Cited by 224Hallucinations in medical conditionsSchizophrenia research and treatmentFunctional Brain Connectivity Studies

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Interaction of language, auditory and memory brain networks in auditory verbal hallucinations

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Ćurčić-Blake, Branislava, Ford, Judith M., Hubl, Daniela, Orlov, Natasza D., Sommer, Iris E., Waters, Flavie, Allen, Paul, Jardri, Renaud, Woodruff, Peter W., David, Olivier, Mulert, Christoph, Woodward, Todd S., Aleman, André·2017·Progress in Neurobiology

DOI 10.1016/j.pneurobio.2016.11.002PMC PMC5240789

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Abstract

Auditory verbal hallucinations (AVH) occur in psychotic disorders, but also as a symptom of other conditions and even in healthy people. Several current theories on the origin of AVH converge, with neuroimaging studies suggesting that the language, auditory and memory/limbic networks are of particular relevance. However, reconciliation of these theories with experimental evidence is missing. We review 50 studies investigating functional (EEG and fMRI) and anatomic (diffusion tensor imaging) connectivity in these networks, and explore the evidence supporting abnormal connectivity in these networks associated with AVH. We distinguish between functional connectivity during an actual hallucination experience (symptom capture) and functional connectivity during either the resting state or a task comparing individuals who hallucinate with those who do not (symptom association studies). Symptom capture studies clearly reveal a pattern of increased coupling among the auditory, language and striatal regions. Anatomical and symptom association functional studies suggest that the interhemispheric connectivity between posterior auditory regions may depend on the phase of illness, with increases in non-psychotic individuals and first episode patients and decreases in chronic patients. Leading hypotheses involving concepts as unstable memories, source monitoring, top-down attention, and hybrid models of hallucinations are supported in part by the published connectivity data, although several caveats and inconsistencies remain. Specifically, possible changes in fronto-temporal connectivity are still under debate. Precise hypotheses concerning the directionality of connections deduced from current theoretical approaches should be tested using experimental approaches that allow for discrimination of competing hypotheses.

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Fig. 1 Illustration of different theories. Arrows illustrate the direction of influence. Blue dashed line – increase in excitation.CC BY-NC-ND · PubMed Central

Fig. 2 Illustration of language and auditory network. The two network share some regions (such as STG) and are difficult to disentangle from each other. Wernicke area is drawn in the most global manner. Some authors include only TPJ part of the temporal lobe (BA22), but often in articles the Wernicke’s area includes parts of parietal lobe with BA 39 and 40 (Mesulam, 1990).CC BY-NC-ND · PubMed Central

Fig. 3 Illustration of memory/limbic network including striatal regions (a possible intermediate step between hippocampus and auditory regions). PHG – para-hippocampal gyrus.CC BY-NC-ND · PubMed Central

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More Is Not Always Better: Increased Fractional Anisotropy of Superior Longitudinal Fasciculus Associated with Poor Visuospatial Abilities in Williams Syndrome
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Background
A New Phenomenological Survey of Auditory Hallucinations: Evidence for Subtypes and Implications for Theory and Practice
McCarthy‐Jones, S., Trauer, T., Mackinnon, A. J., Sims, E., Thomas, N., & Copolov, D. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs156 · Cited by 305 · cited 1×
“, command hallucinations, third-person hallucinations, and thought echo (Blom and Sommer, 2010; McCarthy-Jones et al., 2014).”
Background
Encoding novel face‐name associations: A functional MRI study
Sperling, R. A., Bates, J. F., Cocchiarella, A. J., Schacter, D. L., Rosen, B. R., & Albert, M. (2001) · Human Brain Mapping · doi:10.1002/hbm.1047 · Cited by 303 · cited 1×
“, 1996) and together with striatum in associative memory (Sperling et al., 2001).”
Background
Cerebral processing of linguistic and emotional prosody: fMRI studies
Wildgruber, D., Ackermann, H., Kreifelts, B., & Ethofer, T. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)56013-3 · Cited by 297
Auditory verbal hallucinations predominantly activate the right inferior frontal area
Sommer, I. E. C., Diederen, K. M. J., Blom, J.-D., Willems, A., Kushan, L., Slotema, K., Boks, M. P. M., Daalman, K., Hoek, H. W., Neggers, S. F. W., et al. (2008) · Brain · doi:10.1093/brain/awn251 · Cited by 297 · cited 1×
“This is consistent with ‘over-activation’ of Broca’s area during AVH (Sommer et al., 2008).”
ResultSelf-citation
Hallucinations: The science of idiosyncratic perception.
Aleman, A., & Larøi, F. (2008) · American Psychological Association eBooks · doi:10.1037/11751-000 · Cited by 291
Forms of memory failure in schizophrenia.
Gold, J. M., RANDOLPH, C. C., Carpenter, C. J., Goldberg, T. E., & Weinberger, D. R. (1992) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.101.3.487 · Cited by 291 · cited 1×
“In patients with schizophrenia, errors already occur at the perception level (Gold et al., 1992).”
Background
The Role of the Cerebellum in Schizophrenia: an Update of Clinical, Cognitive, and Functional Evidences
Picard, H., Amado, I., Mouchet-Mages, S., Olié, J., & Krebs, M. (2007) · Schizophrenia bulletin · doi:10.1093/schbul/sbm049 · Cited by 290 · cited 1×
“Cerebellum is important for brain synchrony and action prediction (D'Angelo and Casali, 2013) by coordinating and modulating cortical activity (Picard et al., 2008).”
Background
The “paradoxical” engagement of the primary auditory cortex in patients with auditory verbal hallucinations: A meta-analysis of functional neuroimaging studies
Kompus, K., Westerhausen, R., & Hugdahl, K. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.08.010 · Cited by 286
Hyperconnectivity is a fundamental response to neurological disruption.
Hillary, F. G., Román, C. A. F., Venkatesan, U. M., Rajtmajer, S. M., Bajo, R., & Castellanos, N. P. (2014) · Neuropsychology · doi:10.1037/neu0000110 · Cited by 265 · cited 2×
“Their review of 126 studies showed that after the onset of illness overall connectivity is increased but diminishes in the later stages of the degeneration (Hillary et al., 2015).”
BackgroundResult
The neurophysics of consciousness
John, E. R. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00142-x · Cited by 262 · cited 1×
“The application of FC analyses to the study of AVHs is motivated by a range of studies demonstrating that inter-region functional coordination plays an important role in determining whether neural activity is experienced consciously as percepts (Cosmelli et al., 2004; Sergent and Dehaene, 2004; Melloni et al., 2007; J…”
Method
Auditory hallucinations in schizophrenia are associated with reduced functional connectivity of the temporo-parietal area
Vercammen, A., Knegtering, H., den Boer, J. A., Liemburg, E. J., & Aleman, A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.017 · Cited by 261 · cited 2×
“Symptom association studies Vercammen and colleagues used a region of interest analysis comprising neuronal networks involved in inner speech processing, based around a seed region in the tempo-parietal junction (Vercammen et al., 2010).”
Background
Meta-analysis of corpus callosum size in schizophrenia.
Woodruff, P. W. R., McManus, I. C., & David, A. S. (1995) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.58.4.457 · Cited by 255
A Diffusion Tensor Imaging Study of Fasciculi in Schizophrenia
Shergill, S. S., Kanaan, R., Chitnis, X. A., O’Daly, O., Jones, D. K., Frangou, S., Williams, S. C., Howard, R. J., Barker, G. J., Murray, R. M. L., et al. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.164.3.467 · Cited by 254 · cited 4×
“Decreased FA in various parts of the cingulum has consistently been observed in schizophrenia patients (Hubl et al., 2004; Shergill et al., 2007; Knöchel et al., 2012).”
BackgroundInfluential
Intrusive Thoughts and Auditory Hallucinations: A Cognitive Approach
Morrison, A. P., Haddock, G., & Tarrier, N. (1995) · Behavioural and Cognitive Psychotherapy · doi:10.1017/s1352465800015873 · Cited by 252 · cited 1×
“In support, people who hear voices experience these as intrusive and unwanted (Morrison et al., 1995), as might be expected if memory systems fail to suppress mental associations which are not currently relevant.”
Background
The anatomy of fronto-occipital connections from early blunt dissections to contemporary tractography
Forkel, S. J., Thiebaut de Schotten, M., Kawadler, J. M., Dell'Acqua, F., Danek, A., & Catani, M. (2014) · Cortex · doi:10.1016/j.cortex.2012.09.005 · Cited by 248 · cited 1×
“Another important tract involved in language processing is the inferior fronto-occipital fasciculus, connecting frontal with temporal and parietal parts of the brain and running inferior to the AF (Forkel et al., 2012).”
Background
Synch before you speak: Auditory hallucinations in schizophrenia
Ford, J. M., Roach, B. J., Faustman, W. O., & Mathalon, D. H. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.3.458 · Cited by 245 · cited 2×
“suppression, as the degree of connectivity between these areas during talking is related to the degree of suppression (Ford et al., 2007; Chen et al., 2011; Wang et al., 2014).”
BackgroundSelf-citation
Quantitative meta-analysis on state and trait aspects of auditory verbal hallucinations in schizophrenia
Kuhn, S., & Gallinat, J. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq152 · Cited by 245 · cited 1×
“The STG (left and right) are almost universally active during AVH (Jardri et al., 2011; Kuhn and Gallinat, 2010).”
Background
Clinical and Neuropsychological Correlates of White Matter Abnormalities in Recent Onset Schizophrenia
Szeszko, P. R., Robinson, D. G., Ashtari, M., Vogel, J., Betensky, J. D., Sevy, S. M., Ardekani, B. A., Lencz, T., Malhotra, A. K., McCormack, J., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301480 · Cited by 241
Neuroimaging Auditory Hallucinations in Schizophrenia: From Neuroanatomy to Neurochemistry and Beyond
Allen, P., Modinos, G., Hubl, D., Shields, G., Cachia, A., Jardri, R., Thomas, P., Woodward, T., Shotbolt, P., Plaze, M., et al. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs066 · Cited by 240 · cited 7×
“Functional MRI studies have investigated the functional brain networks during the experience of hallucinations but also compared the functional brain networks between patients who hallucinate and those that do not, based on reports of hearing hallucination during the past (Allen et al., 2012; Woodruff, 2004).”
BackgroundInfluential
Reduced oscillatory gamma-band responses in unmedicated schizophrenic patients indicate impaired frontal network processing
Gallinat, J., Winterer, G., Herrmann, C. S., & Senkowski, D. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2004.03.013 · Cited by 233 · cited 1×
“In principle, the pathophysiology of AVH thus predict impaired EEG synchronisation during sensory processing in patient s with AVH, as shown in a series of studies (Kwon et al., 1999; Gallinat et al., 2004; Uhlhaas et al., 2008; Uhlhaas and Singer, 2010; Engel et al., 2013).”
Result
Auditory hallucinations in schizophrenia: intrusive thoughts and forgotten memories
Waters, F., Badcock, J., Michie, P., & Maybery, M. (2006) · Cognitive Neuropsychiatry · doi:10.1080/13546800444000191 · Cited by 233 · cited 1×
“Inhibitory deficits would also contribute to the failure to control the contents of memories (Jardri et al., 2016; Waters et al., 2006).”
Background
Neuroanatomy of auditory verbal hallucinations in schizophrenia: A quantitative meta-analysis of voxel-based morphometry studies
Modinos, G., Costafreda, S. G., van Tol, M., McGuire, P. K., Aleman, A., & Allen, P. (2012) · Cortex · doi:10.1016/j.cortex.2012.01.009 · Cited by 230 · cited 1×
“Furthermore, decreases in the primary (Modinos et al., 2013) and secondary auditory cortex GM volume (reviewed by Allen et al.”
Background
Abnormal brain white matter in schizophrenia: a diffusion tensor imaging study
Agartz, I., Andersson, J., & Skare, S. T. (2001) · Neuroreport · doi:10.1097/00001756-200107200-00041 · Cited by 225
White Matter Development in Adolescence: Diffusion Tensor Imaging and Meta-Analytic Results
Peters, B. D., Szeszko, P. R., Raduà, J., Ikuta, T., Gruner, P., DeRosse, P., Zhang, J., Giorgio, A., Qiu, D., Tapert, S. F., et al. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs054 · Cited by 214 · cited 1×
“An increase in the total number of whole-brain DTI studies referring to validated whitematter templates would pave the way to coordinate-based metaanalyses, providing a peak effect size and signed maps of positive or negative differences in AVH patients (Peters et al., 2012).”
Background
Cortical and Subcortical Connectivity Changes during Decreasing Levels of Consciousness in Humans: A Functional Magnetic Resonance Imaging Study using Propofol
Mhuircheartaigh, R. N., Rosenorn-Lanng, D., Wise, R. G., Jbabdi, S., Rogers, R., & Tracey, I. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5516-09.2010 · Cited by 213 · cited 1×
“1), and the putamen to translate memories into language experience (Price, 2010) and bring the experience into consciousness (Mhuircheartaigh et al., 2010), as well as speech and auditory network (Wernicke’s, Broca’s areas; Fig.”
Background
How can the brain's resting state activity generate hallucinations? A ‘resting state hypothesis’ of auditory verbal hallucinations
Northoff, G., & Qin, P. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.11.009 · Cited by 209 · cited 3×
“Northoff predicts that elevated resting state activity in the default mode network and auditory cortex coupled with their unaltered communication can enhance the development of AVH (Northoff, 2014; Northoff and Qin, 2011).”
BackgroundResult
Top-down and bottom-up processes in speech comprehension
Zekveld, A. A., Heslenfeld, D. J., Festen, J. M., & Schoonhoven, R. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.04.199 · Cited by 203
Deactivation of the Parahippocampal Gyrus Preceding Auditory Hallucinations in Schizophrenia
Diederen, K. M. J., Neggers, S. F. W., Daalman, K., Blom, J. D., Goekoop, R., Kahn, R. S., & Sommer, I. E. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09040456 · Cited by 202
“Hearing voices”: Auditory hallucinations as failure of top‐down control of bottom‐up perceptual processes
Hugdahl, K. (2009) · Scandinavian Journal of Psychology · doi:10.1111/j.1467-9450.2009.00775.x · Cited by 197 · cited 1×
“also endorsed the idea of an imbalance in top-down/bottom-up influences and suggested that while AVHs originate in perisylvian regions (Hugdahl, 2009), they are in general not as constrained by the PFC in patients as they are in non-psychotic voice-hearers.”
Hallucinations and perceptual inference
Friston, K. J. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05290131 · Cited by 196
How hallucinations may arise from brain mechanisms of learning, attention, and volition
Grossberg, S. (2000) · Journal of the International Neuropsychological Society · doi:10.1017/s135561770065508x · Cited by 192 · cited 2×
“This is in line with abnormal top-down influences on auditory perception in the case of hallucinatory experiences (Behrendt, 2006; Grossberg, 2000), as described in Section 3.”
Background
The Neurodynamic Organization of Modality-Dependent Hallucinations
Jardri, R., Thomas, P., Delmaire, C., Delion, P., & Pins, D. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs082 · Cited by 192 · cited 1×
“found that primary auditory cortex was not systematically active during AVH but when active, this was linked with increased vividness in hallucinatory experiences (Jardri et al., 2013).”
Background
Inner speech models of auditory verbal hallucinations: Evidence from behavioural and neuroimaging studies
Allen, P., Aleman, A., & Mcguire, P. K. (2007) · International Review of Psychiatry · doi:10.1080/09540260701486498 · Cited by 188 · cited 1×
“Source monitoring hypothesis proposes that AVH comprise deficits in self-monitoring and reality discrimination (Bentall and Slade, 1985; McGuire et al., 1993; Allen et al., 2007), whereby internally events (thoughts, inner speech, actions) lack ‘self’ attributes, resulting in broad difficulties in self-recognition.”
BackgroundSelf-citation
Cognitive basis of hallucinations in schizophrenia: role of top-down information processing
Aleman, A., Böcker, K. B. E., Hijman, R., de Haan, E. H. F., & Kahn, R. S. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00060-4 · Cited by 178 · cited 2×
“Another approach that focuses on perception and attentional processes is based on the idea that AVH may be caused by unbalanced mechanisms for bottom-up sensory processing on one hand and top-down mechanisms on the other hand (Behrendt, 1998; Grossberg, 2000; Aleman et al., 2003).”
Background
Misattribution of speech and impaired connectivity in patients with auditory verbal hallucinations
Mechelli, A., Allen, P., Amaro, E., Fu, C. H. Y., Williams, S. C. R., Brammer, M. J., Johns, L. C., & McGuire, P. K. (2007) · Human Brain Mapping · doi:10.1002/hbm.20341 · Cited by 175 · cited 5×
“One study used effective connectivity between monitoring and language areas and interpreted their findings as evidence of source monitoring deficits in the people with AVH and as support for the self-monitoring deficit theory of AVH (Mechelli et al., 2007).”
BackgroundResultInfluential
Resting-state EEG in schizophrenia: Auditory verbal hallucinations are related to shortening of specific microstates
Kindler, J., Hubl, D., Strik, W. K., Dierks, T., & Koenig, T. W. (2010) · Clinical Neurophysiology · doi:10.1016/j.clinph.2010.10.042 · Cited by 174 · cited 1×
“demonstrated the shortening of class D microstates during AVH (Kindler et al., 2011).”
Background
Adaptive Top–Down Suppression of Hippocampal Activity and the Purging of Intrusive Memories from Consciousness
Benoit, R. G., Hulbert, J. C., Huddleston, E., & Anderson, M. C. (2014) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00696 · Cited by 174 · cited 1×
“Memory fragments are usually inhibited during focused attention (Benoit et al., 2015), but may become less inhibited during times of daydreaming and relaxation, when the default mode network is more active.”
Background
White matter abnormalities associated with auditory hallucinations in schizophrenia: A combined study of voxel-based analyses of diffusion tensor imaging and structural magnetic resonance imaging
Seok, J.-H., Park, H.-J., Chun, J.-W., Lee, S.-K., Cho, H. S., Kwon, J. S., & Kim, J.-J. (2007) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2007.02.002 · Cited by 168 · cited 3×
“These authors reported a positive correlation between AVH severity and the left superior longitudinal fasciculus FA – the region with the highest white matter density in AVH compared to all other groups (Seok et al., 2007).”
Result
Hearing voices in the resting brain: A review of intrinsic functional connectivity research on auditory verbal hallucinations
Alderson-Day, B., McCarthy-Jones, S., & Fernyhough, C. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.016 · Cited by 165
Long-range synchrony of gamma oscillations and auditory hallucination symptoms in schizophrenia
Mulert, C., Kirsch, V., Pascual-Marqui, R., McCarley, R. W., & Spencer, K. M. (2011) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2010.08.004 · Cited by 165
Self-citation
Are hallucinations due to an imbalance between excitatory and inhibitory influences on the brain?
Jardri, R., Hugdahl, K., Hughes, M., Brunelin, J., Waters, F., Alderson-Day, B., Smailes, D., Sterzer, P., Corlett, P. R., Leptourgos, P., et al. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw075 · Cited by 157
Self-citation
Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory/verbal hallucinations in patients with schizophrenia
Hoffman, R. E., Fernandez, T., Pittman, B., & Hampson, M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.050 · Cited by 156
Childhood trauma and auditory verbal hallucinations
Daalman, K., Diederen, K. M. J., Derks, E. M., van Lutterveld, R., Kahn, R. S., & Sommer, I. E. C. (2012) · Psychological Medicine · doi:10.1017/s0033291712000761 · Cited by 153 · cited 2×
“This theory could provide a neurobiological explanation for the strong association between childhood trauma and AVH, which is present in patients with schizophrenia, with post-traumatic stress disorder and also in non-clinical populations (Daalman et al., 2012).”
Background
Role of the Corpus Callosum in Speech Comprehension: Interfacing Syntax and Prosody
Friederici, A. D., von Cramon, D. Y., & Kotz, S. A. (2007) · Neuron · doi:10.1016/j.neuron.2006.11.020 · Cited by 148 · cited 1×
“For example, lesion studies demonstrated a crucial role of this pathway in the integration of prosodic and syntactic information (Friederici et al., 2007).”
Background
The multimodal connectivity of the hippocampal complex in auditory and visual hallucinations
Amad, A., Cachia, A., Gorwood, P. A. P. M., Pins, D., Delmaire, C., Rolland, B., Mondino, M., Thomas, P., & Jardri, R. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.181 · Cited by 144 · cited 1×
“(Amad et al., 2014) examined connectivity between the hippocampal complex and other regions that included STG in patients with auditory, and patients with auditory”
Background
Functional connectivity of left Heschl's gyrus in vulnerability to auditory hallucinations in schizophrenia
Shinn, A. K., Baker, J. T., Cohen, B. M., & Öngür, D. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.11.037 · Cited by 136 · cited 3×
“Shinn and colleagues reported contradictory results (Shinn et al., 2013).”
BackgroundInfluential
Neural activity in speech-sensitive auditory cortex during silence
Hunter, M. D., Eickhoff, S. B., Miller, T. W. R., Farrow, T. F. D., Wilkinson, I. D., & Woodruff, P. W. R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506268103 · Cited by 135 · cited 2×
“, who showed increased activity during rest in auditory sensory areas of people more prone to hallucinate (Hunter et al., 2006).”
Background
Putamen-related regional and network functional deficits in first-episode schizophrenia with auditory verbal hallucinations
Cui, L., Liu, K., Li, C., Wang, L., Guo, F., Tian, P., Wu, Y.-J., Guo, L., Liu, W.-M., Xi, Y., et al. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.02.039 · Cited by 134
Anatomical brain connectivity and positive symptoms of schizophrenia: A diffusion tensor imaging study
Rotarska-Jagiela, A., Oertel‐Knoechel, V., Martino, F. D., van de Ven, V. G., Formisano, E., Roebroeck, A. F., Rami, A., Schoenmeyer, R., Haenschel, C., Hendler, T., et al. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2009.03.002 · Cited by 133
Altered Integrity of Perisylvian Language Pathways in Schizophrenia: Relationship to Auditory Hallucinations
Catani, M., Craig, M., Forkel, S. J., Kanaan, R., Picchioni, M., Toulopoulou, T., Shergill, S. S., Williams, S., Murphy, D., & McGuire, P. K. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.06.013 · Cited by 133 · cited 2×
“, 2007), whereas others demonstrate a decrease in fractional anisotropy (FA), implicating decreased connectivity (Catani et al., 2011; De Weijer et al., 2013; Cur9 ci c-Blake et al., 2015) in the same pathway within the network (Geoffroy et al.”
BackgroundResult
Auditory Hallucinations and the Brain’s Resting-State Networks: Findings and Methodological Observations
Alderson‐Day, B., Diederen, K. M. J., Fernyhough, C., Ford, J. M., Horga, G., Margulies, D. S., McCarthy‐Jones, S., Northoff, G., Shine, J. M., Turner, J. A., et al. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw078 · Cited by 132 · cited 2×
“It is possible that the differences arise from different measurement or analysis techniques (Alderson-Day et al., 2016), or the use of different questionnaires.”
Background
Waves of consciousness: ongoing cortical patterns during binocular rivalry
Cosmelli, D., David, O., Lachaux, J.-P., Martinerie, J., Garnero, L., Renault, B., & Varela, F. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.05.008 · Cited by 131 · cited 1×
“The application of FC analyses to the study of AVHs is motivated by a range of studies demonstrating that inter-region functional coordination plays an important role in determining whether neural activity is experienced consciously as percepts (Cosmelli et al., 2004; Sergent and Dehaene, 2004; Melloni et al., 2007; J…”
Method
Resting-state functional connectivity alterations in the default network of schizophrenia patients with persistent auditory verbal hallucinations
Alonso-Solís, A., Vives‐Gilabert, Y., Grasa, E., Portella, M. J., Rabella, M., Sauras-Quetcuti, R. B., Roldán, A., Núñez-Marín, F., Gómez‐Ansón, B., Pérez, V., et al. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.10.047 · Cited by 124
Reduced connectivity of the auditory cortex in patients with auditory hallucinations: A resting state functional magnetic resonance imaging study
Gavrilescu, M., Rossell, S., Stuart, G. W., Shea, T. L., Innes-Brown, H., Henshall, K., McKay, C., Sergejew, A. A., Copolov, D., & Egan, G. F. (2010) · Psychological Medicine · doi:10.1017/s0033291709991632 · Cited by 121 · cited 1×
“Using RS fMRI, Gavrilescu and colleagues investigated interhemispheric connectivity in the primary and secondary auditory cortex in patients with and without AVH and healthy controls (Gavrilescu et al., 2010).”
Background
Paracingulate sulcus morphology is associated with hallucinations in the human brain
Garrison, J. R., Fernyhough, C., McCarthy‐Jones, S., Haggard, M. P., Carr, V. J., Schall, U., Scott, R. J., Jablensky, A. V., Mowry, B. J., Patricia, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms9956 · Cited by 121
Functional Relevance of Interindividual Differences in Temporal Lobe Callosal Pathways: A DTI Tractography Study
Westerhausen, R., Grüner, R., Specht, K., & Hugdahl, K. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn173 · Cited by 120 · cited 1×
“Interestingly, there is a strong relationship between the structure and function of interhemispheric connectivity between the bilateral auditory areas and conscious auditory perception in general (Westerhausen et al., 2009; Steinmann et al., 2014b).”
Background
Coping with hallucinated voices in schizophrenia: A review of self-initiated strategies and therapeutic interventions
Farhall, J., Greenwood, K. M., & Jackson, H. J. (2007) · Clinical Psychology Review · doi:10.1016/j.cpr.2006.12.002 · Cited by 118 · cited 1×
“Certainly patients with stressful AVHs find relief by talking to themselves or to others (Nayani and David, 1996; Farhall and Gehrke, 1997; Farhall et al., 2007).”
Background
Tuning in to the Voices: A Multisite fMRI Study of Auditory Hallucinations
Ford, J. M., Roach, B. J., Jørgensen, K. W., Turner, J. A., Brown, G. G., Notestine, R. J., Bischoff‐Grethe, A., Greve, D. N., Wible, C. G., Lauriello, J., et al. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn140 · Cited by 118 · cited 1×
“The observation that auditory hallucinations reduce responsivity to external speech within STG and related regions such as MTG has led to the ‘saturation theory’ whereby the signal driving hallucinations competes for common neurophysiological resources with those used for perceivingexternal speech (Woodruff et al.,199…”
Background
Interhemispheric hypoconnectivity in schizophrenia: Fiber integrity and volume differences of the corpus callosum in patients and unaffected relatives
Knöchel, C., Oertel‐Knöchel, V., Schönmeyer, R., Rotarska-Jagiela, A., van de Ven, V. G., Prvulovic, D., Haenschel, C., Uhlhaas, P. J., Pantel, J., Hampel, H. J., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.088 · Cited by 116 · cited 1×
“Meanwhile, Knöchel and colleagues investigated FA and mean diffusivity (Knochel et al., 2012), a measure of the compactness of axons and intercellular space (Beaulieu, 2002).”
Background
Not on speaking terms: hallucinations and structural network disconnectivity in schizophrenia
Ćurĉić‐Blake, B., Nanetti, L., van der Meer, L., Cerliani, L., Renken, R. J., Pijnenborg, G. H. M., & Aleman, A. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0663-y · Cited by 110
A computerized magnetic resonance imaging study of corpus callosum morphology in schizophrenia
Woodruff, P. W. R., Pearlson, G. D., Geer, M. J., Barta, P. E., & Chilcoat, H. D. (1993) · Psychological Medicine · doi:10.1017/s0033291700038836 · Cited by 109 · cited 1×
“, 1995b) may also be related to delusions which occur in the same condition (Woodruff et al., 1993).”
Background
Correlated neural activity as the driving force for functional changes in auditory cortex
Eggermont, J. J. (2007) · Hearing Research · doi:10.1016/j.heares.2007.01.008 · Cited by 108 · cited 1×
“Based on findings of hyper-synchrony between the auditory cortices (Eggermont, 2007), Diesch and colleagues suggested that stronger interhemispheric auditory pathways may facilitate the development and persistence of a positive feedback loop between tinnitus generators located in both hemispheres (Diesch et al.”
Background
Resting-State Functional Connectivity of the Nucleus Accumbens in Auditory and Visual Hallucinations in Schizophrenia
Rolland, B., Amad, A., Poulet, E., Bordet, R., Vignaud, A., Bation, R., Delmaire, C., Thomas, P., Cottencin, O., & Jardri, R. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu097 · Cited by 103 · cited 15×
“Specifically, two seed-based studies reported hyperconnectivity in networks involving STG and the dACC/SMA for AVH patients relative to NoAVH (Alonso-Solis et al., 2015; Rolland et al., 2015).”
ResultInfluential
Resting State Functional Connectivity in Patients with Chronic Hallucinations
Sommer, I. E., Clos, M., Meijering, A. L., Diederen, K. M. J., & Eickhoff, S. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043516 · Cited by 103 · cited 2×
“Two studies found evidence for a specific role of connections between memory regions and Broca’s area (the language production area) (Sommer et al., 2012; Diederen et al., 2013) and Hoffman showed that the FC between the putamen and language areas is very important for AVH (Hoffman et al.”
Background
In search of occipital activation during visual mental imagery
Kosslyn, S. M., & Ochsner, K. N. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90059-0 · Cited by 102 · cited 1×
“It has been known for some time that imagery activates the brain areas that overlap with those that sub-serve perception (Kosslyn and Ochsner, 1994; Zatorre et al., 2007).”
Background
Microstructural alterations of the arcuate fasciculus in schizophrenia patients with frequent auditory verbal hallucinations
de Weijer, A. D., Mandl, R. C. W., Diederen, K. M. J., Neggers, S. F. W., Kahn, R. S., Pol, H. E. H., & Sommer, I. E. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.05.010 · Cited by 101
Time course of regional brain activation associated with onset of auditory/verbal hallucinations
Hoffman, R. E., Anderson, A. W., Varanko, M., Gore, J. C., & Hampson, M. (2008) · British Journal of Psychiatry · doi:10.1192/bjp.bp.107.040501 · Cited by 96 · cited 1×
“In support, hippocampal deactivations have been observed immediately prior AVH, pointing to the release of memory (Hoffman et al., 2008; Diederen et al., 2010).”
Background
Reality of auditory verbal hallucinations
Raij, T. T., Valkonen-Korhonen, M., Holi, M., Therman, S., Lehtonen, J., & Hari, R. (2009) · Brain · doi:10.1093/brain/awp186 · Cited by 95
Action planning and predictive coding when speaking
Wang, J., Mathalon, D. H., Roach, B. J., Reilly, J. L., Keedy, S., Sweeney, J. A., & Ford, J. M. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.01.003 · Cited by 95 · cited 2×
“These findings suggest that an efference copy from speech areas in prefrontal cortex is transmitted to auditory cortex, where it is used to suppress processing of anticipated speech sounds (Wang et al., 2014).”
Background
Effective and Structural Connectivity in the Human Auditory Cortex
Upadhyay, J., Silver, A. M., Knaus, T. A., Lindgren, K. A., Ducros, M. G., Kim, D., & Tager-Flusberg, H. B. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4434-07.2008 · Cited by 94 · cited 1×
“(Upadhyay et al., 2008) found that passive listening to female voices revealed effective connectivity between primary auditory cortex and anterior and posterior STG, regions that have also been demonstrated to be responsible for attributing externality to perceived speech (Hunter et al.”
Background
The arcuate fasciculus in auditory-verbal hallucinations: A meta-analysis of diffusion-tensor-imaging studies
Geoffroy, P. A., Houenou, J., Duhamel, A., Amad, A., De Weijer, A. D., Ćurčić-Blake, B., Linden, D. E. J., Thomas, P., & Jardri, R. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.07.014 · Cited by 90
Hearing voices: A role of interhemispheric auditory connectivity?
Mulert, C., Kirsch, V., Whitford, T. J., Alvarado, J., Pelavin, P. E., McCarley, R. W., Kubicki, M. R., Salisbury, D. F., & Shenton, M. E. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.570789 · Cited by 89 · cited 2×
“These results suggest that interhemispheric miscommunication between bilateral auditory areas in patients with AVH is already present during the first episode (Hubl et al., 2004; Mulert et al., 2012), but alters during the course of the disease (Wigand et al.”
BackgroundResult
Aberrations in the arcuate fasciculus are associated with auditory verbal hallucinations in psychotic and in non‐psychotic individuals
de Weijer, A. D., Neggers, S. F. W., Diederen, K. M. J., Mandl, R. C. W., Kahn, R. S., Pol, H. E. H., & Sommer, I. E. (2011) · Human Brain Mapping · doi:10.1002/hbm.21463 · Cited by 86
The corollary discharge in humans is related to synchronous neural oscillations
Chen, C.-M. A., Mathalon, D. H., Roach, B. J., Cavus, I., Spencer, D. D., & Ford, J. M. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2010.21589 · Cited by 86 · cited 3×
“This can be interpreted as a gamma-band mediated neural instantiation of the transmission of a copy of motor commands (Chen et al., 2011).”
BackgroundSelf-citation
A neural basis for the perception of voices in external auditory space
Hunter, M. D., Griffiths, T. D., Farrow, T. F. D., Zheng, Y., Wilkinson, I. D., Hegde, N., Woods, W., Spence, S. A., & Woodruff, P. W. R. (2003) · Brain · doi:10.1093/brain/awg015 · Cited by 85
Aberrant connectivity during self–other source monitoring in schizophrenia
Wang, L. Y., Metzak, P. D., & Woodward, T. S. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.11.012 · Cited by 85
Auditory hallucinations and perception of external speech
Woodruff, P. W. R., Brammer, M. J., Mellers, J. D. C., Wright, I. C., Bullmore, E. T., Williams, S., Colover, J., Lawrie, S., & Abukmeil, S. S. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91715-2 · Cited by 83
Dysregulation of thalamic sensory ‘transmission’ in schizophrenia: neurochemical vulnerability to hallucinations
Behrendt, R. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881105057696 · Cited by 83 · cited 1×
“This is in line with abnormal top-down influences on auditory perception in the case of hallucinatory experiences (Behrendt, 2006; Grossberg, 2000), as described in Section 3.”
Background
Coping with hallucinations: Exploring stress and coping framework
Farhall, J., & Gehrke, M. (1997) · British Journal of Clinical Psychology · doi:10.1111/j.2044-8260.1997.tb01411.x · Cited by 82 · cited 1×
“Certainly patients with stressful AVHs find relief by talking to themselves or to others (Nayani and David, 1996; Farhall and Gehrke, 1997; Farhall et al., 2007).”
Background
Auditory hallucinations: Insights and questions from neuroimaging
Woodruff, P. W. R. (2004) · Cognitive Neuropsychiatry · doi:10.1080/13546800344000165 · Cited by 82 · cited 1×
“Functional MRI studies have investigated the functional brain networks during the experience of hallucinations but also compared the functional brain networks between patients who hallucinate and those that do not, based on reports of hearing hallucination during the past (Allen et al., 2012; Woodruff, 2004).”
Background
Increased amygdala and parahippocampal gyrus activation in schizophrenic patients with auditory hallucinations: An fMRI study using independent component analysis
Escartí, M. J., de la Iglesia-Vayá, M., Martí-Bonmatí, L., Robles, M., Carbonell, J., Lull, J. J., García-Martí, G., Manjón, J. V., Aguilar, E. J., Aleman, A., et al. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2009.12.028 · Cited by 80
Self-citation
When Broca goes uninformed: Reduced information flow to Broca’s area in schizophrenia patients with auditory hallucinations
Curcic-Blake, B., Liemburg, E., Vercammen, A., Swart, M., Knegtering, H., Bruggeman, R., & Aleman, A. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs107 · Cited by 78
Functional Brain Imaging in Schizophrenia: Selected Results and Methods
Brown, G. G., & Thompson, W. K. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_54 · Cited by 75 · cited 1×
“Recent findings from brain imaging have revealed that auditory verbal hallucinations (AVH) in schizophrenia are associated with alterations in brain connectivity (Brown and Thompson, 2010; Jardri et al., 2011) that incorporate both functional and anatomical connections (Allen et al.”
Background
Reduced integrity of the left arcuate fasciculus is specifically associated with auditory verbal hallucinations in schizophrenia
McCarthy‐Jones, S., Oestreich, L., & Whitford, T. J. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.12.041 · Cited by 75 · cited 2×
“The majority of large studies on chronic schizophrenia patients that incorporate both a control group and a group of patients without AVH find decreases in anatomical or functional connectivity of language areas (De Weijer et al., 2013; Oestreich et al., 2015; McCarthy-Jones et al., 2015; Cur9 ci c-Blake et al., 2013)…”
BackgroundResult
White matter pathway organization of the reward system is related to positive and negative symptoms in schizophrenia
Bracht, T., Horn, H., Strik, W. K., Federspiel, A., Razavi, N., Stegmayer, K., Wiest, R., Dierks, T., Müller, T., & Walther, S. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.01.015 · Cited by 75 · cited 1×
“However, this study did not aim to investigate AVH per se (Bracht et al., 2014).”
Background
Localized abnormalities in the cingulum bundle in patients with schizophrenia: a diffusion tensor tractography study
Whitford, T. J., Lee, S. W., Oh, J. S., de Luis-Garcia, R., Savadjiev, P., Alvarado, J. L., Westin, C.-F., Niznikiewicz, M., Nestor, P. G., McCarley, R. W., et al. (2014) · NeuroImage: Clinical · doi:10.1016/j.nicl.2014.06.003 · Cited by 74
Underconstrained perception: A theoretical approach to the nature and function of verbal hallucinations
Behrendt, R. (1998) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(98)90067-0 · Cited by 72 · cited 1×
“Another approach that focuses on perception and attentional processes is based on the idea that AVH may be caused by unbalanced mechanisms for bottom-up sensory processing on one hand and top-down mechanisms on the other hand (Behrendt, 1998; Grossberg, 2000; Aleman et al., 2003).”
Background
Semantic Expectations Can Induce False Perceptions in Hallucination-Prone Individuals
Vercammen, A., & Aleman, A. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn063 · Cited by 72 · cited 1×
“However, healthy controls with a propensity to AVH are more likely to report hearing a word that fits the context of a sentence when it is not actually presented (Vercammen and Aleman, 2010).”
Background
The Neuroscience of Hallucinations
Jardri, R., Cachia, A., Thomas, P., & Pins, D. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4121-2 · Cited by 71
Conscious auditory perception related to long-range synchrony of gamma oscillations
Steinmann, S., Leicht, G., Ertl, M., Andreou, C., Polomac, N., Westerhausen, R., Friederici, A. D., & Mulert, C. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.06.012 · Cited by 70
Aberrant connectivity of areas for decoding degraded speech in patients with auditory verbal hallucinations
Clos, M., Diederen, K. M. J., Meijering, A. L., Sommer, I. E., & Eickhoff, S. B. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0519-5 · Cited by 70
Interhemispheric auditory connectivity: structure and function related to auditory verbal hallucinations
Steinmann, S., Leicht, G., & Mulert, C. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00055 · Cited by 68
Hallucinations: Synchronisation of thalamocortical γ oscillations underconstrained by sensory input
Behrendt, R. (2003) · Consciousness and Cognition · doi:10.1016/s1053-8100(03)00017-5 · Cited by 67
Increased diffusivity in superior temporal gyrus in patients with schizophrenia: A Diffusion Tensor Imaging study
Lee, K., Yoshida, T., Kubicki, M. R., Sylvain Bouix, A., Westin, C., Kindlmann, G., Niznikiewicz, M. A., Cohen, A. S., McCarley, R. W., & Shenton, M. E. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2008.11.024 · Cited by 67
Auditory Verbal Hallucinations and Brain Dysconnectivity in the Perisylvian Language Network: A Multimodal Investigation
Benetti, S., Pettersson‐Yeo, W., Allen, P., Catani, M., Williams, S., Barsaglini, A., Kambeitz‐Ilankovic, L., McGuire, P. K., & Mechelli, A. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt172 · Cited by 67 · cited 2×
“Similar results were recently obtained when comparing ultra-high-risk and first-episode-psychosis individuals following AVH episodes with NoAVH subject (Benetti et al., 2015).”
Result
PET Imaging and Cognition in Schizophrenia
Frith, C., Friston, K. J., Liddle, P. F., & Frackowiak, R. S. J. (1992) · Journal of the Royal Society of Medicine · doi:10.1177/014107689208500414 · Cited by 66 · cited 1×
“One approach has been to explain these impairments in terms of sensory-motor predictions from one’s own actions via forward modelling and efference copy mechanisms (Feinberg, 1978; Frith et al., 1992).”
Background
Association between white matter fiber integrity and subclinical psychotic symptoms in schizophrenia patients and unaffected relatives
Knöchel, C., O’Dwyer, L., Alves, G. S., Reinke, B., Magerkurth, J., Rotarska-Jagiela, A., Prvulovic, D., Hampel, H. J., Linden, D. E. J., & Oertel‐Knöchel, V. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.06.001 · Cited by 65 · cited 3×
“Decreased FA in various parts of the cingulum has consistently been observed in schizophrenia patients (Hubl et al., 2004; Shergill et al., 2007; Knöchel et al., 2012).”
Background
The physical basis of diffusion-weighted MRI
Cercignani, M., & Horsfield, M. A. (2001) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(01)00486-5 · Cited by 64 · cited 1×
“FA has been proven to reflect the integrity of the axonal membrane and myelin sheet (Beaulieu, 2002), as well as the local coherence of myelinated axons (Cercignani and Horsfield, 2001).”
Background
Are Auditory Hallucinations Related to the Brain's Resting State Activity? A 'Neurophenomenal Resting State Hypothesis'
Northoff, G. (2014) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2014.12.3.189 · Cited by 63 · cited 5×
“Northoff predicts that elevated resting state activity in the default mode network and auditory cortex coupled with their unaltered communication can enhance the development of AVH (Northoff, 2014; Northoff and Qin, 2011).”
BackgroundResultInfluential
EEG coherence measures during auditory hallucinations in schizophrenia
Sritharan, A., Line, P., Sergejew, A. A., Silberstein, R. B., Egan, G. F., & Copolov, D. (2005) · Psychiatry Research · doi:10.1016/j.psychres.2005.05.010 · Cited by 62 · cited 1×
“While they did not find significant changes in the coherence between Broca’s region and Wernicke’s area (as estimated from the scalp EEG electrode positions), the authors reported a significant increase of alpha-coherence between the left and the right superior temporal cortices during AVH (Sritharan et al., 2005).”
Background
Anterior cingulate cortex signals the requirement to break inertia when switching tasks: A study of the bivalency effect
Woodward, T. S., Metzak, P. D., Meier, B., & Holroyd, C. B. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.12.049 · Cited by 60
Opposite links of positive and negative symptomatology with memory errors in schizophrenia
Brébion, G., AMADOR, X. F., SMITH, M. J., Malaspina, D., Sharif, Z. A., & Gorman, J. M. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(99)00076-1 · Cited by 55 · cited 1×
“, 2010) and is specifically correlated with positive symptoms (Brebion et al., 1999).”
Background
Mechanisms of Auditory Verbal Hallucination in Schizophrenia
Cho, R., & Wu, W. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00155 · Cited by 54
Aberrant resting-state connectivity in non-psychotic individuals with auditory hallucinations
Diederen, K. M. J., Neggers, S. F. W., de Weijer, A. D., van Lutterveld, R., Daalman, K., Eickhoff, S. B., Clos, M., Kahn, R. S., & Sommer, I. E. (2012) · Psychological Medicine · doi:10.1017/s0033291712002541 · Cited by 53 · cited 2×
“Two studies found evidence for a specific role of connections between memory regions and Broca’s area (the language production area) (Sommer et al., 2012; Diederen et al., 2013) and Hoffman showed that the FC between the putamen and language areas is very important for AVH (Hoffman et al.”
BackgroundResult
Time course of regional brain activity accompanying auditory verbal hallucinations in schizophrenia
Hoffman, R. E., Pittman, B. P., Constable, R. T., Bhagwagar, Z., & Hampson, M. (2011) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.110.086835 · Cited by 52
Biological responses to trauma and the development of intrusive memories: An analog study with the trauma film paradigm
Chou, C., Marca, R. L., Steptoe, A., & Brewin, C. R. (2014) · Biological Psychology · doi:10.1016/j.biopsycho.2014.08.002 · Cited by 49
Auditory verbal hallucinations and the interhemispheric auditory pathway in chronic schizophrenia
Wigand, M. C. C., Kubicki, M. R., von Hohenberg, C. C., Leicht, G., Karch, S., Eckbo, R., Pelavin, P. E., Hawley, K. J., Rujescu, D., Sylvain Bouix, A., et al. (2014) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2014.948063 · Cited by 48 · cited 2×
“, 2012), but alters during the course of the disease (Wigand et al., 2015).”
Background
Arcuate Fasciculus Abnormalities and Their Relationship with Psychotic Symptoms in Schizophrenia
Abdul-Rahman, M. F., Qiu, A., Woon, P. S., Kuswanto, C. N., Collinson, S. L., & Sim, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029315 · Cited by 47 · cited 1×
“Abdul-Rahman and colleagues specifically investigated WM abnormalities in particular loci along the AF as well as its regional lateralization in schizophrenia (Abdul-Rahman et al., 2012) by examining different WM along the whole extent of the AF.”
Background
Formal thought disorder in non-clinical individuals with auditory verbal hallucinations
Sommer, I. E., Derwort, A. M. C., Daalman, K., de Weijer, A. D., Liddle, P. F., & Boks, M. P. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.01.024 · Cited by 44 · cited 1×
“In support of this, tangentiality and loosening of associations, types of formal thought disorder have often been reported in patients and healthy individuals with AVH (Sommer et al., 2010).”
Background
Surprise! A unifying model of dorsal anterior cingulate function?
Egner, T. (2011) · Nature Neuroscience · doi:10.1038/nn.2932 · Cited by 44
Comparison of auditory-vocal interactions across multiple types of vocalizations in marmoset auditory cortex
Eliades, S. J., & Wang, X. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00698.2012 · Cited by 42
Left-Dominant Temporal-Frontal Hypercoupling in Schizophrenia Patients With Hallucinations During Speech Perception
Lavigne, K. M., Rapin, L., Metzak, P. D., Whitman, J. C., Jung, K., Dohen, M., venbruck, H. L., & Woodward, T. S. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu004 · Cited by 42 · cited 2×
“This finding could explain why AVH are such realistic experiences of speech: increased coordinated activity in this circuitry has been observed during speech perception relative to inner verbal thought (Lavigne et al., 2015).”
Background
Perirhinal Cortex and its Neighbours in the Medial Temporal Lobe: Contributions to Memory and Perception
Murray, E. A., Graham, K. S., & Gaffan, D. (2005) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/02724990544000077 · Cited by 41 · cited 1×
“, 2004); the perirhinal cortex, which has a function in sensory integration, semantic and long-term memory (Murray and Richmond, 2001; Murray et al., 2005).”
Background
Auditory hallucinations: Expectation–perception model
Nazimek, J. M., Hunter, M. D., & Woodruff, P. W. R. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.03.014 · Cited by 41 · cited 1×
“suggested that AVHs arise from attenuated prediction error processing (Nazimek et al., 2012).”
Background
Involuntary Cognitions in Everyday Life: Exploration of Type, Quality, Content, and Function
Krans, J., de Bree, J., & Moulds, M. L. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00007 · Cited by 37 · cited 1×
“Indeed, patients often mention their hallucinations occurring most frequently at times when focused attention is low, at the beginning and end of the day (Krans et al., 2015; Nayani and David, 1996).”
Background
Verbal memory intrusions in schizophrenia: Associations with self-reflectivity, symptomatology, and neurocognition
Fridberg, D. J., Brenner, A., & Lysaker, P. H. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.06.026 · Cited by 36 · cited 1×
“This is well documented in the study of schizophrenia (Fridberg et al., 2010) and is specifically correlated with positive symptoms (Brebion et al.”
Background
Decreased integrity of the fronto-temporal fibers of the left inferior occipito-frontal fasciculus associated with auditory verbal hallucinations in schizophrenia
Oestreich, L., McCarthy‐Jones, S., & Whitford, T. J. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9421-5 · Cited by 35 · cited 3×
“The majority of large studies on chronic schizophrenia patients that incorporate both a control group and a group of patients without AVH find decreases in anatomical or functional connectivity of language areas (De Weijer et al., 2013; Oestreich et al., 2015; McCarthy-Jones et al., 2015; Cur9 ci c-Blake et al., 2013)…”
BackgroundMethod
Is gamma band EEG synchronization reduced during auditory driving in schizophrenia patients with auditory verbal hallucinations?
Koenig, T. W., van Swam, C., Dierks, T., & Hubl, D. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.07.016 · Cited by 35
Locating voices in space: A perceptual model for auditory hallucinations?
Hunter, M. D. (2004) · Cognitive Neuropsychiatry · doi:10.1080/13546800344000174 · Cited by 32
Functional brain networks involved in reality monitoring
Metzak, P. D., Lavigne, K. M., & Woodward, T. S. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.05.014 · Cited by 30 · cited 18×
“2), ACC, and insula (Mesulam, 1990).”
BackgroundInfluential
Indication of increased phase coupling between theta and gamma EEG rhythms associated with the experience of auditory verbal hallucinations
Koutsoukos, E., Angelopoulos, E. K., Maillis, A., Papadimitriou, G. N., & Stefanis, C. N. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.12.005 · Cited by 30 · cited 1×
“The average differences of theta-gamma-coupling between hallucinatory and resting stages were significant in the left temporal area (Koutsoukos et al., 2013).”
Background
Early- and late-latency gamma auditory steady-state response in schizophrenia during closed eyes: Does hallucination status matter?
Griškova-Bulanova, I., Hubl, D., van Swam, C., Dierks, T., & Koenig, T. W. (2016) · Clinical Neurophysiology · doi:10.1016/j.clinph.2016.02.009 · Cited by 29
Auditory Hallucinations
Blom, J. D., & Sommer, I. E. (2010) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0b013e3181b2791e · Cited by 28 · cited 2×
“, command hallucinations, third-person hallucinations, and thought echo (Blom and Sommer, 2010; McCarthy-Jones et al., 2014).”
Background
Hallucinatory Experiences in Non-clinical Populations
Hill, K., & Linden, D. E. J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4121-2_2 · Cited by 26 · cited 1×
“1 of this paper) and emotional processing, added to the negative emotional connotation of AVH in patients with schizophrenia (Hill and Linden, 2013), demands further investigation of the memory/limbic network.”
Background
Cortical Interactions During the Experience of Auditory Verbal Hallucinations
Angelopoulos, E. K., Koutsoukos, E., Maillis, A., Papadimitriou, G. N., & Stefanis, C. N. (2011) · Journal of Neuropsychiatry · doi:10.1176/jnp.23.3.jnp287 · Cited by 26
Abnormal synchrony and effective connectivity in patients with schizophrenia and auditory hallucinations
de la Iglesia-Vayá, M., Escartí, M. J., Molina‐Mateo, J., Martí‐Bonmatí, L., Gadea, M., Castellanos, F. X., Aguilar, E. J., Robles, M., Biswal, B. B., & Sanjuán, J. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.08.027 · Cited by 26
Functional MRI Evaluation of Multiple Neural Networks Underlying Auditory Verbal Hallucinations in Schizophrenia Spectrum Disorders
Thoma, R., Chaze, C., Lewine, J., Calhoun, V., Clark, V., Bustillo, J., Houck, J., Ford, J., Bigelow, R., Wilhelmi, C., et al. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00039 · Cited by 26
On the definition and interpretation of voice selective activation in the temporal cortex
Bethmann, A., & Brechmann, A. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00499 · Cited by 25 · cited 1×
“The best such example is the superior temporal area where the secondary auditory cortex overlaps with Wernicke’s area (Bethmann and Brechmann, 2014).”
Background
Insights into hallucinations in schizophrenia: Novel treatment approaches
Aleman, A., & Larøi, F. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.90 · Cited by 24 · cited 1×
“Further studies should be directed towards discerning which of the four abovementioned scenarios (Ford and Hoffman, 2013a; Aleman and Larøi, 2011; Waters et al., 2012; Northoff, 2014) is most plausible by adopting a more specific experimental paradigm and using causal inference analysis methods.”
Background
Voice recognition and altered connectivity in schizophrenic patients with auditory hallucinations
Mou, X., Bai, F., Xie, C., Shi, J., Yao, Z., Hao, G.-F., Chen, N., & Zhang, Z. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.03.006 · Cited by 21
Interhemispheric EEG coherence is reduced in auditory cortical regions in schizophrenia patients with auditory hallucinations
Henshall, K. R., Sergejew, A. A., Rance, G., McKay, C. M., & Copolov, D. (2013) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2013.05.005 · Cited by 20
Structural changes of the corpus callosum in tinnitus
Diesch, E. (2012) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2012.00017 · Cited by 19 · cited 2×
“This might explain why a relationship between interhemispheric auditory connectivity and auditory phantom perception is found not only in the context of AVH in schizophrenia, but also for example in the context of tinnitus (Diesch et al., 2012).”
Background
Functional Brain Imaging of Auditory Hallucinations: From Self-Monitoring Deficits to Co-opted Neural Resources
Ford, J. M., & Hoffman, R. E. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4121-2_19 · Cited by 17
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Revisiting Arieti's "Listening Attitude" and Hallucinated Voices
Hoffman, R. E. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq025 · Cited by 17 · cited 1×
“Similar concepts have been put forward as the breakaway speech and unbidden thoughts account of AVH (David, 1994; Ford and Hoffman, 2013b; Hoffman, 2010).”
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A white matter tract mediating awareness of speech
Koubeissi, M. Z., Vaca, G. F., Maciunas, R. J., & Stephani, C. (2015) · Neurology · doi:10.1212/wnl.0000000000002246 · Cited by 14
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Rockwood, K. J. (2008) · Psychiatry · doi:10.1016/j.mppsy.2007.11.003 · Cited by 7
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See all 224

Authors: Ćurčić-Blake, B., Ford, J. M., Hubl, D., Orlov, N. D., Sommer, I. E., Waters, F., Allen, P., Jardri, R., Woodruff, P. W., David, O., Mulert, C., Woodward, T. S., & Aleman, A.
Affiliations: San Francisco VA Medical Center (US)
University of Bern (CH)
King's College London (GB)
University Medical Center Utrecht (NL)
The University of Western Australia (AU)
Centre National de la Recherche Scientifique (FR)
University of Sheffield (GB)
University Medical Center Hamburg-Eppendorf (DE)
University of British Columbia (CA)
University Medical Center Groningen (NL)
ORCID: Ford, Judith M.
Hubl, Daniela
Orlov, Natasza D.
Sommer, Iris E.
Waters, Flavie
Allen, Paul
Jardri, Renaud
Woodruff, Peter W.
Mulert, Christoph
Woodward, Todd S.
Aleman, André
Venue: Progress in Neurobiology
Publisher: Elsevier BV
Published: 2017-01
Volume: 148
Pages: 1-20
ISSN: 0301-0082 (ISSN-L)
DOI: 10.1016/j.pneurobio.2016.11.002
PMC: PMC5240789
OpenAlex: W2552561399
Cited by: 224
References: 200
Citations by year: 2026: 13 · 2025: 21 · 2024: 20 · 2023: 18 · 2022: 21 · 2021: 28 · 2020: 34 · 2019: 35 · 2018: 20 · 2017: 13
FWCI: 2.43
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Progress in Neurobiology (publishedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, cc-by-nc-nd)
HAL (submittedVersion, cc-by-nc-nd)
UWA Profiles and Research Repository (UWA) (submittedVersion, cc-by-nc-nd)
BORIS (University Library Bern) (submittedVersion, cc-by-nc-nd)
Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
Research Portal (King's College London) (submittedVersion, cc-by-nc-nd)
LillOA (Université de Lille (University Of Lille)) (submittedVersion, cc-by-nc-nd)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by-nc-nd)
Open Access CRIS of the University of Bern
Funders: NWO VICI (453-11-004)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: auditory verbal hallucinations, language network, auditory network, functional connectivity, structural connectivity, symptom association, interhemispheric connectivity, striatum, source monitoring, top-down attention, psychosis, first-episode psychosis, chronic psychosis, fronto-temporal connectivity
MeSH terms: Auditory Perception, Hallucinations, Humans, Language, Memory, Nerve Net

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Interaction of language, auditory and memory brain networks in auditory verbal hallucinations

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