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Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

Levy, Efrat, Carman, Mark D., Fernandez-Madrid, Ivan J., Power, Michael D., Lieberburg, Ivan, van Duinen, Sjoerd G., Bots, Gerard Th. A. M., Luyendijk, Willem, Frangione, Blas·1990·Science

DOI 10.1126/science.2111584

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Abstract

An amyloid protein that precipitates in the cerebral vessel walls of Dutch patients with hereditary cerebral hemorrhage with amyloidosis is similar to the amyloid protein in vessel walls and senile plaques in brains of patients with Alzheimer's disease, Down syndrome, and sporadic cerebral amyloid angiopathy. Cloning and sequencing of the two exons that encode the amyloid protein from two patients with this amyloidosis revealed a cytosine-to-guanine transversion, a mutation that caused a single amino acid substitution (glutamine instead of glutamic acid) at position 22 of the amyloid protein. The mutation may account for the deposition of this amyloid protein in the cerebral vessel walls of these patients, leading to cerebral hemorrhages and premature death.

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APP Function and Lipids: A Bidirectional Link
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Aged Non‐Human Primates: An Animal Model of Age‐Associated Neurodegenerative Disease
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Current Understanding of the Physiopathology, Diagnosis and Therapeutic Approach to Alzheimer’s Disease
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The “Aged Garlic Extract” (AGE) and One of its Active Ingredients S-Allyl-LCysteine (SAC) as Potential Preventive and Therapeutic Agents for Alzheimer's Disease (AD)
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Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease
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Authors: Levy, E., Carman, M. D., Fernandez-Madrid, I. J., Power, M. D., Lieberburg, I., van Duinen, S. G., Bots, G. T. A. M., Luyendijk, W., & Frangione, B.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1990-06
Volume: 248
Issue: 4959
Pages: 1124-1126
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.2111584
OpenAlex: W2063272219
Cited by: 1,381
References: 4
FWCI: 62.12
Type: journal article
Language: en
Open access: closed

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Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

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