Alzheimer's Disease: Genes, Proteins, and Therapy

Cited by (295)

Items 101–200 of 295

1. Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein
   Niwa, Kiyoshi, Kazama, Ken, Younkin, Linda, Younkin, Steven G., Carlson, George A., Iadecola, Costantino · 2002 · American Journal of Physiology-Heart and Circulatory Physiology
2. Adeno-Associated Virus-Based Gene Therapy for CNS Diseases
   Hocquemiller, Michaël, Giersch, Laura, Audrain, Mickael, Parker, Samantha, Cartier, Nathalie · 2016 · Human Gene Therapy
3. Copper and Zinc Binding to Amyloid‐β: Coordination, Dynamics, Aggregation, Reactivity and Metal‐Ion Transfer
   Faller, Peter · 2009 · ChemBioChem
4. Apolipoprotein E ε4 allele, AD pathology, and the clinical expression of Alzheimer’s disease
   Bennett, D.A., Wilson, R.S., Schneider, J.A., Evans, D.A., Aggarwal, N.T., Arnold, S.E., Cochran, E.J., Berry-Kravis, E., Bienias, J.L. · 2003 · Neurology
5. Hippocampal Neuron Loss Exceeds Amyloid Plaque Load in a Transgenic Mouse Model of Alzheimer's Disease
   Schmitz, Christoph, Rutten, Bart P.F., Pielen, Andrea, Schäfer, Stephanie, Wirths, Oliver, Tremp, Günter, Czech, Christian, Blanchard, Veronique, Multhaup, Gerd, Rezaie, Payam et al. · 2004 · The American Journal of Pathology
6. Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration
   Swaroop, Anand, Chew, Emily Y., Bowes Rickman, Catherine, Abecasis, Gonçalo R. · 2009 · Annual Review of Genomics and Human Genetics
7. Aβ-degrading enzymes: potential for treatment of Alzheimer disease
   Miners, James Scott, Barua, Neil, Kehoe, Patrick Gavin, Gill, Steven, Love, Seth · 2011 · Journal of Neuropathology & Experimental Neurology
8. Multifunctional Nanoliposomes with Curcumin-Lipid Derivative and Brain Targeting Functionality with Potential Applications for Alzheimer Disease
   Mourtas, Spyridon, Lazar, Adina N., Markoutsa, Eleni, Duyckaerts, Charles, Antimisiaris, Sophia G. · 2014 · European Journal of Medicinal Chemistry
9. Epigenetic regulation in the pathophysiology of Alzheimer's disease
   Chouliaras, Leonidas, Rutten, Bart P.F., Kenis, Gunter, Peerbooms, Odette, Visser, Pieter Jelle, Verhey, Frans, van Os, Jim, Steinbusch, Harry W.M., van den Hove, Daniel L.A. · 2010 · Progress in Neurobiology
10. Low‐density lipoprotein receptor‐related protein‐1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β‐peptide elimination from the brain
    Zlokovic, Berislav V., Deane, Rashid, Sagare, Abhay P., Bell, Robert D., Winkler, Ethan A. · 2010 · Journal of Neurochemistry
11. Metformin attenuates Alzheimer’s disease-like neuropathology in obese, leptin-resistant mice
    Li, Jiejie, Deng, Jiao, Sheng, Wenli, Zuo, Zhiyi · 2012 · Pharmacology Biochemistry and Behavior
12. A Dynamic Relationship between Intracellular and Extracellular Pools of Aβ
    Oddo, Salvatore, Caccamo, Antonella, Smith, Ian F., Green, Kim N., LaFerla, Frank M. · 2006 · The American Journal of Pathology
13. Aβ-mediated ROS production by Cu ions: Structural insights, mechanisms and relevance to Alzheimer's disease
    Hureau, Christelle, Faller, Peter · 2009 · Biochimie
14. The neurovascular unit in brain function and disease: The neurovascular unit function
    Lecrux, C., Hamel, E. · 2011 · Acta Physiologica
15. On the Seeding and Oligomerization of pGlu-Amyloid Peptides (<i>in vitro</i>)
    Schilling, Stephan, Lauber, Thomas, Schaupp, Michael, Manhart, Susanne, Scheel, Eike, Böhm, Gerald, Demuth, Hans-Ulrich · 2006 · Biochemistry
16. Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders
    Qosa, Hisham, Miller, David S., Pasinelli, Piera, Trotti, Davide · 2015 · Brain Research
17. Microglial Aβ Receptors in Alzheimer’s Disease
    Yu, Yang, Ye, Richard D. · 2015 · Cellular and Molecular Neurobiology
18. Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation
    Jin, Meihua, Shiwaku, Hiroki, Tanaka, Hikari, Obita, Takayuki, Ohuchi, Sakurako, Yoshioka, Yuki, Jin, Xiaocen, Kondo, Kanoh, Fujita, Kyota, Homma, Hidenori et al. · 2021 · Nature Communications
19. MicroRNA Profiling of CSF Reveals Potential Biomarkers to Detect Alzheimer`s Disease
    Denk, Johannes, Boelmans, Kai, Siegismund, Christine, Lassner, Dirk, Arlt, Sönke, Jahn, Holger · 2015 · PLOS ONE
20. The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease
    Hirsch-Reinshagen, Veronica, Maia, Luis F., Burgess, Braydon L., Blain, Jean-Francois, Naus, Kathryn E., McIsaac, Sean A., Parkinson, Pamela F., Chan, Jennifer Y., Tansley, Gavin H., Hayden, Michael R. et al. · 2005 · Journal of Biological Chemistry
21. Soluble forms of tau are toxic in Alzheimer's disease
    Kopeikina, Katherine, Hyman, Bradley, Spires-Jones, Tara · 2012 · Translational Neuroscience
22. Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer’s type (SDAT)
    Ishrat, Tauheed, Hoda, Md Nasrul, Khan, M. Badruzzaman, Yousuf, Seema, Ahmad, Muzamil, Khan, Mohd. Moshahid, Ahmad, Ajmal, Islam, Fakhrul · 2009 · European Neuropsychopharmacology
23. Mitochondrial Medicine for Aging and Neurodegenerative Diseases
    Reddy, P. Hemachandra · 2008 · NeuroMolecular Medicine
24. Pyroglutamate Formation Influences Solubility and Amyloidogenicity of Amyloid Peptides
    Schlenzig, Dagmar, Manhart, Susanne, Cinar, Yeliz, Kleinschmidt, Martin, Hause, Gerd, Willbold, Dieter, Funke, Susanne Aileen, Schilling, Stephan, Demuth, Hans-Ulrich · 2009 · Biochemistry
25. Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer’s disease
    Ling, Yan, Morgan, Kevin, Kalsheker, Noor · 2003 · The International Journal of Biochemistry &amp; Cell Biology
26. Intracellular Mechanisms of Amyloid Accumulation and Pathogenesis in Alzheimer's Disease
    Glabe, Charles · 2001 · Journal of Molecular Neuroscience
27. Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein
    Niwa, Kiyoshi, Kazama, Ken, Younkin, Steven G., Carlson, George A., Iadecola, Costantino · 2002 · Neurobiology of Disease
28. Nitric oxide and nitroxidative stress in Alzheimer's disease
    Malinski, Tadeusz · 2007 · Journal of Alzheimer s Disease
29. Anti-Alzheimer’s Studies on β-Sitosterol Isolated from Polygonum hydropiper L.
    Ayaz, Muhammad, Junaid, Muhammad, Ullah, Farhat, Subhan, Fazal, Sadiq, Abdul, Ali, Gowhar, Ovais, Muhammad, Shahid, Muhammad, Ahmad, Ashfaq, Wadood, Abdul et al. · 2017 · Frontiers in Pharmacology
30. P38 MAP kinase is activated at early stages in Alzheimer's disease brain
    Sun, A · 2003 · Experimental Neurology
31. ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function
    Suh, Jaehong, Choi, Se Hoon, Romano, Donna M., Gannon, Moira A., Lesinski, Andrea N., Kim, Doo Yeon, Tanzi, Rudolph E. · 2013 · Neuron
32. Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease
    Farfara, D., Lifshitz, V., Frenkel, D. · 2008 · Journal of Cellular and Molecular Medicine
33. Implications of the serine protease HtrA1 in amyloid precursor protein processing
    Grau, Sandra, Baldi, Alfonso, Bussani, Rossana, Tian, Xiaodan, Stefanescu, Raluca, Przybylski, Michael, Richards, Peter, Jones, Simon A., Shridhar, Viji, Clausen, Tim et al. · 2005 · Proceedings of the National Academy of Sciences
34. Amyloid-β peptide (Aβ) neurotoxicity is modulated by the rate of peptide aggregation: Aβ dimers and trimers correlate with neurotoxicity
    Hung, Lin Wai, Ciccotosto, Giuseppe D., Giannakis, Eleni, Tew, Deborah J., Perez, Keyla, Masters, Colin L., Cappai, Roberto, Wade, John D., Barnham, Kevin J. · 2008 · The Journal of Neuroscience
35. Gene delivery of human apolipoprotein E alters brain Aβ burden in a mouse model of Alzheimer's disease
    Dodart, Jean-Cosme, Marr, Robert A., Koistinaho, Milla, Gregersen, Beth M., Malkani, Seema, Verma, Inder M., Paul, Steven M. · 2005 · Proceedings of the National Academy of Sciences
36. Determination of β-Amyloid Peptide Signatures in Cerebrospinal Fluid Using Immunoprecipitation-Mass Spectrometry
    Portelius, Erik, Westman-Brinkmalm, Ann, Zetterberg, Henrik, Blennow, Kaj · 2006 · Journal of Proteome Research
37. The potential role of amyloid in the pathogenesis of age-related macular degeneration
    Yoshida, T. · 2005 · Journal of Clinical Investigation
38. Oxidative Nerve Cell Death in Alzheimers Disease and Stroke: Antioxidants as Neuroprotective Compounds
    Behl, C., Moosmann, B. · 2002 · Biological Chemistry
39. The Role of Caspase Cleavage of Tau in Alzheimer Disease Neuropathology
    Cotman, Carl W., Poon, Wayne W., Rissman, Robert A., Blurton-Jones, Mathew · 2005 · Journal of Neuropathology &amp; Experimental Neurology
40. TUDCA, a Bile Acid, Attenuates Amyloid Precursor Protein Processing and Amyloid-β Deposition in APP/PS1 Mice
    Nunes, Ana F., Amaral, Joana D., Lo, Adrian C., Fonseca, Maria B., Viana, Ricardo J. S., Callaerts-Vegh, Zsuzsanna, D’Hooge, Rudi, Rodrigues, Cecília M. P. · 2012 · Molecular Neurobiology
41. Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation
    Obregon, Demian, Hou, Huayan, Deng, Juan, Giunta, Brian, Tian, Jun, Darlington, Donna, Shahaduzzaman, Md, Zhu, Yuyuan, Mori, Takashi, Mattson, Mark P. et al. · 2012 · Nature Communications
42. Gene Transfer of Human <i>Apoe</i> Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain
    Hudry, Eloise, Dashkoff, Jonathan, Roe, Alysson D., Takeda, Shuko, Koffie, Robert M., Hashimoto, Tadafumi, Scheel, Maria, Spires-Jones, Tara, Arbel-Ornath, Michal, Betensky, Rebecca et al. · 2013 · Science Translational Medicine
43. Ageing of the brain
    Anderton, Brian H · 2002 · Mechanisms of Ageing and Development
44. Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPARγ expression in cultured astrocytes
    Valles, Soraya L., Dolz-Gaiton, Pablo, Gambini, Juan, Borras, Consuelo, LLoret, Ana, Pallardo, Federico V., Viña, Jose · 2010 · Brain Research
45. Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease
    Mota, Sandra I., Costa, Rui O., Ferreira, Ildete L., Santana, Isabel, Caldeira, Gladys L., Padovano, Carmela, Fonseca, Ana C., Baldeiras, Inês, Cunha, Catarina, Letra, Liliana et al. · 2015 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
46. Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid β peptides but not on plaque formation
    Buttini, Manuel, Yu, Gui-Qiu, Shockley, Kristina, Huang, Yadong, Jones, Brian, Masliah, Eliezer, Mallory, Margaret, Yeo, Tracy, Longo, Frank M., Mucke, Lennart · 2002 · The Journal of Neuroscience
47. Reactive glia show increased immunoproteasome activity in Alzheimer’s disease
    Orre, Marie, Kamphuis, Willem, Dooves, Stephanie, Kooijman, Lieneke, Chan, Elena T., Kirk, Christopher J., Dimayuga Smith, Vanessa, Koot, Sanne, Mamber, Carlyn, Jansen, Anne H. et al. · 2013 · Brain
48. A <i>β</i> 42 and A <i>β</i> 40: similarities and differences
    Qiu, Tian, Liu, Qian, Chen, Yong‐Xiang, Zhao, Yu‐Fen, Li, Yan‐Mei · 2015 · Journal of Peptide Science
49. Lewy Body Pathology in Alzheimer's Disease
    Kotzbauer, Paul T., Tojanowski, John Q., Lee, Virginia M. V. · 2001 · Journal of Molecular Neuroscience
50. Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model
    Wirths, Oliver, Breyhan, Henning, Cynis, Holger, Schilling, Stephan, Demuth, Hans-Ulrich, Bayer, Thomas A. · 2009 · Acta Neuropathologica
51. N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits
    Bouter, Yvonne, Dietrich, Katharina, Wittnam, Jessica L., Rezaei-Ghaleh, Nasrollah, Pillot, Thierry, Papot-Couturier, Sophie, Lefebvre, Thomas, Sprenger, Frederick, Wirths, Oliver, Zweckstetter, Markus et al. · 2013 · Acta Neuropathologica
52. Resveratrol Brain Delivery for Neurological Disorders Prevention and Treatment
    Andrade, Stephanie, Ramalho, Maria João, Pereira, Maria do Carmo, Loureiro, Joana A. · 2018 · Frontiers in Pharmacology
53. Neurocognitive Effect of Nootropic Drug &lt;b&gt;&lt;i&gt;Brahmi&lt;/i&gt;&lt;/b&gt; (&lt;b&gt;&lt;i&gt;Bacopa monnieri&lt;/i&gt;&lt;/b&gt;) in Alzheimer's Disease
    Chaudhari, Kaustubh S., Tiwari, Nishant R., Tiwari, Rakesh R., Sharma, Rohan S. · 2017 · Annals of Neurosciences
54. Role of Phosphatidylinositol Clathrin Assembly Lymphoid-Myeloid Leukemia (PICALM) in Intracellular Amyloid Precursor Protein (APP) Processing and Amyloid Plaque Pathogenesis
    Xiao, Qingli, Gil, So-Chon, Yan, Ping, Wang, Yan, Han, Sharon, Gonzales, Ernie, Perez, Ronaldo, Cirrito, John R., Lee, Jin-Moo · 2012 · Journal of Biological Chemistry
55. Subcellular Topography of Neuronal Aβ Peptide in APPxPS1 Transgenic Mice
    Langui, Dominique, Girardot, Nadège, El Hachimi, Khalid Hamid, Allinquant, Bernadette, Blanchard, Véronique, Pradier, Laurent, Duyckaerts, Charles · 2004 · The American Journal of Pathology
56. Increased intraneuronal resting [Ca²⁺] in adult Alzheimer’s disease mice
    Lopez, José R., Lyckman, Alvin, Oddo, Salvatore, LaFerla, Frank M., Querfurth, Henry W., Shtifman, Alexander · 2008 · Journal of Neurochemistry
57. The Role of Cathepsin D in the Pathogenesis of Human Neurodegenerative Disorders
    Vidoni, Chiara, Follo, Carlo, Savino, Miriam, Melone, Mariarosa A. B., Isidoro, Ciro · 2016 · Medicinal Research Reviews
58. Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5Y<i>^APP+</i> Cells Through PPARγ Involvement
    Scuderi, Caterina, Steardo, Luca, Esposito, Giuseppe · 2014 · Phytotherapy Research
59. Astrocytic cytoskeletal atrophy in the medial prefrontal cortex of a triple transgenic mouse model of Alzheimer's disease
    Kulijewicz‐Nawrot, Magdalena, Verkhratsky, Alexei, Chvátal, Alexander, Syková, Eva, Rodríguez, José J. · 2012 · Journal of Anatomy
60. L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease
    Anekonda, Thimmappa S., Quinn, Joseph F., Harris, Christopher, Frahler, Kate, Wadsworth, Teri L., Woltjer, Randall L. · 2011 · Neurobiology of Disease
61. β-Amyloid precursor protein transgenic mice that harbor diffuse Aβ deposits but do not form plaques show increased ischemic vulnerability: Role of inflammation
    Koistinaho, Milla, Kettunen, Mikko I., Goldsteins, Gundars, Keinänen, Riitta, Salminen, Antero, Ort, Michael, Bures, Jan, Liu, David, Kauppinen, Risto A., Higgins, Linda S. et al. · 2002 · Proceedings of the National Academy of Sciences
62. Aβ-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Aβ pathology
    Fukami, Shinjiro, Watanabe, Kaori, Iwata, Nobuhisa, Haraoka, Jo, Lu, Bao, Gerard, Norma P., Gerard, Craig, Fraser, Paul, Westaway, David, George-Hyslop, Peter St. et al. · 2002 · Neuroscience Research
63. Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer’s disease
    Ahmed, T., Enam, S.A., Gilani, A.H. · 2010 · Neuroscience
64. Synthesis, Characterization, and Metal Coordinating Ability of Multifunctional Carbohydrate-Containing Compounds for Alzheimer's Therapy
    Storr, Tim, Merkel, Michael, Song-Zhao, George X., Scott, Lauren E., Green, David E., Bowen, Meryn L., Thompson, Katherine H., Patrick, Brian O., Schugar, Harvey J., Orvig, Chris · 2007 · Journal of the American Chemical Society
65. The Role of Zinc in Alzheimer′s Disease
    Watt, Nicole T., Whitehouse, Isobel J., Hooper, Nigel M. · 2011 · International Journal of Alzheimer’s Disease
66. Tau Immunotherapy Modulates Both Pathological Tau and Upstream Amyloid Pathology in an Alzheimer's Disease Mouse Model
    Castillo-Carranza, Diana L., Guerrero-Muñoz, Marcos J., Sengupta, Urmi, Hernandez, Caterina, Barrett, Alan D.T., Dineley, Kelly, Kayed, Rakez · 2015 · The Journal of Neuroscience
67. Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease
    Kwak, Sang Su, Washicosky, Kevin J., Brand, Emma, von Maydell, Djuna, Aronson, Jenna, Kim, Susan, Capen, Diane E., Cetinbas, Murat, Sadreyev, Ruslan, Ning, Shen et al. · 2020 · Nature Communications
68. Effect of Curcumin-Associated and Lipid Ligand-Functionalized Nanoliposomes on Aggregation of the Alzheimer's Aβ Peptide
    Taylor, Mark, Moore, Susan, Mourtas, Spyridon, Niarakis, Anna, Re, Francesca, Zona, Cristiano, Ferla, Barbara La, Nicotra, Francesco, Masserini, Massimo, Antimisiaris, Sophia G. et al. · 2011 · Nanomedicine Nanotechnology Biology and Medicine
69. Rapid Microglial Response Around Amyloid Pathology after Systemic Anti-Aβ Antibody Administration in PDAPP Mice
    Koenigsknecht-Talboo, Jessica, Meyer-Luehmann, Melanie, Parsadanian, Maia, Garcia-Alloza, Monica, Finn, Mary Beth, Hyman, Bradley T., Bacskai, Brian J., Holtzman, David M. · 2008 · The Journal of Neuroscience
70. Amyloid beta-induced glycogen synthase kinase 3β phosphorylated VDAC1 in Alzheimer's disease: Implications for synaptic dysfunction and neuronal damage
    Reddy, P. Hemachandra · 2013 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
71. Can herbs provide a new generation of drugs for treating Alzheimer’s disease?
    Anekonda, Thimmappa S., Reddy, P. Hemachandra · 2005 · Brain Research Reviews
72. Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis
    Dedeoglu, Alpaslan, Cormier, Kerry, Payton, Sandra, Tseitlin, Katya A., Kremsky, Jonathan N., Lai, Li, Li, Xiaohua, Moir, Robert D., Tanzi, Rudolph E., Bush, Ashley I. et al. · 2004 · Experimental Gerontology
73. Cerebrovascular Dysfunction in Amyloid Precursor Protein Transgenic Mice: Contribution of Soluble and Insoluble Amyloid-β Peptide, Partial Restoration via γ-Secretase Inhibition
    Han, Byung Hee, Zhou, Meng-liang, Abousaleh, Fadi, Brendza, Robert P., Dietrich, Hans H., Koenigsknecht-Talboo, Jessica, Cirrito, John R., Milner, Eric, Holtzman, David M., Zipfel, Gregory J. · 2008 · The Journal of Neuroscience
74. Nobiletin, a Citrus Flavonoid, Improves Cognitive Impairment and Reduces Soluble Aβ Levels in a Triple Transgenic Mouse Model of Alzheimer’s Disease (3XTg-AD)
    Nakajima, Akira, Aoyama, Yuki, Shin, Eun-Joo, Nam, Yunsung, Kim, Hyoung-Chun, Nagai, Taku, Yokosuka, Akihito, Mimaki, Yoshihiro, Yokoi, Tsuyoshi, Ohizumi, Yasushi et al. · 2015 · Behavioural Brain Research
75. Biochemistry and Molecular Biology of Amyloid β‐Protein and the Mechanism of Alzheimer's Disease
    2008 · Handbook of Clinical Neurology
76. Impact of aging, Alzheimer's disease and Parkinson's disease on the blood-brain barrier transport of therapeutics
    Pan, Yijun, Nicolazzo, Joseph A. · 2018 · Advanced Drug Delivery Reviews
77. Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models
    Kostylev, Mikhail A., Kaufman, Adam C., Nygaard, Haakon B., Patel, Pujan, Haas, Laura T., Gunther, Erik C., Vortmeyer, Alexander, Strittmatter, Stephen M. · 2015 · Journal of Biological Chemistry
78. ALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy
    Wang, Shuyi, Wang, Lin, Qin, Xing, Turdi, Subat, Sun, Dongdong, Culver, Bruce, Reiter, Russel J., Wang, Xiaoming, Zhou, Hao, Ren, Jun · 2020 · Signal Transduction and Targeted Therapy
79. Drug development for alzheimer’s disease: Microglia induced neuroinflammation as a target
    Dong, Yuan, Li, Xiaoheng, Cheng, Jinbo, Hou, Lin · 2019 · International Journal of Molecular Sciences
80. Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein
    Venkataramani, Vivek, Rossner, Christian, Iffland, Lara, Schweyer, Stefan, Tamboli, Irfan Y., Walter, Jochen, Wirths, Oliver, Bayer, Thomas A. · 2010 · Journal of Biological Chemistry
81. Potential implications of endogenous aldehydes in β‐amyloid misfolding, oligomerization and fibrillogenesis
    Chen, Kun, Maley, Jason, Yu, Peter H. · 2006 · Journal of Neurochemistry
82. Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice
    Han, Byung Hee, Zhou, Meng-liang, Johnson, Andrew W., Singh, Itender, Liao, Fan, Vellimana, Ananth K., Nelson, James W., Milner, Eric, Cirrito, John R., Basak, Jacob et al. · 2015 · Proceedings of the National Academy of Sciences
83. Amyloid-β pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset
    Dionísio, Pedro A., Amaral, Joana D., Ribeiro, Maria F., Lo, Adrian C., D'Hooge, Rudi, Rodrigues, Cecília M.P. · 2015 · Neurobiology of Aging
84. Neuroprotective effects of ginseng protein on PI3K/Akt signaling pathway in the hippocampus of D -galactose/AlCl 3 inducing rats model of Alzheimer’s disease
    Li, Hongyan, Kang, Tingguo, Qi, Bin, Kong, Liang, Jiao, Yanan, Cao, Yang, Zhang, Jianghua, Yang, Jingxian · 2016 · Journal of Ethnopharmacology
85. Developing Effective Alzheimer’s Disease Therapies: Clinical Experience and Future Directions
    Elmaleh, David R., Farlow, Martin R., Conti, Peter S., Tompkins, Ronald G., Kundakovic, Ljiljana, Tanzi, Rudolph E. · 2019 · Journal of Alzheimer’s Disease
86. Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease
    Devi, Latha, Alldred, Melissa J, Ginsberg, Stephen D, Ohno, Masuo · 2010 · Molecular Brain
87. Restoration of dopamine release deficits during object recognition memory acquisition attenuates cognitive impairment in a triple transgenic mice model of Alzheimer’s disease
    Guzmán-Ramos, Kioko, Moreno-Castilla, Perla, Castro-Cruz, Monica, McGaugh, James L., Martínez-Coria, Hilda, LaFerla, Frank M., Bermúdez-Rattoni, Federico · 2012 · Learning &amp; Memory
88. Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain
    Arendash, Gary W, Lewis, Jada, Leighty, Ralph E, McGowan, Eileen, Cracchiolo, Jennifer R, Hutton, Mike, Garcia, Marcos F · 2004 · Brain Research
89. Reactivity of Apolipoprotein E4 and Amyloid β Peptide
    Ji, Zhong-Sheng, Müllendorff, Karin, Cheng, Irene H., Miranda, R. Dennis, Huang, Yadong, Mahley, Robert W. · 2006 · Journal of Biological Chemistry
90. Targeting innate immunity for neurodegenerative disorders of the central nervous system
    Andreasson, Katrin I., Bachstetter, Adam D., Colonna, Marco, Ginhoux, Florent, Holmes, Clive, Lamb, Bruce, Landreth, Gary, Lee, Daniel C., Low, Donovan, Lynch, Marina A. et al. · 2016 · Journal of Neurochemistry
91. Redox proteomic analysis of carbonylated brain proteins in mild cognitive impairment and early Alzheimer’s disease
    Sultana, Rukhsana, Perluigi, Marzia, Newman, Shelley F., Pierce, William M., Cini, Chiara, Coccia, Raffaella, Butterfield, D. Allan · 2010 · Antioxidants &amp; Redox Signaling
92. Methionine-35 of A <i>β</i> (1–42): Importance for Oxidative Stress in Alzheimer Disease
    Butterfield, D. Allan, Sultana, Rukhsana · 2011 · Journal of Amino Acids
93. Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease
    Marzolo, Maria-Paz, Bu, Guojun · 2009 · Seminars in Cell &amp; Developmental Biology
94. Combined administration of resolvin E1 and lipoxin A4 resolves inflammation in a murine model of Alzheimer's disease
    Kantarci, Alpdogan, Aytan, Nurgul, Palaska, Iro, Stephens, Danielle, Crabtree, Leah, Benincasa, Claudia, Jenkins, Bruce G., Carreras, Isabel, Dedeoglu, Alpaslan · 2018 · Experimental Neurology
95. Molecular Basis of Alzheimer’s Disease: Focus on Mitochondria
    Oliver, Darryll M.A., Reddy, P. Hemachandra · 2019 · Journal of Alzheimer s Disease
96. ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice
    Liraz, Ori, Boehm-Cagan, Anat, Michaelson, Daniel M · 2013 · Molecular Neurodegeneration
97. Increased Vulnerability of Brain Mitochondria in Diabetic (Goto-Kakizaki) Rats With Aging and Amyloid-β Exposure
    Moreira, Paula I., Santos, Maria S., Moreno, António M., Seiça, Raquel, Oliveira, Catarina R. · 2003 · Diabetes
98. Disease modifying therapy for AD?¹
    Golde, Todd E. · 2006 · Journal of Neurochemistry
99. Mitochondria-Division Inhibitor 1 Protects Against Amyloid-β induced Mitochondrial Fragmentation and Synaptic Damage in Alzheimer’s Disease
    Reddy, P. Hemachandra, Manczak, Maria, Yin, XiangLing · 2017 · Journal of Alzheimer s Disease
100. <i>In Vivo</i>Detection of Age- and Disease-Related Increases in Neuroinflammation by¹⁸F-GE180 TSPO MicroPET Imaging in Wild-Type and Alzheimer's Transgenic Mice
     Liu, Bin, Le, Kevin X., Park, Mi-Ae, Wang, Shuyan, Belanger, Anthony P., Dubey, Shipra, Frost, Jeffrey L., Holton, Peter, Reiser, Vladimir, Jones, Paul A. et al. · 2015 · The Journal of Neuroscience