The DOI matches its Crossref record; 431 of the 431 references it cites were found in a registry or an index.
Brain corticosteroid receptor balance in health and disease
Abstract
In this review, we have described the function of MR and GR in hippocampal neurons. The balance in actions mediated by the two corticosteroid receptor types in these neurons appears critical for neuronal excitability, stress responsiveness, and behavioral adaptation. Dysregulation of this MR/GR balance brings neurons in a vulnerable state with consequences for regulation of the stress response and enhanced vulnerability to disease in genetically predisposed individuals. The following specific inferences can be made on the basis of the currently available facts. 1. Corticosterone binds with high affinity to MRs predominantly localized in limbic brain (hippocampus) and with a 10-fold lower affinity to GRs that are widely distributed in brain. MRs are close to saturated with low basal concentrations of corticosterone, while high corticosterone concentrations during stress occupy both MRs and GRs. 2. The neuronal effects of corticosterone, mediated by MRs and GRs, are long-lasting, site-specific, and conditional. The action depends on cellular context, which is in part determined by other signals that can activate their own transcription factors interacting with MR and GR. These interactions provide an impressive diversity and complexity to corticosteroid modulation of gene expression. 3. Conditions of predominant MR activation, i.e., at the circadian trough at rest, are associated with the maintenance of excitability so that steady excitatory inputs to the hippocampal CA1 area result in considerable excitatory hippocampal output. By contrast, additional GR activation, e.g., after acute stress, generally depresses the CA1 hippocampal output. A similar effect is seen after adrenalectomy, indicating a U-shaped dose-response dependency of these cellular responses after the exposure to corticosterone. 4. Corticosterone through GR blocks the stress-induced HPA activation in hypothalamic CRH neurons and modulates the activity of the excitatory and inhibitory neural inputs to these neurons. Limbic (e.g., hippocampal) MRs mediate the effect of corticosterone on the maintenance of basal HPA activity and are of relevance for the sensitivity or threshold of the central stress response system. How this control occurs is not known, but it probably involves a steady excitatory hippocampal output, which regulates a GABA-ergic inhibitory tone on PVN neurons. Colocalized hippocampal GRs mediate a counteracting (i.e., disinhibitory) influence. Through GRs in ascending aminergic pathways, corticosterone potentiates the effect of stressors and arousal on HPA activation. The functional interaction between these corticosteroid-responsive inputs at the level of the PVN is probably the key to understanding HPA dysregulation associated with stress-related brain disorders. 5. Fine-tuning of HPA regulation occurs through MR- and GR-mediated effects on the processing of information in higher brain structures. Under healthy conditions, hippocampal MRs are involved in processes underlying integration of sensory information, interpretation of environmental information, and execution of appropriate behavioral reactions. Activation of hippocampal GRs facilitates storage of information and promotes elimination of inadequate behavioral responses. These behavioral effects mediated by MR and GR are linked, but how they influence endocrine regulation is not well understood. 6. Dexamethasone preferentially targets the pituitary in the blockade of stress-induced HPA activation. The brain penetration of this synthetic glucocorticoid is hampered by the mdr1a P-glycoprotein in the blood-brain barrier. Administration of moderate amounts of dexamethasone partially depletes the brain of corticosterone, and this has destabilizing consequences for excitability and information processing. 7. The set points of HPA regulation and MR/GR balance are genetically programmed, but can be reset by early life experiences involving mother-infant interaction. 8. (ABSTRACT TRUNCATED)
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“While GRs are ubiquitously expressed throughout the brain, they are highly expressed in the hippocampus (De Kloet, Vreugdenhil, Oitzl, & Joels, 1998) and hypophysiotropic neurons of the PVN (Kovacs, Foldes, & Sawchenko, 2000; Sawchenko, 1987), two brain regions key to negative feedback.”
From Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity (2017) · cites this paper as De Kloet, Vreugdenhil, Oitzl, & Joels, 1998
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“Low cortisol concentrations during SWS-rich sleep benefit declarative memory consolidation by preventing activation of glucocorticoid receptors that mediate an inhibitory influence on hippocampal LTP and output from CA1 (648, 649, 666).”
From About Sleep's Role in Memory (2013) · cites this paper as [649]
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“Mineralocorticoid receptors have a much higher affinity (Kd = 0.5 nM) for CORT than do GRs (Kd =5.0 nM) (De Kloet, Veldhuis, Wagenaars, & Bergink, 1984; De Kloet, Vreugdenhil, Oitzl, & Joels, 1998)”
From Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity (2017) · cites this paper as De Kloet, Vreugdenhil, Oitzl, & Joels, 1998
In the citing paper
“Briefly, 11β-HSD type 1 generates the bioactive form (cortisol or corticosterone) from inactive 11-keto derivatives while 11β-HSD type 2 catalyzes the opposite reaction. Interestingly, 11-keto derivatives do not bind to CBG in plasma nor are expelled by the efflux pumps of the BBB. As a result, 11-keto-GCs reach the CNS more readily than the bioactive form. 11β-HSD type 1 is widely expressed by”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [66]
In the citing paper
“The binding affinity of cortisol is however 10-fold greater for the MR than the GR (66). MRs are thus heavily bound by basal/low levels of GCs while substantial ligation of GRs only occurs upon stress or when the highest ultraradian peaks are reached.”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [66]
In the citing paper
“CBG is a thermosensitive glycoprotein that binds up to 90% of circulating GCs in the bloodstream. The remaining 10% may also be associated to serum albumin. In consequence, the levels of free circulating GCs are usually about 5% (66, 67).”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [66]
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Citations
Cites
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292
The psychology of fear and stress
(1988) · Choice Reviews Online · doi:10.5860/choice.26-2399 · Cited by 3,133
Physiological functions of glucocorticoids in stress and their relation to pharmacological actions
MUNCK, A., GUYRE, P. M., & HOLBROOK, N. J. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-1-25 · Cited by 3,083
The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
Chrousos, G. P. (1992) · JAMA · doi:10.1001/jama.1992.03480090092034 · Cited by 2,689
Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580
The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation
Chrousos, G. P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322008 · Cited by 2,579
The role of the amygdala in fear and anxiety
Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357
The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis
Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1986) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.38.cp21 · Cited by 2,343
Flagged first, then by citations
Research works printed but not linked: 8
- Tausk, 1951, Das Hormon: Hat die Nebenniere tatsächlich eine Verteidigungsfunktion?, Organon International BV, The Netherlands, vol, 3, 1
- Sapolsky, 1992, Stress, The Aging Brain and the Mechanism of Neuron Death
- De Kloet, 1994, Ann NY Acad Sci
- Nichols, 1994, Gene products of corticosteroid action in hippocampus., Ann NY Acad Sci, 746, 145, 10.1111/j.1749-6632.1994.tb39225.x · DOI
- Sutanto, 1993, The role of GABA in the regulation of the stress response, In: Stanford CS, Salmon P (eds) Stress: From Synapse to Syndrome. Academic Press, New York, pp, 333
- Henry, 1977, A Sociobiologic Approach to Medicine
- Sutanto, 1989, Differential corticosteroid binding characteristics to the mineralocorticoid (type 1) and glucocorticoid (type 2) receptors in the brain of pharmacogenetically-selected apomorphine-susceptible and apomorphine-unsusceptible Wistar rats., Neurosci Res Commun, 5, 19
- Gerlach, 1972, Rat brain binds adrenal steroid hormone: radioautography of hippocampus., Science, 175, 1133, 10.1126/science.175.4026.1133 · DOI · Paper page
Cited by
Sorted by citations
Items 101–200 of 217
Zhou, Q., Hu, Y., Hua, Y., Hu, M., Luo, C., Han, X., Zhu, X., Wang, B., Xu, J., & Zhu, D. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04914.x · Cited by 225
Zou, W., Feng, R., & Yang, Y. (2018) · PLOS ONE · doi:10.1371/journal.pone.0197267 · Cited by 224
Role of adult hippocampal neurogenesis in stress resilience
Levone, B. R., Cryan, J. F., & O'Leary, O. F. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.11.003 · Cited by 218
Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder
Wittenborn, A. K., Rahmandad, H., Rick, J., & Hosseinichimeh, N. (2016) · Psychological Medicine · doi:10.1017/s0033291715002044 · Cited by 207
Cota, D., Steiner, M.-A., Marsicano, G., Cervino, C., Herman, J. P., Grübler, Y., Stalla, J., Pasquali, R., Lutz, B., Stalla, G. K., et al. (2007) · Endocrinology · doi:10.1210/en.2005-1649 · Cited by 205
Mineralocorticoid Receptor Function in Major Depression
Young, E. A., Lopez, J. F., Murphy-Weinberg, V., Watson, S. J., & Akil, H. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.1.24 · Cited by 204
Hippocampal volume reduction and HPA-system activity in major depression
Colla, M., Kronenberg, G., Deuschle, M., Meichel, K., Hagen, T., Bohrer, M., & Heuser, I. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.06.011 · Cited by 200
Stewart, M. G., Davies, H. A., Sandi, C., Kraev, I. V., Rogachevsky, V. V., Peddie, C. J., Rodriguez, J. J., Cordero, M. I., Donohue, H. S., Gabbott, P. L. A., et al. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.031 · Cited by 197
Glucocorticoids, chronic stress, and obesity
Dallman, M. F., Pecoraro, N. C., La Fleur, S. E., Warne, J. P., Ginsberg, A. B., Akana, S. F., Laugero, K. C., Houshyar, H., Strack, A. M., Bhatnagar, S., et al. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)53004-3 · Cited by 198
Arousal and cortisol interact in modulating memory consolidation in healthy young men.
Kuhlmann, S., & Wolf, O. T. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.1.217 · Cited by 194
Woody, E. Z., & Szechtman, H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.08.003 · Cited by 195
Do antidepressants regulate how cortisol affects the brain?
Pariante, C. M., Thomas, S. A., Lovestone, S., Makoff, A., & Kerwin, R. W. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.10.009 · Cited by 194
Alt, S. R., Turner, J. D., Klok, M. D., Meijer, O. C., Lakke, E. A. J. F., DeRijk, R. H., & Muller, C. P. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.09.001 · Cited by 184
Metyrapone as Additive Treatment in Major Depression: A Double-blind and Placebo-Controlled Trial
Jahn, H., Schick, M., Kiefer, F., Kellner, M., Yassouridis, A., & Wiedemann, K. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.12.1235 · Cited by 184
The neurobiology and neuroendocrinology of stress
McEwen, B. S. (2002) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(01)00009-0 · Cited by 184
Sánchez, M. M., Noble, P. M., Lyon, C. K., Plotsky, P. M., Davis, M., Nemeroff, C. B., & Winslow, J. T. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.032 · Cited by 178
Early life nutrition and neural plasticity
Georgieff, M. K., Brunette, K. E., & Tran, P. V. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000061 · Cited by 177
Impact of early adversity on glucocorticoid regulation and later mental disorders
Strüber, N., Strüber, D., & Roth, G. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.10.015 · Cited by 173
Neural Regulation of the Stress Response: The Many Faces of Feedback
Myers, B., McKlveen, J. M., & Herman, J. P. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9801-y · Cited by 175
“The MR has a very high affinity for endogenous GCs and regulates circadian secretory rhythms and ultradian pulsatility (de Kloet et al. 1998; de Kloet and Sarabdjitsingh 2008).”
Tata, D. A., & Anderson, B. J. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.09.008 · Cited by 173
“The rodent hippocampus has a high density of both GR and MR, whereas in primates the hippocampus has a high density of MR [9, 10].”
BackgroundKleiman, A., & Tuckermann, J. P. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.009 · Cited by 165
Differential effects of prenatal stress on the morphological maturation of hippocampal neurons
Fujioka, A., Fujioka, T., Ishida, Y., Maekawa, T., & Nakamura, S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.046 · Cited by 165
Obese men respond to cognitive but not to catabolic brain insulin signaling
Hallschmid, M., Benedict, C., Schultes, B., Born, J., & Kern, W. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803722 · Cited by 165
Andela, C. D., van Haalen, F. M., Ragnarsson, O., Papakokkinou, E., Johannsson, G., Santos, A., Webb, S. M., Biermasz, N. R., van der Wee, N. J. A., & Pereira, A. M. (2015) · European Journal of Endocrinology · doi:10.1530/eje-14-1101 · Cited by 164
Pariante, C. M., Makoff, A., Lovestone, S., Feroli, S., Heyden, A., Miller, A. H., & Kerwin, R. W. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704368 · Cited by 159
Dressle, R. J., Feige, B., Spiegelhalder, K., Schmucker, C., Benz, F., Mey, N. C., & Riemann, D. (2022) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2022.101588 · Cited by 161
Chocyk, A., Bobula, B., Dudys, D., Przyborowska, A., Majcher-Maślanka, I., Hess, G., & Wędzony, K. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12208 · Cited by 153
Pruessner, M., Pruessner, J. C., Hellhammer, D. H., Bruce Pike, G., & Lupien, S. J. (2007) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.12.007 · Cited by 150
Gee, D. G. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2021.21090944 · Cited by 148
The modulatory role of the lateral septum on neuroendocrine and behavioral stress responses
Singewald, G. M., Rjabokon, A., Singewald, N., & Ebner, K. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.213 · Cited by 149
Different responses to dexamethasone and prednisolone in the same depressed patients
Juruena, M. F., Cleare, A. J., Papadopoulos, A. S., Poon, L., Lightman, S., & Pariante, C. M. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0555-4 · Cited by 147
Glucocorticoid Receptor Function In Vitro in Patients with Major Depression
Pariante, C. M. (2004) · Stress · doi:10.1080/10253890500069650 · Cited by 147
Ladd, C. O., Thrivikraman, K. V., Huot, R. L., & Plotsky, P. M. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.12.004 · Cited by 145
Raff, H., Sharma, S. T., & Nieman, L. K. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c130035 · Cited by 141
Filipović, D., Todorović, N., Bernardi, R. E., & Gass, P. (2017) · Brain Structure and Function · doi:10.1007/s00429-016-1218-9 · Cited by 138
Donohue, H. S., Gabbott, P. L. A., Davies, H. A., Rodríguez, J. J., Cordero, M. I., Sandi, C., Medvedev, N. I., Popov, V. I., Colyer, F. M., Peddie, C. J., et al. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.072 · Cited by 139
Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study
Echouffo-Tcheugui, J. B., Conner, S. C., Himali, J. J., Maillard, P., DeCarli, C. S., Beiser, A. S., Vasan, R. S., & Seshadri, S. (2018) · Neurology · doi:10.1212/wnl.0000000000006549 · Cited by 139
Epigenetic programming of the HPA axis: Early life decides
Murgatroyd, C., & Spengler, D. (2011) · Stress · doi:10.3109/10253890.2011.602146 · Cited by 138
Serotonin regulates hippocampal glucocorticoid receptor expression via a 5-HT7 receptor
Laplante, P., Diorio, J., & Meaney, M. J. (2002) · Developmental Brain Research · doi:10.1016/s0165-3806(02)00550-3 · Cited by 135
Kudielka, B. M., Schmidt-Reinwald, A. K., Hellhammer, D. H., & Kirschbaum, C. (1999) · Neuroendocrinology · doi:10.1159/000054504 · Cited by 135
New insights regarding glucocorticoids, stress and gonadotropin suppression
BREEN, K., & KARSCH, F. (2006) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2006.03.335 · Cited by 131
Hypothalamic-pituitary – adrenal axis-feedback control
Keller‐Wood, M. (2015) · Comprehensive Physiology · doi:10.1002/cphy.c140065 · Cited by 131
Fenoglio, K. A., Chen, Y., & Baram, T. Z. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4080-05.2006 · Cited by 124
Armario, A. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.04.005 · Cited by 131
Inflammation and cortisol response in coronary artery disease
Nijm, J., & Jonasson, L. (2009) · Annals of Medicine · doi:10.1080/07853890802508934 · Cited by 128
Saaltink, D.-J., & Vreugdenhil, E. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1568-5 · Cited by 127
Self-citationOuellet-Morin, I., Boivin, M., Dionne, G., Lupien, S. J., Arsenault, L., Barr, R. G., Pérusse, D., & Tremblay, R. E. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.27 · Cited by 125
Vitlic, A., Lord, J. M., & Phillips, A. C. (2014) · AGE · doi:10.1007/s11357-014-9631-6 · Cited by 123
Conway-Campbell, B. L., McKenna, M. A., Wiles, C. C., Atkinson, H. C., de Kloet, E. R., & Lightman, S. L. (2007) · Endocrinology · doi:10.1210/en.2007-0585 · Cited by 125
Jaferi, A., & Bhatnagar, S. (2006) · Endocrinology · doi:10.1210/en.2005-1393 · Cited by 122
REM Sleep Rebound as an Adaptive Response to Stressful Situations
Suchecki, D., Tiba, P. A., & Machado, R. B. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00041 · Cited by 119
Early deprivation and home basal cortisol levels: a study of internationally adopted children
Kertes, D. A., Gunnar, M. R., Madsen, N. J., & Long, J. D. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000230 · Cited by 121
Hartmann, J., Bajaj, T., Klengel, C., Chatzinakos, C., Ebert, T., Dedic, N., McCullough, K. M., Lardenoije, R., Joëls, M., Meijer, O. C., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109185 · Cited by 119
Stress-induced mechanisms in mental illness: A role for glucocorticoid signalling
Cattaneo, A., & Riva, M. A. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.07.021 · Cited by 118
Effects of Cortisol Suppression on Sleep-Associated Consolidation of Neutral and Emotional Memory
Wagner, U., Degirmenci, M., Drosopoulos, S., Perras, B., & Born, J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.008 · Cited by 119
DeRijk, R. H., van Leeuwen, N., Klok, M. D., & Zitman, F. G. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.03.012 · Cited by 117
Zhu, L.-J., Liu, M.-Y., Li, H., Liu, X., Chen, C., Han, Z., Wu, H.-Y., Jing, X., Zhou, H.-H., Suh, H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097689 · Cited by 114
Milligan Armstrong, A., Porter, T., Quek, H., White, A., Haynes, J., Jackaman, C., Villemagne, V., Munyard, K., Laws, S. M., Verdile, G., et al. (2021) · Biological Reviews · doi:10.1111/brv.12750 · Cited by 116
Sarabdjitsingh, R. A., Conway-Campbell, B. L., Leggett, J. D., Waite, E. J., Meijer, O. C., de Kloet, E. R., & Lightman, S. L. (2010) · Endocrinology · doi:10.1210/en.2010-0832 · Cited by 116
Self-citationYoung, A. H. (2004) · Stress · doi:10.1080/10253890500069189 · Cited by 111
Russell, G. M., Henley, D. E., Leendertz, J., Douthwaite, J. A., Wood, S. A., Stevens, A., Woltersdorf, W. W., Peeters, B. W. M. M., Ruigt, G. S. F., White, A., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5332-09.2010 · Cited by 111
Genetic approaches to hypothalamic-pituitary-adrenal axis regulation
Arnett, M. G., Muglia, L. M., Laryea, G., & Muglia, L. J. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.215 · Cited by 105
Memory consolidation during sleep: Interactive effects of sleep stages and HPA regulation: Review
Wagner, U., & Born, J. (2008) · Stress · doi:10.1080/10253890701408822 · Cited by 107
Kolber, B. J., Wieczorek, L., & Muglia, L. J. (2008) · Stress · doi:10.1080/10253890701821081 · Cited by 106
Thrivikraman, K. V., Nemeroff, C. B., & Plotsky, P. M. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02405-7 · Cited by 105
The impact of treatment on HPA axis activity in unipolar major depression
McKay, M. S., & Zakzanis, K. K. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.07.012 · Cited by 103
On the role of corticotropin-releasing hormone receptors in anxiety and depression
Reul, J. M. H. M., & Holsboer, F. (2002) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2002.4.1/jreul · Cited by 103
“The cause for the aberrant—in most cases, hyperactive—HPA axis is presumably a hyperactive central CRH system (for review, see references 24, 30, and 69 to 71) and defunct brain and pituitary corticosteroid receptor systems.(66,72,73) Although it was more than a decade ago that a reduced CRH receptor density was found…”
BackgroundInfluentialGeracioti, T. D., Baker, D. G., Kasckow, J. W., Strawn, J. R., Jeffrey Mulchahey, J., Dashevsky, B. A., Horn, P. S., & Ekhator, N. N. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.12.012 · Cited by 103
Exercising our brains: how physical activity impacts synaptic plasticity in the dentate gyrus.
Christie, B. R., Eadie, B. D., Kannangara, T. S., Robillard, J. M., Shin, J., & Titterness, A. K. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8033-2 · Cited by 99
García-Bueno, B., Madrigal, J. L. M., Pérez-Nievas, B. G., & Leza, J. C. (2008) · Endocrinology · doi:10.1210/en.2007-0482 · Cited by 97
Roles for Oestrogen Receptor β in Adult Brain Function
Handa, R. J., Ogawa, S., Wang, J. M., & Herbison, A. E. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02206.x · Cited by 97
Cohen, H., Kaplan, Z., Kozlovsky, N., Gidron, Y., Matar, M. A., & Zohar, J. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02003.x · Cited by 94
Dexamethasone blocks sleep induced improvement of declarative memory
Plihal, W., Pietrowsky, R., & Born, J. (1999) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00080-8 · Cited by 90
Xing, G.-Q., Russell, S., Webster, M. J., & Post, R. M. (2004) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145703004000 · Cited by 91
Pariante, C. M., Kim, R. B., Makoff, A., & Kerwin, R. W. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705357 · Cited by 89
Sze, Y., & Brunton, P. J. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14615 · Cited by 85
Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress
Diz-Chaves, Y., Herrera-Pérez, S., González-Matías, L. C., Lamas, J. A., & Mallo, F. (2020) · Nutrients · doi:10.3390/nu12113304 · Cited by 84
Sex differences in the functional connectivity of the amygdalae in association with cortisol
Kogler, L., Müller, V. I., Seidel, E.-M., Boubela, R., Kalcher, K., Moser, E., Habel, U., Gur, R. C., Eickhoff, S. B., & Derntl, B. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.03.064 · Cited by 78
Localization of Mineralocorticoid Receptors at Mammalian Synapses
Prager, E. M., Brielmaier, J., Bergstrom, H. C., McGuire, J., & Johnson, L. R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014344 · Cited by 81
Extra-adrenal glucocorticoid synthesis: immune regulation and aspects on local organ homeostasis
Talabér, G., Jondal, M., & Okret, S. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.05.007 · Cited by 80
Wang, X., & DeFranco, D. B. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0383 · Cited by 77
The minimal model of the hypothalamic–pituitary–adrenal axis
Vinther, F., Andersen, M., & Ottesen, J. T. (2011) · Journal of Mathematical Biology · doi:10.1007/s00285-010-0384-2 · Cited by 72
Encoding and decoding mechanisms of pulsatile hormone secretion
Walker, J. J., Terry, J. R., Tsaneva‐Atanasova, K., Armstrong, S. P., McArdle, C. A., & Lightman, S. L. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02087.x · Cited by 78
Pariante, C. M., Hye, A., Williamson, R., Makoff, A., Lovestone, S., & Kerwin, R. W. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300195 · Cited by 70
Atkinson, H. C., Wood, S. A., Castrique, E. S., Kershaw, Y. M., Wiles, C. C. R., & Lightman, S. L. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00721.2007 · Cited by 68
Role of glucocorticoids in dopamine-related neuropsychiatric disorders
Craenenbroeck, K. V., Bosscher, K. D., Berghe, W. V., Vanhoenacker, P., & Haegeman, G. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.10.007 · Cited by 64
Wieck, A., Grassi-Oliveira, R., do Prado, C. H., Rizzo, L. B., de Oliveira, A. S., Kommers-Molina, J., Viola, T. W., Teixeira, A. L., & Bauer, M. E. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.07.005 · Cited by 63
Andersen, M., Vinther, F., & Ottesen, J. T. (2013) · Mathematical Biosciences · doi:10.1016/j.mbs.2013.08.010 · Cited by 56
Corticosteroids and cognition: a meta-analysis
Prado, C. E., & Crowe, S. F. (2019) · Neuropsychology Review · doi:10.1007/s11065-019-09405-8 · Cited by 58
Christiansen, S., Bouzinova, E. V., Palme, R., & Wiborg, O. (2012) · Stress · doi:10.3109/10253890.2011.654370 · Cited by 55
Model-based therapeutic correction of hypothalamic-pituitary-adrenal axis dysfunction
Ben-Zvi, A., Vernon, S. D., & Broderick, G. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000273 · Cited by 56
Huang, Y., Xu, H., Li, H., Yang, H., Chen, Y., & Shi, X. (2012) · BMC Neuroscience · doi:10.1186/1471-2202-13-22 · Cited by 55
Savas, M., Vinkers, C. H., Rosmalen, J. G. M., Hartman, C. A., Wester, V. L., van den Akker, E. L. T., Iyer, A. M., McEwen, B. S., & van Rossum, E. F. C. (2020) · Neuroendocrinology · doi:10.1159/000501617 · Cited by 55
Arnett, M. G., Kolber, B. J., Boyle, M. P., & Muglia, L. J. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.011 · Cited by 53
Exogenous glucocorticoids and adverse cerebral effects in children
Damsted, S. K., Born, A. P., Paulson, O. B., & Uldall, P. (2011) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2011.05.002 · Cited by 51
Modeling the hypothalamus-pituitary-adrenal axis: A review and extension
Hosseinichimeh, N., Rahmandad, H., & Wittenborn, A. K. (2015) · Mathematical Biosciences · doi:10.1016/j.mbs.2015.08.004 · Cited by 51
“There are two other negative feedback loops that are mediated through the binding of cortisol to GRs in the pituitary, and to MRs in the hippocampus which inhibit the secretion of ACTH and CRH respectively (2, 6).”
BackgroundHope, L., Blocksidge, D., Gabbert, F., Sauer, J. D., Lewinski, W., Mirashi, A., & Atuk, E. (2016) · Law and Human Behavior · doi:10.1037/lhb0000159 · Cited by 49
Choy, K. H. C., & van den Buuse, M. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.03.011 · Cited by 47
Aschbacher, K., Rodriguez-Fernandez, M., van Wietmarschen, H., Tomiyama, A. J., Jain, S., Epel, E., Doyle, F. J., & van der Greef, J. (2014) · Interface Focus · doi:10.1098/rsfs.2014.0020 · Cited by 48
Yau, J. L. W., Noble, J., Thomas, S., Kerwin, R., Morgan, P. E., Lightman, S., Seckl, J. R., & Pariante, C. M. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301389 · Cited by 46
Metadata
- Authors
- de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M.
- Affiliations
- Division of Medical Pharmacology (E.R.D.K., E.V., M.S.O.), Leiden/Amsterdam Center for Drug Research, University of Leiden, 2300 RA Leiden, The Netherlands;
- Leiden University (NL)
- Institute for Neurobiology (M.J.), University of Amsterdam, 1098 SM Amsterdam, The Netherlands
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 1998-06-01
- Volume
- 19
- Issue
- 3
- Pages
- 269-301
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2171238991
- Cited by
- 2,614
- References
- 431
- Citations by year
- 2026: 11 · 2025: 38 · 2024: 53 · 2023: 60 · 2022: 69 · 2021: 74 · 2020: 78 · 2019: 70 · 2018: 60 · 2017: 90 · 2016: 86 · 2015: 99 · 2014: 139 · 2013: 128 · 2012: 132
- FWCI
- 8.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine Reviews (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- European Commission (BRST960179)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Internationale Stichting Alzheimer Onderzoek
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- mineralocorticoid receptor, glucocorticoid receptor, corticosterone, hippocampal neurons, neuronal excitability, stress response, hypothalamic-pituitary-adrenal axis, paraventricular nucleus, GABAergic inhibition, adrenalectomy, circadian rhythm, gene expression regulation, neuroendocrine adaptation, limbic system
- MeSH terms
- Adrenal Cortex Hormones, Aging, Brain, Brain Diseases, Health, Humans, Receptors, Steroid, Stress, Physiological
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