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Cited by 669

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Serum Total Cholesterol, Apolipoprotein E {FC12}e4 Allele, and Alzheimer’s Disease

Notkola, Irma-Leena, Sulkava, Raimo, Pekkanen, Juha, Erkinjuntti, Timo, Ehnholm, Christian, Kivinen, Paula, Tuomilehto, Jaakko, Nissinen, Aulikki·1998·Neuroepidemiology
DOI 10.1159/000026149
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Abstract

The σ4 allele of the apolipoprotein E (apoE) is associated with Alzheimer’s disease (AD) and also with elevated serum total cholesterol and low-density lipoprotein levels. However, the interrelationships between apoE genotype, plasma cholesterol levels and AD risk have been studied very little. We examined the possible role of serum total cholesterol in the pathogenesis of AD in a population-based sample of 444 men, aged 70–89 years, who were survivors of the Finnish cohorts of the Seven Countries Study. Previous high serum cholesterol level (mean level ≥6.5 mmol/l) was a significant predictor of the prevalence of AD (odds ratio = 3.1; 95% confidence interval = 1.2, 8.5) after controlling for age and the presence of apoE σ4 allele. In men who subsequently developed AD the cholesterol level decreased before the clinical manifestations of AD. We conclude that high serum total cholesterol may be an independent risk factor for AD and some of the effect of the apoE σ4 allele on risk of AD might be mediated through high serum cholesterol.

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Crossref · 10.1159/000026149

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Metadata

Authors
Notkola, I.-L., Sulkava, R., Pekkanen, J., Erkinjuntti, T., Ehnholm, C., Kivinen, P., Tuomilehto, J., & Nissinen, A.
Venue
Neuroepidemiology
Publisher
S. Karger AG
Published
1998
Volume
17
Issue
1
Pages
14-20
ISSN
  • 0251-5350 (ISSN-L)
  • 1423-0208
DOI
10.1159/000026149
OpenAlex
W1993668532
Cited by
669
References
7
FWCI
10.93
Type
journal article
Language
en
Open access
closed

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