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Mild cognitive impairment as a diagnostic entity
Open accessAbstract
The concept of cognitive impairment intervening between normal ageing and very early dementia has been in the literature for many years. Recently, the construct of mild cognitive impairment (MCI) has been proposed to designate an early, but abnormal, state of cognitive impairment. MCI has generated a great deal of research from both clinical and research perspectives. Numerous epidemiological studies have documented the accelerated rate of progression to dementia and Alzheimer's disease (AD) in MCI subjects and certain predictor variables appear valid. However, there has been controversy regarding the precise definition of the concept and its implementation in various clinical settings. Clinical subtypes of MCI have been proposed to broaden the concept and include prodromal forms of a variety of dementias. It is suggested that the diagnosis of MCI can be made in a fashion similar to the clinical diagnoses of dementia and AD. An algorithm is presented to assist the clinician in identifying subjects and subclassifying them into the various types of MCI. By refining the criteria for MCI, clinical trials can be designed with appropriate inclusion and exclusion restrictions to allow for the investigation of therapeutics tailored for specific targets and populations.
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“Individuals that live with some form of cognitive impairment can experience a range of symptomatic challenges associated with memory loss, deficiencies in verbal communication, functional impairment, as well as other varying deficits of attention, judgment, and insight [17,40,47].”
From Ambient Assisted Living Technologies for Aging Well: A Scoping Review (2016) · cites this paper as [47]
In the citing paper
“First, because standard MCI criteria do not define optimal tests to establish cognitive performance in subjects with MCI, 22 cognitive testing was performed using a battery of well-validated, standardized, and widely used neuropsychological tests exploring only some aspects of the complex cognitive dysfunction in subjects with MCI.1,2”
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Metadata
- Authors
- Petersen, R. C.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Petersen, R. C.
- ORCID
- Petersen, R. C.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2004-08-20
- Volume
- 256
- Issue
- 3
- Pages
- 183-194
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2028436804
- Cited by
- 7,864
- References
- 12
- Citations by year
- 2026: 344 · 2025: 493 · 2024: 478 · 2023: 440 · 2022: 475 · 2021: 535 · 2020: 499 · 2019: 479 · 2018: 433 · 2017: 428 · 2016: 385 · 2015: 402 · 2014: 395 · 2013: 391 · 2012: 367
- FWCI
- 13.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 10483, AG-06786, AG 16574, U01AG006786, P50AG016574)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- mild cognitive impairment, dementia, Alzheimer's disease, prodromal dementia, MCI classification, diagnostic criteria, conversion to dementia, cognitive aging
- MeSH terms
- Aged, Alzheimer Disease, Cognition Disorders, Humans, Neuropsychological Tests, Terminology as Topic, Psychiatric Status Rating Scales
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