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Hearing Loss and Cognitive Decline in Older Adults
Open accessAbstract
BACKGROUND Whether hearing loss is independently associated with accelerated cognitive decline in older adults is unknown. METHODS We studied 1984 older adults (mean age, 77.4 years) enrolled in the Health ABC Study, a prospective observational study begun in 1997-1998. Our baseline cohort consisted of participants without prevalent cognitive impairment (Modified Mini-Mental State Examination [3MS] score, ≥80) who underwent audiometric testing in year 5. Participants were followed up for 6 years. Hearing was defined at baseline using a pure-tone average of thresholds at 0.5 to 4 kHz in the better-hearing ear. Cognitive testing was performed in years 5, 8, 10, and 11 and consisted of the 3MS (measuring global function) and the Digit Symbol Substitution test (measuring executive function). Incident cognitive impairment was defined as a 3MS score of less than 80 or a decline in 3MS score of more than 5 points from baseline. Mixed-effects regression and Cox proportional hazards regression models were adjusted for demographic and cardiovascular risk factors. RESULTS In total, 1162 individuals with baseline hearing loss (pure-tone average >25 dB) had annual rates of decline in 3MS and Digit Symbol Substitution test scores that were 41% and 32% greater, respectively, than those among individuals with normal hearing. On the 3MS, the annual score changes were -0.65 (95% CI, -0.73 to -0.56) vs -0.46 (95% CI, -0.55 to -0.36) points per year (P = .004). On the Digit Symbol Substitution test, the annual score changes were -0.83 (95% CI, -0.94 to -0.73) vs -0.63 (95% CI, -0.75 to -0.51) points per year (P = .02). Compared to those with normal hearing, individuals with hearing loss at baseline had a 24% (hazard ratio, 1.24; 95% CI, 1.05-1.48) increased risk for incident cognitive impairment. Rates of cognitive decline and the risk for incident cognitive impairment were linearly associated with the severity of an individual's baseline hearing loss. CONCLUSIONS Hearing loss is independently associated with accelerated cognitive decline and incident cognitive impairment in community-dwelling older adults. Further studies are needed to investigate what the mechanistic basis of this association is and whether hearing rehabilitative interventions could affect cognitive decline.
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“Loss of hearing can significantly impact QoL and generally contributes to isolation, depression, and cognitive retardation 6 .”
From The effect of psychological inflexibility on health-related quality of life, depression, and anxiety in patients with chronic tinnitus without hearing loss (2023) · cites this paper as [6]
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Cites
(1987) · PubMed · Cited by 2,657
Diabetes mellitus and the risk of dementia: The Rotterdam Study
Ott, A., Stolk, R. P., van Harskamp, F., Pols, H. A. P., Hofman, A., & Breteler, M. M. B. (1999) · Neurology · doi:10.1212/wnl.53.9.1937 · Cited by 2,175
15-year longitudinal study of blood pressure and dementia
Skoog, I., Nilsson, L., Persson, G., Lernfelt, B., Landahl, S., Palmertz, B., Andreasson, L.-A., Odén, A., & Svanborg, A. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90608-x · Cited by 1,726
Hearing Loss and Incident Dementia
Lin, F. R., Metter, E. J., O’Brien, R., Resnick, S. M., Zonderman, A. B., & Ferrucci, L. (2011) · Archives of Neurology · doi:10.1001/archneurol.2010.362 · Cited by 1,633
Self-citationMonetary Costs of Dementia in the United States
Hurd, M. D., Martorell, P., Delavande, A., Mullen, K. J., & Langa, K. M. (2013) · New England Journal of Medicine · doi:10.1056/nejmsa1204629 · Cited by 1,484
Influence of social network on occurrence of dementia: a community-based longitudinal study
Fratiglioni, L., Wang, H.-X., Ericsson, K., Maytan, M., & Winblad, B. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02113-9 · Cited by 1,361
Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers
Reitz, C., & Mayeux, R. P. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.024 · Cited by 1,271
Sensory functioning and intelligence in old age: A strong connection.
Lindenberger, U., & Baltes, P. B. (1994) · Psychology and Aging · doi:10.1037//0882-7974.9.3.339 · Cited by 1,226
How young and old adults listen to and remember speech in noise.
Pichora-Fuller, M. K., Schneider, B. A., & Daneman, M. (1995) · The Journal of the Acoustical Society of America · doi:10.1121/1.412282 · Cited by 1,089
Bennett, D. A., Schneider, J. A., Tang, Y., Arnold, S. E., & Wilson, R. S. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70417-3 · Cited by 718
Flagged first, then by citations
Research works printed but not linked: 4
- [17]Kurella M Chertow GM Fried LF Chronic kidney disease and cognitive impairment in the elderly: the health, aging, and body composition study J Am Soc Nephrol 7 2005 16 7 2127 2133 15888561
- [31]Pickles JO An introduction to the physiology of hearing 2008 Bingley, UK Emerald Group Publishing
- [34]Strawbridge WJ Wallhagen MI Shema SJ Kaplan GA Negative consequences of hearing impairment in old age: a longitudinal analysis Gerontologist 2000 40 3 320 326 10853526
- [46]Lin FR Hearing loss in older adults: who's listening? JAMA 2012 3 21 307 11 1147 1148 22436953 PMC3518399
Cited by
Sorted by citations
Items 101–200 of 227
Prospective study of type 2 diabetes and cognitive decline in women aged 70-81 years
Logroscino, G., Kang, J. H., & Grodstein, F. (2004) · BMJ · doi:10.1136/bmj.37977.495729.ee · Cited by 190
Meier, S., Bell, M., Lyons, D. N., Rodriguez-Rivera, J., Ingram, A., Fontaine, S. N., Mechas, E., Chen, J., Wolozin, B., LeVine, H., et al. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.3029-15.2016 · Cited by 190
Sex and gender differences in the causes of dementia: A narrative review
Rocca, W. A., Mielke, M. M., Vemuri, P., & Miller, V. M. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.05.008 · Cited by 186
The economic burden of dementia in low- and middle-income countries (LMICs): a systematic review
Mattap, S. M., Mohan, D., McGrattan, A. M., Allotey, P., Stephan, B. C., Reidpath, D. D., Siervo, M., Robinson, L., & Chaiyakunapruk, N. (2022) · BMJ Global Health · doi:10.1136/bmjgh-2021-007409 · Cited by 182
Age of onset of hypertension and risk of dementia in the oldest‐old: The 90+ Study
Corrada, M. M., Hayden, K. M., Paganini-Hill, A., Bullain, S. S., DeMoss, J., Aguirre, C., Brookmeyer, R., & Kawas, C. H. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.09.007 · Cited by 176
Association of subclinical hearing loss with cognitive performance
Golub, J. S., Brickman, A. M., Ciarleglio, A. J., Schupf, N., & Luchsinger, J. A. (2020) · JAMA Otolaryngology–Head & Neck Surgery · doi:10.1001/jamaoto.2019.3375 · Cited by 176
Chow, H.-M., Shi, M., Cheng, A., Gao, Y., Chen, G., Song, X., So, R. W. L., Zhang, J., & Herrup, K. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0505-1 · Cited by 171
Metabolic syndrome and dementia risk in a multiethnic elderly cohort
Muller, M., Tang, M.-X., Schupf, N., Manly, J. J., Mayeux, R., & Luchsinger, J. A. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000105927 · Cited by 175
Thomas, J., Thomas, C. J., Radcliffe, J., & Itsiopoulos, C. (2015) · BioMed Research International · doi:10.1155/2015/172801 · Cited by 173
Ray, J., Popli, G., & Fell, G. (2018) · JAMA Otolaryngology–Head & Neck Surgery · doi:10.1001/jamaoto.2018.1656 · Cited by 163
Tau Oligomers: The Toxic Player at Synapses in Alzheimer’s Disease
Guerrero-Muñoz, M. J., Gerson, J., & Castillo-Carranza, D. L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00464 · Cited by 168
Societal and Family Lifetime Cost of Dementia: Implications for Policy
Jutkowitz, E., Kane, R. L., Gaugler, J. E., MacLehose, R. F., Dowd, B., & Kuntz, K. M. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15043 · Cited by 164
Gene-environment interactions in Alzheimer's disease: A potential path to precision medicine
Eid, A., Mhatre, I., & Richardson, J. R. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.03.005 · Cited by 164
Drabo, E. F., Barthold, D., Joyce, G., Ferido, P., Chang Chui, H., & Zissimopoulos, J. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.07.005 · Cited by 155
Preclinical Assessment of Young Blood Plasma for Alzheimer Disease
Middeldorp, J., Lehallier, B., Villeda, S. A., Miedema, S. S. M., Evans, E., Czirr, E., Zhang, H., Luo, J., Stan, T., Mosher, K. I., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.3185 · Cited by 153
Thambisetty, M., Metter, E. J., Yang, A., Dolan, H., Marano, C., Zonderman, A. B., Troncoso, J. C., Zhou, Y., Wong, D. F., Ferrucci, L., et al. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.284 · Cited by 155
Self-citationFredriksen-Goldsen, K. I., Jen, S., Bryan, A. E. B., & Goldsen, J. (2018) · Journal of Applied Gerontology · doi:10.1177/0733464816672047 · Cited by 148
Sabogal-Guáqueta, A. M., Osorio, E., & Cardona-Gómez, G. P. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.11.002 · Cited by 148
Shi, Q., Liu, S., Fonseca, V. A., Thethi, T. K., & Shi, L. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-024954 · Cited by 144
Zhu, C. W., Scarmeas, N., Ornstein, K., Albert, M., Brandt, J., Blacker, D., Sano, M., & Stern, Y. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2013.12.018 · Cited by 137
Mick, P., Reed, M., & Pichora-Fuller, M. (2015) · Seminars in Hearing · doi:10.1055/s-0035-1555116 · Cited by 138
Jennings, L. A., Laffan, A. M., Schlissel, A. C., Colligan, E., Tan, Z., Wenger, N. S., & Reuben, D. B. (2019) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2018.5579 · Cited by 128
The Impact of Type 2 Diabetes in Parkinson's Disease
Athauda, D., Evans, J., Wernick, A., Virdi, G., Choi, M. L., Lawton, M., Vijiaratnam, N., Girges, C., Ben‐Shlomo, Y., Ismail, K., et al. (2022) · Movement Disorders · doi:10.1002/mds.29122 · Cited by 132
Kehoe, P. G. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-171119 · Cited by 133
Chakrabarti, S., Kumar Khemka, V., Banerjee, A., Chatterjee, G., Ganguly, A., & Biswas, A. (2015) · Aging and disease · doi:10.14336/ad.2014.002 · Cited by 134
Geng, J., Wang, L., Zhang, L., Qin, C., Song, Y., Ma, Y., Chen, Y., Chen, S., Wang, Y., Zhang, Z., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00129 · Cited by 123
Alasmari, F., Alshammari, M. A., Alasmari, A. F., Alanazi, W. A., & Alhazzani, K. (2018) · BioMed Research International · doi:10.1155/2018/3087475 · Cited by 125
Blood-brain barrier leakage in Alzheimer’s disease: From discovery to clinical relevance
Nehra, G., Bauer, B., & Hartz, A. M. S. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108119 · Cited by 127
Emerging links between type 2 diabetes and Alzheimer's disease
Sridhar, G. R. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i5.744 · Cited by 123
Spousal Caregivers Are Caregiving Alone In The Last Years Of Life
Ornstein, K. A., Wolff, J. L., Bollens-Lund, E., Rahman, O.-K., & Kelley, A. S. (2019) · Health Affairs · doi:10.1377/hlthaff.2019.00087 · Cited by 123
Deardorff, W. J., & Grossberg, G. (2016) · Drug Design, Development and Therapy · doi:10.2147/dddt.s86463 · Cited by 125
Cerebrospinal Fluid Biomarkers of Neurovascular Dysfunction in Mild Dementia and Alzheimer'S Disease
Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.76 · Cited by 122
Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer's Disease
Gurney, M. E., D'Amato, E. C., & Burgin, A. B. (2015) · Neurotherapeutics · doi:10.1007/s13311-014-0309-7 · Cited by 121
Machine learning and digital biomarkers can detect early stages of neurodegenerative diseases
Chudzik, A., Śledzianowski, A., & Przybyszewski, A. W. (2024) · Sensors · doi:10.3390/s24051572 · Cited by 122
Microbial involvement in Alzheimer disease development and progression
Bulgart, H. R., Neczypor, E. W., Wold, L. E., & Mackos, A. R. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00378-4 · Cited by 116
Is dementia incidence declining in high-income countries? A systematic review and meta-analysis
Roehr, S., Pabst, A., Luck, T., & Riedel-Heller, S. (2018) · Clinical Epidemiology · doi:10.2147/clep.s163649 · Cited by 115
Bile acids as key modulators of the brain-Gut-Microbiota axis in alzheimer’s disease
Mulak, A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210608 · Cited by 114
The effect of white matter hyperintensities on neurodegeneration in mild cognitive impairment
Tosto, G., Zimmerman, M. E., Hamilton, J. L., Carmichael, O. T., Brickman, A. M., & Initiative, A. D. N. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.05.014 · Cited by 112
Transitions in Care in a Nationally Representative Sample of Older Americans with Dementia
Callahan, C. M., Tu, W., Unroe, K. T., LaMantia, M. A., Stump, T. E., & Clark, D. O. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13540 · Cited by 107
Leibson, C. L., Long, K. H., Ransom, J. E., Roberts, R. O., Hass, S. L., Duhig, A. M., Smith, C. Y., Emerson, J. A., Pankratz, V. S., & Petersen, R. C. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.01.007 · Cited by 110
Shen, Y., Ye, B., Chen, P., Wang, Q., Fan, C., Shu, Y., & Xiang, M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00394 · Cited by 105
Lourida, I., Abbott, R. A., Rogers, M., Lang, I. A., Stein, K., Kent, B., & Thompson Coon, J. (2017) · BMC Geriatrics · doi:10.1186/s12877-017-0528-y · Cited by 100
Multi-domain interventions for the prevention of dementia and cognitive decline
Hafdi, M., Hoevenaar-Blom, M. P., & Richard, E. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013572.pub2 · Cited by 124
Physical Exercise and Brain Mitochondrial Fitness: The Possible Role Against Alzheimer's Disease
Bernardo, T. C., Marques‐Aleixo, I., Beleza, J., Oliveira, P. J., Ascensão, A., & Magalhães, J. (2016) · Brain Pathology · doi:10.1111/bpa.12403 · Cited by 108
Low dose aspirin and cognitive function in the women's health study cognitive cohort
Kang, J. H., Cook, N., Manson, J., Buring, J. E., & Grodstein, F. (2007) · BMJ · doi:10.1136/bmj.39166.597836.be · Cited by 103
The Proteasome and Oxidative Stress in Alzheimer's Disease
Bonet-Costa, V., Pomatto, L. C.-D., & Davies, K. J. A. (2016) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6802 · Cited by 99
Release of insulin produced by the choroid plexis is regulated by serotonergic signaling
Mazucanti, C. H., Liu, Q.-R., Lang, D., Huang, N., O’Connell, J. F., Camandola, S., & Egan, J. M. (2019) · JCI Insight · doi:10.1172/jci.insight.131682 · Cited by 101
Cellular Receptors of Amyloid β Oligomers (AβOs) in Alzheimer’s Disease
Mroczko, B., Groblewska, M., Litman-Zawadzka, A., Kornhuber, J., & Lewczuk, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071884 · Cited by 97
Hayden, M., Grant, D., Aroor, A., & DeMarco, V. (2019) · Brain Sciences · doi:10.3390/brainsci9030057 · Cited by 93
Sensory-cognitive interactions in older adults
Humes, L. E., & Young, L. A. (2016) · Ear & Hearing · doi:10.1097/aud.0000000000000303 · Cited by 94
Calsolaro, V., & Edison, P. (2015) · CNS Drugs · doi:10.1007/s40263-015-0301-8 · Cited by 93
Stokes, A. C., Weiss, J., Lundberg, D. J., Xie, W., Kim, J. K., Preston, S. H., & Crimmins, E. M. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.2831 · Cited by 94
Xiang, S., Ji, J.-L., Li, S., Cao, X.-P., Xu, W., Tan, L., & Tan, C.-C. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.730036 · Cited by 89
Tang, A. S., Rankin, K. P., Cerono, G., Miramontes, S., Mills, H., Roger, J., Zeng, B., Nelson, C., Soman, K., Woldemariam, S., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00573-8 · Cited by 86
Auditory cortical plasticity in cochlear implant users.
Glennon, E., Svirsky, M. A., & Froemke, R. C. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.11.003 · Cited by 81
Testing Family-Centered, Function-Focused Care in Hospitalized Persons with Dementia
Boltz, M., Chippendale, T., Resnick, B., & Galvin, J. E. (2015) · Neurodegenerative Disease Management · doi:10.2217/nmt.15.10 · Cited by 85
Trends in inequalities in the prevalence of dementia in the United States
Hudomiet, P., Hurd, M. D., & Rohwedder, S. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2212205119 · Cited by 83
Worries About Getting Alzheimer’s: Who’s Concerned?
Cutler, S. J. (2015) · American Journal of Alzheimer's Disease & Other Dementias® · doi:10.1177/1533317514568889 · Cited by 82
McMillan, J. M., Mele, B. S., Hogan, D. B., & Leung, A. A. (2018) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2018-000563 · Cited by 80
Datta, D., & Arnsten, A. (2019) · Brain Sciences · doi:10.3390/brainsci9050113 · Cited by 78
Boots, L. M., de Vugt, M. E., Withagen, H. E., Kempen, G. I., & Verhey, F. R. (2016) · JMIR Research Protocols · doi:10.2196/resprot.5142 · Cited by 79
Innes, K. E., & Selfe, T. K. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00040 · Cited by 72
Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration
van Dijk, G., van Heijningen, S., Reijne, A. C., Nyakas, C., van der Zee, E. A., & Eisel, U. L. M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00173 · Cited by 75
Umbrella review and Delphi study on modifiable factors for dementia risk reduction
Rosenau, C., Köhler, S., Soons, L. M., Anstey, K. J., Brayne, C., Brodaty, H., Engedal, K., Farina, F. R., Ganguli, M., Livingston, G., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13577 · Cited by 74
The Role of Care Navigators Working with People with Dementia and Their Caregivers
Bernstein, A., Harrison, K. L., Dulaney, S., Merrilees, J., Bowhay, A., Heunis, J., Choi, J., Feuer, J. E., Clark, A. M., Chiong, W., et al. (2019) · Journal of Alzheimer’s Disease · doi:10.3233/jad-180957 · Cited by 67
The impact of diabetes on cerebral structure and function
Seaquist, E. R. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000207 · Cited by 74
Repurposing of the β-Lactam Antibiotic, Ceftriaxone for Neurological Disorders: A Review
Yimer, E. M., Hishe, H. Z., & Tuem, K. B. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00236 · Cited by 72
Ciccone, L., Shi, C., di Lorenzo, D., Van Baelen, A.-C., & Tonali, N. (2020) · Molecules · doi:10.3390/molecules25102439 · Cited by 69
Dementia severity and the longitudinal costs of informal care in the Cache County population
Rattinger, G. B., Schwartz, S., Mullins, C. D., Corcoran, C., Zuckerman, I. H., Sanders, C., Norton, M. C., Fauth, E. B., Leoutsakos, J. S., Lyketsos, C. G., et al. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.11.004 · Cited by 71
Memantine ER/Donepezil: A Review in Alzheimer’s Disease
Greig, S. L. (2015) · CNS Drugs · doi:10.1007/s40263-015-0287-2 · Cited by 69
Kiss, T., Nyúl-Tóth, Á., DelFavero, J., Balasubramanian, P., Tarantini, S., Faakye, J., Gulej, R., Ahire, C., Ungvari, A., Yabluchanskiy, A., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00521-7 · Cited by 66
Ribarič, S. (2023) · Biomedicines · doi:10.3390/biomedicines11020355 · Cited by 66
Geng, L., Zhang, T., Liu, W., & Chen, Y. (2018) · Yonsei Medical Journal · doi:10.3349/ymj.2018.59.9.1096 · Cited by 65
Revisiting rodent models: Octodon degus as Alzheimer’s disease model?
Steffen, J., Krohn, M., Paarmann, K., Schwitlick, C., Brüning, T., Marreiros, R., Müller-Schiffmann, A., Korth, C., Braun, K., & Pahnke, J. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0363-y · Cited by 62
Rabarison, K. M., Bouldin, E. D., Bish, C. L., McGuire, L. C., Taylor, C. A., & Greenlund, K. J. (2018) · American Journal of Public Health · doi:10.2105/ajph.2018.304573 · Cited by 62
Yang, H., Leaver, A. M., Siddarth, P., Paholpak, P., Ercoli, L., St. Cyr, N. M., Eyre, H. A., Narr, K. L., Khalsa, D. S., & Lavretsky, H. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00277 · Cited by 61
Boltz, M., Chippendale, T., Resnick, B., & Galvin, J. E. (2015) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000072 · Cited by 61
Vidoni, E. D., Perales, J., Alshehri, M., Giles, A.-M., Siengsukon, C. F., & Burns, J. M. (2019) · Journal of Geriatric Physical Therapy · doi:10.1519/jpt.0000000000000172 · Cited by 61
Ferreira, A. R., Dias, C. C., & Fernandes, L. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00072 · Cited by 55
Sex-specific DNA methylation differences in Alzheimer’s disease pathology
Zhang, L., Young, J. I., Gomez, L., Silva, T. C., Schmidt, M. A., Cai, J., Chen, X., Martin, E. R., & Wang, L. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01177-8 · Cited by 58
A New Hypothesis for Alzheimer’s Disease: The Lipid Invasion Model
Rudge, J. D. (2022) · Journal of Alzheimer's Disease Reports · doi:10.3233/adr-210299 · Cited by 58
Su, Y., Blazey, T. M., Owen, C. J., Christensen, J. J., Friedrichsen, K., Joseph-Mathurin, N., Wang, Q., Hornbeck, R. C., Ances, B. M., Snyder, A. Z., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0152082 · Cited by 56
Family caregiving in the community up to 8-years after onset of dementia
Jutkowitz, E., Gaugler, J. E., Trivedi, A. N., Mitchell, L. L., & Gozalo, P. (2020) · BMC Geriatrics · doi:10.1186/s12877-020-01613-9 · Cited by 50
Exercise-Induced Modulation of Neuroinflammation in Models of Alzheimer’s Disease
Kelly, Á. M. (2018) · Brain Plasticity · doi:10.3233/bpl-180074 · Cited by 55
Barone, E., Head, E., Butterfield, D. A., & Perluigi, M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.508 · Cited by 53
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Metadata
- Authors
- Lin, F. R., Yaffe, K., Xia, J., Xue, Q.-L., Harris, T. B., Purchase-Helzner, E., Satterfield, S., Ayonayon, H. N., Ferrucci, L., Simonsick, E. M., & Health ABC Study Group, F. T.
- Affiliations
- Johns Hopkins University (US)
- University of California, San Francisco (US)
- National Institute on Aging (US)
- State University of New York (US)
- University of Tennessee Health Science Center (US)
- Corresponding author
- Lin, Frank R.
- Venue
- JAMA Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2013-02-25
- Volume
- 173
- Issue
- 4
- Pages
- 293
- ISSN
- 2168-6106 (ISSN-L)
- PMC
- PMC3869227
- OpenAlex
- W2122522567
- Cited by
- 4,017
- References
- 64
- Citations by year
- 2026: 105 · 2025: 194 · 2024: 296 · 2023: 360 · 2022: 351 · 2021: 355 · 2020: 330 · 2019: 331 · 2018: 345 · 2017: 307 · 2016: 326 · 2015: 332 · 2014: 134 · 2013: 56
- FWCI
- 155.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAMA Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (n01ag062101-007, n01ag062103-006, n01ag062106-007)
- National Institute on Aging (R01AG028050, P30AG02133, N01 AG062106, N01 AG062103, N01 AG062101)
- National Institute on Deafness and Other Communication Disorders (K23DC011279)
- National Institute of Nursing Research (R01NR012459)
- Topics
- Health Sciences › Health Professions › Speech and Hearing › Hearing Loss and Rehabilitation
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Keywords
- hearing loss, cognitive decline, cognitive impairment, older adults, pure-tone average, executive function, incident cognitive impairment, hearing loss severity, community-dwelling older adults, Health ABC Study, audiometry, Modified Mini-Mental State Examination, Digit Symbol Substitution Test, cardiovascular risk factors, dementia risk, Alzheimer's disease risk, stroke risk
- MeSH terms
- Aged, Aged, 80 and over, Aging, Audiometry, Cognition Disorders, Female, Humans, Male, Neuropsychological Tests, Prospective Studies, Risk Factors, Incidence, Linear Models, Proportional Hazards Models, Hearing Loss
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