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Dietary Patterns and Risk for Type 2 Diabetes Mellitus in U.S. Men
Abstract
BACKGROUND: The role of diet in the development of type 2 diabetes mellitus remains unsettled. OBJECTIVE: To examine the association between major dietary patterns and risk for type 2 diabetes mellitus. DESIGN: Prospective cohort study. SETTING: United States. PARTICIPANTS: 42 504 male health professionals, 40 to 75 years of age, without diagnosed diabetes, cardiovascular disease, or cancer at baseline. MEASUREMENTS: Using factor analysis based on data from food-frequency questionnaires, we identified and validated two major dietary patterns that we labeled "prudent" (characterized by higher consumption of vegetables, fruit, fish, poultry and whole grains) and "western" (characterized by higher consumption of red meat, processed meat, French fries, high-fat dairy products, refined grains, and sweets and desserts). Relative risks and 95% CIs were adjusted for potential confounders, including body mass index (BMI), physical activity, and cigarette smoking. RESULTS: During 12 years of follow-up (466 508 person-years), we documented 1321 cases of type 2 diabetes. The prudent dietary pattern score was associated with a modestly lower risk for type 2 diabetes (relative risk for extreme quintiles, 0.84 [CI, 0.70 to 1.00]). In contrast, the western dietary pattern score was associated with an increased risk for type 2 diabetes (relative risk, 1.59 [CI, 1.32 to 1.93]; P < 0.001 for trend). A high score for the western dietary pattern combined with low physical activity (relative risk comparing extreme quintiles of dietary pattern score and physical activity, 1.96 [CI, 1.35 to 2.84]) or obesity (relative risk for BMI > or = 30 kg/m2 vs. <25 kg/m2, 11.2 [CI, 8.07 to 15.6]) was associated with a particularly high risk for type 2 diabetes. CONCLUSION: Our findings suggest that a western dietary pattern is associated with a substantially increased risk for type 2 diabetes in men.
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Metadata
- Authors
- van Dam, R. M., Rimm, E. B., Willett, W. C., Stampfer, M. J., & Hu, F. B.
- Affiliations
- From Harvard School of Public Health, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, and National Institute for Public Health and the Environment, the Netherlands.
- Brigham and Women's Hospital (US)
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 2002-02-05
- Volume
- 136
- Issue
- 3
- Pages
- 201-209
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W1979568632
- Cited by
- 801
- References
- 31
- Citations by year
- 2025: 6 · 2024: 12 · 2023: 14 · 2022: 26 · 2021: 25 · 2020: 29 · 2019: 28 · 2018: 26 · 2017: 39 · 2016: 41 · 2015: 40 · 2014: 40 · 2013: 34 · 2012: 48
- FWCI
- 38.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (publishedVersion)
- Rivm Repository (Netherlands National Institute for Public Health and the Environment) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL035464, HL35464)
- National Cancer Institute (CA-55075)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- type 2 diabetes, dietary habits, prudent diet, Western diet, diabetes risk, men, physical activity, obesity, body mass index, red meat consumption, processed meat, refined grains, whole grains, fruit and vegetable intake
- MeSH terms
- Adult, Aged, Diabetes Mellitus, Type 2, Diet, Factor Analysis, Statistical, Feeding Behavior, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Surveys and Questionnaires, Regression Analysis, Risk Factors, Smoking, Exercise, Body Mass Index
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