Exosomes – vesicular carriers for intercellular communication

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834

Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766

B lymphocytes secrete antigen-presenting vesicles.

Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546

Identification of Tim4 as a phosphatidylserine receptor

Miyanishi, M., Tada, K., Koike, M., Uchiyama, Y., Kitamura, T., & Nagata, S. (2007) · Nature · doi:10.1038/nature06307 · Cited by 1,180

Exosomes are released by cultured cortical neurones

Fauré, J., Lachenal, G., Court, M., Hirrlinger, J., Chatellard-Causse, C., Blot, B., Grange, J., Schoehn, G., Goldberg, Y., Boyer, V., et al. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.12.003 · Cited by 896

Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization

Matsuo, H., Chevallier, J., Mayran, N., Le Blanc, I., Ferguson, C., Fauré, J., Blanc, N. S., Matile, S., Dubochet, J., Sadoul, R., et al. (2004) · Science · doi:10.1126/science.1092425 · Cited by 705

Extracellular vesicles: Exosomes, microvesicles, and friends

Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

Vickers, K. C., Palmisano, B. T., Shoucri, B. M., Shamburek, R. D., & Remaley, A. T. (2011) · Nature Cell Biology · doi:10.1038/ncb2210 · Cited by 2,741

Exosomes: biogenesis, biologic function and clinical potential

Zhang, Y., Liu, Y., Liu, H., & Tang, W. H. (2019) · Cell & Bioscience · doi:10.1186/s13578-019-0282-2 · Cited by 2,119

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

Becker, A., Thakur, B. K., Weiss, J. M., Kim, H. S., Peinado, H., & Lyden, D. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.10.009 · Cited by 2,003

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

Ha, D., Yang, N., & Nadithe, V. (2016) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.02.001 · Cited by 1,346

Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications

Zhang, Y., Bi, J., Huang, J., Tang, Y., Du, S., & Li, P. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s264498 · Cited by 1,323

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

Tian, T., Zhang, H.-X., He, C.-P., Fan, S., Zhu, Y.-L., Qi, C., Huang, N.-P., Xiao, Z.-D., Lu, Z.-H., Tannous, B. A., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2017.10.012 · Cited by 1,154

Strategies for delivering therapeutics across the blood–brain barrier

Terstappen, G. C., Meyer, A. H., Bell, R. D., & Zhang, W. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00139-y · Cited by 1,138

The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis

van Niel, G., Charrin, S., Simoes, S., Romao, M., Rochin, L., Saftig, P., Marks, M. S., Rubinstein, E., & Raposo, G. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.08.019 · Cited by 950

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

Zhao, H., Yang, L., Baddour, J., Achreja, A., Bernard, V., Moss, T., Marini, J. C., Tudawe, T., Seviour, E. G., San Lucas, F. A., et al. (2016) · eLife · doi:10.7554/elife.10250 · Cited by 927

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

Frühbeis, C., Fröhlich, D., Kuo, W. P., Amphornrat, J., Thilemann, S., Saab, A. S., Kirchhoff, F., Möbius, W., Goebbels, S., Nave, K.-A., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001604 · Cited by 902

NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo

Jia, G., Han, Y., An, Y., Ding, Y., He, C., Wang, X., & Tang, Q. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.06.029 · Cited by 753

Secreted microRNAs: a new form of intercellular communication

Chen, X., Liang, H., Zhang, J., Zen, K., & Zhang, C.-Y. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.12.001 · Cited by 690

Lysosomal storage disorders: The cellular impact of lysosomal dysfunction

Platt, F. M., Boland, B., & van der Spoel, A. C. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201208152 · Cited by 689

Exosome Processing and Characterization Approaches for Research and Technology Development

Lai, J. J., Chau, Z. L., Chen, S., Hill, J. J., Korpany, K. V., Liang, N., Lin, L., Lin, Y., Liu, J. K., Liu, Y., et al. (2022) · Advanced Science · doi:10.1002/advs.202103222 · Cited by 623

Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells.

Squadrito, M. L., Baer, C., Burdet, F., Maderna, C., Gilfillan, G. D., Lyle, R., Ibberson, M., & De Palma, M. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.035 · Cited by 604

Exosomes from M1-Polarized Macrophages Enhance Paclitaxel Antitumor Activity by Activating Macrophages-Mediated Inflammation

Wang, P., Wang, H., Huang, Q., Peng, C., Yao, L., Chen, H., Qiu, Z., Wu, Y., Wang, L., & Chen, W. (2019) · Theranostics · doi:10.7150/thno.30716 · Cited by 494

Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo

Zhu, W., Huang, L., Li, Y., Zhang, X., Gu, J., Yan, Y., Xu, X., Wang, M., Qian, H., & Xu, W. (2012) · Cancer Letters · doi:10.1016/j.canlet.2011.10.002 · Cited by 488

Schwann cell‐derived exosomes enhance axonal regeneration in the peripheral nervous system

Lopez‐Verrilli, M. A., Picou, F., & Court, F. A. (2013) · Glia · doi:10.1002/glia.22558 · Cited by 453

ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes

Larios, J., Mercier, V., Roux, A., & Gruenberg, J. (2020) · Journal of Cell Biology · doi:10.1083/jcb.201904113 · Cited by 422

Mechanisms associated with biogenesis of exosomes in cancer

McAndrews, K. M., & Kalluri, R. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0963-9 · Cited by 394

Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth

Bellavia, D., Raimondo, S., Calabrese, G., Forte, S., Cristaldi, M., Patinella, A., Memeo, L., Manno, M., Raccosta, S., Diana, P., et al. (2017) · Theranostics · doi:10.7150/thno.17092 · Cited by 368

Endocytosis and signaling: Cell logistics shape the eukaryotic cell plan

Sigismund, S., Confalonieri, S., Ciliberto, A., Polo, S., Scita, G., & Di Fiore, P. P. (2012) · Physiological Reviews · doi:10.1152/physrev.00005.2011 · Cited by 338

Heparanase Regulates Secretion, Composition, and Function of Tumor Cell-derived Exosomes

Thompson, C. A., Purushothaman, A., Ramani, V. C., Vlodavsky, I., & Sanderson, R. D. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.c112.444562 · Cited by 322

A Nanodrug Consisting Of Doxorubicin And Exosome Derived From Mesenchymal Stem Cells For Osteosarcoma Treatment In Vitro

Wei, H., Chen, J., Wang, S., Fu, F., Zhu, X., Wu, C., Liu, Z., Zhong, G., & Lin, J. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s218988 · Cited by 317

Exosomes Derived from HIV-1-infected Cells Contain Trans-activation Response Element RNA

Narayanan, A., Iordanskiy, S., Das, R., Van Duyne, R., Santos, S., Jaworski, E., Guendel, I., Sampey, G., Dalby, E., Iglesias-Ussel, M., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.438895 · Cited by 316

Clinical and Biological Characterization of Skin Pigmentation Diversity and Its Consequences on UV Impact

Del Bino, S., Duval, C., & Bernerd, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092668 · Cited by 315

C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transduction

Guescini, M., Guidolin, D., Vallorani, L., Casadei, L., Gioacchini, A. M., Tibollo, P., Battistelli, M., Falcieri, E., Battistin, L., Agnati, L. F., et al. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.04.006 · Cited by 294

The function and clinical application of extracellular vesicles in innate immune regulation

Zhou, X., Xie, F., Wang, L., Zhang, L., Zhang, S., Fang, M., & Zhou, F. (2020) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-0391-1 · Cited by 294

Ticket to a bubble ride: Cargo sorting into exosomes and extracellular vesicles

Anand, S., Samuel, M., Kumar, S., & Mathivanan, S. (2019) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2019.02.005 · Cited by 284

Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes

Jiang, D., Gong, F., Ge, X., Lv, C., Huang, C., Feng, S., Zhou, Z., Rong, Y., Wang, J., Ji, C., et al. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00665-8 · Cited by 282

Emerging roles of exosomes in neuron-glia communication

Frühbeis, C., Fröhlich, D., & Krämer-Albers, E.-M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00119 · Cited by 275

Melanosomes are transferred from melanocytes to keratinocytes through the processes of packaging, release, uptake, and dispersion

Ando, H., Niki, Y., Ito, M., Akiyama, K., Matsui, M. S., Yarosh, D. B., & Ichihashi, M. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.413 · Cited by 258

Exosomes released by keratinocytes modulate melanocyte pigmentation

Cicero, A. L., Delevoye, C., Gilles-Marsens, F., Loew, D., Dingli, F., Guéré, C., André, N., Vié, K., van Niel, G., & Raposo, G. (2015) · Nature Communications · doi:10.1038/ncomms8506 · Cited by 255

Regulation of Postsynaptic Retrograde Signaling by Presynaptic Exosome Release

Korkut, C., Li, Y., Koles, K., Brewer, C., Ashley, J., Yoshihara, M., & Budnik, V. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.013 · Cited by 250

Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes

Statello, L., Maugeri, M., Garre, E., Nawaz, M., Wahlgren, J., Papadimitriou, A., Lundqvist, C., Lindfors, L., Collén, A., Sunnerhagen, P., et al. (2018) · PLOS ONE · doi:10.1371/journal.pone.0195969 · Cited by 242

Active endocannabinoids are secreted on extracellular membrane vesicles

Gabrielli, M., Battista, N., Riganti, L., Prada, I., Antonucci, F., Cantone, L., Matteoli, M., Maccarrone, M., & Verderio, C. (2015) · The EMBO Reports · doi:10.15252/embr.201439668 · Cited by 231

Serotonin stimulates secretion of exosomes from microglia cells

Glebov, K., Löchner, M., Jabs, R., Lau, T., Merkel, O., Schloss, P., Steinhäuser, C., & Walter, J. (2015) · Glia · doi:10.1002/glia.22772 · Cited by 221

Long noncoding RNA CCAL transferred from fibroblasts by exosomes promotes chemoresistance of colorectal cancer cells

Deng, X., Ruan, H., Zhang, X., Xu, X., Zhu, Y., Peng, H., Zhang, X., Kong, F., & Guan, M. (2020) · International Journal of Cancer · doi:10.1002/ijc.32608 · Cited by 218

Delivery of Small Interfering RNA to Inhibit Vascular Endothelial Growth Factor in Zebrafish Using Natural Brain Endothelia Cell-Secreted Exosome Nanovesicles for the Treatment of Brain Cancer

Yang, T., Fogarty, B., LaForge, B., Aziz, S., Pham, T., Lai, L., & Bai, S. (2017) · The AAPS Journal · doi:10.1208/s12248-016-0015-y · Cited by 204

Circulating Exosomal MicroRNA-21 as a Biomarker in Each Tumor Stage of Colorectal Cancer

Tsukamoto, M., Iinuma, H., Yagi, T., Matsuda, K., & Hashiguchi, Y. (2017) · Oncology · doi:10.1159/000463387 · Cited by 203

Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications

Amiri, A., Bagherifar, R., Ansari Dezfouli, E., Kiaie, S. H., Jafari, R., & Ramezani, R. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03325-7 · Cited by 186

Tetherin is an exosomal tether

Edgar, J. R., Manna, P. T., Nishimura, S., Banting, G., & Robinson, M. S. (2016) · eLife · doi:10.7554/elife.17180 · Cited by 161

Exosome as drug delivery system: Current advancements

Sharma, V., & Mukhopadhyay, C. D. (2024) · Extracellular Vesicle · doi:10.1016/j.vesic.2023.100032 · Cited by 156

Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis

Hu, M., Wang, Y., Liu, Z., Yu, Z., Guan, K., Liu, M., Wang, M., Tan, J., & Huang, L. (2021) · Nature Nanotechnology · doi:10.1038/s41565-020-00836-6 · Cited by 136

Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers

Ramirez, S. H., Andrews, A. M., Paul, D., & Pachter, J. S. (2018) · Fluids and Barriers of the CNS · doi:10.1186/s12987-018-0104-7 · Cited by 128

Identification and characterization of the nano-sized vesicles released by muscle cells

Romancino, D. P., Paterniti, G., Campos, Y., De Luca, A., Di Felice, V., d'Azzo, A., & Bongiovanni, A. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.03.012 · Cited by 120

Propagation of Tau via Extracellular Vesicles

Pérez, M., Avila, J., & Hernández, F. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00698 · Cited by 118

Stem cell‐derived exosomes: A promising strategy for fracture healing

Hao, Z., Lu, J., Wang, S., Wu, H., Zhang, Y., & Xu, S. (2017) · Cell Proliferation · doi:10.1111/cpr.12359 · Cited by 106

Human Immunodeficiency Virus type 1 Endocytic Trafficking Through Macrophage Bridging Conduits Facilitates Spread of Infection

Kadiu, I., & Gendelman, H. E. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9298-z · Cited by 100

Research progress in membrane fusion-based hybrid exosomes for drug delivery systems

Liu, A., Yang, G., Liu, Y., & Liu, T. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.939441 · Cited by 88

Extracellular miR-1246 promotes lung cancer cell proliferation and enhances radioresistance by directly targeting DR5

Yuan, D., Xu, J., Wang, J., Pan, Y., Fu, J., Bai, Y., Zhang, J., & Shao, C. (2016) · Oncotarget · doi:10.18632/oncotarget.9017 · Cited by 86

Profiling of circulating microRNAs for prostate cancer biomarker discovery

Haldrup, C., Kosaka, N., Ochiya, T., Borre, M., Høyer, S., Orntoft, T. F., & Sorensen, K. D. (2014) · Drug Delivery and Translational Research · doi:10.1007/s13346-013-0169-4 · Cited by 83

Information transfer by exosomes: A new frontier in hematologic malignancies

Boyiadzis, M., & Whiteside, T. L. (2015) · Blood Reviews · doi:10.1016/j.blre.2015.01.004 · Cited by 79

Circulating exosomes in cardiovascular disease: Novel carriers of biological information

Liu, Q., Piao, H., Wang, Y., Zheng, D., & Wang, W. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111148 · Cited by 70

Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation

Cheng, H. S., Njock, M.-S., Khyzha, N., Dang, L. T., & Fish, J. E. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00422 · Cited by 69

The Protective Effect of Exercise in Neurodegenerative Diseases: The Potential Role of Extracellular Vesicles

Fuller, O. K., Whitham, M., Mathivanan, S., & Febbraio, M. A. (2020) · Cells · doi:10.3390/cells9102182 · Cited by 60

Extracellular RNAs: A Secret Arm of Immune System Regulation

de Candia, P., De Rosa, V., Casiraghi, M., & Matarese, G. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.708842 · Cited by 53

Physiology of Cholangiocytes

Tabibian, J. H., Masyuk, A. I., Masyuk, T. V., O'Hara, S. P., & LaRusso, N. F. (2013) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2013.tb00495.x · Cited by 52

Extracellular Vesicles in Modifying the Effects of Ionizing Radiation

Szatmári, T., Hargitai, R., Sáfrány, G., & Lumniczky, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225527 · Cited by 52

Bone Marrow Mesenchymal Stromal Cells in Multiple Myeloma: Their Role as Active Contributors to Myeloma Progression

Maiso, P., Mogollón, P., Ocio, E. M., & Garayoa, M. (2021) · Cancers · doi:10.3390/cancers13112542 · Cited by 48

Inhibition of the Expression of the Small Heat Shock Protein αB-Crystallin Inhibits Exosome Secretion in Human Retinal Pigment Epithelial Cells in Culture

Gangalum, R. K., Bhat, A. M., Kohan, S. A., & Bhat, S. P. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.698530 · Cited by 36

Cancer Extracellular Vesicles: Next-Generation Diagnostic and Drug Delivery Nanotools

Palazzolo, S., Memeo, L., Hadla, M., Duzagac, F., Steffan, A., Perin, T., Canzonieri, V., Tuccinardi, T., Caligiuri, I., & Rizzolio, F. (2020) · Cancers · doi:10.3390/cancers12113165 · Cited by 34

Diabetes Mellitus Reveals Its Micro-Signature

Regazzi, R. (2010) · Circulation Research · doi:10.1161/circresaha.110.228841 · Cited by 12

Extracellular vesicles: emerging therapeutic agents for liver fibrosis

Chiabotto, G., Semnani, A., Ceccotti, E., & Bruno, S. (2025) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2025.08 · Cited by 13

A new integrated method for tissue extracellular vesicle enrichment and proteome profiling

Zhang, M., Liu, T., Du, Z., Li, H., & Qin, W. (2022) · RSC Advances · doi:10.1039/d2ra06185f · Cited by 10

Biogenesis of Melanosomes

Delevoye, C., Giordano, F., Marks, M. S., & Raposo, G. (2011) · Melanins and Melanosomes · doi:10.1002/9783527636150.ch9 · Cited by 10