The genetics of ageing

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766

A C. elegans mutant that lives twice as long as wild type

Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., et al. (2004) · Nature · doi:10.1038/nature02866 · Cited by 1,677

Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., Keller, C., & Rando, T. A. (2007) · Science · doi:10.1126/science.1144090 · Cited by 1,564

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

Rogina, B., & Helfand, S. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404184101 · Cited by 1,361

The plasticity of aging: insights from long-lived mutants

Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.059 · Cited by 1,293

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2005) · Science · doi:10.1126/science.1115535 · Cited by 1,293

Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans

Meléndez, A., Tallóczy, Z., Seaman, M., Eskelinen, E.-L., Hall, D. H., & Levine, B. (2003) · Science · doi:10.1126/science.1087782 · Cited by 1,270

Systemic DNA damage responses in aging and diseases

Ribezzo, F., Shiloh, Y., & Schumacher, B. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.12.005 · Cited by 116

The pathophysiology of defective proteostasis in the hypothalamus — from obesity to ageing

Cavadas, C., Aveleira, C. A., Souza, G. F. P., & Velloso, L. A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.107 · Cited by 105

hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling

Wang, X., Chrysovergis, K., Kosak, J., Kissling, G., Streicker, M., Moser, G., Li, R., & Eling, T. E. (2014) · Aging · doi:10.18632/aging.100687 · Cited by 106

Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice

Kim, K. H., Choi, S., Zhou, Y., Kim, E. Y., Lee, J. M., Saha, P. K., Anakk, S., & Moore, D. D. (2017) · Hepatology · doi:10.1002/hep.29199 · Cited by 107

miR‐186 is decreased in aged brain and suppresses BACE 1 expression

Kim, J., Yoon, H., Chung, D., Brown, J. L., Belmonte, K. C., & Kim, J. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13507 · Cited by 102

Proteasome activation delays aging in vitro and in vivo

Chondrogianni, N., Sakellari, M., Lefaki, M., Papaevgeniou, N., & Gonos, E. S. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.03.031 · Cited by 94

Histone methylation and aging: Lessons learned from model systems

McCauley, B. S., & Dang, W. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.05.008 · Cited by 93

Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism

Foukas, L. C., Bilanges, B., Bettedi, L., Pearce, W., Ali, K., Sancho, S., Withers, D. J., & Vanhaesebroeck, B. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201201953 · Cited by 91

Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity

Ma, S., Upneja, A., Galecki, A., Tsai, Y.-M., Burant, C. F., Raskind, S., Zhang, Q., Zhang, Z. D., Seluanov, A., Gorbunova, V., et al. (2016) · eLife · doi:10.7554/elife.19130 · Cited by 89

Translational Geroscience: Emphasizing function to achieve optimal longevity

Seals, D. R., & Melov, S. (2014) · Aging · doi:10.18632/aging.100694 · Cited by 90

Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network

Vonk, W. I. M., Rainbolt, T. K., Dolan, P. T., Webb, A. E., Brunet, A., & Frydman, J. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.03.009 · Cited by 84

Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans

Honda, Y., Higashibata, A., Matsunaga, Y., Yonezawa, Y., Kawano, T., Higashitani, A., Kuriyama, K., Shimazu, T., Tanaka, M., Szewczyk, N. J., et al. (2012) · Scientific Reports · doi:10.1038/srep00487 · Cited by 87

Genetic evidence for common pathways in human age‐related diseases

Johnson, S. C., Dong, X., Vijg, J., & Suh, Y. (2015) · Aging Cell · doi:10.1111/acel.12362 · Cited by 78

Characterization of cellular senescence in doxorubicin-induced aging mice

Sun, T., Zhang, L., Feng, J., Bao, L., Wang, J., Song, Z., Mao, Z., Li, J., & Hu, Z. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111800 · Cited by 73

Bacterially produced metabolites protect C. elegans neurons from degeneration

Urrutia, A., García-Angulo, V. A., Fuentes, A., Caneo, M., Legüe, M., Urquiza, S., Delgado, S. E., Ugalde, J., Burdisso, P., & Calixto, A. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000638 · Cited by 71

The Aryl Hydrocarbon Receptor (AhR) in the Aging Process: Another Puzzling Role for This Highly Conserved Transcription Factor

Brinkmann, V., Ale-Agha, N., Haendeler, J., & Ventura, N. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01561 · Cited by 71

Gut microbiota and aging-A focus on centenarians

Cӑtoi, A. F., Corina, A., Katsiki, N., Vodnar, D. C., Andreicuț, A. D., Stoian, A. P., Rizzo, M., & Pérez-Martínez, P. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165765 · Cited by 70

Intervening in ageing to prevent the diseases of ageing

Partridge, L. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2014.08.003 · Cited by 69

Protein homeostasis and aging: Role of ubiquitin protein ligases

Jana, N. R. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.02.009 · Cited by 67

Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology

Shavlakadze, T., Zhu, J., Wang, S., Zhou, W., Morin, B., Egerman, M. A., Fan, L., Wang, Y., Iartchouk, O., Meyer, A., et al. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx249 · Cited by 59

Ubiquitin sets the timer: impacts on aging and longevity

Kevei, É., & Hoppe, T. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2806 · Cited by 61

ATM Mutations Benefit Bladder Cancer Patients Treated With Immune Checkpoint Inhibitors by Acting on the Tumor Immune Microenvironment

Yi, R., Lin, A., Cao, M., Xu, A., Luo, P., & Zhang, J. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00933 · Cited by 60

Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms

Lodato, M. A., & Walsh, C. A. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz191 · Cited by 56

Mindspan: lessons from rat models of neurocognitive aging

Gallagher, M., Stocker, A. M., & Koh, M. T. (2011) · ILAR Journal · doi:10.1093/ilar.52.1.32 · Cited by 53

C/EBPα deficiency in podocytes aggravates podocyte senescence and kidney injury in aging mice

Zhang, L., Zhou, F., Yu, X., Zhu, Y., Zhou, Y., Liu, J., Liu, Y., Ma, Q., Zhang, Y., Wang, W., et al. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1933-2 · Cited by 48

Mitochondrial turnover and homeostasis in ageing and neurodegeneration

Markaki, M., & Tavernarakis, N. (2020) · FEBS Letters · doi:10.1002/1873-3468.13802 · Cited by 50

p53: Pro-aging or pro-longevity?

de Keizer, P. L. J., Laberge, R.-M., & Campisi, J. (2010) · Aging · doi:10.18632/aging.100178 · Cited by 48

Supplementation of Spirulina ( Arthrospira platensis ) Improves Lifespan and Locomotor Activity in Paraquat-Sensitive DJ-1β Δ93 Flies, a Parkinson's Disease Model in Drosophila melanogaster

Kumar, A., Christian, P. K., Panchal, K., Guruprasad, B. R., & Tiwari, A. K. (2017) · Journal of Dietary Supplements · doi:10.1080/19390211.2016.1275917 · Cited by 44

Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy

Bareja, A., Lee, D. E., & White, J. P. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00183 · Cited by 41

Peptides from sesame cake extend healthspan of Caenorhabditis elegans via upregulation of skn-1 and inhibition of intracellular ROS levels

Wang, Z., Ma, X., Li, J., & Cui, X. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.07.001 · Cited by 39

GHK and DNA: Resetting the human genome to health

Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2014) · BioMed Research International · doi:10.1155/2014/151479 · Cited by 39

Aging and the Biological Response to Liver Injury

Marzioni, M., Pinto, C., Ninfole, E., Gaggiano, L., Benedetti, A., & Maroni, L. (2020) · Seminars in Liver Disease · doi:10.1055/s-0039-3402033 · Cited by 36

Quinolinic acid and glutamatergic neurodegeneration in Caenorhabditis elegans

da Silveira, T. L., Zamberlan, D. C., Arantes, L. P., Machado, M. L., da Silva, T. C., Câmara, D. D. F., Santamaría, A., Aschner, M., & Soares, F. A. A. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.04.015 · Cited by 30

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms: Table 1.

Burd, C. E., Gill, M. S., Niedernhofer, L. J., Robbins, P. D., Austad, S. N., Barzilai, N., & Kirkland, J. L. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw112 · Cited by 28

ATP-dependent chromatin remodelers in ageing and age-related disorders

Swer, P. B., & Sharma, R. (2021) · Biogerontology · doi:10.1007/s10522-020-09899-3 · Cited by 25

PACRG, a protein linked to ciliary motility, mediates cellular signaling

Loucks, C. M., Bialas, N. J., Dekkers, M. P. J., Walker, D. S., Grundy, L. J., Li, C., Inglis, P. N., Kida, K., Schafer, W. R., Blacque, O. E., et al. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-07-0490 · Cited by 23

A cocktail of rapamycin, acarbose, and phenylbutyrate prevents age-related cognitive decline in mice by targeting multiple aging pathways

Jiang, Z., He, Q., Wezeman, J., Darvas, M., & Ladiges, W. (2024) · GeroScience · doi:10.1007/s11357-024-01198-w · Cited by 10

Comparative genetics: A third model nematode species

Sommer, R. J. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00815-0 · Cited by 15

MUTATIONS WITH DOMINANT EFFECTS ON THE BEHAVIOR AND MORPHOLOGY OF THE NEMATODE CAENORHABDITIS ELEGANS

Park, E.-C., & Horvitz, H. R. (1986) · Genetics · doi:10.1093/genetics/113.4.821 · Cited by 192

IDENTIFICATION AND CHARACTERIZATION OF 22 GENES THAT AFFECT THE VULVAL CELL LINEAGES OF THE NEMATODE CAENORHABDITIS ELEGANS

Ferguson, E. L., & Horvitz, H. R. (1985) · Genetics · doi:10.1093/genetics/110.1.17 · Cited by 547

A subset of naturally isolated Bacillus strains show extreme virulence to the free‐living nematodes Caenorhabditis elegans and Pristionchus pacificus

Rae, R. G., Iatsenko, I., Witte, H. A., et al. (2010) · Environmental Microbiology · doi:10.1111/j.1462-2920.2010.02278.x · Cited by 59

A Limited Number of Caenorhabditis elegans Genes Are Readily Mutable to Dominant, Temperature-Sensitive Maternal-Effect Embryonic Lethality

Mitenko, N. L., Eisner, J. R., Swiston, J. R., & Mains, P. E. (1997) · Genetics · doi:10.1093/genetics/147.4.1665 · Cited by 7