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Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTNucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)Ulrich Lächelt*†‡ and Ernst Wagner*†‡View Author Information† Pharmaceutical Biotechnology, Department of Pharmacy, Ludwig Maximilians Universität, 81377 Munich, Germany‡ Nanosystems Initiative Munich (NIM), 80799 Munich, Germany*E-mail: [email protected]*E-mail: [email protected]Cite this: Chem. Rev. 2015, 115, 19, 11043–11078Publication Date (Web):April 15, 2015Publication History Received30 November 2014Published online15 April 2015Published inissue 14 October 2015https://pubs.acs.org/doi/10.1021/cr5006793https://doi.org/10.1021/cr5006793review-articleACS PublicationsCopyright © 2015 American Chemical SocietyRequest reuse permissionsArticle Views9095Altmetric-Citations486LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Gene delivery,Genetics,Nucleic acids,Polyethylenimine,Polymers Get e-Alerts
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Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid
WATSON, J. D., & CRICK, F. H. C. (1953) · Nature · doi:10.1038/171737a0 · Cited by 13,584
Tuerk, C., & Gold, L. (1990) · Science · doi:10.1126/science.2200121 · Cited by 10,405
In vitro selection of RNA molecules that bind specific ligands
Ellington, A. D., & Szostak, J. W. (1990) · Nature · doi:10.1038/346818a0 · Cited by 9,812
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., & Tuschl, T. (2001) · Nature · doi:10.1038/35078107 · Cited by 9,456
A map of human genome variation from population-scale sequencing.
The 1000 Genomes Project Consortium (2010) · Nature · doi:10.1038/nature09534 · Cited by 7,877
Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide
Merrifield, R. B. (1963) · Journal of the American Chemical Society · doi:10.1021/ja00897a025 · Cited by 7,647
MicroRNAs: small RNAs with a big role in gene regulation
He, L., & Hannon, G. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1379 · Cited by 7,118
Boussif, O., Lezoualc'h, F., Zanta, M. A., Mergny, M. D., Scherman, D., Demeneix, B., & Behr, J. P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7297 · Cited by 6,247
Identification of Novel Genes Coding for Small Expressed RNAs
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., & Tuschl, T. (2001) · Science · doi:10.1126/science.1064921 · Cited by 4,956
Block copolymer micelles for drug delivery: design, characterization and biological significance
Kataoka, K., Harada, A., & Nagasaki, Y. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00124-1 · Cited by 3,506
Central Dogma of Molecular Biology
CRICK, F. (1970) · Nature · doi:10.1038/227561a0 · Cited by 3,444
The dawning era of polymer therapeutics
Duncan, R. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1088 · Cited by 3,269
Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome
Gibson, D. G., Glass, J. I., Lartigue, C., Noskov, V. N., Chuang, R.-Y., Algire, M. A., Benders, G. A., Montague, M. G., Ma, L., Moodie, M. M., et al. (2010) · Science · doi:10.1126/science.1190719 · Cited by 2,638
Design and development of polymers for gene delivery
Pack, D. W., Hoffman, A. S., Pun, S., & Stayton, P. S. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1775 · Cited by 2,568
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
Pasquinelli, A. E., Reinhart, B. J., Slack, F., Martindale, M. Q., Kuroda, M. I., Maller, B., Hayward, D. C., Ball, E. E., Degnan, B., Müller, P., et al. (2000) · Nature · doi:10.1038/35040556 · Cited by 2,565
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Davis, M. E., Zuckerman, J. E., Choi, C. H. J., Seligson, D., Tolcher, A., Alabi, C. A., Yen, Y., Heidel, J. D., & Ribas, A. (2010) · Nature · doi:10.1038/nature08956 · Cited by 2,505
Gene transfer into mouse lyoma cells by electroporation in high electric fields.
Neumann, E., Schaefer-Ridder, M., Wang, Y., & Hofschneider, P. H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01257.x · Cited by 2,502
Maeda, H. (2001) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(00)00013-3 · Cited by 2,495
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Cabral, H., Matsumoto, Y., Mizuno, K., Chen, Q., Murakami, M., Kimura, M., Terada, Y., Kano, M. R., Miyazono, K., Uesaka, M., et al. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.166 · Cited by 2,429
Nonviral vectors for gene delivery
Mintzer, M. A., & Simanek, E. E. (2009) · Chemical Reviews · doi:10.1021/cr800409e · Cited by 2,366
Keefe, A. D., Pai, S., & Ellington, A. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3141 · Cited by 2,289
ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS
Mellman, I., Fuchs, R., & Helenius, A. (1986) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.55.070186.003311 · Cited by 2,032
Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B
Nathwani, A. C., Tuddenham, E. G. D., Rangarajan, S., Rosales, C., McIntosh, J., Linch, D. C., Chowdary, P., Riddell, A., Pie, A. J., Harrington, C., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1108046 · Cited by 1,864
The Basic Science of Gene Therapy
Mulligan, R. C. (1993) · Science · doi:10.1126/science.8493530 · Cited by 1,741
Maxfield, F. R., & McGraw, T. E. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1315 · Cited by 1,729
Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.
Yuan, F., Dellian, M., Fukumura, D., Leunig, M., Berk, D. A., Torchilin, V. P., & Jain, R. K. (1995) · PubMed · Cited by 1,711
LNA-mediated microRNA silencing in non-human primates
Elmén, J., Lindow, M., Schütz, S., Lawrence, M., Petri, A., Obad, S., Lindholm, M., Hedtjärn, M., Hansen, H. F., Berger, U., et al. (2008) · Nature · doi:10.1038/nature06783 · Cited by 1,589
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease
Ng, E. W. M., Shima, D. T., Calias, P., Cunningham, E. T., Guyer, D. R., & Adamis, A. P. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1955 · Cited by 1,588
Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model
Kota, J., Chivukula, R. R., O'Donnell, K. A., Wentzel, E. A., Montgomery, C. L., Hwang, H.-W., Chang, T.-C., Vivekanandan, P., Torbenson, M., Clark, K. R., et al. (2009) · Cell · doi:10.1016/j.cell.2009.04.021 · Cited by 1,452
Non–coding RNA genes and the modern RNA world
Eddy, S. R. (2001) · Nature Reviews Genetics · doi:10.1038/35103511 · Cited by 1,426
Lutz, J.-F., Ouchi, M., Liu, D. R., & Sawamoto, M. (2013) · Science · doi:10.1126/science.1238149 · Cited by 1,381
Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery
Cheng, R., Meng, F., Deng, C., Klok, H.-A., & Zhong, Z. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.084 · Cited by 1,354
Exploring polyethylenimine‐mediated DNA transfection and the proton sponge hypothesis
Akinc, A., Thomas, M., Klibanov, A. M., & Langer, R. (2005) · The Journal of Gene Medicine · doi:10.1002/jgm.696 · Cited by 1,337
Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery
Khalil, I. A., Kogure, K., Akita, H., & Harashima, H. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.1.8 · Cited by 1,240
Polyamidoamine cascade polymers mediate efficient transfection of cells in culture
Haensler, J., & Szoka, F. C. (1993) · Bioconjugate Chemistry · doi:10.1021/bc00023a012 · Cited by 1,207
Intracellular pattern recognition receptors in the host response
Meylan, E., Tschopp, J., & Karin, M. (2006) · Nature · doi:10.1038/nature04946 · Cited by 1,206
Gene therapy clinical trials worldwide to 2012 – an update
Ginn, S. L., Alexander, I. E., Edelstein, M. L., Abedi, M. R., & Wixon, J. (2013) · The Journal of Gene Medicine · doi:10.1002/jgm.2698 · Cited by 1,159
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
Akinc, A., Zumbuehl, A., Goldberg, M., Leshchiner, E. S., Busini, V., Hossain, N., Bacallado, S. A., Nguyen, D. N., Fuller, J., Alvarez, R., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1402 · Cited by 1,150
Nair, J. K., Willoughby, J. L. S., Chan, A., Charisse, K., Alam, M. R., Wang, Q., Hoekstra, M., Kandasamy, P., Kel’in, A. V., Milstein, S., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja505986a · Cited by 1,141
Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
Li, X.-D., Wu, J., Gao, D., Wang, H., Sun, L., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1244040 · Cited by 1,113
Gelatin as a delivery vehicle for the controlled release of bioactive molecules
Young, S., Wong, M., Tabata, Y., & Mikos, A. G. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.09.023 · Cited by 1,097
A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy
Moghimi, S. M., Symonds, P., Murray, J. C., Hunter, A. C., Debska, G., & Szewczyk, A. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.02.010 · Cited by 1,092
Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA Polyplexes
Sonawane, N. D., Szoka, F. C., & Verkman, A. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308643200 · Cited by 1,081
Mercer, J., Schelhaas, M., & Helenius, A. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060208-104626 · Cited by 1,057
Bioapplications of RAFT Polymerization
Boyer, C., Bulmus, V., Davis, T. P., Ladmiral, V., Liu, J., & Perrier, S. (2009) · Chemical Reviews · doi:10.1021/cr9001403 · Cited by 1,015
Kukowska-Latallo, J. F., Bielinska, A. U., Johnson, J., Spindler, R., Tomalia, D. A., & Baker, J. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4897 · Cited by 1,006
Cell type–specific delivery of siRNAs with aptamer-siRNA chimeras
McNamara, J. O., Andrechek, E. R., Wang, Y., Viles, K. D., Rempel, R. E., Gilboa, E., Sullenger, B. A., & Giangrande, P. H. (2006) · Nature Biotechnology · doi:10.1038/nbt1223 · Cited by 1,002
High efficiency transformation by direct microinjection of DNA into cultured mammalian cells
Capecchi, M. R. (1980) · Cell · doi:10.1016/0092-8674(80)90358-x · Cited by 1,001
DUFES, C., UCHEGBU, I., & SCHATZLEIN, A. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.09.017 · Cited by 984
Nanomedicine(s) under the Microscope
Duncan, R., & Gaspar, R. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200394t · Cited by 981
Davis, M. E. (2009) · Molecular Pharmaceutics · doi:10.1021/mp900015y · Cited by 977
Lipid-like materials for low-dose, in vivo gene silencing
Love, K. T., Mahon, K. P., Levins, C. G., Whitehead, K. A., Querbes, W., Dorkin, J. R., Qin, J., Cantley, W., Qin, L. L., Racie, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910603106 · Cited by 969
Current status of polymeric gene delivery systems☆
PARK, T., JEONG, J., & KIM, S. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.03.007 · Cited by 944
The proton sponge: a trick to enter cells the viruses did not exploit
Behr, J.-P. (1997) · CHIMIA · doi:10.2533/chimia.1997.34 · Cited by 933
Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo
Scherer, F., Anton, M., Schillinger, U., Henke, J., Bergemann, C., Krüger, A., Gänsbacher, B., & Plank, C. (2002) · Gene Therapy · doi:10.1038/sj.gt.3301624 · Cited by 932
Schiffelers, R. M. (2004) · Nucleic Acids Research · doi:10.1093/nar/gnh140 · Cited by 901
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
Schoggins, J. W., MacDuff, D. A., Imanaka, N., Gainey, M. D., Shrestha, B., Eitson, J. L., Mar, K. B., Richardson, R. B., Ratushny, A. V., Litvak, V., et al. (2014) · Nature · doi:10.1038/nature12862 · Cited by 896
He, C., Lu, K., Liu, D., & Lin, W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja4098862 · Cited by 885
Cationic Polymer Based Gene Delivery Systems
De Smedt, S. C., Demeester, J., & Hennink, W. E. (2000) · Pharmaceutical Research · doi:10.1023/a:1007548826495 · Cited by 884
Receptor-mediated in vitro gene transformation by a soluble DNA carrier system.
Wu, G. Y., & Wu, C. H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61209-8 · Cited by 855
Godbey, W. T., Wu, K. K., & Mikos, A. G. (1999) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19990605)45:3<268::aid-jbm15>3.0.co;2-q · Cited by 825
Small RNAs in transcriptional gene silencing and genome defence
Moazed, D. (2009) · Nature · doi:10.1038/nature07756 · Cited by 823
Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery
Godbey, W. T., Wu, K. K., & Mikos, A. G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5177 · Cited by 822
Lopata, M. A., Cleveland, D. W., & Sollner-Webb, B. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.14.5707 · Cited by 822
Friedmann, T., & Roblin, R. (1972) · Science · doi:10.1126/science.175.4025.949 · Cited by 815
Tang, M., & Szoka, F. (1997) · Gene Therapy · doi:10.1038/sj.gt.3300454 · Cited by 814
In Vitro Gene Delivery by Degraded Polyamidoamine Dendrimers
Tang, M. X., Redemann, C. T., & Szoka, F. C. (1996) · Bioconjugate Chemistry · doi:10.1021/bc9600630 · Cited by 808
Bartlett, D. W., Su, H., Hildebrandt, I. J., Weber, W. A., & Davis, M. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707461104 · Cited by 803
Prospects for cationic polymers in gene and oligonucleotide therapy against cancer
Merdan, T., Kopec̆ek, J., & Kissel, T. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00046-7 · Cited by 785
(1968) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/41.2.351 · Cited by 775
Evidence for the role of proteoglycans in cation-mediated gene transfer.
Mislick, K. A., & Baldeschwieler, J. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12349 · Cited by 772
Design considerations for tumour-targeted nanoparticles
Choi, H. S., Liu, W., Liu, F., Nasr, K., Misra, P., Bawendi, M. G., & Frangioni, J. V. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2009.314 · Cited by 754
Size-dependent DNA Mobility in Cytoplasm and Nucleus
Lukacs, G. L., Haggie, P., Seksek, O., Lechardeur, D., Freedman, N., & Verkman, A. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.3.1625 · Cited by 752
Benjaminsen, R. V., Mattebjerg, M. A., Henriksen, J. R., Moghimi, S. M., & Andresen, T. L. (2013) · Molecular Therapy · doi:10.1038/mt.2012.185 · Cited by 735
Expression of therapeutic proteins after delivery of chemically modified mRNA in mice
Kormann, M. S. D., Hasenpusch, G., Aneja, M. K., Nica, G., Flemmer, A. W., Herber-Jonat, S., Huppmann, M., Mays, L. E., Illenyi, M., Schams, A., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1733 · Cited by 733
Zanta, M. A., Belguise-Valladier, P., & Behr, J.-P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.1.91 · Cited by 722
Condensation of DNA by multivalent cations: Considerations on mechanism
Bloomfield, V. A. (1991) · Biopolymers · doi:10.1002/bip.360311305 · Cited by 720
Tabernero, J., Shapiro, G. I., LoRusso, P. M., Cervantes, A., Schwartz, G. K., Weiss, G. J., Paz-Ares, L., Cho, D. C., Infante, J. R., Alsina, M., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0429 · Cited by 698
Different behavior of branched and linear polyethylenimine for gene deliveryin vitro andin vivo
Wightman, L., Kircheis, R., R�ssler, V., Carotta, S., Ruzicka, R., Kursa, M., & Wagner, E. (2001) · The Journal of Gene Medicine · doi:10.1002/jgm.187 · Cited by 697
Self-citationNatural Polymers for Gene Delivery and Tissue Engineering
DANG, J., & LEONG, K. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.03.001 · Cited by 694
TLR3: Interferon induction by double-stranded RNA including poly(I:C)☆
MATSUMOTO, M., & SEYA, T. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.11.005 · Cited by 685
High efficiency polyoma DNA transfection of chloroquine treated cells
Luthman, H., & Magnusson, G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1295 · Cited by 677
Plank, C., Oberhauser, B., Mechtler, K., Koch, C., & Wagner, E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99963-1 · Cited by 666
Self-citationWagner, E., Plank, C., Zatloukal, K., Cotten, M., & Birnstiel, M. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.17.7934 · Cited by 658
Self-citationDynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes
Rozema, D. B., Lewis, D. L., Wakefield, D. H., Wong, S. C., Klein, J. J., Roesch, P. L., Bertin, S. L., Reppen, T. W., Chu, Q., Blokhin, A. V., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703778104 · Cited by 658
Transferrin-polycation conjugates as carriers for DNA uptake into cells.
Wagner, E., Zenke, M., Cotten, M., Beug, H., & Birnstiel, M. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.9.3410 · Cited by 655
Self-citationRetro-translocation of proteins from the endoplasmic reticulum into the cytosol
Tsai, B., Ye, Y., & Rapoport, T. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm780 · Cited by 647
Lipid-based Nanoparticles for Nucleic Acid Delivery
Li, W., & Szoka, F. C. (2007) · Pharmaceutical Research · doi:10.1007/s11095-006-9180-5 · Cited by 641
Gene regulation by antisense transcription
Pelechano, V., & Steinmetz, L. M. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3594 · Cited by 634
Silencing of microRNA families by seed-targeting tiny LNAs
Obad, S., dos Santos, C. O., Petri, A., Heidenblad, M., Broom, O., Ruse, C., Fu, C., Lindow, M., Stenvang, J., Straarup, E. M., et al. (2011) · Nature Genetics · doi:10.1038/ng.786 · Cited by 627
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity
Whitehead, K. A., Dorkin, J. R., Vegas, A. J., Chang, P. H., Veiseh, O., Matthews, J., Fenton, O. S., Zhang, Y., Olejnik, K. T., Yesilyurt, V., et al. (2014) · Nature Communications · doi:10.1038/ncomms5277 · Cited by 615
Wirth, T., Parker, N., & Ylä-Herttuala, S. (2013) · Gene · doi:10.1016/j.gene.2013.03.137 · Cited by 607
Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery
MacLaughlin, F. C., Mumper, R. J., Wang, J., Tagliaferri, J. M., Gill, I., Hinchcliffe, M., & Rolland, A. P. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00097-2 · Cited by 601
In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment.
Yang, N. S., Burkholder, J., Roberts, B., Martinell, B., & McCabe, D. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9568 · Cited by 600
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
Dahlman, J. E., Barnes, C., Khan, O. F., Thiriot, A., Jhunjunwala, S., Shaw, T. E., Xing, Y., Sager, H. B., Sahay, G., Speciner, L., et al. (2014) · Nature Nanotechnology · doi:10.1038/nnano.2014.84 · Cited by 592
Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists
Vollmer, J., & Krieg, A. M. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.12.008 · Cited by 585
RNA Interference in Vitro and in Vivo Using a Novel Chitosan/siRNA Nanoparticle System
Howard, K. A., Rahbek, U. L., Liu, X., Damgaard, C. K., Glud, S. Z., Andersen, M. Ø., Hovgaard, M. B., Schmitz, A., Nyengaard, J. R., Besenbacher, F., et al. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.04.010 · Cited by 585
Plank, C., Mechtler, K., Szoka, F. C., & Wagner, E. (1996) · Human Gene Therapy · doi:10.1089/hum.1996.7.12-1437 · Cited by 583
Self-citationMeng, H., Mai, W. X., Zhang, H., Xue, M., Xia, T., Lin, S., Wang, X., Zhao, Y., Ji, Z., Zink, J. I., et al. (2013) · ACS Nano · doi:10.1021/nn3044066 · Cited by 575
Maxfield, F. R. (1982) · The Journal of cell biology · doi:10.1083/jcb.95.2.676 · Cited by 568
Hu-Lieskovan, S., Heidel, J. D., Bartlett, D. W., Davis, M. E., & Triche, T. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0565 · Cited by 567
Simonelli, F., Maguire, A. M., Testa, F., Pierce, E. A., Mingozzi, F., Bennicelli, J. L., Rossi, S., Marshall, K., Banfi, S., Surace, E. M., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2009.277 · Cited by 553
Nucleic-acid therapeutics: basic principles and recent applications
Opalinska, J. B., & Gewirtz, A. M. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd837 · Cited by 537
Erbacher, P., Zou, S., Bettinger, T., Steffan, A.-M., & Remy, J.-S. (1998) · Pharmaceutical Research · doi:10.1023/a:1011981000671 · Cited by 536
Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus
Brunner, S., Sauer, T., Carotta, S., Cotten, M., Saltik, M., & Wagner, E. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301102 · Cited by 533
Self-citationMansouri, S., Lavigne, P., Corsi, K., Benderdour, M., Beaumont, E., & Fernandes, J. C. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(03)00155-3 · Cited by 532
Köping-Höggård, M., Tubulekas, I., Guan, H., Edwards, K., Nilsson, M., Vårum, K., & Artursson, P. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301492 · Cited by 532
Polyethylenimine-mediated gene delivery: a mechanistic study
Kichler, A., Leborgne, C., Coeytaux, E., & Danos, O. (2001) · The Journal of Gene Medicine · doi:10.1002/jgm.173 · Cited by 517
Gary, D. J., Puri, N., & Won, Y.-Y. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.05.021 · Cited by 514
Polylysine-based transfection systems utilizing receptor-mediated delivery
Zauner, W., Ogris, M., & Wagner, E. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00110-5 · Cited by 504
Self-citationAnderson, D. G., Lynn, D. M., & Langer, R. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200351244 · Cited by 504
Efficient Gene Transfer by Histidylated Polylysine/pDNA Complexes
Midoux, P., & Monsigny, M. (1999) · Bioconjugate Chemistry · doi:10.1021/bc9801070 · Cited by 501
Protein Disulfide Isomerase Acts as a Redox-Dependent Chaperone to Unfold Cholera Toxin
Tsai, B., Rodighiero, C., Lencer, W. I., & Rapoport, T. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00289-6 · Cited by 483
Wagner, E., Zatloukal, K., Cotten, M., Kirlappos, H., Mechtler, K., Curiel, D. T., & Birnstiel, M. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.6099 · Cited by 481
Self-citationFirst microRNA mimic enters clinic
Bouchie, A. (2013) · Nature Biotechnology · doi:10.1038/nbt0713-577 · Cited by 472
Katayose, S., & Kataoka, K. (1997) · Bioconjugate Chemistry · doi:10.1021/bc9701306 · Cited by 469
Simple Modifications of Branched PEI Lead to Highly Efficient siRNA Carriers with Low Toxicity
Zintchenko, A., Philipp, A., Dehshahri, A., & Wagner, E. (2008) · Bioconjugate Chemistry · doi:10.1021/bc800065f · Cited by 467
Self-citationEfficient Gene Transfer Using Reversibly Cross-Linked Low Molecular Weight Polyethylenimine
Gosselin, M. A., Guo, W., & Lee, R. J. (2001) · Bioconjugate Chemistry · doi:10.1021/bc0100455 · Cited by 454
Chemical Modification of siRNAs for In Vivo Use
Behlke, M. A. (2008) · Oligonucleotides · doi:10.1089/oli.2008.0164 · Cited by 454
Wyman, T. B., Nicol, F., Zelphati, O., Scaria, P. V., Plank, C., & Szoka, F. C. (1997) · Biochemistry · doi:10.1021/bi9618474 · Cited by 453
Miyata, K., Nishiyama, N., & Kataoka, K. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15258k · Cited by 451
Nomenclature for Synthetic Gene Delivery Systems
(1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.5-511 · Cited by 448
Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer
Boeckle, S., von Gersdorff, K., van der Piepen, S., Culmsee, C., Wagner, E., & Ogris, M. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.598 · Cited by 447
Self-citationCurrent progress of siRNA/shRNA therapeutics in clinical trials
Burnett, J. C., Rossi, J. J., & Tiemann, K. (2011) · Biotechnology Journal · doi:10.1002/biot.201100054 · Cited by 444
PEG-SS-PPS: Reduction-Sensitive Disulfide Block Copolymer Vesicles for Intracellular Drug Delivery
Cerritelli, S., Velluto, D., & Hubbell, J. A. (2007) · Biomacromolecules · doi:10.1021/bm070085x · Cited by 443
Breaking up the correlation between efficacy and toxicity for nonviral gene delivery
Breunig, M., Lungwitz, U., Liebl, R., & Goepferich, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703882104 · Cited by 443
Sequence-controlled polymerizations: the next Holy Grail in polymer science?
Lutz, J.-F. (2010) · Polymer Chemistry · doi:10.1039/b9py00329k · Cited by 443
Sun, H., Guo, B., Cheng, R., Meng, F., Liu, H., & Zhong, Z. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.07.051 · Cited by 438
Ribozymes, riboswitches and beyond: regulation of gene expression without proteins
Serganov, A., & Patel, D. J. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2172 · Cited by 436
Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles.
Williams, R. S., Johnston, S. A., Riedy, M., DeVit, M. J., McElligott, S. G., & Sanford, J. C. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.7.2726 · Cited by 427
Sato, T., Ishii, T., & Okahata, Y. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00385-9 · Cited by 426
Photochemical internalization: a novel technology for delivery of macromolecules into cytosol.
Berg, K., Selbo, P. K., Prasmickaite, L., Tjelle, T. E., Sandvig, K., Moan, J. E., Gaudernack, G., Fodstad, Ø., Kjølsrud, S., Anholt, H., et al. (1999) · PubMed · Cited by 423
Adenovirus enhancement of transferrin-polylysine-mediated gene delivery.
Curiel, D. T., Agarwal, S., Wagner, E., & Cotten, M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8850 · Cited by 423
Self-citationTakae, S., Miyata, K., Oba, M., Ishii, T., Nishiyama, N., Itaka, K., Yamasaki, Y., Koyama, H., & Kataoka, K. (2008) · Journal of the American Chemical Society · doi:10.1021/ja800336v · Cited by 400
Physical methods for gene transfer: Improving the kinetics of gene delivery into cells
MEHIERHUMBERT, S., & GUY, R. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.12.007 · Cited by 395
Toll‐like receptors, endogenous ligands, and systemic autoimmune disease
Rifkin, I. R., Leadbetter, E. A., Busconi, L., Viglianti, G., & Marshak‐Rothstein, A. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00239.x · Cited by 389
5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
Poeck, H., Besch, R., Maihoefer, C., Renn, M., Tormo, D., Morskaya, S. S., Kirschnek, S., Gaffal, E., Landsberg, J., Hellmuth, J., et al. (2008) · Nature Medicine · doi:10.1038/nm.1887 · Cited by 387
TLR9 as a key receptor for the recognition of DNA☆
KUMAGAI, Y., TAKEUCHI, O., & AKIRA, S. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.12.004 · Cited by 387
A Degradable Polyethylenimine Derivative with Low Toxicity for Highly Efficient Gene Delivery
Forrest, M. L., Koerber, J. T., & Pack, D. W. (2003) · Bioconjugate Chemistry · doi:10.1021/bc034014g · Cited by 387
Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications
Shim, M. S., & Kwon, Y. J. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.01.018 · Cited by 384
Development of Biomaterials for Gene Therapy
Han, S.-O., Mahato, R. I., Sung, Y. K., & Kim, S. W. (2000) · Molecular Therapy · doi:10.1006/mthe.2000.0142 · Cited by 384
Enhanced transfection efficiency of PAMAM dendrimer by surface modification with l-arginine
Choi, J. S., Nam, K., Park, J.-Y., Kim, J.-B., Lee, J.-K., & Park, J.-S. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.07.027 · Cited by 382
Akinc, A., Lynn, D. M., Anderson, D. G., & Langer, R. (2003) · Journal of the American Chemical Society · doi:10.1021/ja034429c · Cited by 376
A peptide nucleic acid–nuclear localization signal fusion that mediates nuclear transport of DNA
Brandén, L. J., Mohamed, A. J., & Smith, C. I. E. (1999) · Nature Biotechnology · doi:10.1038/11726 · Cited by 375
Side‐effects of a systemic injection of linear polyethylenimine–DNA complexes
Chollet, P., Favrot, M. C., Hurbin, A., & Coll, J. (2002) · The Journal of Gene Medicine · doi:10.1002/jgm.237 · Cited by 373
Quaternized chitosan oligomers as novel gene delivery vectors in epithelial cell lines
Thanou, M., Florea, B. I., Geldof, M., Junginger, H. E., & Borchard, G. (2002) · Biomaterials · doi:10.1016/s0142-9612(01)00090-4 · Cited by 372
Miyata, K., Oba, M., Nakanishi, M., Fukushima, S., Yamasaki, Y., Koyama, H., Nishiyama, N., & Kataoka, K. (2008) · Journal of the American Chemical Society · doi:10.1021/ja804561g · Cited by 371
Polycation gene delivery systems: escape from endosomes to cytosol
Cho, Y. W., Kim, J.-D., & Park, K. (2003) · Journal of Pharmacy and Pharmacology · doi:10.1211/002235703765951311 · Cited by 370
Wolfert, M. A., Schacht, E. H., Toncheva, V., Ulbrich, K., Nazarova, O., & Seymour, L. W. (1996) · Human Gene Therapy · doi:10.1089/hum.1996.7.17-2123 · Cited by 365
Efficient active transport of gene nanocarriers to the cell nucleus
Suh, J., Wirtz, D., & Hanes, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0636277100 · Cited by 362
Structure/property studies of polymeric gene delivery using a library of poly(β-amino esters)
Anderson, D. G., Akinc, A., Hossain, N., & Langer, R. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2004.11.015 · Cited by 360
Polycation-based DNA complexes for tumor-targeted gene deliveryin vivo
Kircheis, R., Schüller, S., Brunner, S., Ogris, M., Heider, K.-H., Zauner, W., & Wagner, E. (1999) · The Journal of Gene Medicine · doi:10.1002/(sici)1521-2254(199903/04)1:2<111::aid-jgm22>3.0.co;2-y · Cited by 356
Self-citationEfficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo
Takeshita, F., Minakuchi, Y., Nagahara, S., Honma, K., Sasaki, H., Hirai, K., Teratani, T., Namatame, N., Yamamoto, Y., Hanai, K., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501753102 · Cited by 355
Characterization of DNA condensates induced by poly(ethylene oxide) and polylysine.
Laemmli, U. K. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.11.4288 · Cited by 354
Toll‐like receptors 7, 8, and 9: linking innate immunity to autoimmunity
Krieg, A. M., & Vollmer, J. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00572.x · Cited by 350
Transferrin-Containing, Cyclodextrin Polymer-Based Particles for Tumor-Targeted Gene Delivery
Bellocq, N. C., Pun, S. H., Jensen, G. S., & Davis, M. E. (2003) · Bioconjugate Chemistry · doi:10.1021/bc034125f · Cited by 350
Cherng, J.-Y., van de Wetering, P., Talsma, H., Crommelin, D. J. A., & Hennink, W. E. (1996) · Pharmaceutical Research · doi:10.1023/a:1016054623543 · Cited by 344
DNA condensation with polyamines
Gosule, L. C., & Schellman, J. A. (1978) · Journal of Molecular Biology · doi:10.1016/0022-2836(78)90366-2 · Cited by 344
Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer
Nishiyama, N., Iriyama, A., Jang, W.-D., Miyata, K., Itaka, K., Inoue, Y., Takahashi, H., Yanagi, Y., Tamaki, Y., Koyama, H., et al. (2005) · Nature Materials · doi:10.1038/nmat1524 · Cited by 340
siRNA Conjugate Delivery Systems
Jeong, J. H., Mok, H., Oh, Y.-K., & Park, T. G. (2009) · Bioconjugate Chemistry · doi:10.1021/bc800278e · Cited by 338
Ke, W., Shao, K., Huang, R., Han, L., Liu, Y., Li, J., Kuang, Y., Ye, L., Lou, J., & Jiang, C. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.08.049 · Cited by 337
Cotten, M., Längle-Rouault, F., Kirlappos, H., Wagner, E., Mechtler, K., Zenke, M., Beug, H., & Birnstiel, M. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.11.4033 · Cited by 337
Self-citationDuncan, R., & Richardson, S. C. W. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300293n · Cited by 332
Taratula, O., Garbuzenko, O. B., Kirkpatrick, P., Pandya, I., Savla, R., Pozharov, V. P., He, H., & Minko, T. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.06.019 · Cited by 328
Polyethylenimine with acid-labile linkages as a biodegradable gene carrier
Kim, Y. H., Park, J. H., Lee, M., Kim, Y.-H., Park, T. G., & Kim, S. W. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.11.008 · Cited by 328
DNA condensation with polyamines
Chattoraj, D. K., Gosule, L. C., & Schellman, J. A. (1978) · Journal of Molecular Biology · doi:10.1016/0022-2836(78)90367-4 · Cited by 327
2-(dimethylamino)ethyl methacrylate based (co)polymers as gene transfer agents
van de Wetering, P., Cherng, J.-Y., Talsma, H., Crommelin, D. J. A., & Hennink, W. E. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00248-4 · Cited by 326
Plank, C., Zatloukal, K., Cotten, M., Mechtler, K., & Wagner, E. (1992) · Bioconjugate Chemistry · doi:10.1021/bc00018a012 · Cited by 324
Self-citationA model for non‐viral gene delivery: through syndecan adhesion molecules and powered by actin
Kopatz, I., Remy, J., & Behr, J. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.558 · Cited by 323
Walker, G. F., Fella, C., Pelisek, J., Fahrmeir, J., Boeckle, S., Ogris, M., & Wagner, E. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2004.11.006 · Cited by 321
Self-citationSystemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse
Zou, S.-M., Erbacher, P., Remy, J.-S., & Behr, J.-P. (2000) · The Journal of Gene Medicine · doi:10.1002/(sici)1521-2254(200003/04)2:2<128::aid-jgm95>3.0.co;2-w · Cited by 317
Magnetically enhanced nucleic acid delivery. Ten years of magnetofection—Progress and prospects
Plank, C., Zelphati, O., & Mykhaylyk, O. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.08.002 · Cited by 316
von Gersdorff, K., Sanders, N. N., Vandenbroucke, R., De Smedt, S. C., Wagner, E., & Ogris, M. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.07.006 · Cited by 314
Self-citationThe Lower-Generation Polypropylenimine Dendrimers Are Effective Gene-Transfer Agents
Zinselmeyer, B. H., Mackay, S. P., Schatzlein, A. G., & Uchegbu, I. F. (2002) · Pharmaceutical Research · doi:10.1023/a:1016458104359 · Cited by 312
Huang, R.-Q., Qu, Y.-H., Ke, W.-L., Zhu, J.-H., Pei, Y.-Y., & Jiang, C. (2007) · The FASEB Journal · doi:10.1096/fj.06-7380com · Cited by 311
Kursa, M., Walker, G. F., Roessler, V., Ogris, M., Roedl, W., Kircheis, R., & Wagner, E. (2003) · Bioconjugate Chemistry · doi:10.1021/bc0256087 · Cited by 310
Self-citationPolymers for siRNA Delivery: Inspired by Viruses to be Targeted, Dynamic, and Precise
Wagner, E. (2012) · Accounts of Chemical Research · doi:10.1021/ar2002232 · Cited by 308
Self-citationVoit, T., Topaloglu, H., Straub, V., Muntoni, F., Deconinck, N., Campion, G., De Kimpe, S. J., Eagle, M., Guglieri, M., Hood, S., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70195-4 · Cited by 306
Novel classes of non-coding RNAs and cancer
Sana, J., Faltejskova, P., Svoboda, M., & Slaby, O. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-103 · Cited by 304
EL Andaloussi, S., Lehto, T., Mäger, I., Rosenthal-Aizman, K., Oprea, I. I., Simonson, O. E., Sork, H., Ezzat, K., Copolovici, D. M., Kurrikoff, K., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1299 · Cited by 301
Simian Virus 40 Depends on ER Protein Folding and Quality Control Factors for Entry into Host Cells
Schelhaas, M., Malmström, J., Pelkmans, L., Haugstetter, J., Ellgaard, L., Grünewald, K., & Helenius, A. (2007) · Cell · doi:10.1016/j.cell.2007.09.038 · Cited by 300
Konstan, M. W., Davis, P. B., Wagener, J. S., Hilliard, K. A., Stern, R. C., Milgram, L. J. H., Kowalczyk, T. H., Hyatt, S. L., Fink, T. L., Gedeon, C. R., et al. (2004) · Human Gene Therapy · doi:10.1089/hum.2004.15.1255 · Cited by 298
Cyclodextrin-Modified Polyethylenimine Polymers for Gene Delivery
Pun, S. H., Bellocq, N. C., Liu, A., Jensen, G., Machemer, T., Quijano, E., Schluep, T., Wen, S., Engler, H., Heidel, J., et al. (2004) · Bioconjugate Chemistry · doi:10.1021/bc049891g · Cited by 297
Erbacher, P., Bettinger, T., Belguise-Valladier, P., Zou, S., Coll, J.-L., Behr, J.-P., & Remy, J.-S. (1999) · The Journal of Gene Medicine · doi:10.1002/(sici)1521-2254(199905/06)1:3<210::aid-jgm30>3.0.co;2-u · Cited by 295
Biodegradable poly(ethylenimine) for plasmid DNA delivery
Ahn, C.-H., Chae, S. Y., Bae, Y. H., & Kim, S. W. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00547-8 · Cited by 291
Synthesis of Poly(β-amino ester)s Optimized for Highly Effective Gene Delivery
Akinc, A., Anderson, D. G., Lynn, D. M., & Langer, R. (2003) · Bioconjugate Chemistry · doi:10.1021/bc034067y · Cited by 285
Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells
Midoux, P., Mendes, C., Legrand, A., Raimond, J., Mayer, R., Monsigny, M., & Roche, A. C. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.4.871 · Cited by 285
Murphy, R. F., Powers, S., & Cantor, C. R. (1984) · The Journal of cell biology · doi:10.1083/jcb.98.5.1757 · Cited by 285
Oupicky, D., Ogris, M., Howard, K. A., Dash, P. R., Ulbrich, K., & Seymour, L. W. (2002) · Molecular Therapy · doi:10.1006/mthe.2002.0568 · Cited by 284
Werth, S., Urban-Klein, B., Dai, L., Höbel, S., Grzelinski, M., Bakowsky, U., Czubayko, F., & Aigner, A. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.02.009 · Cited by 281
Liu, Y., Huang, R., Han, L., Ke, W., Shao, K., Ye, L., Lou, J., & Jiang, C. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.02.051 · Cited by 281
Yu, D., Pendergraff, H., Liu, J., Kordasiewicz, H. B., Cleveland, D. W., Swayze, E. E., Lima, W. F., Crooke, S. T., Prakash, T. P., & Corey, D. R. (2012) · Cell · doi:10.1016/j.cell.2012.08.002 · Cited by 278
Gene therapy progress and prospects: synthetic polymer-based systems
Schaffert, D., & Wagner, E. (2008) · Gene Therapy · doi:10.1038/gt.2008.105 · Cited by 277
Self-citationDesign of imidazole-containing endosomolytic biopolymers for gene delivery
Pack, D. W., Putnam, D., & Langer, R. (2000) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(20000120)67:2<217::aid-bit11>3.0.co;2-q · Cited by 274
Zenke, M., Steinlein, P., Wagner, E., Cotten, M., Beug, H., & Birnstiel, M. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3655 · Cited by 272
Self-citationFunhoff, A. M., van Nostrum, C. F., Koning, G. A., Schuurmans-Nieuwenbroek, N. M. E., Crommelin, D. J. A., & Hennink, W. E. (2004) · Biomacromolecules · doi:10.1021/bm034041+ · Cited by 272
Biocleavable Polyrotaxane−Plasmid DNA Polyplex for Enhanced Gene Delivery
Ooya, T., Choi, H. S., Yamashita, A., Yui, N., Sugaya, Y., Kano, A., Maruyama, A., Akita, H., Ito, R., Kogure, K., et al. (2006) · Journal of the American Chemical Society · doi:10.1021/ja055868+ · Cited by 270
Erythropoietin Derived by Chemical Synthesis
Wang, P., Dong, S., Shieh, J.-H., Peguero, E., Hendrickson, R., Moore, M. A. S., & Danishefsky, S. J. (2013) · Science · doi:10.1126/science.1245095 · Cited by 269
In Vitro Gene Transfection Using Dendritic Poly(l-lysine)
Ohsaki, M., Okuda, T., Wada, A., Hirayama, T., Niidome, T., & Aoyagi, H. (2002) · Bioconjugate Chemistry · doi:10.1021/bc015525a · Cited by 264
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Metadata
- Authors
- Lächelt, U., & Wagner, E.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-04-15
- Volume
- 115
- Issue
- 19
- Pages
- 11043-11078
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2091651723
- Cited by
- 600
- References
- 502
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
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