Cited by 458Treatment of Major DepressionAntioxidant Activity and Oxidative StressTryptophan and brain disorders

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Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors

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Khanzode, Suchet D., Dakhale, Ganesh N., Khanzode, Shruti S., Saoji, Anand, Palasodkar, R.·2003·Redox Report

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Abstract

There is evidence of derangement of oxidant and antioxidant defense systems in depression. The present study examined the effects of fluoxetine and citalopram, standard selective serotonin re-uptake inhibitors, on lipid peroxidation, superoxide dismutase (SOD) activity and ascorbic acid concentrations. For this, a prospective open-labeled, randomized design was utilized. Patients with major depression (n = 62) were compared with age- and sex-matched healthy volunteers (n = 40). There was a significant increase in serum SOD, serum MDA and decrease in plasma ascorbic acid levels in patients of major depression as compared to control subjects. The trend reversed significantly after treatment with fluoxetine and citalopram. Results indicate a greater reduction in oxidative stress with citalopram than fluoxetine. The Hamilton Rating Scale for Depression (HRSD) score also improved with fluoxetine and citalopram treatment. These findings indicate that major depression is associated with increased levels of serum SOD, serum MDA and decreased levels of plasma ascorbic acid. Treatment with fluoxetine and citalopram reversed these biochemical parameters. This study can be used as a predictor of drug response by fluoxetine and citalopram in major depression.

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“In fact, in MDD, while most of the authors have generally described decreased levels of GPX and increased levels of malondialdehyde (MDA), as a lipid peroxidation marker [123, 126], there are also controversies regarding the specific activity of some antioxidant enzymes such as SOD,whichwas reported to be decreased in…”
Result
Major Differences in Neurooxidative and Neuronitrosative Stress Pathways Between Major Depressive Disorder and Types I and II Bipolar Disorder
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Efficacy of vitamin C as an adjunct to fluoxetine therapy in pediatric major depressive disorder: a randomized, double-blind, placebo-controlled pilot study
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Major Depressive Disorder and Oxidative Stress: A Review of Peripheral and Genetic Biomarkers According to Clinical Characteristics and Disease Stages
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Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats
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The Association between Conventional Antidepressants and the Metabolic Syndrome
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Authors: Khanzode, S. D., Dakhale, G. N., Khanzode, S. S., Saoji, A., & Palasodkar, R.
Affiliations: Government Medical College (IN)
ORCID: Dakhale, Ganesh N.
Venue: Redox Report
Publisher: Informa UK Limited
Published: 2003-12
Volume: 8
Issue: 6
Pages: 365-370
ISSN: 1351-0002 (ISSN-L)
1743-2928
DOI: 10.1179/135100003225003393
OpenAlex: W2090999800
Cited by: 458
References: 27
Citations by year: 2026: 11 · 2025: 17 · 2024: 24 · 2023: 14 · 2022: 27 · 2021: 19 · 2020: 24 · 2019: 25 · 2018: 29 · 2017: 23 · 2016: 25 · 2015: 29 · 2014: 35 · 2013: 29 · 2012: 30
FWCI: 3.00
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Redox Report (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: major depressive disorder, oxidative stress, selective serotonin reuptake inhibitors, fluoxetine, citalopram, lipid peroxidation, malondialdehyde, superoxide dismutase, vitamin C, antioxidant defense, antidepressant response prediction
MeSH terms: Adult, Antioxidants, Ascorbic Acid, Depression, Female, Fluoxetine, Humans, Male, Malondialdehyde, Middle Aged, Prospective Studies, Superoxide Dismutase, Time Factors, Lipid Peroxidation, Citalopram, Selective Serotonin Reuptake Inhibitors, Oxidative Stress

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Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors

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