Cited by 107Treatment of Major DepressionTryptophan and brain disordersSchizophrenia research and treatment

The DOI matches its Crossref record; 252 of the 252 references it cites were found in a registry or an index.

Cognitive Dysfunction in Depression – Pathophysiology and Novel Targets

Open access

Carvalho, Andre, Miskowiak, Kamilla, Hyphantis, Thomas, Kohler, Cristiano, Alves, Gilberto, Bortolato, Beatrice, G. Sales, Paulo, Machado-Vieira, Rodrigo, Berk, Michael, McIntyre, Roger·2015·CNS & Neurological Disorders - Drug Targets

DOI 10.2174/1871527313666141130203627

Open this paper in CoChat — free account

Abstract

Major depressive disorder (MDD) is associated with cognitive dysfunction encompassing several domains, including memory, executive function, processing speed and attention. Cognitive deficits persist in a significant proportion of patients even in remission, compromising psychosocial functioning and workforce performance. While monoaminergic antidepressants may improve cognitive performance in MDD, most antidepressants have limited clinical efficacy. The overarching aims of this review were: (1) to synthesize extant literature on putative biological pathways related to cognitive dysfunction in MDD and (2) to review novel neurotherapeutic targets for cognitive enhancement in MDD. We found that reciprocal and overlapping biological pathways may contribute to cognitive dysfunction in MDD, including an hyperactive hypothalamic-pituitary-adrenal axis, an increase in oxidative and nitrosative stress, inflammation (e.g., enhanced production of pro-inflammatory cytokines), mitochondrial dysfunction, increased apoptosis as well as a diminished neurotrophic support. Several promising neurotherapeutic targets were identified such as minocycline, statins, anti-inflammatory compounds, N-acetylcysteine, omega-3 poliunsaturated fatty acids, erythropoietin, thiazolidinediones, glucagon-like peptide-1 analogues, S-adenosyl-l-methionine (SAMe), cocoa flavonols, creatine monohydrate and lithium. Erythropoietin and SAMe had pro-cognitive effects in randomized controlled trials (RCT) involving MDD patients. Despite having preclinical and/or preliminary evidences from trials suggesting possible efficacy as novel cognitive enhancing agents for MDD, no RCT to date was performed for most of the other therapeutic targets reviewed herein. In conclusion, multiple biological pathways are involved in cognitive dysfunction in MDD. RCTs testing genuinely novel pro-cognitive compounds for MDD are warranted.

Integrity signals

Registry

Crossref · 10.2174/1871527313666141130203627

Cites

252 of 252 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

3 retracted

Retracted : Depression as a risk factor for dementia and mild cognitive impairment: a meta‐analysis of longitudinal studies
Gao, Y., Changquan, H., Zhao, K., Ma, L., Qiu, X., Zhang, L., Xiu, Y., Chen, L., Lü, W., Huang, C., et al. (2012) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3845 · Cited by 165
Retracted
RETRACTED: Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia
Bhattacharya, P., Pandey, A. K., Paul, S., & Patnaik, R. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.01.085 · Cited by 52
Retracted
Minocycline is cytoprotective in human trabecular meshwork cells and optic nerve head astrocytes by increasing expression of XIAP, survivin, and Bcl-2
Kernt, M. (2010) · Clinical ophthalmology · doi:10.2147/opth.s11216 · Cited by 34
Retracted
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice
Trivedi, M. H., Rush, A. J., Wisniewski, S. R., Nierenberg, A. A., Warden, D., Ritz, L., Norquist, G., Howland, R. H., Lebowitz, B., McGrath, P. J., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.28 · Cited by 3,879
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009
The Epidemiology of Depression Across Cultures
Kessler, R. C., & Bromet, E. J. (2013) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-031912-114409 · Cited by 2,657
The Corticosteroid Receptor Hypothesis of Depression
Holsboer, F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00159-7 · Cited by 2,181
Diathesis-stress theories in the context of life stress research: implications for the depressive disorders
Monroe, S. M., & Simons, A. D. (1991) · Psychological Bulletin · doi:10.1037/0033-2909.110.3.406 · Cited by 2,143
Hippocampal volume and depression: a meta-analysis of MRI studies
Videbech, P., & Ravnkilde, B. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.1957 · Cited by 1,590
Neurogenesis in the Dentate Gyrus of the Adult Tree Shrew Is Regulated by Psychosocial Stress and NMDA Receptor Activation
Gould, E., McEwen, B. S., Tanapat, P., Galea, L. A. M., & Fuchs, E. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02492.1997 · Cited by 1,496
Depression and Risk for Alzheimer Disease: Systematic Review, Meta-analysis, and Metaregression Analysis
Ownby, R. L., Crocco, E., Acevedo, A., John, V., & Loewenstein, D. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.5.530 · Cited by 1,493
Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients
Nemeroff, C. B., Widerlöv, E., Bissette, G., Walléus, H., Karlsson, I., Eklund, K., Kilts, C. D., Loosen, P. T., & Vale, W. (1984) · Science · doi:10.1126/science.6334362 · Cited by 1,485
Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus
Smith, M., Makino, S., Květňanský, R., & Post, R. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-01768.1995 · Cited by 1,449
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., Pace, T. W. W., Mercer, K. B., Mayberg, H. S., Bradley, B., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3275 · Cited by 1,447
Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses
Oberlander, T. F., Weinberg, J., Papsdorf, M., Grunau, R., Misri, S., & Devlin, A. M. (2008) · Epigenetics · doi:10.4161/epi.3.2.6034 · Cited by 1,432
So depression is an inflammatory disease, but where does the inflammation come from?
Berk, M., Williams, L. J., Jacka, F. N., O’Neil, A., Pasco, J. A., Moylan, S., Allen, N. B., Stuart, A. L., Hayley, A. C., Byrne, M. L., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-200 · Cited by 1,423
Self-citation
Cost of Lost Productive Work Time Among US Workers With Depression
Stewart, W. F. (2003) · JAMA · doi:10.1001/jama.289.23.3135 · Cited by 1,421
iNOS-mediated nitric oxide production and its regulation
Aktan, F. (2004) · Life Sciences · doi:10.1016/j.lfs.2003.10.042 · Cited by 1,385
Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits
Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09101452 · Cited by 1,346
Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013
Yatham, L. N., Kennedy, S. H., Parikh, S. V., Schaffer, A., Beaulieu, S., Alda, M., O’Donovan, C., MacQUEEN, G. M., McIntyre, R. S., Sharma, V., et al. (2012) · Bipolar Disorders · doi:10.1111/bdi.12025 · Cited by 1,230
Self-citation
When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders
Raison, C. L., & Miller, A. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.9.1554 · Cited by 1,197
Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
Pariante, C. M., & Miller, A. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01088-x · Cited by 1,147
The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course
McEwen, B. S., & Morrison, J. H. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.028 · Cited by 1,079
A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression
Brunoni, A. R., Lopes, M., & Fregni, F. (2008) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009309 · Cited by 972
Interleukin (IL)-6, Tumour Necrosis Factor Alpha (TNF-α) and Soluble Interleukin-2 Receptors (SIL-2R) Are Elevated in Patients with Major Depressive Disorder: A Meta-Analysis and Meta-Regression
Liu, Y., Ho, R. C.-M., & Mak, A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.003 · Cited by 948
Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis
Cipriani, A., Hawton, K., Stockton, S., & Geddes, J. R. (2013) · BMJ · doi:10.1136/bmj.f3646 · Cited by 920 · cited 1×
“Lithium also is an effective augmenting agent for treatmentresistant depression [253], and evidences indicate its effectiveness for suicide prevention among populations with mood disorders [254].”
Background
The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression
Maes, M., Yirmyia, R., Noraberg, J., Brene, S., Hibbeln, J., Perini, G., Kubera, M., Bob, P., Lerer, B., & Maj, M. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-008-9118-1 · Cited by 894
Chronic Stress Causes Frontostriatal Reorganization and Affects Decision-Making
Dias-Ferreira, E., Sousa, J. C., Melo, I., Morgado, P., Mesquita, A. R., Cerqueira, J. J., Costa, R. M., & Sousa, N. (2009) · Science · doi:10.1126/science.1171203 · Cited by 858
Cytokine, Sickness Behavior, and Depression
Dantzer, R. (2009) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2009.02.002 · Cited by 789
COGNITIVE DEFICITS AND FUNCTIONAL OUTCOMES IN MAJOR DEPRESSIVE DISORDER: DETERMINANTS, SUBSTRATES, AND TREATMENT INTERVENTIONS: Review: Cognitive Deficits and Functional Outcomes in MDD
McIntyre, R. S., Cha, D. S., Soczynska, J. K., Woldeyohannes, H. O., Gallaugher, L. A., Kudlow, P., Alsuwaidan, M., & Baskaran, A. (2013) · Depression and Anxiety · doi:10.1002/da.22063 · Cited by 765
Self-citation
Gray matter abnormalities in major depressive disorder: A meta-analysis of voxel based morphometry studies
Bora, E., Fornito, A., Pantelis, C., & Yücel, M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.03.049 · Cited by 763
Acute cortisone administration impairs retrieval of long-term declarative memory in humans
de Quervain, D. J.-F., Roozendaal, B., Nitsch, R. M., McGaugh, J. L., & Hock, C. (2000) · Nature Neuroscience · doi:10.1038/73873 · Cited by 745
A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder
McKinnon, M. C., Yucel, K., Nazarov, A., & MacQueen, G. M. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0905 · Cited by 742
Inflammation-associated depression: From serotonin to kynurenine
Dantzer, R., O’Connor, J. C., Lawson, M. A., & Kelley, K. W. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.09.012 · Cited by 726
The Genetics of Major Depression
Flint, J., & Kendler, K. S. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.027 · Cited by 724
Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484)
Molendijk, M. L., Spinhoven, P., Polak, M., Bus, B. A. A., Penninx, B. W. J. H., & Elzinga, B. M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.105 · Cited by 702 · cited 1×
“However, this has not been a universal finding across studies [172].”
Background
The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression
Maes, M., Leonard, B. E., Myint, A. M., Kubera, M., & Verkerk, R. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.12.017 · Cited by 700
The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death
Sapolsky, R. M. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00971-9 · Cited by 699
Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis
Kreisel, T., Frank, M. G., Licht, T., Reshef, R., Ben-Menachem-Zidon, O., Baratta, M. V., Maier, S. F., & Yirmiya, R. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.155 · Cited by 663
Repeated Stress Causes Cognitive Impairment by Suppressing Glutamate Receptor Expression and Function in Prefrontal Cortex
Yuen, E. Y., Wei, J., Liu, W., Zhong, P., Li, X., & Yan, Z. (2012) · Neuron · doi:10.1016/j.neuron.2011.12.033 · Cited by 558
Glucocorticoids, cytokines and brain abnormalities in depression
Zunszain, P. A., Anacker, C., Cattaneo, A., Carvalho, L. A., & Pariante, C. M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.04.011 · Cited by 554
Erythropoietin Gene Expression in Human, Monkey and Murine Brain
Marti, H. H., Wenger, R. H., Rivas, L. A., Straumann, U., Oigicaylioglu, M., Henn, V. S., Yonekawa, Y., Bauer, C., & Gassmann, M. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01252.x · Cited by 553
Cognitive impairment in euthymic major depressive disorder: a meta-analysis
Bora, E., Harrison, B. J., Yücel, M., & Pantelis, C. (2013) · Psychological Medicine · doi:10.1017/s0033291712002085 · Cited by 551
Decreased memory performance in healthy humans induced by stress-level cortisol treatment
Newcomer, J. W. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.6.527 · Cited by 546
Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression
Maes, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.014 · Cited by 544
The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications
Moylan, S., Maes, M., Wray, N. R., & Berk, M. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.33 · Cited by 529
Self-citation
The neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519
Neurocognitive impairment in drug-free patients with major depressive disorder
Porter, R. J., Gallagher, P., Thompson, J. M., & Young, A. H. (2003) · British Journal of Psychiatry · doi:10.1192/bjp.182.3.214 · Cited by 519
Polyunsaturated fatty acids are potent neuroprotectors
Lauritzen, I., Blondeau, N., Heurteaux, C., Widmann, C., Romey, G., & Lazdunski, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.8.1784 · Cited by 500
Magnetic resonance imaging studies in unipolar depression: Systematic review and meta-regression analyses
Arnone, D., McIntosh, A. M., Ebmeier, K. P., Munafò, M. R., & Anderson, I. M. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.05.003 · Cited by 495
Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative-antioxidative systems
Sarandol, A., Sarandol, E., Eker, S. S., Erdinc, S., Vatansever, E., & Kirli, S. (2007) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.829 · Cited by 486
Potential Mechanisms of Action of Lithium in Bipolar Disorder
Malhi, G. S., Tanious, M., Das, P., Coulston, C. M., & Berk, M. (2013) · CNS Drugs · doi:10.1007/s40263-013-0039-0 · Cited by 484
Self-citation
Neurocognitive deficits and disability in major depressive disorder
Jaeger, J., Berns, S., Uzelac, S., & Davis-Conway, S. (2006) · Psychiatry Research · doi:10.1016/j.psychres.2005.11.011 · Cited by 484
Hippocampal volume, memory, and cortisol status in major depressive disorder: Effects of treatment
Vythilingam, M., Vermetten, E., Anderson, G. M., Luckenbaugh, D., Anderson, E. R., Snow, J., Staib, L. H., Charney, D. S., & Bremner, J. D. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.04.002 · Cited by 477
Cytokines as mediators of depression: what can we learn from animal studies?
Dunn, A. J., Swiergiel, A. H., & Beaurepaire, R. D. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.023 · Cited by 459
Role of Omega-3 Fatty Acids in the Treatment of Depressive Disorders: A Comprehensive Meta-Analysis of Randomized Clinical Trials
Grosso, G., Pajak, A., Marventano, S., Castellano, S., Galvano, F., Bucolo, C., Drago, F., & Caraci, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096905 · Cited by 449
Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor
Anacker, C., Zunszain, P. A., Cattaneo, A., Carvalho, L. A., Garabedian, M. J., Thuret, S., Price, J., & Pariante, C. M. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.26 · Cited by 435
A randomized, double-blind, placebo-controlled study of vortioxetine on cognitive function in depressed adults
McIntyre, R. S., Lophaven, S., & Olsen, C. K. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000546 · Cited by 433
Self-citation
N -acetylcysteine for antioxidant therapy: pharmacology and clinical utility
Dodd, S., Dean, O., Copolov, D. L., Malhi, G. S., & Berk, M. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14728220802517901 · Cited by 413
Self-citation
Oxidative & nitrosative stress in depression: Why so much stress?
Moylan, S., Berk, M., Dean, O. M., Samuni, Y., Williams, L. J., O'Neil, A. E., Hayley, A. C., Pasco, J. A., Anderson, G., Jacka, F. N., et al. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.05.007 · Cited by 412
Self-citation
Cognitive impairment in the remitted state of unipolar depressive disorder: A systematic review
Hasselbalch, B. J., Knorr, U., & Kessing, L. V. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.11.011 · Cited by 406
Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex
Zhou, W., Wang, N., Yang, C., Li, X.-M., Zhou, Z.-Q., & Yang, J.-J. (2014) · European Psychiatry · doi:10.1016/j.eurpsy.2013.10.005 · Cited by 390
A Double-Blind, Randomized Study of Minocycline for the Treatment of Negative and Cognitive Symptoms in Early-Phase Schizophrenia
Levkovitz, Y., Mendlovich, S., Riwkes, S., Braw, Y., Levkovitch-Verbin, H., Gal, G., Fennig, S., Treves, I., & Kron, S. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04666yel · Cited by 387
Cytokine–serotonin interaction through IDO: a neurodegeneration hypothesis of depression
Myint, A.-M., & Kim, Y. K. (2003) · Medical Hypotheses · doi:10.1016/s0306-9877(03)00207-x · Cited by 387
Child maltreatment and HPA axis dysregulation: relationship to major depressive disorder and post traumatic stress disorder in females
Shea, A., Walsh, C., MacMillan, H., & Steiner, M. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.07.001 · Cited by 378
Neuropsychological dysfunction in depressed suicide attempters
Keilp, J. G., Sackeim, H. A., Brodsky, B. S., Oquendo, M. A., Malone, K. M., & Mann, J. J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.5.735 · Cited by 372
Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mrna and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation
Ladd, C. O., Huot, R. L., Thrivikraman, K. V., Nemeroff, C. B., & Plotsky, P. M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.10.007 · Cited by 368
HPA axis and aging in depression: Systematic review and meta-analysis
Belvederi Murri, M., Pariante, C., Mondelli, V., Masotti, M., Atti, A. R., Mellacqua, Z., Antonioli, M., Ghio, L., Menchetti, M., Zanetidou, S., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.12.004 · Cited by 367
Functions and dysfunctions of adult hippocampal neurogenesis
Christian, K. M., Song, H., & Ming, G.-L. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014134 · Cited by 362
A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder
Khairova, R. A., Machado-Vieira, R., Du, J., & Manji, H. K. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709009924 · Cited by 350
Self-citation
Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy
Liu, R.-J., & Aghajanian, G. K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706679105 · Cited by 346
Chronic Stress Induced Remodeling of the Prefrontal Cortex: Structural Re-Organization of Microglia and the Inhibitory Effect of Minocycline
Hinwood, M., Tynan, R. J., Charnley, J. L., Beynon, S. B., Day, T. A., & Walker, F. R. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs151 · Cited by 336
Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling
McEwen, B. S. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05568.x · Cited by 335
Decreased plasma BDNF level in depressive patients
Lee, B.-H., Kim, H., Park, S., & Kim, Y. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.11.005 · Cited by 327
Adenosine Deaminase, Nitric Oxide, Superoxide Dismutase, and Xanthine Oxidase in Patients with Major Depression: Impact of Antidepressant Treatment
Herken, H., Gurel, A., Selek, S., Armutcu, F., Ozen, M. E., Bulut, M., Kap, O., Yumru, M., Savas, H. A., & Akyol, O. (2007) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.10.005 · Cited by 322
Kindling and sensitization as models for affective episode recurrence, cyclicity, and tolerance phenomena
Post, R. M. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.04.003 · Cited by 312
Sex Differences in the Pathways to Major Depression: A Study of Opposite-Sex Twin Pairs
Kendler, K. S., & Gardner, C. O. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13101375 · Cited by 307
Interferon-Induced Depression in Chronic Hepatitis C: A Systematic Review and Meta-Analysis
Udina, M., Castellví, P., Moreno-España, J., Navinés, R., Valdés, M., Forns, X., Langohr, K., Solà, R., Vieta, E., & Martín-Santos, R. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12r07694 · Cited by 297
S -Adenosyl Methionine (SAMe) Augmentation of Serotonin Reuptake Inhibitors for Antidepressant Nonresponders With Major Depressive Disorder: A Double-Blind, Randomized Clinical Trial
Papakostas, G. I., Mischoulon, D., Shyu, I., Alpert, J. E., & Fava, M. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09081198 · Cited by 297
The biological and psychological basis of neuroticism: Current status and future directions
Ormel, J., Bastiaansen, J. A., Riese, H., Bos, E. H., Servaas, M. N., Ellenbogen, M. A., Rosmalen, J. G. M., & Aleman, A. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.09.004 · Cited by 288
Gene–environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism
Zannas, A. S., & Binder, E. B. (2013) · Genes Brain & Behavior · doi:10.1111/gbb.12104 · Cited by 286
Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects
Neumeister, A., Wood, S. E., Bonne, O. B., Nugent, A. C., Luckenbaugh, D. A., Young, T. A., Bain, E., Charney, D. S., & Drevets, W. C. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.016 · Cited by 285
Adrenal Gland Enlargement in Major Depression: A Computed Tomographic Study
Nemeroff, C. B. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820050048008 · Cited by 283
Depression and Oxidative Stress: Results From a Meta-Analysis of Observational Studies
Palta, P., Samuel, L. J., Miller, E. R., & Szanton, S. L. (2014) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000009 · Cited by 277
Stress System – Organization, Physiology and Immunoregulation
Elenkov, I. J., & Chrousos, G. P. (2006) · NeuroImmunoModulation · doi:10.1159/000104853 · Cited by 276
Alterations of mitochondrial function and correlations with personality traits in selected major depressive disorder patients
Gardner, A. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00067-8 · Cited by 272
Early-life stress and HPA axis trigger recurrent adulthood depression
Juruena, M. F. (2013) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2013.10.020 · Cited by 270
Depression‐related disturbances in mitogen‐induced lymphocyte responses and interleukin‐1β and soluble interleukin‐2 receptor production
Maes, M., Bosmans, E., Suy, E., Vandervorst, C., DeJonckheere, C., & Raus, J. (1991) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1991.tb03163.x · Cited by 268 · cited 1×
“Furthermore, GR resistance in depression may be mediated by IL-2 and IL-1β [95].”
Background
Neuroinflammation, Neurodegeneration, and Depression
Hurley, L. L., & Tizabi, Y. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9348-1 · Cited by 264
Interaction of FKBP5 Gene Variants and Adverse Life Events in Predicting Depression Onset: Results From a 10-Year Prospective Community Study
Zimmermann, P., Brückl, T., Nocon, A., Pfister, H., Binder, E. B., Uhr, M., Lieb, R., Moffitt, T. E., Caspi, A., Holsboer, F., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10111577 · Cited by 262
Cognitive deficits in major depression
Ravnkilde, B., Videbech, P., Clemmensen, K., Egander, A., Rasmussen, N. A., & Rosenberg, R. (2002) · Scandinavian Journal of Psychology · doi:10.1111/1467-9450.00292 · Cited by 259
Mast cells, glia and neuroinflammation: partners in crime?
Skaper, S. D., Facci, L., & Giusti, P. (2013) · Immunology · doi:10.1111/imm.12170 · Cited by 256
Effects of omega-3 fatty acids on cognitive performance: a meta-analysis
Mazereeuw, G., Lanctôt, K. L., Chau, S. A., Swardfager, W., & Herrmann, N. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.12.014 · Cited by 253
Neuropsychological function in nonpsychotic unipolar major depression.
Landrø, N. I., Stiles, T. C., & Sletvold, H. (2001) · PubMed · Cited by 241
Statins and Cognition: A Systematic Review and Meta-analysis of Short- and Long-term Cognitive Effects
Swiger, K. J., Manalac, R. J., Blumenthal, R. S., Blaha, M. J., & Martin, S. S. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.07.013 · Cited by 233
Smaller hippocampal volumes in patients with bipolar disorder are masked by exposure to lithium: a meta-analysis
Hájek, T., Kopeček, M., Höschl, C., & Alda, M. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110143 · Cited by 230
Chronic stress impairs recall of extinction of conditioned fear
Miracle, A. D., BRACE, M., HUYCK, K., SINGLER, S., & Wellman, C. L. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.10.005 · Cited by 230
Melatonin stimulates antioxidant enzymes and reduces oxidative stress in experimental traumatic brain injury: the Nrf2–ARE signaling pathway as a potential mechanism
Ding, K., Wang, H., Xu, J., Li, T., Zhang, L., Ding, Y., Zhu, L., He, J., & Zhou, M. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.04.031 · Cited by 228
The role of immune genes in the association between depression and inflammation: A review of recent clinical studies
Bufalino, C., Hepgul, N., Aguglia, E., & Pariante, C. M. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.04.009 · Cited by 228
Efficacy and Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial
Sanmukhani, J., Satodiya, V., Trivedi, J. S., Patel, T. K., Tiwari, D., Panchal, B. N., Goel, A., & Tripathi, C. B. (2013) · Phytotherapy Research · doi:10.1002/ptr.5025 · Cited by 218
Evidence for oxidative stress in the frontal cortex in patients with recurrent depressive disorder—A postmortem study
Michel, T. M., Frangou, S., Thiemeyer, D., Camara, S., Jecel, J., Nara, K., Brunklaus, A., Zoechling, R., & Riederer, P. (2007) · Psychiatry Research · doi:10.1016/j.psychres.2006.04.013 · Cited by 218
Increased 5-HT 2A Receptor Binding in Euthymic, Medication-Free Patients Recovered From Depression: A Positron Emission Study With [ 11 C]MDL 100,907
Bhagwagar, Z., Hinz, R., Taylor, M. J., Fancy, S., Cowen, P. J., & Grasby, P. M. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1580 · Cited by 214
N -acetylserotonin activates TrkB receptor in a circadian rhythm
Jang, S., Liu, X., Sompol, P. M., Tosini, G., Chang, Q., Iuvone, P. M., & Ye, K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912531107 · Cited by 213
Glucocorticoid Generates ROS to Induce Oxidative Injury in the Hippocampus, Leading to Impairment of Cognitive Function of Rats
Sato, H., Takahashi, T., Sumitani, K., Takatsu, H., & Urano, S. (2010) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.10-58 · Cited by 211
Amelioration of Acute Sequelae of Blast Induced Mild Traumatic Brain Injury by N-Acetyl Cysteine: A Double-Blind, Placebo Controlled Study
Hoffer, M. E., Balaban, C., Slade, M. D., Tsao, J. W., & Hoffer, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054163 · Cited by 207
Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration
Ferreira Mello, B. S., Monte, A. S., McIntyre, R. S., Soczynska, J. K., Custódio, C. S., Cordeiro, R. C., Chaves, J. H., Mendes Vasconcelos, S. M., Nobre Júnior, H. V., Florenço de Sousa, F. C., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.06.008 · Cited by 195
Effect of Simvastatin on Cognitive Functioning in Children With Neurofibromatosis Type 1
Krab, L. C. (2008) · JAMA · doi:10.1001/jama.300.3.287 · Cited by 194
Novel therapeutic targets in depression: Minocycline as a candidate treatment
Soczynska, J. K., Mansur, R. B., Brietzke, E. M., Swardfager, W., Kennedy, S. H., Woldeyohannes, H. O., Powell, A. M., Manierka, M. S., & McIntyre, R. S. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.026 · Cited by 192
Self-citation
Chronic Unpredictable Stress (CUS)-Induced Anxiety and Related Mood Disorders in a Zebrafish Model: Altered Brain Proteome Profile Implicates Mitochondrial Dysfunction
Chakravarty, S., Reddy, B. R., Sudhakar, S. R., Saxena, S., Das, T., Vuppalapaty, M., Swamy, C. V. B., Kumar, A., & Idris, M. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063302 · Cited by 187
Altered Functioning of the Executive Control Circuit in Late-Life Depression: Episodic and Persistent Phenomena
Aizenstein, H. J., Butters, M. A., Wu, M., Mazurkewicz, L. M., Stenger, V. A., Gianaros, P. J., Becker, J. T., Reynolds, C. F., & Carter, C. S. (2009) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31817b60af · Cited by 187
Low GABA concentrations in occipital cortex and anterior cingulate cortex in medication-free, recovered depressed patients
Bhagwagar, Z., Wylezinska, M., Jezzard, P., Evans, J., Boorman, E. D., Matthews, P. M., & Cowen, P. J. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707007924 · Cited by 186
NADPH Oxidase Mediates Depressive Behavior Induced by Chronic Stress in Mice
Seo, J., Park, J., Choi, J., Kim, T.-K., Shin, J., Lee, J.-K., & Han, P. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0794-12.2012 · Cited by 186
Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production
Xie, L., Li, X., Funeshima, N., Kimura, H., Matsumoto, Y., Isaka, Y., & Takahara, S. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2009.01.025 · Cited by 182
Chocolate and the brain: Neurobiological impact of cocoa flavanols on cognition and behavior
Sokolov, A. N., Pavlova, M. A., Klosterhalfen, S., & Enck, P. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.013 · Cited by 181
Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: A meta-analysis
Na, K., Lee, K. J., Lee, J. S., Cho, Y. S., & Jung, H. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.09.006 · Cited by 181
A meta‐analysis of executive dysfunctions in unipolar major depressive disorder without psychotic symptoms and their changes during antidepressant treatment
Wagner, S., Doering, B., Helmreich, I., Lieb, K., & Tadić, A. (2012) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2011.01762.x · Cited by 180
Depressive symptoms and neurocognitive test scores in patients passing symptom validity tests
Rohling, M. L., Green, P., Allen, L. M., & Iverson, G. L. (2002) · Archives of Clinical Neuropsychology · doi:10.1016/s0887-6177(01)00109-3 · Cited by 180
Curcumin Enhances Neurogenesis and Cognition in Aged Rats: Implications for Transcriptional Interactions Related to Growth and Synaptic Plasticity
Dong, S., Zeng, Q., Mitchell, E. S., Xiu, J., Duan, Y., Li, C., Tiwari, J. K., Hu, Y., Cao, X., & Zhao, Z. Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031211 · Cited by 179
The relevance of oxidative stress status in first episode and recurrent depression
Stefanescu, C., & Ciobica, A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.05.022 · Cited by 179
The serotonin-BDNF duo: developmental implications for the vulnerability to psychopathology
Homberg, J. R., Molteni, R., Calabrese, F., & Riva, M. A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.012 · Cited by 177
Tnf-α and IL-1α inhibit both pyruvate dehydrogenase activity and mitochondrial function in cardiomyocytes: Evidence for primary impairment of mitochondrial function
Zell, R., Geck, P., Werdan, K., & Boekstegers, P. (1997) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006896832582 · Cited by 175
The Efficacy of Adjunctive N-Acetylcysteine in Major Depressive Disorder: A Double-Blind, Randomized, Placebo-Controlled Trial
Berk, M., Dean, O. M., Cotton, S. M., Jeavons, S., Tanious, M., Kohlmann, K., Hewitt, K., Moss, K., Allwang, C., Schapkaitz, I., et al. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13m08454 · Cited by 172
Self-citation
Neuropsychological Performance in Patients With Depression is Associated With Clinical, Etiological and Genetic Risk Factors
Naismith, S. L., Hickie, I. B., Turner, K., Little, C. L., Winter, V., Ward, P. B., Wilhelm, K. A., Mitchell, P. B., & Parker, G. B. (2003) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/jcen.25.6.866.16472 · Cited by 170
Activation of cell-mediated immunity in depression: Association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression
Maes, M. H. J., Mihaylova, I., Kubera, M., & Ringel, K. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.09.006 · Cited by 170
Effect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisol
McMorris, T., Harris, R. C., Swain, J., Corbett, J., Collard, K., Dyson, R. J., Dye, L., Hodgson, C., & Draper, N. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0269-z · Cited by 168
Total antioxidant capacity and total oxidant status in patients with major depression: Impact of antidepressant treatment
Cumurcu, B. E., Ozyurt, H., Etikan, I., Demir, S., & Karlidag, R. (2009) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2009.02004.x · Cited by 165
N-acetylcysteine prevents memory deficits, the decrease in acetylcholinesterase activity and oxidative stress in rats exposed to cadmium
Gonçalves, J. F., Fiorenza, A. M., Spanevello, R. M., Mazzanti, C. M. D. A., Bochi, G. V., Antes, F. G., Stefanello, N., Rubin, M. A., Dressler, V. L., Morsch, V. M., et al. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.04.011 · Cited by 165
Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment
Larsen, M. H., Mikkelsen, J. D., Hay-Schmidt, A., & Sandi, C. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.01.005 · Cited by 165
Anatomical and functional correlates in major depressive disorder: The contribution of neuroimaging studies
Rigucci, S., Serafini, G., Pompili, M., Kotzalidis, G., & Tatarelli, R. (2009) · The World Journal of Biological Psychiatry · doi:10.1080/15622970903131571 · Cited by 161
Effects of selective serotonin reuptake and dual serotonergic–noradrenergic reuptake treatments on memory and mental processing speed in patients with major depressive disorder
Herrera-Guzmán, I., Gudayol-Ferré, E., Herrera-Guzmán, D., Guàrdia-Olmos, J., Hinojosa-Calvo, E., & Herrera-Abarca, J. E. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.10.015 · Cited by 160
The Fibroblast Growth Factor Family: Neuromodulation of Affective Behavior
Turner, C. A., Watson, S. J., & Akil, H. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.037 · Cited by 160
Increased 8-hydroxy-deoxyguanosine, a marker of oxidative damage to DNA, in major depression and myalgic encephalomyelitis / chronic fatigue syndrome.
Maes, M. H. J., Mihaylova, I., Kubera, M., Uytterhoeven, M., Vrydags, N., & Bosmans, E. (2009) · PubMed · Cited by 157
Mechanism of glucocorticoid-induced oxidative stress in rat hippocampal slice cultures
You, J., Yun, S., Nam, K. N., Kang, C., Won, R., & Lee, E. H. (2009) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y09-027 · Cited by 155
Pioglitazone Adjunctive Therapy for Moderate-to-Severe Major Depressive Disorder: Randomized Double-Blind Placebo-Controlled Trial
Sepanjnia, K., Modabbernia, A., Ashrafi, M., Modabbernia, M.-J., & Akhondzadeh, S. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.58 · Cited by 153
Influence of age and executive functioning on verbal memory of inpatients with depression
Fossati, P., Coyette, F., Ergis, A.-M., & Allilaire, J. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00362-1 · Cited by 152
Inflammatory and Neurodegenerative Pathways in Depression: A New Avenue for Antidepressant Development?
Catena-Dell’Osso, M., Bellantuono, C., Consoli, G., Baroni, S., Rotella, F., & Marazziti, D. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711794088353 · Cited by 152
Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects
Lopresti, A. L., Hood, S. D., & Drummond, P. D. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112458732 · Cited by 151
Erythropoietin as neuroprotective and neuroregenerative treatment strategy: Comprehensive overview of 12 years of preclinical and clinical research
Sargin, D., Friedrichs, H., El-Kordi, A., & Ehrenreich, H. (2010) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2010.10.005 · Cited by 150
Oxidative/Nitrosative Stress and Immuno-inflammatory Pathways in Depression: Treatment Implications
Anderson, G., & Maes, M. H. J. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660738 · Cited by 148
Tumor necrosis factor-α impairs oligodendroglial differentiation through a mitochondria-dependent process
Bonora, M., Marchi, E. D., Patergnani, S., Suski, J. M., Celsi, F., Bononi, A., Giorgi, C., Marchi, S., Rimessi, A., Duszyński, J., et al. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.35 · Cited by 147
The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder
Gałecki, P., Gałecka, E., Maes, M., Chamielec, M., Orzechowska, A., Bobińska, K., Lewiński, A., & Szemraj, J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.01.016 · Cited by 141
Pathological parainflammation and endoplasmic reticulum stress in depression: potential translational targets through the CNS insulin, klotho and PPAR-γ systems
Gold, P. W., Licinio, J., & Pavlatou, M. G. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.167 · Cited by 132
Simvastatin for cognitive deficits and behavioural problems in patients with neurofibromatosis type 1 (NF1-SIMCODA): a randomised, placebo-controlled trial
van der Vaart, T., Plasschaert, E., Rietman, A. B., Renard, M., Oostenbrink, R., Vogels, A., de Wit, M. Y., Descheemaeker, M., Vergouwe, Y., Catsman‐Berrevoets, C. E., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70227-8 · Cited by 128
Omega-3 Polyunsaturated Fatty Acid Supplementation Confers Long-Term Neuroprotection Against Neonatal Hypoxic–Ischemic Brain Injury Through Anti-Inflammatory Actions
Zhang, W., Hu, X., Yang, W., Gao, Y., & Chen, J. (2010) · Stroke · doi:10.1161/strokeaha.110.586081 · Cited by 127
Mediators of the association between depression and role functioning
Buist‐Bouwman, M. A., Ormel, J., De Graaf, R., De Jonge, P., Van Sonderen, E., Alonso, J., Bruffaerts, R., Vollebergh, W. A. M., & the ESEMeD/MHEDEA 2000 investigators (2008) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2008.01285.x · Cited by 127
Aspirin-triggered lipoxin A4attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells
Wang, Y., Wu, Y., Li, L., Zheng, J., Liu, R., Zhou, J.-P., Yuan, S., Shang, Y., & Yao, S. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-95 · Cited by 126
Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid‐β1–42
Zhou, J., Zhang, S., Zhao, X., & Wei, T. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00570.x · Cited by 125
Oxidative stress parameters after combined fluoxetine and acetylsalicylic acid therapy in depressive patients
Gałecki, P., Szemraj, J., Bieńkiewicz, M., Zboralski, K., & Gałecka, E. (2009) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.1014 · Cited by 124
The Integrative Management of Treatment-Resistant Depression: A Comprehensive Review and Perspectives
Carvalho, A. F., Berk, M., Hyphantis, T. N., & McIntyre, R. S. (2014) · Psychotherapy and Psychosomatics · doi:10.1159/000357500 · Cited by 123
Self-citation
Early parental loss and depression history: Associations with recent life stress in major depressive disorder
Slavich, G. M., Monroe, S. M., & Gotlib, I. H. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.03.004 · Cited by 122
Effects of etanercept therapy on fatigue and symptoms of depression in subjects treated for moderate to severe plaque psoriasis for up to 96 weeks
Krishnan, R. R., Cella, D. F., Leonardi, C., Papp, K. A., Gottlieb, A. B., Dunn, M. E., Chiou, C. F., Patel, V. D., & Jahreis, A. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.08205.x · Cited by 121
Creatine monohydrate in resistant depression: A preliminary study
Roitman, S., Green, T., Osher, Y., Karni, N., & Levine, J. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00532.x · Cited by 118
Increased xanthine oxidase in the thalamus and putamen in depression
Michel, T. M., Camara, S., Tatschner, T., Frangou, S., Sheldrick, A. J., Riederer, P., & Grünblatt, E. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622970802123695 · Cited by 114 · cited 1×
“XO is increased in the CNS of patients with MDD; antidepressants decrease XO [124, 125].”
Background
Expression of neuronal nitric oxide synthase in the hippocampal formation in affective disorders
de Oliveira, R. M. W., Guimarães, F. S., & Deakin, J. F. W. (2008) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2008000400012 · Cited by 113
The neuroprotective effects of GLP-1: Possible treatments for cognitive deficits in individuals with mood disorders
McIntyre, R. S., Powell, A. M., Kaidanovich-Beilin, O., Soczynska, J. K., Alsuwaidan, M., Woldeyohannes, H. O., Kim, A. S., & Gallaugher, L. A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.09.021 · Cited by 110
Self-citation
Inflammation, mitochondria, and the inhibition of adult neurogenesis
Voloboueva, L. A., & Giffard, R. G. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22768 · Cited by 109
Erythropoietin Enhances Hippocampal Response during Memory Retrieval in Humans
Miskowiak, K. W., O’Sullivan, U., & Harmer, C. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5013-06.2007 · Cited by 108
Self-citation
Neuroprotection by Minocycline Caused by Direct and Specific Scavenging of Peroxynitrite
Schildknecht, S., Pape, R., Müller, N., Robotta, M., Marquardt, A., Bürkle, A., Drescher, M., & Leist, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.169565 · Cited by 107
Melatonin reduces endoplasmic reticulum stress and preserves sirtuin 1 expression in neuronal cells of newborn rats after hypoxia–ischemia
Carloni, S., Albertini, M. C., Galluzzi, L., Buonocore, G., Proietti, F., & Balduini, W. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12156 · Cited by 106
Cognitive deficits in the remitted state of unipolar depressive disorder.
Hasselbalch, B., Knorr, U., Hasselbalch, S. G., Gade, A., & Kessing, L. V. (2012) · Neuropsychology · doi:10.1037/a0029301 · Cited by 105
Recombinant Human Erythropoietin for Treating Treatment-Resistant Depression: A Double-Blind, Randomized, Placebo-Controlled Phase 2 Trial
Miskowiak, K. W., Vinberg, M., Christensen, E. M., Bukh, J. D., Harmer, C. J., Ehrenreich, H., & Kessing, L. V. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.335 · Cited by 104
Self-citation
Antidepressant-like effect of nitric oxide synthase inhibitors and sildenafil against lipopolysaccharide-induced depressive-like behavior in mice
Tomaz, V. D. S., Cordeiro, R. C., Costa, A. M. N., de Lucena, D. F., Júnior, H. V. N., de Sousa, F. C. F., Vasconcelos, S. M. M., Vale, M. L., Quevedo, J., & Macêdo, D. S. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.03.025 · Cited by 104
Severe and nonsevere events in first onsets versus recurrences of depression: Evidence for stress sensitization.
Stroud, C. B., Davila, J., Hammen, C., & Vrshek-Schallhorn, S. (2011) · Journal of Abnormal Psychology · doi:10.1037/a0021659 · Cited by 103
Cognitive performance and subjective complaints before and after remission of major depression
Lahr, D., Beblo, T., & Hartje, W. (2006) · Cognitive Neuropsychiatry · doi:10.1080/13546800600714791 · Cited by 103
Statins use and risk of depression: A systematic review and meta-analysis
Parsaik, A. K., Singh, B., M. Hassan, M., Singh, K., Mascarenhas, S. S., Williams, M. D., Lapid, M. I., Richardson, J. W., West, C. P., & Rummans, T. A. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.11.026 · Cited by 100
S-100B is increased in melancholic but not in non-melancholic major depression
Rothermundt, M., Arolt, V., Wiesmann, M., Missler, U., Peters, M., Rudolf, S., & Kirchner, H. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00321-9 · Cited by 99
Evaluation of late cognitive impairment and anxiety states following traumatic brain injury in mice: The effect of minocycline
Siopi, E., Llufriu-Dabén, G., Fanucchi, F., Plotkine, M., Marchand‐Leroux, C., & Jafarian-Tehrani, M. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.01.051 · Cited by 98
Epicatechin attenuates doxorubicin-induced brain toxicity: Critical role of TNF-α, iNOS and NF-κB
Mohamed, R. H., Karam, R. A., & Amer, M. G. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.07.001 · Cited by 97
Neuroprotection of Creatine Supplementation in Neonatal Rats with Transient Cerebral Hypoxia-Ischemia
Adcock, K. H., Nedelcu, J., Loenneker, T., Martin, E., Wallimann, T., & Wagner, B. P. (2002) · Developmental Neuroscience · doi:10.1159/000069043 · Cited by 97
Minocycline and Risperidone Prevent Microglia Activation and Rescue Behavioral Deficits Induced by Neonatal Intrahippocampal Injection of Lipopolysaccharide in Rats
Zhu, F., Zheng, Y., Ding, Y., Liu, Y. H., Zhang, X., Wu, R., Guo, X., & Zhao, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093966 · Cited by 96
Low dose aspirin and cognitive function in middle aged to elderly adults: randomised controlled trial
Price, J. F., Stewart, M. C., Deary, I. J., Murray, G. D., Sandercock, P., Butcher, I., Fowkes, F. G. R., & Trialists, O. B. O. T. A. (2008) · BMJ · doi:10.1136/bmj.a1198 · Cited by 96
Clinical Implications of the Cytokine Hypothesis of Depression: The Association between Use of Statins and Aspirin and the Risk of Major Depression
Pasco, J. A., Jacka, F. N., Williams, L. J., Henry, M. J., Nicholson, G. C., Kotowicz, M. A., & Berk, M. (2010) · Psychotherapy and Psychosomatics · doi:10.1159/000319530 · Cited by 95
Self-citation
Major Depressive Disorder in recovery and neuropsychological functioning: Effects of selective serotonin reuptake inhibitor and dual inhibitor depression treatments on residual cognitive deficits in patients with Major Depressive Disorder in recovery
Herrera-Guzmán, I., Gudayol-Ferré, E., Herrera-Abarca, J. E., Herrera-Guzmán, D., Montelongo-Pedraza, P., Padrós Blázquez, F., Peró-Cebollero, M., & Guàrdia-Olmos, J. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.10.009 · Cited by 94
The Use of Statins After a Cardiac Intervention Is Associated With Reduced Risk of Subsequent Depression
Stafford, L., & Berk, M. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05825blu · Cited by 93
Self-citation
Acute atorvastatin treatment exerts antidepressant-like effect in mice via the l-arginine–nitric oxide–cyclic guanosine monophosphate pathway and increases BDNF levels
Ludka, F. K., Zomkowski, A. D. E., Cunha, M. P., Dal-Cim, T., Zeni, A. L. B., Rodrigues, A. L. S., & Tasca, C. I. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.05.005 · Cited by 92
Curcumin as an Add-On to Antidepressive Treatment
Bergman, J., Miodownik, C., Bersudsky, Y., Sokolik, S., Lerner, P. P., Kreinin, A., Polakiewicz, J., & Lerner, V. (2013) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e31828ef969 · Cited by 92
Do personality traits predict first onset in depressive and bipolar disorder?
Vinberg, M., & Kessing, L. V. (2006) · Nordic Journal of Psychiatry · doi:10.1080/08039480600600300 · Cited by 92
Celecoxib: a new augmentation strategy for depressive mood episodes. A systematic review and meta‐analysis of randomized placebo‐controlled trials
Faridhosseini, F., Sadeghi, R., Farid, L., & Pourgholami, M. (2014) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.2401 · Cited by 89
Interaction of Serotonin Transporter Gene-Linked Polymorphic Region and Stressful Life Events Predicts Cortisol Stress Response
Mueller‐Alcazar, A., Armbruster, D., Moser, D., Canli, T., Lesch, K., Brocke, B., & Kirschbaum, C. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.11 · Cited by 89
Diagnostic classifications in depression and somatization should include biomarkers, such as disorders in the tryptophan catabolite (TRYCAT) pathway
Maes, M. H. J., & Rief, W. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2011.09.029 · Cited by 88
Plasma levels of vascular endothelial growth factor and fibroblast growth factor 2 in patients with major depressive disorders
Takebayashi, M., Hashimoto, R., Hisaoka, K., Okada‐Tsuchioka, M., & Kunugi, H. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0452-1 · Cited by 88
Minocycline treatment for HIV-associated cognitive impairment: Results from a randomized trial
Sacktor, N., Miyahara, S., Deng, L., Evans, S., Schifitto, G., Cohen, B. A., Paul, R., Robertson, K., Jarocki, B., Scarsi, K., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31822f0412 · Cited by 87
Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: Implications for the pathways to chronic depression and neuroprogression
Maes, M. H. J., Kubera, M., Mihaylova, I., Geffard, M., Gałecki, P., Leunis, J.-C., & Berk, M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.06.039 · Cited by 87
Self-citation
N-acetylcysteine possesses antidepressant-like activity through reduction of oxidative stress: Behavioral and biochemical analyses in rats
Smaga, I., Pomierny, B., Krzyżanowska, W., Pomierny-Chamioło, L., Miszkiel, J., Niedzielska, E., Ogorka, A. Z. T., & Filip, M. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.06.018 · Cited by 86
Brain volume abnormalities and neurocognitive deficits in diabetes mellitus: Points of pathophysiological commonality with mood disorders?
McIntyre, R. S., Kenna, H. A., Nguyen, H. T., Law, C. W. Y., Sultan, F., Woldeyohannes, H. O., Alsuwaidan, M. T., Soczynska, J. K., Adams, A. K., Cheng, J. S. H., et al. (2010) · Advances in Therapy · doi:10.1007/s12325-010-0011-z · Cited by 83
Self-citation
AUGMENTATION OF FLUOXETINE WITH LOVASTATIN FOR TREATING MAJOR DEPRESSIVE DISORDER, A RANDOMIZED DOUBLE-BLIND PLACEBO CONTROLLED-CLINICAL TRIAL: Lovastatin for Treating Depression
Ghanizadeh, A., & Hedayati, A. (2013) · Depression and Anxiety · doi:10.1002/da.22195 · Cited by 81
Inhibition of iNOS induces antidepressant-like effects in mice: Pharmacological and genetic evidence
Montezuma, K., Biojone, C., Lisboa, S. F. D. S., Cunha, F. Q., Guimarães, F. S., & Joca, S. R. L. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.09.004 · Cited by 81
Inhibitory action of minocycline on lipopolysaccharide-lnduced release of nitric oxide and prostaglandin E2 in BV2 microglial cells
Kim, S., Kong, P., Kim, B.-S., Sheen, D., Nam, S.-Y., & Chun, W. (2004) · Archives of Pharmacal Research · doi:10.1007/bf02980066 · Cited by 81
A study on nitric oxide, β-adrenergic receptors and antioxidant status in the polymorphonuclear leukocytes from the patients of depression
Srivastava, N., Barthwal, M. K., Dalal, P., Agarwal, A., Nag, D., Seth, P. K., Srimal, R. C., & Dikshit, M. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00421-9 · Cited by 80
Curcumin regulated shift from Th1 to Th2 in trinitrobenzene sulphonic acid-induced chronic colitis
Zhang, M., Deng, C., Zheng, J., et al. (2006) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2006.00322.x · Cited by 78
Mitochondrial modulators for bipolar disorder: A pathophysiologically informed paradigm for new drug development
Nierenberg, A. A., Kansky, C., Brennan, B. P., Shelton, R. C., Perlis, R. H., & Iosifescu, D. V. (2012) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867412449303 · Cited by 78
The impact of statins on psychological wellbeing: a systematic review and meta-analysis
O'Neil, A., Sanna, L., Redlich, C., Sanderson, K., Jacka, F., Williams, L. J., Pasco, J. A., & Berk, M. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-154 · Cited by 78
Self-citation
Differences Between Early and Late Onset Adult Depression
Bukh, J. D., Bock, C., Vinberg, M., Gether, U., & Kessing, L. V. (2011) · Clinical Practice and Epidemiology in Mental Health · doi:10.2174/1745017901107010140 · Cited by 76
Cognitive dysfunctions in recovered melancholic patients
Marcos, T., Salamero, M., Gutiérrez, F., Catalán, R., Gastó, C., & Lázaro, L. (1994) · Journal of Affective Disorders · doi:10.1016/0165-0327(94)90071-x · Cited by 75
Lisdexamfetamine Dimesylate Augmentation in Adults With Persistent Executive Dysfunction After Partial or Full Remission of Major Depressive Disorder
Madhoo, M., Keefe, R. S., Roth, R. M., Sambunaris, A., Wu, J., Trivedi, M. H., Anderson, C. S., & Lasser, R. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.334 · Cited by 74
The association between serum levels of neopterin and number of depressive episodes of major depression
Çelik, C., Erdem, M., Çaycı, T., Özdemir, B. H., Akgül, E. Ö., Kurt, Y. G., Yaman, H., Isıntas, M., Özgen, F., & Özşahin, A. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.01.002 · Cited by 74
Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity
Ahuja, M., Bishnoi, M., & Chopra, K. (2007) · Toxicology · doi:10.1016/j.tox.2007.11.003 · Cited by 74

Sorted by citations

Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders
Malhi, G. S., Bassett, D., Boyce, P., Bryant, R., Fitzgerald, P. B., Fritz, K., Hopwood, M., Lyndon, B., Mulder, R., Murray, G., et al. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415617657 · Cited by 842
“Therefore, this is an issue which is receiving increasing attention with research into both pharmacological (Carvalho et al., 2014b) and psychological strategies (Porter et al., 2014) to improve cognition.”
Background
Cognitive remission: a novel objective for the treatment of major depression?
Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016) · BMC Medicine · doi:10.1186/s12916-016-0560-3 · Cited by 252
Self-citation
Inflammatory theory of depression
Gałecki, P., & Talarowska, M. (2018) · Psychiatria Polska · doi:10.12740/pp/76863 · Cited by 192
Prefrontal cortex executive processes affected by stress in health and disease
Girotti, M., Adler, S. M., Bulin, S. E., Fucich, E. A., Paredes, D., & Morilak, D. A. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.004 · Cited by 176
T helper 17 cells may drive neuroprogression in major depressive disorder: Proposal of an integrative model
Slyepchenko, A., Maes, M., Köhler, C. A., Anderson, G., Quevedo, J., Alves, G. S., Berk, M., Fernandes, B. S., & Carvalho, A. F. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.002 · Cited by 89
Self-citation

See all 107

Authors: Carvalho, A., Miskowiak, K., Hyphantis, T., Kohler, C., Alves, G., Bortolato, B., G. Sales, P., Machado-Vieira, R., Berk, M., & McIntyre, R.
Affiliations: Universidade Federal do Ceará (BR)
Corresponding author: McIntyre, Roger
ORCID: Carvalho, Andre
Miskowiak, Kamilla
Hyphantis, Thomas
Alves, Gilberto
McIntyre, Roger
Venue: CNS & Neurological Disorders - Drug Targets
Publisher: Bentham Science Publishers Ltd.
Published: 2015-01-22
Volume: 13
Issue: 10
Pages: 1819-1835
ISSN: 1568-007X (ISSN-L)
1871-5273
DOI: 10.2174/1871527313666141130203627
OpenAlex: W2150071717
Cited by: 107
References: 252
Citations by year: 2026: 3 · 2025: 5 · 2024: 10 · 2023: 7 · 2022: 12 · 2021: 13 · 2020: 4 · 2019: 9 · 2018: 12 · 2017: 9 · 2016: 17 · 2015: 6
FWCI: 10.62
Type: journal article
Language: en
Open access: green
figshare.com
Licence: cc-by
Locations: CNS & Neurological Disorders - Drug Targets (publishedVersion)
PubMed (publishedVersion)
Deakin Research Online (Deakin University) (submittedVersion)
Figshare (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: major depressive disorder, cognitive impairment, cognitive enhancement, hypothalamic-pituitary-adrenal axis, oxidative stress, nitrosative stress, neuroinflammation, inflammatory cytokines, mitochondrial dysfunction, apoptosis, neurotrophic support, minocycline, statins, N-acetylcysteine, omega-3 polyunsaturated fatty acids, erythropoietin, S-adenosylmethionine, creatine monohydrate, lithium, thiazolidinediones, glucagon-like peptide-1 analogues
MeSH terms: Cognition Disorders, Depression, Humans, Nootropic Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cognitive Dysfunction in Depression – Pathophysiology and Novel Targets

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks