one. 47
- Probably not a substantial claim. 8
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Irrespective of how sarcopenia is defined, both low muscle mass and poor muscle strength are clearly highly prevalent and important risk factors for disability and potentially mortality in individuals as they age.”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Abstract
What the sources say
- Supportedcites [10] Fielding, 2011, Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia, J Am Med Dir Assoc source
The Epidemiology section (page unavailable) says reduced muscle mass is highly prevalent in older people and increases with age; Muscle Aging describes a substantial age-related decline in strength. Sarcopenia and Disability (page unavailable) links sarcopenia to disability and possible increased mortality, and reports that weakness predicts mortality more strongly than muscle mass. (LLM, conf=0.89)
- Not checked yetcites [13] Visser, 2005, Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons, J Gerontol A Biol Sci Med Sci source
boostedcorrelational- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“This decrease in IGF-1 is associated with decreased muscle size and strength, decreased protein synthesis, and increased cell death,93 which in turn leads to increased visceral fat and decreased lean body mass.94”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Growth hormone deficiency
What the sources say
- Supportedcites [93] Perrini, 2010, The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis, J Endocrinol source
The section “Abnormalities in GH/IGF1 signaling and age-related muscle mass wasting” states that age-associated reductions in GH and IGF1 are associated with decreased muscle size and strength, diminished protein synthesis, and increased cell apoptosis. This supports the clause attached to citation 93. The visceral-fat and lean-body-mass clause is attached to citation 94, so it is not assessed against this source. (LLM, conf=0.92)
- Not checked yetcites [94] Nass, 2002, Impact of the GH-cortisol ratio on the age-dependent changes in body composition, Growth Horm IGF Res source
plaindirect- Asserted: passes — The authors put it forward as true.
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- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“Glucocorticoids inhibit protein synthesis and stimulate protein degradation in skeletal muscles. IGF-1 is decreased and myostatin is increased.99”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Hypercortisolism
What the sources say
- Supportedcites [99] Schakman, 2008, Mechanisms of glucocorticoid-induced myopathy, J Endocrinol source
The Anti-anabolic action and mTOR sections state that glucocorticoids inhibit muscle protein synthesis. The IGF-I section says they reduce muscle IGF-I, while the Myostatin section says they increase myostatin and links glucocorticoids to increased muscle proteolysis. (LLM, conf=0.92)
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Supported
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Development of treatments for age-related and disease-related muscle loss might improve active life expectancy in older people, and lead to substantial health-care savings and improved quality of life.”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Abstract
hedgedconditional- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper may give no reason why it holds. It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“The contribution of chronic diseases such as diabetes and obesity, the prevalence of which also increase with ageing, to age-related muscle loss is unclear;”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Introduction
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
None of the sources cited for this claim have been checked yet.
In the paper
“Ageing is accompanied by major changes in body composition that can negatively affect functional status in older adults, including a progressive decrease in muscle mass, strength, and quality, accompanied by an increase in fat mass.1,2”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Introduction
What the sources say
- Not checked yetcites [1] Candow, 2005, Differences in size, strength, and power of upper and lower body muscle groups in young and older men, J Gerontol A Biol Sci Med Sci source
- Not checked yetcites [2] Lauretani, 2003, Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia, J Appl Physiol (1985) source
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In the paper
“Lean muscle mass generally contributes up to about 50% of total bodyweight in young adults, but decreases with age to be about 25% of total bodyweight by age 75–80 years.15”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Age-related muscle loss
What the sources say
- Not checked yetcites [15] Short, 2004, Age and aerobic exercise training effects on whole body and muscle protein metabolism, Am J Physiol Endocrinol Metab source
hedgeddirect- Asserted: passes — The authors put it forward as true.
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The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“No standardly used definition exists for assessment of sarcopenia, and consensus definitions based on critical analyses of large databases are being developed.”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Introduction
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Many chronic diseases, in addition to ageing, could also accelerate decrease of muscle mass and strength, and this effect could be a main underlying mechanism by which chronic diseases cause physical disability.”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Abstract
hedgedconditional- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“arguably, definitions of sarcopenia that have been developed cannot necessarily differentiate the effects of ageing on muscle loss independent of other age-associated disease conditions that are prevalent in older individuals.”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Introduction
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In the paper
“Notwithstanding uncertainties, it has been estimated that a 10% reduction in age-related muscle loss would result in savings of US$1·1 billion per year in health-care costs in the USA.14”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Introduction
What the sources say
- Not checked yetcites [14] Janssen, 2004, The healthcare costs of sarcopenia in the United States, J Am Geriatr Soc source
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In the paper
“Nonetheless, skeletal muscle ATP production increases in response to exogenous insulin in people without diabetes, but this increment is reduced in individuals with diabetes and is related to impaired insulin response.52”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Diabetes
What the sources say
- Not checked yetcites [52] Stump, 2003, Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts, Proc Natl Acad Sci USA source
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In the paper
“However, the causal link from adiposity to intramyocellular lipid deposition is unclear,”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Age-related muscle loss
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“In both cross-sectional and longitudinal studies, accelerated loss of muscle mass and strength is recorded in individuals with diabetes, is greater with longer diabetes duration or higher HbA1c, and is attenuated by use of insulin sensitisers.36-38”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Diabetes
What the sources say
- Not checked yetcites [36] Park, 2009, Excessive loss of skeletal muscle mass in older adults with type 2 diabetes, Diabetes Care source
- Not checked yetcites [37] Park, 2007, Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: the health, aging, and body composition study, Diabetes Care source
- Not checked yetcites [38] Lee, 2011, Insulin sensitizers may attenuate lean mass loss in older men with diabetes, Diabetes Care source
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In the paper
“PGC-1α is a transcriptional coactivator that has reduced gene expression in muscles of patients with type 2 diabetes,55 and might have a role in preventing muscle atrophy.53,56”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Diabetes
What the sources say
- Not checked yetcites [55] Patti, 2003, Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1, Proc Natl Acad Sci USA source
- Not checked yetcites [53] Sandri, 2006, PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription, Proc Natl Acad Sci USA source
- Not checked yetcites [56] Lira, 2010, PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity, Am J Physiol Endocrinol Metab source
hedgedconditional- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Insulin resistance results in decreased stimulation of protein synthesis pathways and increased activation of protein degradation pathways that might ultimately lead to muscle loss in type 2 diabetes (figure 1).”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Diabetes
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In the paper
“The global prevalence of diabetes is projected to rise exponentially during the next few decades, with the greatest burden in older individuals (aged >65 years).32,33”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Diabetes
What the sources say
plaincorrelational- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“Insulin is a powerful anabolic signal and substantially stimulates muscle protein synthesis in young people but not in older people.”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Diabetes
What the sources say
- Not checked yetcites [45] Fujita, 2009, Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism, Diabetologia source
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In the paper
“Up to 70% of adults with diabetes have difficulty carrying out routine physical tasks, with lower extremity mobility limitations particularly evident, and diabetes is a potent risk factor for most geriatric syndromes.34”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Diabetes
What the sources say
- Not checked yetcites [34] Kalyani, 2010, Association of diabetes, comorbidities, and A1C with functional disability in older adults: results from the National Health and Nutrition Examination Survey (NHANES), 1999-2006, Diabetes Care source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“In insulin resistance, insulin or IGF-1 signalling is suppressed, leading to downregulation of the phosphatidylinositol 3 kinase/Akt pathway and decreased protein synthesis, as well as to forkhead box protein O1 phosphorylation. Phosphorylated forkhead box protein O1 stimulates expression of the E3 enzymes atrogin-1 and muscle ring finger-1 via increased activation of the ubiquitin-proteasome”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Diabetes
What the sources say
- Not checked yetcites [47] Wang, 2006, Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling, Endocrinology source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“However, loss of height and lean body mass and increasing fat mass that occur with ageing uncouple the relationship of BMI and obesity, and attenuate associations with mortality.”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Obesity
What the sources say
- Not checked yetcites [58] Waters, 2011, Sarcopenia and obesity, Clin Geriatr Med source
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In the paper
“A systematic review noted that individuals treated with GH had a significant decrease in fat mass (−2·08 kg, 95% CI −1·35 to −2·80 kg) and a significant increase in lean body mass (+2·13 kg, 95% CI 1·32 to 2·94 kg).”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Growth hormone deficiency
What the sources say
- Not checked yetcites [96] Liu, 2007, Systematic review: the safety and efficacy of growth hormone in the healthy elderly, Ann Intern Med source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“However, results of studies of body composition have shown that this adaptive mechanism might be impaired in older individuals who are obese. As a result, obese individuals might have relatively low muscle strength in view of their body size and have an increased risk of disability.62”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Obesity
What the sources say
- Not checked yetcites [62] Alley, 2007, The changing relationship of obesity and disability, 1988–2004, JAMA source
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In the paper
“In men, total testosterone concentrations decrease by 1% per year and bioavailable testosterone by 2% per year from the age of 30 years.”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Hypogonadism in men
What the sources say
- Not checked yetcites [77] Maggio, 2011, Gonadal status and physical performance in older men, Aging Male source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Increased adiposity and circulating concentrations of free fatty acids inhibit GH production and decrease plasma concentrations of IGF-1.”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Growth hormone deficiency
What the sources say
- Not checked yetcites [93] Perrini, 2010, The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis, J Endocrinol source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Dihydroepiandrosterone sulphate is a precursor to testosterone, with concentrations that also decrease with ageing—in men aged 70–80 years, dihydroepiandrosterone sulphate concentrations are only about 20% of their peak concentrations at the age of 20 years.78”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Hypogonadism in men
What the sources say
- Not checked yetcites [78] Labrie, 1997, Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging, J Clin Endocrinol Metab source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“GH treatment in adults with hypopituitarism and associated GH deficiency can improve body composition and increase lean body mass.95”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Growth hormone deficiency
What the sources say
- Not checked yetcites [95] Salomon, 1989, The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency, N Engl J Med source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Baumgartner and colleagues66 showed that both men and women older than 60 years with sarcopenic obesity had a significantly increased risk of having three or more physical disabilities compared with non-obese individuals after adjustment for age, and this association was stronger than with either sarcopenia or obesity alone.66”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Obesity
What the sources say
- Not checked yetcites [66] Baumgartner, 2000, Body composition in healthy aging, Ann N Y Acad Sci source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“After 6 months of treatment, androgen-deprived older men have decreased appendicular skeletal muscle, decreased lean tissue, and increased body fat compared with untreated controls.79”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Hypogonadism in men
What the sources say
- Not checked yetcites [79] Boxer, 2005, The effect of 6 months of androgen deprivation therapy on muscle and fat mass in older men with localized prostate cancer, Aging Male source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Sarcopenia and obesity can co-occur, and synergistically are associated with worse functional decline and outcomes than is either condition alone.70”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Obesity
What the sources say
- Not checked yetcites [70] Stenholm, 2009, The effect of obesity combined with low muscle strength on decline in mobility in older persons: results from the InCHIANTI study, Int J Obes (Lond) source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“Additionally, testosterone replacement is not without potential risks, including increased respiratory disorders (eg, cough, shortness of breath, asthma or chronic obstructive pulmonary disease (COPD) exacerbation, sleep apnoea) and skin and subcutaneous tissue disorders (eg, application site reactions, itching, erythema, foot ulcers, and increased hair growth).84”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Hypogonadism in men
What the sources say
- Not checked yetcites [84] Basaria, 2010, Adverse events associated with testosterone administration, N Engl J Med source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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It may state two separate claims as one.
In the paper
“Findings from few studies suggest that obesity alone might contribute more to lower physical function than does sarcopenia alone, but this probably depends on the degree of muscle loss.71”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Obesity
What the sources say
- Not checked yetcites [71] Bouchard, 2009, Sarcopenic/obesity and physical capacity in older men and women: data from the Nutrition as a Determinant of Successful Aging (NuAge)-the Quebec longitudinal Study, Obesity (Silver Spring) source
hedgedconditional- Asserted: passes — The authors put it forward as true.
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In the paper
“Generally, irrespective of definition, the prevalence increased with each decade of age and was lower in non-Hispanic black people than in white people.”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Obesity
What the sources say
- Not checked yetcites [69] Batsis, 2013, Variation in the prevalence of sarcopenia and sarcopenic obesity in older adults associated with different research definitions: dual-energy X-ray absorptiometry data from the National Health and Nutrition Examination Survey 1999–2004, J Am Geriatr Soc source
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
In the paper
“In healthy young and older individuals, bone and muscle tend to be correlated with bodyweight, probably because gravity and inertial forces during movement stimulate mechano-receptors in both bone and muscle that modulate the production of growth factors.61”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Obesity
What the sources say
- Not checked yetcites [61] Russo, 2000, True osteoporosis and frailty-related osteopenia: two different clinical entities, J Am Geriatr Soc source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“Age-related loss of muscle mass is typically offset by gains in fat mass. As a result, bodyweight in men and women might be quite stable in middle age, or slightly increased even though the relative amount of body fat actually increases in comparison with lean tissue—an important step in the development of sarcopenic obesity.65”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Obesity
What the sources say
- Not checked yetcites [65] Newman, 2005, Weight change and the conservation of lean mass in old age: the Health, Aging and Body Composition Study, Am J Clin Nutr source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
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It may state two separate claims as one.
In the paper
“With normalisation of thyroid concentrations, muscle mass and strength are re-established, but this can take up to 9 months to occur.98”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Hyperthyroidism
What the sources say
- Not checked yetcites [98] Nørrelund, 1999, Muscle mass and function in thyrotoxic patients before and during medical treatment, Clin Endocrinol (Oxf) source
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
In the paper
“Resistance exercise stimulates protein synthesis and results in increased muscle mass and strength.121”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Treatments for age-related and disease-related muscle loss > Exercise
What the sources say
- Not checked yetcites [121] Cauza, 2009, Effects of progressive strength training on muscle mass in type 2 diabetes mellitus patients determined by computed tomography, Wien Med Wochenschr source
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
In the paper
“Although decreased caloric intake and anorexia associated with cancer might contribute to muscle loss, this is not the only factor; aggressive caloric supplementation alone cannot reverse the skeletal muscle loss.116”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Muscle loss in other disease states
What the sources say
- Not checked yetcites [116] Muscaritoli, 2010, Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics”, Clin Nutr source
hedgedconditional- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
In the paper
“Vitamin D supplementation might also have wide-ranging beneficial effects in reducing falls and improving muscle strength, but evidence is inconclusive; large randomised controlled trials are addressing this hypothesis.102”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Vitamin D deficiency
What the sources say
- Not checked yetcites [102] Kalyani, 2010, Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis, J Am Geriatr Soc source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
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It may state two separate claims as one.
In the paper
“Osteoporosis is also associated with the loss of muscle function and mobility limitations, although the direction of this association is unclear.103”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Osteoporosis
What the sources say
- Not checked yetcites [103] Ferrucci, 2013, Interaction between bone and muscle in older persons with mobility limitations, Curr Pharm Des
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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It may state two separate claims as one.
In the paper
“Several factors are likely to contribute to muscle loss, including the presence of pro-inflammatory cytokines in rheumatoid arthritis. Additionally, reduced protein synthesis in myocytes, physical activity limitations, insulin resistance, and inadequate protein ingestion could occur.106”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Muscle loss in other disease states
What the sources say
- Not checked yetcites [106] de Oliveira Nunes Teixeira, 2013, Muscle wasting in collagen-induced arthritis and disuse atrophy, Exp Biol Med (Maywood) source
hedgedconditional- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
In the paper
“Patients with HIV have lower muscle strength than do healthy individuals; however, resistance exercise can safely increase the strength of older patients with HIV to equal that of counterparts.119”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Muscle loss in other disease states
What the sources say
- Not checked yetcites [119] Souza, 2011, Effect of progressive resistance exercise on strength evolution of elderly patients living with HIV compared to healthy controls, Clinics (Sao Paulo) source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Tumour-induced inflammation can lead to increased production of tumour necrosis factor alpha, interleukin 6, interferon gamma, and other cytokines, which results in increased protein catabolism, decreased protein anabolism, insulin resistance, and lipolysis.115”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Muscle loss in other disease states
What the sources say
- Not checked yetcites [115] Dodson, 2011, Muscle wasting in cancer cachexia: clinical implications, diagnosis, and emerging treatment strategies, Annu Rev Med source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Oxandrolone is an anabolic steroid treatment that has been used to treat muscle loss in diseases such as HIV, and also in patients with other catabolic disorders such as neuromuscular diseases, or in individuals who have had severe trauma, burn injury, or infections, with notable improvements in muscle function and faster recovery.120”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Muscle loss in other disease states
What the sources say
- Not checked yetcites [120] Porro, 2012, Five-year outcomes after oxandrolone administration in severely burned children: a randomized clinical trial of safety and efficacy, J Am Coll Surg source
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
In the paper
“Resistance exercise is effective and safe to prevent muscle loss even in old (mean age 87 years) and frail individuals, potentially by also decreasing skeletal muscle apoptosis and improving mitochondrial function.123”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Treatments for age-related and disease-related muscle loss > Exercise
What the sources say
- Not checked yetcites [123] Fiatarone, 1994, Exercise training and nutritional supplementation for physical frailty in very elderly people, N Engl J Med source
hedgeddirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Muscle loss might also occur in other disease states, including rheumatoid arthritis, peripheral arterial disease, COPD, congestive heart failure, advanced kidney disease, cirrhosis, cancer, and HIV, which we describe briefly here;”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Muscle loss in other disease states
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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It may state two separate claims as one.
In the paper
“The increase in muscle strength occurs almost immediately, after a few days of exercise, and much before a noticeable increase in muscle mass, suggesting that the primary effect of exercise might not be on hypertrophy but rather on muscle quality.”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Treatments for age-related and disease-related muscle loss > Exercise
What the sources say
- Not checked yetcites [121] Cauza, 2009, Effects of progressive strength training on muscle mass in type 2 diabetes mellitus patients determined by computed tomography, Wien Med Wochenschr source
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
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It may state two separate claims as one.
In the paper
“Muscle mass can be reduced by up to 20% and muscle strength by 40% in patients with severe thyrotoxicosis.”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Muscle loss in endocrine diseases > Hyperthyroidism
What the sources say
- Not checked yetcites [98] Nørrelund, 1999, Muscle mass and function in thyrotoxic patients before and during medical treatment, Clin Endocrinol (Oxf) source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Contrary to the clear beneficial effects of exercise on muscle health”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Treatments for age-related and disease-related muscle loss > Diet
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. The paper may give no reason why it holds.
In the paper
“findings from several studies have shown the benefits of exercise (aerobic and resistance) for improvement of glucose metabolism and insulin sensitivity in people with type 2 diabetes.130”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Treatments for age-related and disease-related muscle loss > Exercise
What the sources say
- Not checked yetcites [130] Boulé, 2001, Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials, JAMA source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“In parallel, increased contractile activity promotes oxidative fibre type transformation, PGC-1α expression, mitochondrial biogenesis, and muscle protein synthesis, and could lead to reduced inflammation and oxidative stress.56”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Treatments for age-related and disease-related muscle loss > Exercise
What the sources say
- Not checked yetcites [56] Lira, 2010, PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity, Am J Physiol Endocrinol Metab source
hedgeddirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Moderate weight loss of about 5% in older women was found to improve insulin resistance, fat distribution, and muscle lipid infiltration, and preserve thigh muscle mass, with only a slight decrease in appendicular lean mass.136”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Treatments for age-related and disease-related muscle loss > Diet
What the sources say
- Not checked yetcites [136] Mazzali, 2006, Interrelations between fat distribution, muscle lipid content, adipocytokines, and insulin resistance: effect of moderate weight loss in older women, Am J Clin Nutr source
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
In the paper
“In preliminary studies of older men and women with sarcopenia, oral supplementation with 16 g per day of essential aminoacids was associated with increased lean mass at 6 months and a further increase at 18 months, along with improved insulin sensitivity.135”
§ Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases > Treatments for age-related and disease-related muscle loss > Diet
What the sources say
- Not checked yetcites [135] Solerte, 2008, Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia, Am J Cardiol source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
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It may state two separate claims as one.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Hence, impaired insulin signaling is commonly observed in sarcopenic obesity [10,11].”
From Sarcopenic obesity, insulin resistance, and their implications in cardiovascular and metabolic consequences (2020) · cites this paper as [11]
In the citing paper
“Skeletal muscle is the largest insulin-sensitive tissue and has the largest requirement for postprandial glucose through insulin dependent mechanism.”
From Sarcopenic obesity, insulin resistance, and their implications in cardiovascular and metabolic consequences (2020) · cites this paper as [11]
In the citing paper
“Hypogonadal status also contributes to sarcopenic obesity by increasing levels of TNF-α and IL-6, which leads to central obesity [11,47].”
From Sarcopenic obesity, insulin resistance, and their implications in cardiovascular and metabolic consequences (2020) · cites this paper as [11]
In the citing paper
“In older adults with type 2 diabetes mellitus (T2DM), the prevalence of sarcopenia is 2–3 times higher than in non-diabetic peers.1”
From Semaglutide Therapy and Accelerated Sarcopenia in Older Adults with Type 2 Diabetes: A 24-Month Retrospective Cohort Study (2025) · cites this paper as [1]
Citations
Cites
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601
Global estimates of the prevalence of diabetes for 2010 and 2030
Shaw, J. E., Sicree, R. A., & Zimmet, P. Z. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.10.007 · Cited by 7,216
Epidemiology of Sarcopenia among the Elderly in New Mexico
Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004
Fielding, R. A., Vellas, B., Evans, W. J., Bhasin, S., Morley, J. E., Newman, A. B., Abellan van Kan, G., Andrieu, S., Bauer, J., Breuille, D., et al. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.01.003 · Cited by 3,256
Janssen, I., Heymsfield, S. B., & Ross, R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50216.x · Cited by 3,139
Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., Newman, A. B., et al. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1059 · Cited by 3,083
Exercise training and nutritional supplementation for physical frailty in very elderly people
Fiatarone, M. A., O'Neill, E. F., Ryan, N. D., Clements, K. M., Solares, G. R., Nelson, M. E., Roberts, S. B., Kehayias, J. J., Lipsitz, L. A., & Evans, W. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302501 · Cited by 2,857
Sarcopenia: origins and clinical relevance
Rosenberg, I. H. (1997) · The Journal of Nutrition · doi:10.1093/jn/127.5.990s · Cited by 2,399
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321
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“It is important also to point out that increasing age leads to reduction in body mass, which can be related to decreases in body weight, regardless of weight control [20, 21].”
BackgroundSrivastav, A. K., Goyal, M., & Samuel, A. J. (2023) · Revista Pesquisa em Fisioterapia · doi:10.17267/2238-2704rpf.2023.e5069
Bouwer, J. (2016) · Cited by 1
Noggin Combined With Dental Pulp Stem Cells Repair Muscle Injury Through Smad/Pax7 Signaling PathwayPreprint
Zhang, M., Yu, L.-M., Zhang, W., Deng, J., Sun, B., Chen, M., Huang, W., He, H., Han, X., & Liu, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-861400/v1 · Cited by 1
Maximal Strength Training for Breast Cancer Patients Undergoing Adjuvant Treatment. Doctoral Thesis
Cešeiko, R. (2021) · doi:10.25143/prom-rsu_2021-07_dt · Cited by 1
Computer Science & Information Technology ( CS & IT )
(2016) · doi:10.5121/csit.2016.60600 · Cited by 1
Revista Española de Discapacidad
(2021) · Revista Española de Discapacidad · doi:10.5569/2340-5104.09.01 · Cited by 1
Pfeifer, L. O., Nardi, A. T. D., da Silva, L. X. N., do Nascimento, D. M., Botton, C. E., Teodoro, J. L., Schaan, B. D., & Umpierre, D. (2020) · doi:10.31219/osf.io/kpg2m · Cited by 1
The antiviral Interferon pathway drives astrocyte aging and motor declinePreprint
Labarta-Bajo, L., Thanawalla, A., Gutierrez, I. L., Soe, S. M. L., Chick, B. Y., Andritsogianni, I., Metanat, S., Hargreaves, D. C., Kaech, S. M., Azim, E., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.12.688147 · Cited by 2
Ma, X., Sun, G., Liu, C., Yan, X., Liang, W., & Ma, Z. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1859967
“Disease-related muscle loss is also amplified by obesity, diabetes and other chronic conditions that are common in later life (27).”
Adeyemi, A. (2014) · Texas ScholarWorks (Texas Digital Library)
Dreder, A., Tahir, M. A., Şeker, H., & Anwar, M. N. (2016) · doi:10.5121/csit.2016.60619
“Sexual dimorphism of skeletal muscle can occur due to age [1] and many of these age-related changes in skeletal muscle appear to be influenced by gender [2], [17], [18].”
BackgroundEvolving Concepts for Use of Stem Cells and Tissue Engineering for Cardiac Regeneration
Jahnavi, S., Santhakumar, R., & Verma, R. S. (2015) · Advances in medical technologies and clinical practice book series · doi:10.4018/978-1-4666-9530-6.ch011
The Relationship Between Adiponectin Levels and Appendicular Lean Mass in Postmenopausal Women
Puchala, S. (2015) · OhioLink ETD Center (Ohio Library and Information Network)
Macon, E. L., Graham-Thiers, P. M., & Bowen, K. L. (2017) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2017.03.034
Healthy Foods for Healthy Aging
Kubena, K. S., & McIntosh, W. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805376-8.00029-0
Músculo esquelético: del nacimiento a la vejez, rutas hacia la falla mecánica y metabólica
Gitler, S., Ramírez, I. M., Ramírez, R., Medina, J., Vázquez, P., & Ortega, A. (2017) · Gaceta Médica de México · doi:10.24875/gmm.m17000018
Edmunds, K. J. (2017) · Opin vísindi (Opin vísindi)
Sundaram, S. G. (2017) · Research in Medical & Engineering Sciences · doi:10.31031/rmes.2017.01.000505
da Cruz, C. M., Holanda, I. M. M., Noronha, M. A. P., da Cruz, M. P. M., da Silva, R. M. C. A., da Silva, H. A. B., Rego, J. D. C. M., & Canuto, K. M. (2018) · European Scientific Journal ESJ · doi:10.19044/esj.2018.v14n15p37
A Model-Based Approach for Jump Analyses Regarding Strength and Balance
Hellmers, S., Fudickar, S. J. F., Dasenbrock, L., Heinks, A., Bauer, J. M., & Hein, A. (2018) · Communications in computer and information science · doi:10.1007/978-3-319-94806-5_19
Viggars, M. R. (2018) · Liverpool John Moores University · doi:10.24377/researchonline.ljmu.ac.uk.00009368
Fappi, A. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2018.tde-14082018-103310
Role of c-Cbl Gene in Muscle Energy Metabolism
(2018) · International journal of research studies in biosciences · doi:10.20431/2349-0365.0605001
“Loss of skeletal muscle mass or function may cause obesity [10].”
BackgroundIshihara, Y., Ozaki, H., Nakagata, T., Yoshihara, T., Natsume, T., Kitada, T., ISHIBASHI, M., Sato, N., Arikawa‐Hirasawa, E., Ikuta, N., et al. (2018) · Juntendō Igaku/Juntendo igaku · doi:10.14789/jmj.2018.64.jmj18-p515
Exploring Design Factors in Designing Horticultural Garments for Older Adults
Min, S., Koo, S. H., & Wilson, J. (2019) · Journal of Aging and Physical Activity · doi:10.1123/japa.2018-0467
Sex Steroids, Cognate Receptors, and Aging
Bagchi, G., Dash, A. K., Kumar, S., Jiang, S., Ahn, S., Chatterjee, B., & Tyagi, R. K. (2019) · Springer eBooks · doi:10.1007/978-981-13-3585-3_13
Molecular Insights into the Pathophysiology of Neurological Disorders
Devi, A. (2019) · Springer eBooks · doi:10.1007/978-981-13-7142-4_23
Fausnacht, D. W. (2018) · VTechWorks (Virginia Tech)
Musembi, H. M., & Sundin, D. (2019) · Geriatric Care · doi:10.4081/gc.2019.8358
Accurate Methods Of Determining Body Composition Of Senior Patients
Pîslaru, A. I., Ilie, A. C., Sandu, I. A., & Alexa, I. D. (2019) · E-Health and Bioengineering Conference (EHB) · doi:10.1109/ehb47216.2019.8969916
“There is a reduction of about 20 – 40% of muscle mass up to the age of 70, which leads to sarcopenia [3].”
BackgroundObesity and Weight Gain in Older People
Valencia, W. M., & Sood, R. (2016) · Springer eBooks · doi:10.1007/978-981-287-080-3_350-1
Ghazwan, A. M., Al-Saadan, W. A., & Rany, N. (2021) · IOP Conference Series Materials Science and Engineering · doi:10.1088/1757-899x/1067/1/012138
“OA progression is frequently accompanied by muscle weakness, decline in muscle strength [2, 3], and functional disability [4].”
BackgroundRevue critique des recommandations de perte de poids avant une arthroplastie totale de genou
Godziuk, K., Prado, C. M. M., Beaupré, L. A., Jones, C. A., Werle, J. R., & Forhan, M. A. (2021) · Revue du Rhumatisme · doi:10.1016/j.rhum.2021.03.003
Koçak, F. Ö. K., Savaş, S., & Akçiçek, S. (2021) · Ege Tıp Dergisi · doi:10.19161/etd.915688
Relationship between skeletal muscle mass with metabolic syndrome in Chinese eldersPreprint
Yang, T., Guo, X., Wang, C., Zhao, T., & Li, D. (2021) · Research Square · doi:10.21203/rs.3.rs-428604/v1
Does pre-operative frailty predict cardiac rehabilitation completion in cardiac surgery patients?
Kimber, D. E. (2016) · Mspace (University of Manitoba)
Zarali, M., Etemad, Z., Azizbeigi, K., & Karimi, P. (2021) · Medical Journal of Tabriz University of Medical Sciences and Health Services · doi:10.34172/mj.2021.037
Chino, Y., Inoue, D., Yamamoto, M., Onuma, T., & Yoshida, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-737198/v1
EVALUATION OF GERIATRIC PATIENTS THAT ADMITTED TO THE EMERGENCY DEPARTMENT WITH ACUTE ABDOMINAL PAIN
Kavak, N., & Kavalcı, C. (2021) · SDÜ Tıp Fakültesi Dergisi · doi:10.17343/sdutfd.953443
Zhao, Y., Li, G., Jiang, Y., Wu, H., Dai, J., Cui, Y., Mao, H. Z., Ju, S., Wei, Q., & Peng, X. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab817
(280) 負の制御によるタバコ感染特異的(PR)タンパク質-1遺伝子発現 (日本植物病理大会)
大島, 正., 平佐, 総., 西宮, 総., 中村, 茂., & 大橋, 祐. (1993) · 日本植物病理學會報
New Advances in the Research of Antioxidant Food Peptides
Amigo, L., & Hernández-Ledesma, B. (2021) · MDPI eBooks · doi:10.3390/books978-3-0365-2521-1
Shibuki, T., Harada, S., Iida, M., Osawa, Y., Katoh, S., Kuwabara, K., Hirata, A., Sata, M., Matsumoto, M., Okamura, T., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3972757
Sasaki, K., Fukumoto, Y., & Kakuma, T. (2020) · Journal of Cardiology · doi:10.1016/j.jjcc.2020.06.012
Pitchumoni, C. S. (2020) · Springer eBooks · doi:10.1007/978-3-319-90761-1_110-1
Perspective Chapter: Early Diagnosis of Malnutrition
Nakamura, T., & Imamura, H. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.104655
Evolving Concepts for Use of Stem Cells and Tissue Engineering for Cardiac Regeneration
Jahnavi, S., Santhakumar, R., & Verma, R. S. (2019) · IGI Global eBooks · doi:10.4018/978-1-5225-8185-7.ch024
VÁZIZOMSÉRÜLÉS KEZELÉSEK JELENLEGI MÓDJAINAK ÁTTEKINTÉSE
Gyenes, D., Budai, Z., & Sarang, Z. (2020) · STADIUM - Hungarian Journal of Sport Sciences · doi:10.36439/sjsc.v3i1.5423
Fu, L., Shao, B., Guo, J., Chen, X., Xing, Y., Hou, L., Zhang, Y., Song, P., Yang, F., & Guo, Q. (2019) · doi:10.21203/rs.2.16444/v1
VÁZIZOMSÉRÜLÉS KEZELÉSEK JELENLEGI MÓDJAINAK ÁTTEKINTÉSE
Gyenes, D., Budai, Z., & Sarang, Z. (2020) · STADIUM - Hungarian Journal of Sport Sciences · doi:10.36439/hjsc/2020/1/5423
Wang, X., Chen, Z., Yang, F., Ding, X., Cao, C., Hu, H., & Zou, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-360026/v1
“Page 3/20 muscle protein balance, and may cause a decline in skeletal muscle quality[10].”
BackgroundTian, G., Katchur, S. R., Jiang, Y., Briand, J., Schaber, M. D., Kreatsoulas, C., Schwartz, B. J., Thrall, S. H., Davis, A., Duvall, S., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1786284/v1
Association between Residential Green Space and Body Composition in the ElderlyPreprint
Huang, Y.-C., Chen, C., Pan, S., Chin, W., Guo, Y. L., & Chio, C. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4181454
Asano‐Hayami, E., Morishita, Y., Hayami, T., Shibata, Y., Kiyose, T., Sasajima, S., Hayashi, Y., Motegi, M., Kato, M., Asano, S., et al. (2022) · Diabetology International · doi:10.1007/s13340-022-00602-0
Kim, J. E., Jeong, K., Lim, S., Lee, S., & Baek, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-2037581/v1
Body Composition in Geriatric Patients
Gómez, M. P. A., Aparisi, F., Guglielmi, G., & Bazzocchi, A. (2023) · Practical issues in geriatrics · doi:10.1007/978-3-031-14877-4_15
Makrogiannis, S. K. (2023) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.28685
“Sarcopenia has important health and economic implications; it is related to functional disabilities, risk of falling, and a higher rate of outpatient visits in the elderly.(2) Furthermore, it is a common complication of cirrhosis.”
Biological sciences underpinning biomechanics
Horwood, A., & Chockalingam, N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85212-8.00005-5
Tsuru, R., Fujihara, Y., Akehi, Y., Iwaya, C., Asakawa, H., Kitajima, Y., Harada, S., Takashi, Y., Kawanami, D., Yanase, T., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2704315/v1
Estimativa da composição corporal por análise multivariada em idosos
Venturini, A. C. R. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.83.2022.tde-09032023-085551
Active adults have thicker peripheral muscles and diaphragm: A cross-sectional study
Shetty, A., Chandrasekaran, B., Kamath, K., Ravichandran, S., Kadavigere, R., David, L. R., Karuppaya, B., VIJAYASARATHI, G., & Sukumar, S. (2023) · F1000Research · doi:10.12688/f1000research.135379.1
Wang, J., Zeng, L., Hong, C., Cui, H., Zhu, H., Li, Q., Li, Y., Li, R., He, J., Zhu, H., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3125284/v1
Research Progress of Chronic Obstructive Pulmonary Disease Associated with Sarcopenia
杜, 丽. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.1391979
Zakeri, R., Karimabad, M. N., Hajizadeh, M. R., Wong, A., Zarei, S., Hosseiniara, R., & Mahmoodi, M. (2023) · The Open Medicinal Chemistry Journal · doi:10.2174/18741045-v17-230822-2023-1
Development of high protein beverage from hydrolyzed egg white
Charoensak, N. (2022) · Chula Digiverse · doi:10.58837/chula.the.2022.161
Frailty and Mobility Degeneration in Diabetes and Diabetic Foot Ulceration
Najafi, B., & Kang, G. E. (2023) · Springer eBooks · doi:10.1007/978-3-031-27725-2_10
Active adults have thicker peripheral muscles and diaphragm: A cross-sectional study
Shetty, A., Chandrasekaran, B., Kamath, K., Ravichandran, S., Kadavigere, R., David, L. R., Karuppaya, B., Vijayasarathi, G., & Sukumar, S. (2023) · F1000Research · doi:10.12688/f1000research.135379.2
Hollands, T. (2023) · CABI eBooks · doi:10.1079/9781789245134.0016
Jose, R. M., Lee, D., Luakian, F. C., Majarais, M. Z., & Alam, Z. F. (2023) · Malaysian Journal of Public Health Medicine · doi:10.37268/mjphm/vol.23/no.2/art.1770
“Changes in muscle and fat mass are linked to aging wherein muscle mass decreases while fat mass increases with aging 27 .”
BackgroundA Rare Case of Atypical Anti-glomerular Basement Membrane Disease
Gupta, S., Kashiv, P., Sejpal, K. N., Dubey, S., Malde, S., Gurjar, P., Mahajan, V., Pasari, A. S., & Balwani, M. R. (2023) · Cureus · doi:10.7759/cureus.49064
Vitamin d supplementation and physical performance in knee osteoarthritis patients
Manoy, P. (2016) · Chula Digiverse · doi:10.58837/chula.the.2016.1715
Park, D. Y., Kim, Y. S., & Kim, E. (2023) · The Korean Journal of Sports Medicine · doi:10.5763/kjsm.2023.41.4.216
Bonsu, I. M., Brandt, C., Ajidahun, A. T., Omoniyi, M., & Myezwa, H. (2023) · Women s Health · doi:10.1177/17455057231184508
“The earlier studies of sedentary postmenopausal women with obesity and age-related disease by Kalyani et al. 46 and Davenport et al. 47 described the existence of declines in aerobic fitness, muscle mass, muscle strength, and bone mineral density.”
BackgroundKumari, R., Chaudhary, V., & Sharma, S. (2024) · Journal Of Advanced Zoology · doi:10.53555/jaz.v45i1.3520
Ajao, F. O., Balogun, D. A., Iyedupe, M. O., Ayobami, O., Esther, O., Adeniji, L., Victor, A., & Olaleye, F. E. (2024) · Journal of Cardiology and Cardiovascular Medicine · doi:10.29328/journal.jccm.1001177
A Review of the Potential of Probiotic Bacteria in Managing the Body Weight of Obese Individuals
Didban, A., Manafi, L., & Mahmoudi, R. (2023) · Journal of Health and Hygiene · doi:10.61186/j.health.14.4.388
Advances in Research Related to Post-Stroke Sarcopenia
陈, 晓. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.143808
Annasamudram, N., Okorie, A. M., Spencer, R. G. S., Kalyani, R. R., Yang, Q., Landman, B. A., Ferrucci, L., & Makrogiannis, S. K. (2024) · SPIE Medical Imaging: Image Processing · doi:10.1117/12.3006894
“Previous studies 1–3 have shown that more detailed analysis of individual thigh muscle groups offers further insight into these metabolic and age-related diseases.”
BackgroundSelf-citationShi, L., Wang, J., He, C., Huang, Y. Q., Fu, W., Zhang, H., An, Y., Wang, M., Shan, Z., Li, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24089377
Wan, R., Zhou, J., Wei, N., Zhao, S.-H., Ying, W., & Shang, Y. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4784230
Debruin, D. A., Murphy, J., Campelj, D. G., Bagaric, R. M., Timpani, C. A., Goodman, C. A., Hanson, E. D., Rybalka, E., & Hayes, A. (2024) · JCSM Communications · doi:10.1002/rco2.90
Zhang, L., Wang, L., Long, J., Yin, Y., & Patil, S. (2024) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s463796
“43 This cascade of effects contributes to muscle loss in children and establishes a negative nitrogen balance in the body.”
BackgroundFrailty in Older People with Diabetes Mellitus
Sinclair, A. J., & Abdelhafiz, A. H. (2024) · Springer eBooks · doi:10.1007/978-3-031-57361-3_42
Übersicht über die Komorbidität zwischen medizinischen Erkrankungen und Übergewicht/Fettleibigkeit
Nolan, C. J. (2024) · Springer eBooks · doi:10.1007/978-3-031-55637-1_4
Piñón-Ruiz, M. J., Franco, M. R. H., Vargas-Luna, F.-M., Apolinar‐Jiménez, E., & Encalada, J. S. (2024) · Clinics · doi:10.1016/j.clinsp.2024.100505
Askari, R., Azarniveh, M. S., Haghighi, A. H., Shahrabadi, H., & Gentil, P. (2024) · European Journal of Translational Myology · doi:10.4081/ejtm.2024.12761
Kim, A., Kang, D., Choi, S. C., Sinn, D. H., & Gwak, G. (2024) · Hepatology Research · doi:10.1111/hepr.14126
“Because the key pathophysiology of these diseases, insulin resistance or chronic inflammation, 27–30 share the mechanism by which stea-tohepatitis affects sarcopenia, metabolic disorders combined with steatohepatitis are considered to have a synergistic effect on sarcopenia.”
Muscle Atrophy and Weakness in Metabolic Disease
Eshima, H. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815313925124010007
Álvarez, M., Negrón, R., Neira-Maldonado, C., Ponce‐Fuentes, F., & Cuyúl-Vásquez, I. (2024) · Cureus · doi:10.7759/cureus.74432
Shin, J. H., & Yoon, J. Y. (2024) · Public Health Nursing · doi:10.1111/phn.13494
Yoo, S., & Park, D. Y. (2024) · The Korean Journal of Sports Medicine · doi:10.5763/kjsm.2024.42.4.262
Metadata
- Authors
- Kalyani, R. R., Corriere, M., & Ferrucci, L.
- Affiliations
- Johns Hopkins University (US)
- National Institute on Aging (US)
- Venue
- The Lancet Diabetes & Endocrinology
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 2
- Issue
- 10
- Pages
- 819-829
- ISSN
- 2213-8587 (ISSN-L)
- PMC
- PMC4156923
- OpenAlex
- W2139789661
- Semantic Scholar
- 3c56fce30ecb0e77c93458bf0fbc85a0747736ea
- Cited by
- 1,102
- References
- 145
- Citations by year
- 2026: 76 · 2025: 117 · 2024: 110 · 2023: 133 · 2022: 128 · 2021: 114 · 2020: 106 · 2019: 82 · 2018: 72 · 2017: 79 · 2016: 51 · 2015: 18 · 2014: 15
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet Diabetes & Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- US National Institute of Diabetes and Digestive and Kidney Diseases (K23-DK093583, T32-DK062707)
- Johns Hopkins Older Americans Independence Center (P30-AG021334)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- sarcopenia, muscle mass loss, muscle strength, aging, diabetes mellitus, obesity, chronic disease, physical disability, functional decline, sarcopenia treatment, older adults
- MeSH terms
- Endocrine System Diseases, Humans, Male, Obesity, Diabetes Complications, Sarcopenia
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