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Long-Term Cytomegalovirus Infection Leads to Significant Changes in the Composition of the CD8+T-Cell Repertoire, Which May Be the Basis for an Imbalance in the Cytokine Production Profile in Elderly Persons
Open accessAbstract
In spite of the present belief that latent cytomegalovirus (CMV) infection drives CD8+T-cell differentiation and induces premature immune senescence, no systematic studies have so far been performed to compare phenotypical and functional changes in the CD8+T-cell repertoire in CMV-infected and noninfected persons of different age groups. In the present study, number, cytokine production, and growth potential of naïve (CD45RA+CD28+), memory (CD45RA−CD28+), and effector (CD45RA+CD28−or CD45RA−CD28−) CD8+T cells were analyzed in young, middle-aged, and elderly clinically healthy persons with a positive or negative CMV antibody serology. Numbers and functional properties of CMVpp65 495-503-specific CD8+T cells were also studied. We demonstrate that aging as well as CMV infection lead to a decrease in the size of the naïve CD8+T-cell pool but to an increase in the number of CD8+effector T cells, which produce gamma interferon but lack substantial growth potential. The size of the CD8+memory T-cell population, which grows well and produces interleukin-2 (IL-2) and IL-4, also increases with aging, but this increase is missing in CMV carriers. Life-long latent CMV infection seems thus to diminish the size of the naïve and the early memory T-cell pool and to drive a Th1 polarization within the immune system. This can lead to a reduced diversity of CD8 responses and to chronic inflammatory processes which may be the basis of severe health problems in elderly persons.
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Cites
MCGEER, P., & MCGEER, E. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(95)00011-9 · Cited by 1,287 · cited 1×
“Proinflammatory cytokines are now believed to exacerbate the functional pathology and disease course of age-related disorders such as Alzheimer’s disease and atherosclerosis (23, 24, 34).”
BackgroundBrenchley, J. M., Karandikar, N. J., Betts, M. R., Ambrozak, D. R., Hill, B. J., Crotty, L. E., Casazza, J. P., Kuruppu, J., Migueles, S. A., Connors, M., et al. (2003) · Blood · doi:10.1182/blood-2002-07-2103 · Cited by 1,073
Saurwein-Teissl, M., Lung, T. L., Marx, F., Gschösser, C., Asch, E., Blasko, I., Parson, W., Böck, G., Schönitzer, D., Trannoy, E., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5893 · Cited by 499
Self-citationGoronzy, J. J., Fulbright, J. W., Crowson, C. S., Poland, G. A., O'Fallon, W. M., & Weyand, C. M. (2001) · Journal of Virology · doi:10.1128/jvi.75.24.12182-12187.2001 · Cited by 402
Cited by
Inflammaging: a new immune–metabolic viewpoint for age-related diseases
Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0059-4 · Cited by 3,586
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
Trautmann, L., Janbazian, L., Chomont, N., Said, E. A., Gimmig, S., Bessette, B., Boulassel, M.-R., Delwart, E., Sepulveda, H., Balderas, R. S., et al. (2006) · Nature Medicine · doi:10.1038/nm1482 · Cited by 1,565
Sylwester, A. W., Mitchell, B. L., Edgar, J. B., Taormina, C., Pelte, C., Ruchti, F., Sleath, P. R., Grabstein, K. H., Hosken, N. A., Kern, F., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050882 · Cited by 1,339
The aging of the immune system
Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908
Self-citationAgeing and life-long maintenance of T-cell subsets in the face of latent persistent infections.
Nikolich-Žugich, J. (2008) · Nature reviews. Immunology · doi:10.1038/nri2318 · Cited by 463
Human immunosenescence: is it infectious?
Pawelec, G., Akbar, A., Caruso, C., Solana, R., Grubeck‐Loebenstein, B., & Wikby, A. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00271.x · Cited by 405
Self-citationFrom “truly naïve” to “exhausted senescent” T cells: When markers predict functionality
Larbi, A., & Fulop, T. (2014) · Cytometry Part A · doi:10.1002/cyto.a.22351 · Cited by 359
Wertheimer, A. M., Bennett, M. S., Park, B., Uhrlaub, J. L., Martinez, C., Pulko, V., Currier, N. L., Nikolich-Žugich, D., Kaye, J., & Nikolich-Žugich, J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301721 · Cited by 352
Human T Cell Aging and the Impact of Persistent Viral Infections
Fülöp, T., Larbi, A., & Pawelec, G. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00271 · Cited by 347
Immunosenescence: what does it mean to health outcomes in older adults?
McElhaney, J. E., & Effros, R. B. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.023 · Cited by 340
Aging and Immune Function: Molecular Mechanisms to Interventions
Ponnappan, S., & Ponnappan, U. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3228 · Cited by 339
Inflammaging as a prodrome to Alzheimer's disease
Giunta, B., Fernandez, F., Nikolic, W. V., Obregon, D., Rrapo, E., Town, T., & Tan, J. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-51 · Cited by 327
Harris, S. A., & Harris, E. A. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142853 · Cited by 279
Immunosenescence and vaccine failure in the elderly
Grubeck-Loebenstein, B., Della Bella, S., Iorio, A. M., Michel, J.-P., Pawelec, G., & Solana, R. (2009) · Aging Clinical and Experimental Research · doi:10.1007/bf03324904 · Cited by 269
Self-citationFunctional skewing of the global CD8 T cell population in chronic hepatitis B virus infection
Das, A., Hoare, M., Davies, N., Lopes, A. R., Dunn, C., Kennedy, P. T. F., Alexander, G., Finney, H., Lawson, A., Plunkett, F. J., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072076 · Cited by 256
McElhaney, J. E., Zhou, X., Talbot, H. K., Soethout, E., Bleackley, R. C., Granville, D. J., & Pawelec, G. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.01.015 · Cited by 229
Yang, L., Li, A., Lei, Q., & Zhang, Y. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0804-8 · Cited by 215
Pourgheysari, B., Khan, N., Best, D., Bruton, R., Nayak, L., & Moss, P. A. H. (2007) · Journal of Virology · doi:10.1128/jvi.01262-06 · Cited by 214
The Influence of Latent Viral Infection on Rate of Cognitive Decline over 4 Years
Aiello, A. E., Haan, M. N., Blythe, L., Moore, K., Gonzalez, J. M., & Jagust, W. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00796.x · Cited by 210
Role of CMV in immune senescence.
Pawelec, G., & Derhovanessian, E. (2011) · Virus Research · doi:10.1016/j.virusres.2010.09.010 · Cited by 201
Memory T cell homeostasis and senescence during aging
Akbar, A. N., & Fletcher, J. M. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.07.019 · Cited by 194
Rizzo, L. B., Costa, L. G., Mansur, R. B., Swardfager, W., Belangero, S. I., Grassi-Oliveira, R., McIntyre, R. S., Bauer, M. E., & Brietzke, E. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.004 · Cited by 183
Vescovini, R., Biasini, C., Fagnoni, F. F., Telera, A. R., Zanlari, L., Pedrazzoni, M., Bucci, L., Monti, D., Medici, M. C., Chezzi, C., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.4283 · Cited by 173
Gain and loss of T cell subsets in old age: age-related reshaping of the T cell repertoire.
Arnold, C. R., Wolf, J., Brunner, S., Herndler-Brandstetter, D., & Grubeck-Loebenstein, B. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9499-x · Cited by 170
Self-citationImmunosenenescence: role of cytomegalovirus
Pawelec, G. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2013.11.010 · Cited by 163
Lurain, N. S., Hanson, B. A., Martinson, J., Leurgans, S. E., Landay, A. L., Bennett, D. A., & Schneider, J. A. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit210 · Cited by 159
. Persistent viral infections and immune aging.
Brunner, S., Herndler-Brandstetter, D., Weinberger, B., & Grubeck-Loebenstein, B. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.003 · Cited by 143
Di Benedetto, S., Derhovanessian, E., Steinhagen-Thiessen, E., Goldeck, D., Müller, L., & Pawelec, G. (2015) · Biogerontology · doi:10.1007/s10522-015-9563-2 · Cited by 131
Weltevrede, M., Eilers, R., de Melker, H. E., & van Baarle, D. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.02.005 · Cited by 128
Derhovanessian, E., Theeten, H., Hähnel, K., Van Damme, P., Cools, N., & Pawelec, G. (2013) · Vaccine · doi:10.1016/j.vaccine.2012.11.041 · Cited by 121
Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine
Frasca, D., Diaz, A., Romero, M., Landin, A. M., & Blomberg, B. B. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.01.071 · Cited by 116
CD58/CD2 Is the Primary Costimulatory Pathway in Human CD28−CD8+ T Cells
Leitner, J., Herndler-Brandstetter, D., Zlabinger, G. J., Grubeck-Loebenstein, B., & Steinberger, P. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401917 · Cited by 104
Self-citationDerhovanessian, E., Maier, A. B., Hähnel, K., Zelba, H., de Craen, A. J. M., Roelofs, H., Slagboom, E. P., Westendorp, R. G. J., & Pawelec, G. (2013) · AGE · doi:10.1007/s11357-012-9425-7 · Cited by 102
Overcoming immune dysfunction in the elderly: trained immunity as a novel approach
Bulut, O., Kilic, G., Domínguez-Andrés, J., & Netea, M. G. (2020) · International Immunology · doi:10.1093/intimm/dxaa052 · Cited by 99
Nutrition, diet and immunosenescence
Maijó, M., Clements, S. J., Ivory, K., Nicoletti, C., & Carding, S. R. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.12.003 · Cited by 85
Age-Associated Increase of Low-Avidity Cytomegalovirus-Specific CD8+ T Cells That Re-Express CD45RA
Griffiths, S. J., Riddell, N. E., Masters, J., Libri, V., Henson, S. M., Wertheimer, A., Wallace, D., Sims, S., Rivino, L., Larbi, A., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203267 · Cited by 82
Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection
Merani, S., Pawelec, G., Kuchel, G. A., & McElhaney, J. E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00784 · Cited by 74
Rizzo, L. B., Do Prado, C. H., Grassi-Oliveira, R., Wieck, A., Correa, B. L., Teixeira, A. L., & Bauer, M. E. (2013) · Bipolar Disorders · doi:10.1111/bdi.12121 · Cited by 73
The silent war of CMV in aging and HIV infection
Effros, R. B. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.09.003 · Cited by 63
Riddell, N. E., Griffiths, S. J., Rivino, L., King, D. C. B., Teo, G. H., Henson, S. M., Cantisan, S., Solana, R., Kemeny, D. M., MacAry, P. A., et al. (2015) · Immunology · doi:10.1111/imm.12409 · Cited by 60
Vescovini, R., Fagnoni, F. F., Telera, A. R., Bucci, L., Pedrazzoni, M., Magalini, F., Stella, A., Pasin, F., Medici, M. C., Calderaro, A., et al. (2014) · AGE · doi:10.1007/s11357-013-9594-z · Cited by 48
Immune senescence and cancer in elderly patients: Results from an exploratory study
Falci, C., Gianesin, K., Sergi, G., Giunco, S., De Ronch, I., Valpione, S., Soldà, C., Fiduccia, P., Lonardi, S., Zanchetta, M., et al. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.09.011 · Cited by 46
Zlamy, M., Almanzar, G., Parson, W., Schmidt, C., Leierer, J., Weinberger, B., Jeller, V., Unsinn, K., Eyrich, M., Würzner, R., et al. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0058-z · Cited by 29
Self-citationCantisán, S., Torre-Cisneros, J., Lara, R., Rodríguez-Benot, A., Santos, F., Gutiérrez-Aroca, J., Gayoso, I., González-Padilla, M., Casal, M., Rivero, A., et al. (2009) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00214-09 · Cited by 27
Immunosenescence and juvenile idiopathic arthritis.
Mayerl, C., & Prelog, M. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2010.02.015 · Cited by 25
Wennberg, A. M., Maher, B. S., Rabinowitz, J. A., Holingue, C., Felder, W. R., Wells, J. L., Munro, C. A., Lyketsos, C. G., Eaton, W. W., Walker, K. A., et al. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.13070 · Cited by 19
Metadata
- Authors
- Almanzar, G., Schwaiger, S., Jenewein, B., Keller, M., Herndler-Brandstetter, D., Würzner, R., Schönitzer, D., & Grubeck-Loebenstein, B.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2005-03-15
- Volume
- 79
- Issue
- 6
- Pages
- 3675-3683
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2103059589
- Cited by
- 357
- References
- 4
- FWCI
- 14.40
- Type
- journal article
- Language
- en
- Open access
- green
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