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Development of the human placenta

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Turco, Margherita Y., Moffett, Ashley·2019·Development

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Abstract

The placenta is essential for normal in utero development in mammals. In humans, defective placental formation underpins common pregnancy disorders such as pre-eclampsia and fetal growth restriction. The great variation in placental types across mammals means that animal models have been of limited use in understanding human placental development. However, new tools for studying human placental development, including 3D organoids, stem cell culture systems and single cell RNA sequencing, have brought new insights into this field. Here, we review the morphological, molecular and functional aspects of human placental formation, with a focus on the defining cell of the placenta – the trophoblast.

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Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors Driving Pathogenesis of SARS-CoV-2
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See all 698

Authors: Turco, M. Y., & Moffett, A.
Venue: Development
Publisher: The Company of Biologists
Published: 2019-11-15
Volume: 146
Issue: 22
ISSN: 0950-1991 (ISSN-L)
1477-9129
DOI: 10.1242/dev.163428
OpenAlex: W2990237704
Cited by: 698
References: 193
FWCI: 59.53
Type: journal article
Language: en
Open access: hybrid
Licence: creativecommons.org/licenses/by/4.0 (vor, 451 d)
Funders: Wellcome Trust (200841/Z/16/Z)
Medical Research Council (MR/P001092/1)
Royal Society (DH160216 RGF\R1\180028)

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