A C. elegans mutant that lives twice as long as wild type

Kenyon, Cynthia, Chang, Jean, Gensch, Erin, Rudner, Adam, Tabtiang, Ramon·1993·Nature
DOI 10.1038/366461a0

Cited by (170)

Items 101–170 of 170

  1. Probiotic Bacillus subtilis protects against α-synuclein aggregation in C. elegans
    Goya, María Eugenia, Xue, Feng, Sampedro-Torres-Quevedo, Cristina, Arnaouteli, Sofia, Riquelme-Dominguez, Lourdes, Romanowski, Andrés, Brydon, Jack, Ball, Kathryn L., Stanley-Wall, Nicola R., Doitsidou, Maria · 2020 · Cell Reports
  2. Impact of genomic damage and ageing on stem cell function
    Behrens, Axel, van Deursen, Jan M., Rudolph, K. Lenhard, Schumacher, Björn · 2014 · Nature Cell Biology
  3. The microRNA cluster miR-106b 25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation
    Brett, Jamie O., Renault, Valérie M., Rafalski, Victoria A., Webb, Ashley E., Brunet, Anne · 2011 · Aging
  4. Indoles from commensal bacteria extend healthspan
    Sonowal, Robert, Swimm, Alyson, Sahoo, Anusmita, Luo, Liping, Matsunaga, Yohei, Wu, Ziqi, Bhingarde, Jui A., Ejzak, Elizabeth A., Ranawade, Ayush, Qadota, Hiroshi et al. · 2017 · Proceedings of the National Academy of Sciences
  5. Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity
    Dansen, Tobias B, Smits, Lydia M M, van Triest, Miranda H, de Keizer, Peter L J, van Leenen, Dik, Koerkamp, Marian Groot, Szypowska, Anna, Meppelink, Amanda, Brenkman, Arjan B, Yodoi, Junji et al. · 2009 · Nature Chemical Biology
  6. Characterization of the direct targets of<scp>FOXO</scp>transcription factors throughout evolution
    Webb, Ashley E., Kundaje, Anshul, Brunet, Anne · 2016 · Aging Cell
  7. The search for DAF-16/FOXO transcriptional targets: Approaches and discoveries
    Murphy, Coleen T. · 2006 · Experimental Gerontology
  8. Cytoplasmic and Mitochondrial NADPH-Coupled Redox Systems in the Regulation of Aging
    Bradshaw, Patrick C. · 2019 · Nutrients
  9. Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan
    Reis‐Rodrigues, Pedro, Czerwieniec, Gregg, Peters, Theodore W., Evani, Uday S., Alavez, Silvestre, Gaman, Emily A., Vantipalli, Maithili, Mooney, Sean D., Gibson, Bradford W., Lithgow, Gordon J. et al. · 2012 · Aging Cell
  10. Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice
    Mao, Kai, Quipildor, Gabriela Farias, Tabrizian, Tahmineh, Novaj, Ardijana, Guan, Fangxia, Walters, Ryan O., Delahaye, Fabien, Hubbard, Gene B., Ikeno, Yuji, Ejima, Keisuke et al. · 2018 · Nature Communications
  11. Mitochondrial uncoupling and lifespan
    Mookerjee, Shona A., Divakaruni, Ajit S., Jastroch, Martin, Brand, Martin D. · 2010 · Mechanisms of Ageing and Development
  12. A causal role for hyperinsulinemia in obesity
    Templeman, Nicole M, Skovsø, Søs, Page, Melissa M, Lim, Gareth E, Johnson, James D · 2017 · Journal of Endocrinology
  13. Senescent cell turnover slows with age providing an explanation for the Gompertz law
    Karin, Omer, Agrawal, Amit, Porat, Ziv, Krizhanovsky, Valery, Alon, Uri · 2019 · Nature Communications
  14. ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians’ Perspective
    Vitale, Giovanni, Pellegrino, Giuseppe, Vollery, Maria, Hofland, Leo J. · 2019 · Frontiers in Endocrinology
  15. Signaling networks determining life span
    Riera, Celine E., Merkwirth, Carsten, De Magalhaes Filho, C. Daniel, Dillin, Andrew · 2016 · Annual Review of Biochemistry
  16. FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells
    Audesse, Amanda J., Dhakal, Shleshma, Hassell, Lexi-Amber, Gardell, Zachary, Nemtsova, Yuliya, Webb, Ashley E. · 2019 · PLOS Genetics
  17. Functional aging in the nervous system contributes to age-dependent motor activity decline in C. elegans
    Liu, Jie, Zhang, Bi, Lei, Haoyun, Feng, Zhaoyang, Liu, Jianfeng, Hsu, Ao-Lin, Xu, X.Z. Shawn · 2013 · Cell Metabolism
  18. Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances
    Jiang, Qiu, Liu, Jie, Huang, Shan, Wang, Xuan-Yue, Chen, Xiaowei, Liu, Guang-Hui, Ye, Keqiang, Song, Weihong, Masters, Colin L., Wang, Jun et al. · 2025 · Signal Transduction and Targeted Therapy
  19. Genetics of Aging in the Fruit Fly,<i>Drosophila melanogaster</i>
    Helfand, Stephen L., Rogina, Blanka · 2003 · Annual Review of Genetics
  20. The somatotropic axis in human aging: framework for the current state of knowledge and future research
    Milman, Sofiya, Huffman, Derek M., Barzilai, Nir · 2016 · Cell Metabolism
  21. Calcium signaling alterations, oxidative stress, and autophagy in aging
    Ureshino, Rodrigo Portes, Rocha, Katiucha Karolina, Lopes, Guiomar Silva, Bincoletto, Cláudia, Smaili, Soraya Soubhi · 2014 · Antioxidants &amp; Redox Signaling
  22. Genetic and epigenetic regulation of human aging and longevity
    Morris, Brian J., Willcox, Bradley J., Donlon, Timothy A. · 2019 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  23. Genome-environment interactions that modulate aging: powerful targets for drug discovery
    de Magalhães, João Pedro, Wuttke, Daniel, Wood, Shona H., Plank, Michael, Vora, Chintan · 2012 · Pharmacological Reviews
  24. Genetics of Longevity and Aging
    Vijg, Jan, Suh, Yousin · 2005 · Annual Review of Medicine
  25. The evolutionary theories of aging revisited - a mini-review
    Ljubuncic, Predrag, Reznick, Abraham Z. · 2009 · Gerontology
  26. Regulation of <i>Caenorhabditis elegans</i> lifespan by a proteasomal E3 ligase complex
    Ghazi, Arjumand, Henis-Korenblit, Sivan, Kenyon, Cynthia · 2007 · Proceedings of the National Academy of Sciences
  27. Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging
    Tang, Duozhuang, Tao, Si, Chen, Zhiyang, Koliesnik, Ievgen Oleksandrovich, Calmes, Philip Gerald, Hoerr, Verena, Han, Bing, Gebert, Nadja, Zörnig, Martin, Löffler, Bettina et al. · 2016 · Journal of Experimental Medicine
  28. Forkhead Box O as a Sensor, Mediator, and Regulator of Redox Signaling
    de Keizer, Peter L.J., Burgering, Boudewijn M.T., Dansen, Tobias B. · 2011 · Antioxidants &amp; Redox Signaling
  29. <scp>TOR</scp>‐mediated regulation of metabolism in aging
    Antikainen, Henri, Driscoll, Monica, Haspel, Gal, Dobrowolski, Radek · 2017 · Aging Cell
  30. Drugs that modulate aging: the promising yet difficult path ahead
    Kennedy, Brian K., Pennypacker, Juniper K. · 2014 · Translational research
  31. Deep proteome analysis identifies age-related processes in C. elegans
    Narayan, Vikram, Ly, Tony, Pourkarimi, Ehsan, Murillo, Alejandro Brenes, Gartner, Anton, Lamond, Angus I., Kenyon, Cynthia · 2016 · Cell Systems
  32. Mouse Models to Disentangle the Hallmarks of Human Aging
    Folgueras, Alicia R., Freitas-Rodríguez, Sandra, Velasco, Gloria, López-Otín, Carlos · 2018 · Circulation Research
  33. Caloric restriction: Beneficial effects on brain aging and Alzheimer’s disease
    Van Cauwenberghe, Caroline, Vandendriessche, Charysse, Libert, Claude, Vandenbroucke, Roosmarijn E. · 2016 · Mammalian Genome
  34. Animal models of sarcopenia
    Christian, Courtney J., Benian, Guy M. · 2020 · Aging Cell
  35. Neurosecretory control of aging in <i>Caenorhabditis</i> <i>elegans</i>
    Ailion, Michael, Inoue, Takao, Weaver, Carole I., Holdcraft, Robert W., Thomas, James H. · 1999 · Proceedings of the National Academy of Sciences
  36. Caloric restriction and its mimetics
    Lee, Shin-Hae, Min, Kyung-Jin · 2013 · BMB Reports
  37. The role of estrogen deficiency in skin ageing and wound healing
    Emmerson, Elaine, Hardman, Matthew J. · 2012 · Biogerontology
  38. Longevity in untreated congenital growth hormone deficiency due to a homozygous mutation in the GHRH receptor gene
    Aguiar-Oliveira, Manuel H., Oliveira, Francielle T., Pereira, Rossana M. C., Oliveira, Carla R. P., Blackford, Amanda, Valenca, Eugenia H. O., Santos, Elenilde G., Gois-Junior, Miburge B., Meneguz-Moreno, Rafael A., Araujo, Vanessa P. et al. · 2010 · The Journal of Clinical Endocrinology &amp; Metabolism
  39. Systemic DNA damage responses in aging and diseases
    Ribezzo, Flavia, Shiloh, Yosef, Schumacher, Björn · 2016 · Seminars in Cancer Biology
  40. From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes
    Byun, Hae-Ok, Lee, Young-Kyoung, Kim, Jeong-Min, Yoon, Gyesoon · 2015 · BMB Reports
  41. DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage
    Mueller, Michael M., Castells-Roca, Laia, Babu, Vipin, Ermolaeva, Maria A., Müller, Roman-Ulrich, Frommolt, Peter, Williams, Ashley B., Greiss, Sebastian, Schneider, Jennifer I., Benzing, Thomas et al. · 2014 · Nature Cell Biology
  42. FoxO1 is involved in the antineoplastic effect of calorie restriction
    Yamaza, Haruyoshi, Komatsu, Toshimitsu, Wakita, Saori, Kijogi, Carole, Park, Seongjoon, Hayashi, Hiroko, Chiba, Takuya, Mori, Ryoichi, Furuyama, Tatsuo, Mori, Nozomu et al. · 2010 · Aging Cell
  43. Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence.
    de Keizer, Peter L.J., Packer, Leisl M., Szypowska, Anna A., Riedl-Polderman, Paulien E., van den Broek, Niels J.F., de Bruin, Alain, Dansen, Tobias B., Marais, Richard, Brenkman, Arjan B., Burgering, Boudewijn M.T. · 2010 · Cancer Research
  44. Age-Related Phasic Patterns of Mitochondrial Maintenance in Adult<i>Caenorhabditis elegans</i>Neurons
    Morsci, Natalia S., Hall, David H., Driscoll, Monica, Sheng, Zu-Hang · 2016 · The Journal of Neuroscience
  45. Metallothionein and the biology of aging
    Swindell, William R. · 2011 · Ageing Research Reviews
  46. Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans
    Honda, Yoko, Higashibata, Akira, Matsunaga, Yohei, Yonezawa, Yukiko, Kawano, Tsuyoshi, Higashitani, Atsushi, Kuriyama, Kana, Shimazu, Toru, Tanaka, Masashi, Szewczyk, Nathaniel J. et al. · 2012 · Scientific Reports
  47. Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons
    Stavoe, Andrea KH, Gopal, Pallavi P, Gubas, Andrea, Tooze, Sharon A, Holzbaur, Erika LF · 2019 · eLife
  48. Contributions of DNA interstrand cross-links to aging of cells and organisms
    Grillari, J., Katinger, H., Voglauer, R. · 2007 · Nucleic Acids Research
  49. Neural ageing and synaptic plasticity: prioritizing brain health in healthy longevity
    Navakkode, Sheeja, Kennedy, Brian K. · 2024 · Frontiers in Aging Neuroscience
  50. Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans
    Brys, Kristel, Castelein, Natascha, Matthijssens, Filip, Vanfleteren, Jacques R, Braeckman, Bart P · 2010 · BMC Biology
  51. Regulation of Chemosensory Receptor Expression and Sensory Signaling by the KIN-29 Ser/Thr Kinase
    Lanjuin, Anne, Sengupta, Piali · 2002 · Neuron
  52. Physical performance and longevity in aged rats
    Carter, C. S., Sonntag, W. E., Onder, G., Pahor, M. · 2002 · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
  53. The dynamin‐related protein DRP‐1 and the insulin signaling pathway cooperate to modulate <i>Caenorhabditis elegans</i> longevity
    Yang, Christine C., Chen, Diana, Lee, Siu Sylvia, Walter, Ludivine · 2011 · Aging Cell
  54. ETS-4 Is a Transcriptional Regulator of Life Span in Caenorhabditis elegans
    Thyagarajan, Bargavi, Blaszczak, Adam G., Chandler, Katherine J., Watts, Jennifer L., Johnson, W. Evan, Graves, Barbara J. · 2010 · PLoS Genetics
  55. The role of mitochondria in <scp>mTOR</scp>‐regulated longevity
    Wei, Yuehua, Zhang, Yan‐Jie, Cai, Ying, Xu, Mang‐Hua · 2015 · Biological Reviews
  56. Novel Insights into the Anti-Aging Role of Mitophagy
    2018 · International Review of Cell and Molecular Biology
  57. Involvement of Redox State in the Aging of <i>Drosophila melanogaster</i>
    Orr, William C., Radyuk, Svetlana N., Sohal, Rajindar S. · 2013 · Antioxidants &amp; Redox Signaling
  58. Bring Back the Rat!
    Carter, Christy S, Richardson, Arlan, Huffman, Derek M, Austad, Steven · 2020 · The Journals of Gerontology: Series A
  59. Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans
    Lans, Hannes, Jansen, Gert · 2007 · Developmental Biology
  60. Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs
    Iser, Wendy B., Gami, Minaxi S., Wolkow, Catherine A. · 2007 · Developmental Biology
  61. The Geroscience Hypothesis: Is It Possible to Change the Rate of Aging?
    Austad, Steven N. · 2016 · Advances in Geroscience
  62. Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy
    Bareja, Akshay, Lee, David E., White, James P. · 2019 · Frontiers in Cell and Developmental Biology
  63. Peptides from sesame cake extend healthspan of Caenorhabditis elegans via upregulation of skn-1 and inhibition of intracellular ROS levels
    Wang, Zhuanhua, Ma, Xiaoli, Li, Jiao, Cui, Xiaodong · 2016 · Experimental Gerontology
  64. Gene-diet interactions and aging in C. elegans
    Yen, Chia An, Curran, Sean P. · 2016 · Experimental Gerontology
  65. Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan
    Merry, Troy L., Kuhlow, Doreen, Laube, Beate, Pöhlmann, Doris, Pfeiffer, Andreas F. H., Kahn, C. Ronald, Ristow, Michael, Zarse, Kim · 2017 · Aging Cell
  66. Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms: Table 1.
    Burd, Christin E., Gill, Matthew S., Niedernhofer, Laura J., Robbins, Paul D., Austad, Steven N., Barzilai, Nir, Kirkland, James L. · 2016 · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
  67. PACRG, a protein linked to ciliary motility, mediates cellular signaling
    Loucks, Catrina M., Bialas, Nathan J., Dekkers, Martijn P. J., Walker, Denise S., Grundy, Laura J., Li, Chunmei, Inglis, P. Nick, Kida, Katarzyna, Schafer, William R., Blacque, Oliver E. et al. · 2016 · Molecular Biology of the Cell
  68. Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks
    Mallikarjun, Venkatesh, Swift, Joe · 2016 · EBioMedicine
  69. Alive and well? Exploring disease by studying lifespan
    Brett, Jamie O, Rando, Thomas A · 2014 · Current Opinion in Genetics &amp; Development
  70. Stage dependent nutritional regulation of transgenerational longevity
    Roussou, Ilianna G., Savakis, Charalambos, Tavernarakis, Nektarios, Metaxakis, Athanasios · 2016 · Nutrition and Healthy Aging