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Cited by 9,304Immune Response and InflammationInflammasome and immune disordersImmunotherapy and Immune Responses

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

Kawai, Taro, Akira, Shizuo·2010·Nature Immunology
DOI 10.1038/ni.1863
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Abstract

The discovery of Toll-like receptors (TLRs) as components that recognize conserved structures in pathogens has greatly advanced understanding of how the body senses pathogen invasion, triggers innate immune responses and primes antigen-specific adaptive immunity. Although TLRs are critical for host defense, it has become apparent that loss of negative regulation of TLR signaling, as well as recognition of self molecules by TLRs, are strongly associated with the pathogenesis of inflammatory and autoimmune diseases. Furthermore, it is now clear that the interaction between TLRs and recently identified cytosolic innate immune sensors is crucial for mounting effective immune responses. Here we describe the recent advances that have been made by research into the role of TLR biology in host defense and disease.

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Metadata

Authors
Kawai, T., & Akira, S.
Affiliations
Immunology Frontier Research Center, The University of Osaka (JP)
Corresponding author
Akira, Shizuo
ORCID
Venue
Nature Immunology
Publisher
Springer Science and Business Media LLC
Published
2010-04-20
Volume
11
Issue
5
Pages
373-384
ISSN
  • 1529-2908 (ISSN-L)
  • 1529-2916
DOI
10.1038/ni.1863
OpenAlex
W2109491705
Cited by
9,304
References
21
Citations by year
2026: 553 · 2025: 545 · 2024: 542 · 2023: 525 · 2022: 554 · 2021: 661 · 2020: 654 · 2019: 622 · 2018: 558 · 2017: 568 · 2016: 611 · 2015: 588 · 2014: 622 · 2013: 575 · 2012: 568
FWCI
42.97
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Nature Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology
  • National Institutes of Health (AI070167)
  • National Institute of Allergy and Infectious Diseases (P01AI070167)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
Toll-like receptors, pattern recognition receptors, innate immunity, host defense, autoimmunity, inflammatory diseases, pathogen recognition
MeSH terms
Animals, Autoimmune Diseases, Humans, Immunity, Innate, Nucleic Acids, Nucleoproteins, Signal Transduction, Toll-Like Receptors, Host-Pathogen Interactions, Adaptive Immunity

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