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Revising the definition of Alzheimer's disease: a new lexicon
Open accessAbstract
Alzheimer's disease (AD) is classically defined as a dual clinicopathological entity. The recent advances in use of reliable biomarkers of AD that provide in-vivo evidence of the disease has stimulated the development of new research criteria that reconceptualise the diagnosis around both a specific pattern of cognitive changes and structural/biological evidence of Alzheimer's pathology. This new diagnostic framework has stimulated debate about the definition of AD and related conditions. The potential for drugs to intercede in the pathogenic cascade of the disease adds some urgency to this debate. This paper by the International Working Group for New Research Criteria for the Diagnosis of AD aims to advance the scientific discussion by providing broader diagnostic coverage of the AD clinical spectrum and by proposing a common lexicon as a point of reference for the clinical and research communities. The cornerstone of this lexicon is to consider AD solely as a clinical and symptomatic entity that encompasses both predementia and dementia phases.
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“Nonamnestic clinical presentations, that is, language, visuospatial, and executive disorders, may also be due to AD [63–66].”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [64]
In the citing paper
“Hippocampal volume has thus been proposed as a neuroimaging biomarker for early AD diagnosis (Albert et al., 2011; Dubois et al., 2010).”
From Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer's disease and semantic dementia (2013) · cites this paper as Dubois et al., 2010
In the citing paper
“Because the presence of Aβ deposition significantly increases the likelihood of having AD pathology in patients with aMCI according to current diagnosis recommendations (Albert et al., 2011; Dubois et al., 2010)”
From Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer's disease and semantic dementia (2013) · cites this paper as Dubois et al., 2010
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Metadata
- Authors
- Dubois, B., Feldman, H. H., Jacova, C., Cummings, J. L., DeKosky, S. T., Barberger-Gateau, P., Delacourte, A., Frisoni, G., Fox, N. C., Galasko, D., Gauthier, S., Hampel, H., Jicha, G. A., Meguro, K., O'Brien, J., Pasquier, F., Robert, P., Rossor, M., Salloway, S., Sarazin, M., de Souza, L. C., Stern, Y., Visser, P. J., & Scheltens, P.
- Affiliations
- Assistance Publique – Hôpitaux de Paris (FR)
- University of British Columbia (CA)
- University of California, Los Angeles (US)
- University of Virginia (US)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- UCL Queen Square Institute of Neurology (GB)
- University of California San Diego (US)
- Douglas Mental Health University Institute (CA)
- Goethe University Frankfurt (DE)
- University of Kentucky (US)
- Tohoku University (JP)
- Newcastle University (GB)
- Centre Hospitalier Universitaire de Lille (FR)
- Centre Hospitalier Universitaire de Nice (FR)
- NewYork–Presbyterian Hospital (US)
- Maastricht University Medical Centre (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Dubois, Bruno
- ORCID
- Dubois, Bruno
- Feldman, Howard H
- Jacova, Claudia
- Cummings, Jeffrey L
- DeKosky, Steven T
- Frisoni, Giovanni
- Fox, Nick C
- Galasko, Douglas
- Gauthier, Serge
- Hampel, Harald
- Jicha, Gregory A
- Meguro, Kenichi
- O'Brien, John
- Pasquier, Florence
- Robert, Philippe
- Rossor, Martin
- Sarazin, Marie
- Stern, Yaakov
- Visser, Pieter J
- Scheltens, Philip
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 9
- Issue
- 11
- Pages
- 1118-1127
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2157110881
- Semantic Scholar
- 05f87cd51d602a643bf8f0ce8468ef827dda6a1b
- Cited by
- 1,869
- References
- 94
- Citations by year
- 2026: 27 · 2025: 56 · 2024: 67 · 2023: 66 · 2022: 63 · 2021: 80 · 2020: 104 · 2019: 97 · 2018: 109 · 2017: 128 · 2016: 134 · 2015: 144 · 2014: 203 · 2013: 209 · 2012: 213
- FWCI
- 128.35
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Columbia Academic Commons (Columbia University)
- Funders
- National Institute for Health and Care Research (NF-SI-0508-10123)
- Eisai
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Keywords
- Alzheimer's disease, diagnostic criteria, disease definition, vocabulary, biomarkers, pre-dementia, dementia, cognitive impairment, clinical spectrum
- MeSH terms
- Alzheimer Disease, Chicago, Dementia, Humans, Biomarkers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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