Obesity and diabetes as high‐risk factors for severe coronavirus disease 2019 (Covid‐19)

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884

Epidemiological and clinical characteristics of 99 cases of 2019 novel Coronavirus pneumonia in Wuhan, China: a descriptive study.

Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415

Clinical characteristics of 138 hospitalized patients with 2019 Novel Coronavirus-Infected pneumonia in Wuhan, China

Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., et al. (2020) · JAMA · doi:10.1001/jama.2020.1585 · Cited by 20,148

La certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19

Martínez González, M. (2020) · DSPACE System - Metalibrary (University of the Coast) · Cited by 18,463

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention

Wu, Z., & McGoogan, J. M. (2020) · JAMA · doi:10.1001/jama.2020.2648 · Cited by 17,016

Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia

Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, K. S. M., Lau, E. H. Y., Wong, J. Y., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001316 · Cited by 16,575

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Song, H., Huang, B., Zhu, N., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30251-8 · Cited by 11,907

A new coronavirus associated with human respiratory disease in China

Wu, F., Zhao, S., Yu, B., Chen, Y.-M., Wang, W., Song, Z.-G., Hu, Y., Tao, Z.-W., Tian, J.-H., Pei, Y.-Y., et al. (2020) · Nature · doi:10.1038/s41586-020-2008-3 · Cited by 11,688

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., Wu, Y., Zhang, L., Yu, Z., Fang, M., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30079-5 · Cited by 10,066

COVID-19: consider cytokine storm syndromes and immunosuppression

Mehta, P., McAuley, D. F., Brown, M., Sanchez, E., Tattersall, R. S., & Manson, J. J. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30628-0 · Cited by 9,664

Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area

Richardson, S., Hirsch, J. S., Narasimhan, M., Crawford, J. M., McGinn, T., Davidson, K. W., and the Northwell COVID-19 Research Consortium, Barnaby, D. P., Becker, L. B., Chelico, J. D., et al. (2020) · JAMA · doi:10.1001/jama.2020.6775 · Cited by 9,254

Inflammation and metabolic disorders

Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199

Biochemistry and molecular cell biology of diabetic complications

Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Wrapp, D., Wang, N., Corbett, K. S., Goldsmith, J. A., Hsieh, C.-L., Abiona, O., Graham, B. S., & McLellan, J. S. (2020) · Science · doi:10.1126/science.abb2507 · Cited by 8,897

Child abuse: Adolescent records vs. adult recall

Femina, D. D., Yeager, C. A., & Lewis, D. O. (1990) · Child Abuse & Neglect · doi:10.1016/0145-2134(90)90033-p · Cited by 8,820

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

Xu, Z., Shi, L., Wang, Y., Zhang, J., Huang, L., Zhang, C., Liu, S., Zhao, P., Liu, H., Zhu, L., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30076-x · Cited by 8,545

A novel coronavirus outbreak of global health concern

Wang, C., Horby, P. W., Hayden, F. G., & Gao, G. F. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30185-9 · Cited by 7,700

Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis

Hamming, I., Timens, W., Bulthuis, M., Lely, A., Navis, G., & van Goor, H. (2004) · The Journal of Pathology · doi:10.1002/path.1570 · Cited by 5,676

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

Qin, C., Zhou, L., Hu, Z., Zhang, S., Yang, S., Tao, Y., Xie, C., Ma, K., Shang, K., Wang, W., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa248 · Cited by 4,775

Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany

Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Zimmer, T., Thiel, V., Janke, C., Guggemos, W., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2001468 · Cited by 4,144

Inflammatory Mechanisms in Obesity

Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury

Kuba, K., Imai, Y., Rao, S., Gao, H., Guo, F., Guan, B., Huan, Y., Yang, P., Zhang, Y., Deng, W., et al. (2005) · Nature Medicine · doi:10.1038/nm1267 · Cited by 3,445

COVID-19 and Italy: what next?

Remuzzi, A., & Remuzzi, G. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30627-9 · Cited by 3,119

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

Fang, L., Karakiulakis, G., & Roth, M. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30116-8 · Cited by 2,911

Excess Deaths Associated With Underweight, Overweight, and Obesity

Flegal, K. M. (2005) · JAMA · doi:10.1001/jama.293.15.1861 · Cited by 2,824

A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9

Donoghue, M., Hsieh, F., Baronas, E., Godbout, K., Gosselin, M., Stagliano, N., Donovan, M., Woolf, B., Robison, K., Jeyaseelan, R., et al. (2000) · Circulation Research · doi:10.1161/01.res.87.5.e1 · Cited by 2,485

Angiotensin-converting enzyme 2 protects from severe acute lung failure

Imai, Y., Kuba, K., Rao, S., Huan, Y., Guo, F., Guan, B., Yang, P., Sarao, R., Wada, T., Leong-Poi, H., et al. (2005) · Nature · doi:10.1038/nature03712 · Cited by 2,453

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2391 · Cited by 2,292

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230

Human Chemokines: An Update

Baggiolini, M., Dewald, B., & Moser, B. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.675 · Cited by 2,192

High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) Requiring Invasive Mechanical Ventilation

Simonnet, A., Chetboun, M., Poissy, J., Raverdy, V., Noulette, J., Duhamel, A., Labreuche, J., Mathieu, D., Pattou, F., Jourdain, M., et al. (2020) · Obesity · doi:10.1002/oby.22831 · Cited by 2,079

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

Raj, V. S., Mou, H., Smits, S. L., Dekkers, D. H. W., Müller, M. A., Dijkman, R., Muth, D., Demmers, J. A. A., Zaki, A., Fouchier, R. A. M., et al. (2013) · Nature · doi:10.1038/nature12005 · Cited by 2,061

Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China

Li, B., Yang, J., Zhao, F., Zhi, L., Wang, X., Liu, L., Bi, Z., & Zhao, Y. (2020) · Clinical Research in Cardiology · doi:10.1007/s00392-020-01626-9 · Cited by 2,057

A first case of meningitis/encephalitis associated with SARS-Coronavirus-2

Moriguchi, T., Harii, N., Goto, J., Harada, D., Sugawara, H., Takamino, J., Ueno, M., Sakata, H., Kondo, K., Myose, N., et al. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.03.062 · Cited by 2,024

The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease

McGonagle, D., Sharif, K., O'Regan, A., & Bridgewood, C. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102537 · Cited by 1,654

Effect of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockers on Cardiac Angiotensin-Converting Enzyme 2

Ferrario, C. M., Jessup, J., Chappell, M. C., Averill, D. B., Brosnihan, K. B., Tallant, E. A., Diz, D. I., & Gallagher, P. E. (2005) · Circulation · doi:10.1161/circulationaha.104.510461 · Cited by 1,565

Clinical Features and Short-term Outcomes of 144 Patients With SARS in the Greater Toronto Area

Booth, C. M. (2003) · JAMA · doi:10.1001/jama.289.21.joc30885 · Cited by 1,406

Diabetes is a risk factor for the progression and prognosis of COVID‐19

Guo, W., Li, M., Dong, Y., Zhou, H., Zhang, Z., Tian, C., Qin, R., Wang, H., Shen, Y., Du, K., et al. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3319 · Cited by 1,404

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15693 · Cited by 1,320

Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis

Wang, B., Li, R., Lu, Z., & Huang, Y. (2020) · Aging · doi:10.18632/aging.103000 · Cited by 1,304

Obesity in Patients Younger Than 60 Years Is a Risk Factor for COVID-19 Hospital Admission

Lighter, J., Phillips, M., Hochman, S., Sterling, S., Johnson, D., Francois, F., & Stachel, A. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa415 · Cited by 1,225

Monocyte chemoattractant protein 1 in obesity and insulin resistance

Sartipy, P., & Loskutoff, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133870100 · Cited by 1,201

Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam

Phan, L. T., Nguyen, T. V., Luong, Q. C., Nguyen, T. V., Nguyen, H. T., Le, H. Q., Nguyen, T. T., Cao, T. M., & Pham, Q. D. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2001272 · Cited by 1,137

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215693 · Cited by 1,105

Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes

Yang, J.-K., Lin, S.-S., Ji, X.-J., & Guo, L.-M. (2010) · Acta Diabetologica · doi:10.1007/s00592-009-0109-4 · Cited by 1,084

Mechanisms of leptin action and leptin resistance.

Myers, M. G., Cowley, M. A., & Münzberg, H. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100707 · Cited by 1,074

Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19

Liu, Y., Du, X., Chen, J., Jin, Y., Peng, L., Wang, H. H. X., Luo, M., Chen, L., & Zhao, Y. (2020) · Journal of Infection · doi:10.1016/j.jinf.2020.04.002 · Cited by 1,033

Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients

Zheng, H.-Y., Zhang, M., Yang, C.-X., Zhang, N., Wang, X.-C., Yang, X.-P., Dong, X.-Q., & Zheng, Y.-T. (2020) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-0401-3 · Cited by 940

The weight of leptin in immunity

Cava, A. L., & Matarese, G. (2004) · Nature Reviews Immunology · doi:10.1038/nri1350 · Cited by 927

The effect of obesity on lung function

Dixon, A. E., & Peters, U. (2018) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2018.1506331 · Cited by 889

Adiponectin as an anti-inflammatory factor

Ouchi, N., & Walsh, K. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.01.026 · Cited by 872

Quasispecies Theory and the Behavior of RNA Viruses

Lauring, A. S., & Andino, R. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001005 · Cited by 846

Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics

Gurwitz, D. (2020) · Drug Development Research · doi:10.1002/ddr.21656 · Cited by 802

Characteristics of and Public Health Responses to the Coronavirus Disease 2019 Outbreak in China

Deng, S.-Q., & Peng, H.-J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020575 · Cited by 718

ACE2 Expression in Pancreas May Cause Pancreatic Damage After SARS-CoV-2 Infection

Liu, F., Long, X., Zhang, B., Zhang, W., Chen, X., & Zhang, Z. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.04.040 · Cited by 718

T-lymphocyte Infiltration in Visceral Adipose Tissue: A Primary Event in Adipose Tissue Inflammation and the Development of Obesity-Mediated Insulin Resistance

Kintscher, U., Hartge, M., Hess, K., Foryst-Ludwig, A., Clemenz, M., Wabitsch, M., Fischer-Posovszky, P., Barth, T. F. E., Dragun, D., Skurk, T., et al. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.165100 · Cited by 692

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

Gralinski, L. E., Sheahan, T. P., Morrison, T. E., Menachery, V. D., Jensen, K., Leist, S. R., Whitmore, A., Heise, M. T., & Baric, R. S. (2018) · mBio · doi:10.1128/mbio.01753-18 · Cited by 655

Pharmacology, Physiology, and Mechanisms of Action of Dipeptidyl Peptidase-4 Inhibitors

Mulvihill, E. E., & Drucker, D. J. (2014) · Endocrine Reviews · doi:10.1210/er.2014-1035 · Cited by 609

Clinical characteristics and outcomes of patients with severe COVID-19 with diabetes

Yan, Y., Yang, Y., Wang, F., Ren, H., Zhang, S., Shi, X., Yu, X., & Dong, K. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-001343 · Cited by 572

Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice

Howard, J. K., Lord, G. M., Matarese, G., Vendetti, S., Ghatei, M. A., Ritter, M. A., Lechler, R. I., & Bloom, S. R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6762 · Cited by 567

Prevalence and impact of diabetes among people infected with SARS-CoV-2

Fadini, G. P., Morieri, M. L., Longato, E., & Avogaro, A. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01236-2 · Cited by 549

B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile

DeFuria, J., Belkina, A. C., Jagannathan-Bogdan, M., Snyder-Cappione, J., Carr, J. D., Nersesova, Y. R., Markham, D., Strissel, K. J., Watkins, A. A., Zhu, M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215840110 · Cited by 521

Clinical considerations for patients with diabetes in times of COVID-19 epidemic

Gupta, R., Ghosh, A., Singh, A. K., & Misra, A. (2020) · Diabetes & Metabolic Syndrome: Clinical Research & Reviews · doi:10.1016/j.dsx.2020.03.002 · Cited by 518

Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition

Hameed, I., Masoodi, S. R., Mir, S. A., Nabi, M., Ghazanfar, K., & Ganai, B. A. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i4.598 · Cited by 506

Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival

MacIver, N. J., Jacobs, S. R., Wieman, H. L., Wofford, J. A., Coloff, J. L., & Rathmell, J. C. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0108024 · Cited by 505

A role for leptin and its cognate receptor in hematopoiesis

Bennett, B. D., Solar, G. P., Yuan, J. Q., Mathias, J., Thomas, G. R., & Matthews, W. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70684-2 · Cited by 478

Obesity Is a Risk Factor for Greater COVID-19 Severity

Gao, F., Zheng, K. I., Wang, X.-B., Sun, Q.-F., Pan, K.-H., Wang, T.-Y., Chen, Y.-P., Targher, G., Byrne, C. D., George, J., et al. (2020) · Diabetes Care · doi:10.2337/dc20-0682 · Cited by 476

[Clinical characteristics and outcomes of 112 cardiovascular disease patients infected by 2019-nCoV].

Peng, Y., Meng, K., Guan, H., Leng, L., Zhu, R., Wang, B. Y., He, M. A., Cheng, L., Huang, K., & Zeng, Q. (2020) · PubMed · doi:10.3760/cma.j.cn112148-20200220-00105 · Cited by 469

Pancreatic Injury Patterns in Patients With Coronavirus Disease 19 Pneumonia

Wang, F., Wang, H., Fan, J., Zhang, Y., Wang, H., & Zhao, Q. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.03.055 · Cited by 459

Impact of Obesity on Influenza A Virus Pathogenesis, Immune Response, and Evolution

Honce, R., & Schultz-Cherry, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01071 · Cited by 457

The vasoprotective axes of the renin-angiotensin system: Physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases

Li, X. C., Zhang, J., & Zhuo, J. L. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.06.005 · Cited by 435

Obesity could shift severe COVID-19 disease to younger ages

Kass, D. A., Duggal, P., & Cingolani, O. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31024-2 · Cited by 435

A Novel Risk Factor for a Novel Virus: Obesity and 2009 Pandemic Influenza A (H1N1)

Louie, J. K., Acosta, M., Samuel, M. C., Schechter, R., Vugia, D. J., Harriman, K., Matyas, B. T., & the California Pandemic (H1N1) Working Group (2011) · Clinical Infectious Diseases · doi:10.1093/cid/ciq152 · Cited by 425

Obesity and immune function relationships

Martí, A., Marcos, A., & Martínez, J. A. (2001) · Obesity Reviews · doi:10.1046/j.1467-789x.2001.00025.x · Cited by 418

Elevated Proinflammatory Cytokine Production by a Skewed T Cell Compartment Requires Monocytes and Promotes Inflammation in Type 2 Diabetes

Jagannathan-Bogdan, M., McDonnell, M. E., Shin, H., Rehman, Q., Hasturk, H., Apovian, C. M., & Nikolajczyk, B. S. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002615 · Cited by 417

Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility

Ji, H.-L., Zhao, R., Matalon, S., & Matthay, M. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00013.2020 · Cited by 399

The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities

Ying, W., Fu, W., Lee, Y. S., & Olefsky, J. M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0286-3 · Cited by 391

Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic

Luzi, L., & Radaelli, M. G. (2020) · Acta Diabetologica · doi:10.1007/s00592-020-01522-8 · Cited by 382

Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection

Kulcsar, K. A., Coleman, C. M., Beck, S. E., & Frieman, M. B. (2019) · JCI Insight · doi:10.1172/jci.insight.131774 · Cited by 373

Aging, obesity, and inflammatory age-related diseases

Frasca, D., Blomberg, B. B., & Paganelli, R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01745 · Cited by 371

Management of Critically Ill Adults With COVID-19

Poston, J. T., Patel, B. K., & Davis, A. M. (2020) · JAMA · doi:10.1001/jama.2020.4914 · Cited by 367

T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans

McLaughlin, T., Liu, L.-F., Lamendola, C., Shen, L., Morton, J., Rivas, H., Winer, D., Tolentino, L., Choi, O., Zhang, H., et al. (2014) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.114.304636 · Cited by 364

Joint HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID-19

Bozkurt, B., Kovacs, R., & Harrington, B. (2020) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2020.04.013 · Cited by 355

Long-term treatment with interleukin-1β induces insulin resistance in murine and human adipocytes

Lagathu, C., Yvan-Charvet, L., Bastard, J.-P., Maachi, M., Quignard-Boulangé, A., Capeau, J., & Caron, M. (2006) · Diabetologia · doi:10.1007/s00125-006-0335-z · Cited by 321

Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation, and Cytokine Amplification in Coronavirus Disease 2019?

Ryan, P. M., & Caplice, N. M. (2020) · Obesity · doi:10.1002/oby.22843 · Cited by 321

Covid‐19 and diabetes mellitus: unveiling the interaction of two pandemics

Maddaloni, E., & Buzzetti, R. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3321 · Cited by 305

The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease

Garidou, L., Pomié, C., Klopp, P., Waget, A., Charpentier, J., Aloulou, M., Giry, A., Serino, M., Stenman, L., Lahtinen, S., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.001 · Cited by 303

Human adenovirus-36 is associated with increased body weight and paradoxical reduction of serum lipids

Atkinson, R. L., Dhurandhar, N. V., Allison, D. B., Bowen, R. L., Israel, B. A., Albu, J. B., & Augustus, A. S. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802830 · Cited by 302

Characterization of ACE and ACE2 Expression within Different Organs of the NOD Mouse

Roca-Ho, H., Riera, M., Palau, V., Pascual, J., & Soler, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030563 · Cited by 301

Obesity and type 2 diabetes mellitus drive immune dysfunction, infection development, and sepsis mortality

Frydrych, L. M., Bian, G., O’Lone, D. E., Ward, P. A., & Delano, M. J. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.5vmr0118-021rr · Cited by 299

Diabetes and the Severity of Pandemic Influenza A (H1N1) Infection

Allard, R., Leclerc, P., Tremblay, C., & Tannenbaum, T.-N. (2010) · Diabetes Care · doi:10.2337/dc09-2215 · Cited by 297

Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury

Yang, P., Gu, H., Zhao, Z., Wang, W., Cao, B., Lai, C., Yang, X., Zhang, L., Duan, Y., Zhang, S., et al. (2014) · Scientific Reports · doi:10.1038/srep07027 · Cited by 283

Systematic review of the association between lung function and Type 2 diabetes mellitus

Klein, O. L., Krishnan, J. A., Glick, S., & Smith, L. J. (2010) · Diabetic Medicine · doi:10.1111/j.1464-5491.2010.03073.x · Cited by 274

Angiotensin-I-converting enzyme and its relatives.

Riordan, J. F. (2003) · Genome biology · doi:10.1186/gb-2003-4-8-225 · Cited by 272

Leptin Promotes Differentiation and Survival of Human Dendritic Cells and Licenses Them for Th1 Priming

Mattioli, B., Straface, E., Quaranta, M. G., Giordani, L., & Viora, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.6820 · Cited by 271

The Role of Adipocytes and Adipocyte‐Like Cells in the Severity of COVID‐19 Infections

Kruglikov, I. L., & Scherer, P. E. (2020) · Obesity · doi:10.1002/oby.22856 · Cited by 252

Inflammation-Sensitive Plasma Proteins Are Associated With Future Weight Gain

Engström, G., Hedblad, B., Stavenow, L., Lind, P., Janzon, L., & Lindgärde, F. (2003) · Diabetes · doi:10.2337/diabetes.52.8.2097 · Cited by 249

Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009)

Nguyen-Van-Tam, J. S., Openshaw, P. J. M., Hashim, A., Gadd, E. M., Lim, W. S., Semple, M. G., Read, R. C., Taylor, B. L., Brett, S. J., McMenamin, J., et al. (2010) · Thorax · doi:10.1136/thx.2010.135210 · Cited by 248

The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications

Zeng, C., Shi, X., Zhang, B., Liu, H., Zhang, L., Ding, W., & Zhao, Y. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0816-5 · Cited by 245

Obesity increases the duration of influenza a virus shedding in adults

Maier, H. E., Lopez, R., Sanchez, N., Ng, S., Gresh, L., Ojeda, S., Burger-Calderon, R., Kuan, G., Harris, E., Balmaseda, A., et al. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy370 · Cited by 245

Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation

Xia, C., Rao, X., & Zhong, J. (2017) · Journal of Diabetes Research · doi:10.1155/2017/6494795 · Cited by 237

Increased adiposity in animals due to a human virus

Dhurandhar, N., Israel, B., Kolesar, J., Mayhew, G., Cook, M., & Atkinson, R. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801319 · Cited by 221

Metabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profiling

Ritter, J. B., Wahl, A. S., Freund, S., Genzel, Y., & Reichl, U. (2010) · BMC Systems Biology · doi:10.1186/1752-0509-4-61 · Cited by 218

Role of adipose tissue renin–angiotensin system in metabolic and inflammatory diseases associated with obesity

Yvan-Charvet, L., & Quignard-Boulangé, A. (2011) · Kidney International · doi:10.1038/ki.2010.391 · Cited by 217

Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality

Fernandez, C., Rysä, J., Almgren, P., Nilsson, J., Engström, G., Orho‐Melander, M., Ruskoaho, H., & Melander, O. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12783 · Cited by 211

The clinical characteristics and outcomes of patients with diabetes and secondary hyperglycaemia with coronavirus disease 2019: A single‐centre, retrospective, observational study in Wuhan

Zhang, Y., Li, H., Zhang, J., Cao, Y., Zhao, X., Yu, N., Gao, Y., Ma, J., Zhang, H., Zhang, J., et al. (2020) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.14086 · Cited by 205

ACE2 is expressed in mouse adipocytes and regulated by a high-fat diet

Gupte, M., Boustany-Kari, C. M., Bharadwaj, K., Police, S., Thatcher, S., Gong, M. C., English, V. L., & Cassis, L. A. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00183.2008 · Cited by 204

Neutrophils and monocytes as potentially important sources of proinflammatory cytokines in diabetes

Hatanaka, E., Monteagudo, P. T., Marrocos, M. S. M., & Campa, A. (2006) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2006.03229.x · Cited by 203

Organ-specific distribution of ACE2 mRNA and correlating peptidase activity in rodents

Gembardt, F., Sterner-Kock, A., Imboden, H., Spalteholz, M., Reibitz, F., Schultheiss, H.-P., Siems, W.-E., & Walther, T. (2005) · Peptides · doi:10.1016/j.peptides.2005.01.009 · Cited by 190

Virus-Induced Interferon-γ Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity

Šestan, M., Marinović, S., Kavazović, I., Cekinović, Đ., Wueest, S., Turk Wensveen, T., Brizić, I., Jonjić, S., Konrad, D., Wensveen, F. M., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.05.005 · Cited by 189

Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 Influenza a virus: Obese/Overweight Response to Influenza

Paich, H. A., Sheridan, P. A., Handy, J., Karlsson, E. A., Schultz-Cherry, S., Hudgens, M. G., Noah, T. L., Weir, S. S., & Beck, M. A. (2013) · Obesity · doi:10.1002/oby.20383 · Cited by 184

Diabetes and COVID-19: evidence, current status and unanswered research questions

Gupta, R., Hussain, A., & Misra, A. (2020) · European Journal of Clinical Nutrition · doi:10.1038/s41430-020-0652-1 · Cited by 182

Glycosylated hemoglobin is associated with systemic inflammation, hypercoagulability, and prognosis of COVID-19 patients

Wang, Z., Du, Z., & Zhu, F. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108214 · Cited by 179

Human monocytes and macrophages undergo M1-type inflammatory polarization in response to high levels of glucose

Torres-Castro, I., Arroyo-Camarena, Ú. D., Martínez-Reyes, C. P., Gómez-Arauz, A. Y., Dueñas-Andrade, Y., Hernández-Ruiz, J., Béjar, Y. L., Zaga-Clavellina, V., Morales-Montor, J., Terrazas, L. I., et al. (2016) · Immunology Letters · doi:10.1016/j.imlet.2016.06.001 · Cited by 172

Systematic Review of the Toxicity of Long-Course Oral Corticosteroids in Children

Aljebab, F., Choonara, I., & Conroy, S. (2017) · PLOS ONE · doi:10.1371/journal.pone.0170259 · Cited by 172

Natural Killer Cell Function, an Important Target for Infection and Tumor Protection, Is Impaired in Type 2 Diabetes

Berrou, J., Fougeray, S., Venot, M., Chardiny, V., Gautier, J., Dulphy, N., Toubert, A., & Péraldi, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062418 · Cited by 166

SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects

Michalakis, K., & Ilias, I. (2020) · Diabetes & Metabolic Syndrome: Clinical Research & Reviews · doi:10.1016/j.dsx.2020.04.033 · Cited by 162

Patients with diabetes are at higher risk for severe illness from COVID-19

Targher, G., Mantovani, A., Wang, X.-B., Yan, H.-D., Sun, Q.-F., Pan, K.-H., Byrne, C. D., Zheng, K. I., Chen, Y.-P., Eslam, M., et al. (2020) · Diabetes & Metabolism · doi:10.1016/j.diabet.2020.05.001 · Cited by 161

Human Adenovirus 36 Induces Adiposity, Increases Insulin Sensitivity, and Alters Hypothalamic Monoamines in Rats

Pasarica, M., Shin, A. C., Yu, M., Yang, H. O., Rathod, M., Jen, K. C., Kumar, S. M., MohanKumar, P. S., Markward, N., & Dhurandhar, N. V. (2006) · Obesity · doi:10.1038/oby.2006.222 · Cited by 160

Role of T Cells in Malnutrition and Obesity

Gerriets, V. A., & MacIver, N. J. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00379 · Cited by 159

Obesity Expands a Distinct Population of T Cells in Adipose Tissue and Increases Vulnerability to Infection

Misumi, I., Starmer, J., Uchimura, T., Beck, M. A., Magnuson, T., & Whitmire, J. K. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.030 · Cited by 157

Pathogenesis of Middle East respiratory syndrome coronavirus

van den Brand, J. M. A., Smits, S. L., & Haagmans, B. L. (2014) · The Journal of Pathology · doi:10.1002/path.4458 · Cited by 154

Targeting the Adipose Tissue in COVID‐19

Malavazos, A. E., Romanelli, M. M. C., Bandera, F., & Iacobellis, G. (2020) · Obesity · doi:10.1002/oby.22844 · Cited by 153

IL-17+ CD8+ T cells: Differentiation, phenotype and role in inflammatory disease

Srenathan, U., Steel, K. J. A., & Taams, L. S. (2016) · Immunology Letters · doi:10.1016/j.imlet.2016.05.001 · Cited by 143

Impairment of Dendritic Cell Functionality and Steady-State Number in Obese Mice

Macia, L., Delacre, M., Abboud, G., Ouk, T., Delanoye, A., Verwaerde, C., Saule, P., & Wolowczuk, I. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.5997 · Cited by 142

Letter to the Editor: Diabetes patients with COVID-19 need better blood glucose management in Wuhan, China

Zhou, J., & Tan, J. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154216 · Cited by 137

Tissue resident macrophages: Key players in the pathogenesis of type 2 diabetes and its complications

Meshkani, R., & Vakili, S. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.08.015 · Cited by 136

Alterations in T-Cell Subset Frequency in Peripheral Blood in Obesity

O’Rourke, R. W., Kay, T., Scholz, M. H., Diggs, B. S., Jobe, B. A., Lewinsohn, D. M., & Bakke, A. C. (2005) · Obesity Surgery · doi:10.1381/096089205774859308 · Cited by 130

Impact of Obesity in Patients Infected With 2009 Influenza A(H1N1)

Dı́az, E., Rodríguez, A. H., Martín‐Loeches, I., Lorente, L., Martín, M. D. M., Laderas, J. C. P., Montejo, J. C., Estella, Á., Arenzana, Á., & Rello, J. (2010) · CHEST Journal · doi:10.1378/chest.10-1160 · Cited by 129

Viruses and Diabetes

Jaeckel, E., Manns, M. P., & von Herrath, M. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02943.x · Cited by 129

Advanced Glycosylation End Products Might Promote Atherosclerosis Through Inducing the Immune Maturation of Dendritic Cells

Ge, J., Jia, Q., Liang, C., Luo, Y., Huang, D., Sun, A., Wang, K., Zou, Y., & Chen, H. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000181744.58265.63 · Cited by 128

SGLT2 inhibitors increase the risk of diabetic ketoacidosis developing in the community and during hospital admission

Hamblin, P. S., Wong, R., Ekinci, E. I., Fourlanos, S., Shah, S., Jones, A. R., Hare, M. J. L., Calder, G. L., Epa, D. S., George, E. M., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00139 · Cited by 126

A systematic review of the effect of oral glucocorticoids on energy intake, appetite, and body weight in humans

Berthon, B. S., MacDonald‐Wicks, L. K., & Wood, L. G. (2014) · Nutrition Research · doi:10.1016/j.nutres.2013.12.006 · Cited by 126

Diet-Induced Obesity in Mice Reduces the Maintenance of Influenza-Specific CD8+ Memory T Cells ,

Karlsson, E. A., Sheridan, P. A., & Beck, M. A. (2010) · Journal of Nutrition · doi:10.3945/jn.110.123653 · Cited by 126

Potential Biochemical Mechanisms of Lung Injury in Diabetes

Zheng, H., Wu, J., Jin, Z. H., & Yan, L. (2017) · Aging and Disease · doi:10.14336/ad.2016.0627 · Cited by 124

Adipogenic human adenovirus-36 reduces leptin expression and secretion and increases glucose uptake by fat cells

Vangipuram, S. D., Yu, M., Tian, J., Stanhope, K. L., Pasarica, M., Havel, P. J., Heydari, A. R., & Dhurandhar, N. V. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803366 · Cited by 122

A Human Adenovirus Enhances Preadipocyte Differentiation

Vangipuram, S. D., Sheele, J., Atkinson, R. L., Holland, T. C., & Dhurandhar, N. V. (2004) · Obesity Research · doi:10.1038/oby.2004.93 · Cited by 121

Obesity-Related Microenvironment Promotes Emergence of Virulent Influenza Virus Strains

Honce, R., Karlsson, E. A., Wohlgemuth, N., Estrada, L. D., Meliopoulos, V., Yao, J., & Schultz‐Cherry, S. (2020) · mBio · doi:10.1128/mbio.03341-19 · Cited by 121

The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: a two-step, two-sample Mendelian randomisation study

Xu, L., Borges, M. C., Hemani, G., & Lawlor, D. A. (2017) · Diabetologia · doi:10.1007/s00125-017-4396-y · Cited by 104

ACE2/Ang 1-7 axis: A critical regulator of epicardial adipose tissue inflammation and cardiac dysfunction in obesity

Patel, V. B., Basu, R., & Oudit, G. Y. (2016) · Adipocyte · doi:10.1080/21623945.2015.1131881 · Cited by 104

Obesity and malnutrition similarly alter the renin–angiotensin system and inflammation in mice and human adipose

Pinheiro, T. D. A., Barcala-Jorge, A. S., Andrade, J. M. O., Pinheiro, T. D. A., Ferreira, E. C. N., Crespo, T. S., Batista-Jorge, G. C., Vieira, C. A., Lelis, D. D. F., Paraíso, A. F., et al. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.06.008 · Cited by 104

Exercise against SARS-CoV-2 (COVID-19): Does workout intensity matter? (A mini review of some indirect evidence related to obesity)

Rahmati-Ahmadabad, S., & Hosseini, F. (2020) · Obesity Medicine · doi:10.1016/j.obmed.2020.100245 · Cited by 103

Activated T Lymphocytes in Type 2 Diabetes: Implications From in Vitro Studies

Stentz, F. B., & Kitabchi, A. E. (2003) · Current Drug Targets · doi:10.2174/1389450033490966 · Cited by 99

Association between obesity and vulnerability and serologic response to influenza vaccination in older adults

Talbot, H. K., Coleman, L. A., Crimin, K. S., Zhu, Y., Rock, M. T., Meece, J. K., Shay, D. K., Belongia, E. A., & Griffin, M. R. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.03.071 · Cited by 98

Exposure to dipeptidyl‐peptidase‐4 inhibitors and COVID ‐19 among people with type 2 diabetes: A case‐control study

Fadini, G. P., Morieri, M. L., Longato, E., Bonora, B. M., Pinelli, S., Selmin, E., Voltan, G., Falaguasta, D., Tresso, S., Costantini, G., et al. (2020) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14097 · Cited by 98

Obesity and SARS‐CoV ‐2: A population to safeguard

Watanabe, M., Risi, R., Tuccinardi, D., Baquero, C. J., Manfrini, S., & Gnessi, L. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3325 · Cited by 93

Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality

Teoh, H., Quan, A., Bang, K. W. A., Wang, G., Lovren, F., Vu, V. P., Haitsma, J. J., Szmitko, P. E., Al-Omran, M. A., Wang, C., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90384.2008 · Cited by 92

Regular Exercise Enhances the Immune Response Against Microbial Antigens Through Up-Regulation of Toll-like Receptor Signaling Pathways

Zheng, Q., Cui, G., Chen, J., Gao, H., Wei, Y., Uede, T., Chen, Z., & Diao, H. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430391 · Cited by 90

Obesity Impairs γδ T Cell Homeostasis and Antiviral Function in Humans

Costanzo, A. E., Taylor, K. R., Dutt, S., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120918 · Cited by 85

Adenovirus 36 as an Obesity Agent Maintains the Obesity State by Increasing MCP-1 and Inducing Inflammation

Na, H.-N., & Nam, J. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir864 · Cited by 80

Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARγ

Al-Qahtani, A. A., Lyroni, K., Aznaourova, M., Tseliou, M., Al‐Anazi, M. R., Al‐Ahdal, M. N., Alkahtani, S. H., Sourvinos, G., & Tsatsanis, C. (2017) · Oncotarget · doi:10.18632/oncotarget.14754 · Cited by 80

Obesity-Induced Changes in T-Cell Metabolism Are Associated With Impaired Memory T-Cell Response to Influenza and Are Not Reversed With Weight Loss

Rebeles, J., Green, W. D., Alwarawrah, Y., Nichols, A., Eisner, W., Danzaki, K., MacIver, N. J., & Beck, M. A. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy700 · Cited by 80

The Relationship Among Food Addiction, Negative Mood, and Eating-Disordered Behaviors in Patients Seeking to Have Bariatric Surgery

Koball, A. M., Clark, M. M., Collazo-Clavell, M., Kellogg, T., Ames, G., Ebbert, J., & Grothe, K. B. (2016) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2015.04.009 · Cited by 78

Increased urinary angiotensin converting enzyme 2 and neprilysin in patients with type 2 diabetes

Gutta, S., Grobe, N., Kumbaji, M., Osman, H., Saklayen, M. G., Li, G., & Elased, K. M. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00565.2017 · Cited by 72

Obesity is strongly and independently associated with a higher prevalence of pulmonary embolism

Movahed, M. R., Khoubyari, R., Hashemzadeh, M., & Hashemzadeh, M. (2019) · Respiratory Investigation · doi:10.1016/j.resinv.2019.01.003 · Cited by 70

Remdesivir attenuates high fat diet (HFD)-induced NAFLD by regulating hepatocyte dyslipidemia and inflammation via the suppression of STING

Li, Y., & Su, Y. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.03.034 · Cited by 63

Influence of Obesity on Pneumococcus Infection Risk in the Elderly

Frasca, D., & McElhaney, J. E. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00071 · Cited by 58

Obesity-related immunodeficiency in patients with pandemic influenza H1N1

Nave, H., Beutel, G., & Kielstein, J. T. (2010) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(10)70304-2 · Cited by 51

Sepsis in diabetes: A bad duo

Tiwari, S., Pratyush, D. D., Gahlot, A., & Singh, S. K. (2011) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2012.02.026 · Cited by 51

The effect of lipopolysaccharide-induced obesity and its chronic inflammation on influenza virus-related pathology

Ahn, S., Sohn, S., Lee, S., Park, H.-L., Park, Y.-W., Kim, H., & Nam, J. (2015) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2015.09.020 · Cited by 48

Metabolic and neurologic consequences of chronic lopinavir/ritonavir administration to C57BL/6 mice

Pistell, P. J., Gupta, S., Knight, A. G., Domingue, M., Uranga, R. M., Ingram, D. K., Kheterpal, I., Ruiz, C., Keller, J. N., & Bruce‐Keller, A. J. (2010) · Antiviral Research · doi:10.1016/j.antiviral.2010.10.006 · Cited by 44

Association of serum complement C3 with metabolic syndrome components in normal weight obese women

Karkhaneh, M., Qorbani, M., Mohajeri-Tehrani, M. R., & Hoseini, S. (2017) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/s40200-017-0330-6 · Cited by 44

Hydroxychloroquine Improves Obesity-Associated Insulin Resistance and Hepatic Steatosis by Regulating Lipid Metabolism

Qiao, X., Zhou, Z., Niu, R., Su, Y., Sun, Y., Liu, H.-L., Teng, J., Ye, J., Shi, H., Yang, C., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00855 · Cited by 43

Pulmonary System and Obesity

Ashburn, D. D., DeAntonio, A., & Reed, M. J. (2010) · Critical Care Clinics · doi:10.1016/j.ccc.2010.06.008 · Cited by 40

The relationship between urinary renin-angiotensin system markers, renal function, and blood pressure in adolescents with type 1 diabetes

Burns, K. D., Lytvyn, Y., Mahmud, F. H., et al. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00438.2016 · Cited by 39

Body mass index and infectious disease mortality in midlife in a cohort of 2.3 million adolescents

Twig, G., Geva, N., Levine, H., Derazne, E., Goldberger, N., Haklai, Z., Leiba, A., & Kark, J. D. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.263 · Cited by 39

Urinary Angiotensin Converting Enzyme 2 Increases in Patients With Type 2 Diabetic Mellitus

Liang, Y., Deng, H., Bi, S., Cui, Z., Lata, A., Zheng, D., & Wang, Y. (2015) · Kidney & Blood Pressure Research · doi:10.1159/000368486 · Cited by 34

Oseltamivir and Oseltamivir Carboxylate Pharmacokinetics in Obese Adults: Dose Modification for Weight Is Not Necessary

Pai, M. P., & Lodise, T. P. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00422-11 · Cited by 32

RNA virus evolution, population dynamics, and nutritional status

Domingo, E. (1997) · Biological Trace Element Research · doi:10.1007/bf02778981 · Cited by 28

Impact of Glucose Loading on Variations in CD4+ and CD8+ T Cells in Japanese Participants with or without Type 2 Diabetes

Miya, A., Nakamura, A., Miyoshi, H., Takano, Y., Sunagoya, K., Hayasaka, K., Shimizu, C., Terauchi, Y., & Atsumi, T. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00081 · Cited by 28

Diet-induced obesity reduces the production of influenza vaccine-induced antibodies via impaired macrophage function

Cho, W., LEE, D.-K., LEE, S.-Y., SOHN, S.-H., Park, H.-S., PARK, Y.-W., Kim, H. M., & NAM, J.-H. (2016) · Acta Virologica · doi:10.4149/av_2016_03_298 · Cited by 26

Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming

Mattioli, B., Straface, E., Quaranta, M. G., Giordani, L., & Viora, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.5.3446-a · Cited by 26

Adiposity and incident diabetes within 4 years of follow‐up: the Guangzhou Biobank Cohort Study

Xu, L., Lam, T., Jiang, C. Q., Zhang, W. S., Jin, Y. L., Zhu, T., Zhu, F., Thomas, G. N., & Cheng, K. K. (2017) · Diabetic Medicine · doi:10.1111/dme.13378 · Cited by 25

Transient diabetes following chicken pox.

Jali, M. V., & Shankar, P. S. (1990) · PubMed · Cited by 24

Population pharmacokinetics of oseltamivir and oseltamivir carboxylate in obese and non‐obese volunteers

Chairat, K., Jittamala, P., Hanpithakpong, W., Day, N., White, N. J., Pukrittayakamee, S., & Tärning, J. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12892 · Cited by 22

Adiposity and mortality in older Chinese: an 11-year follow-up of the Guangzhou Biobank Cohort Study

Jiang, C. Q., Xu, L., Zhang, W. S., Jin, Y. L., Zhu, F., Cheng, K. K., & Lam, T. H. (2020) · Scientific Reports · doi:10.1038/s41598-020-58633-z · Cited by 21

Obesity alters the topographical distribution of ventilation and the regional response to bronchoconstriction

Rutting, S., Mahadev, S., Tonga, K. O., Bailey, D. L., Carroll, J. R. D., Farrow, C. E., Thamrin, C., Chapman, D. G., & King, G. G. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00482.2019 · Cited by 16

Long term azithromycin therapy in patients with cystic fibrosis

Emiralioğlu, N., Öztürk, Z., Yalçın, E., Doğru, D., Özçelik, U., & Kiper, N. (2016) · The Turkish Journal of Pediatrics · doi:10.24953/turkjped.2016.01.005 · Cited by 7

Farnesyltransferase inhibitors prevent HIV protease inhibitor (lopinavir/ritonavir)-induced lipodystrophy and metabolic syndrome in mice

Tanaka, T., Nakazawa, H., Kuriyama, N., & Kaneki, M. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5526 · Cited by 7

State of the science on brain insulin resistance and cognitive decline due to Alzheimer's disease

Rhea, E. M., Leclerc, M., Yassine, H. N., Capuano, A. W., Tong, H., Petyuk, V. A., Macauley, S. L., Fioramonti, X., Carmichael, O., Calon, F., et al. (2023) · Aging and disease · doi:10.14336/ad.2023.0814 · Cited by 70

A review on biochemical constituents of pumpkin and their role as pharma foods; a key strategy to improve health in post COVID 19 period

Hussain, A., Kausar, T., Sehar, S., Sarwar, A., Quddoos, M. Y., Aslam, J., Liaqat, A., Siddique, T., An, Q. U., Kauser, S., et al. (2023) · Food Production, Processing and Nutrition · doi:10.1186/s43014-023-00138-z · Cited by 61