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Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans
Open accessAbstract
The origins of the First Americans remain contentious. Although Native Americans seem to be genetically most closely related to east Asians, there is no consensus with regard to which specific Old World populations they are closest to. Here we sequence the draft genome of an approximately 24,000-year-old individual (MA-1), from Mal'ta in south-central Siberia, to an average depth of 1×. To our knowledge this is the oldest anatomically modern human genome reported to date. The MA-1 mitochondrial genome belongs to haplogroup U, which has also been found at high frequency among Upper Palaeolithic and Mesolithic European hunter-gatherers, and the Y chromosome of MA-1 is basal to modern-day western Eurasians and near the root of most Native American lineages. Similarly, we find autosomal evidence that MA-1 is basal to modern-day western Eurasians and genetically closely related to modern-day Native Americans, with no close affinity to east Asians. This suggests that populations related to contemporary western Eurasians had a more north-easterly distribution 24,000 years ago than commonly thought. Furthermore, we estimate that 14 to 38% of Native American ancestry may originate through gene flow from this ancient population. This is likely to have occurred after the divergence of Native American ancestors from east Asian ancestors, but before the diversification of Native American populations in the New World. Gene flow from the MA-1 lineage into Native American ancestors could explain why several crania from the First Americans have been reported as bearing morphological characteristics that do not resemble those of east Asians. Sequencing of another south-central Siberian, Afontova Gora-2 dating to approximately 17,000 years ago, revealed similar autosomal genetic signatures as MA-1, suggesting that the region was continuously occupied by humans throughout the Last Glacial Maximum. Our findings reveal that western Eurasian genetic signatures in modern-day Native Americans derive not only from post-Columbian admixture, as commonly thought, but also from a mixed ancestry of the First Americans.
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In the citing paper
“We combined our data with previously published ancient data7,8,9,10,8,10-15 to form a dataset of 281 ancient individuals.”
From Genomic insights into the origin of farming in the ancient Near East (2016) · cites this paper as [15]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Application of this methods highlights the impact of Ancient North Eurasian (ANE) ancestry related to the ~22,000 BCE Mal'ta 1 and ~15,000 BCE Afontova Gora 215 on populations living in Europe, the Americas, and Eastern Eurasia.”
From Genomic insights into the origin of farming in the ancient Near East (2016) · cites this paper as [15]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“We sequenced the genome to an average depth of 14.4× and show that the gene flow from the Siberian Upper Palaeolithic Mal′ta individual5 into Native American ancestors is also shared by the Anzick-1 individual and thus happened prior to 12,600 years BP.”
From The genome of a Late Pleistocene human from a Clovis burial site in western Montana (2014) · cites this paper as [5]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“A second regional population with roots in western Eurasia (Ancient North Eurasians (ANE)) expanded into Northeast Asia before 30 ka and contributed to the East Asian genome and—both indirectly and directly—to the Native American genome.”
From Beringia and the peopling of the Western Hemisphere (2023) · cites this paper as [78]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Eastern Eurasians can be modelled as arrayed along a cline with different proportions of ANE ancestry (Supplementary Information, section 11; Extended Data Fig. 8), ranging from ~40% ANE in Native Americans matching previous findings13,15, to no less than ~5-10% ANE in diverse East Asian groups including Han Chinese (Extended Data Fig. 5; Extended Data Fig. 7f).”
From Genomic insights into the origin of farming in the ancient Near East (2016) · cites this paper as [15]
The cited source says what the claim attributes to it.
In the citing paper
“We sequenced the genome to an average depth of 14.4× and show that the gene flow from the Siberian Upper Palaeolithic Mal′ta individual5 into Native American ancestors is also shared by the Anzick-1 individual and thus happened prior to 12,600 years BP.”
From The genome of a Late Pleistocene human from a Clovis burial site in western Montana (2014) · cites this paper as [5]
The cited source says what the claim attributes to it.
In the citing paper
“f3 statistics can reveal unambiguous evidence for situations in which one individual (or population) is formed by the admixture of two others 219 , but they can also provide a measure of shared genetic drift when an outgroup is included 220 .”
From Ancient DNA analysis (2021) · cites this paper as [220]
The cited source says what the claim attributes to it.
In the citing paper
“The ANE population is present in southern Siberia during middle and late Upper Palaeolithic times at Mal'ta (24 ka) and Afontova Gora (17 ka), and their immediate ancestors (see below) are found in the Arctic and western Beringia as early as 33 ka [39,61,78].”
From Beringia and the peopling of the Western Hemisphere (2023) · cites this paper as [78]
In the citing paper
“This finding provided an explanation for some of the western Eurasian genetic signatures in present-day Native Americans, previously thought to be from post-Columbian admixture [30].”
From Ancient DNA and the rewriting of human history: be sparing with Occam’s razor (2016) · cites this paper as [30]
In the citing paper
“Analysis showed that at least three different ancient populations contributed to the genetics of present-day Europeans: (1) West European hunter-gatherers, (2) ancient north Eurasians related to Upper Paleolithic Siberians, and (3) early European farmers, who were mainly of Near Eastern origin [29].”
From Ancient DNA and the rewriting of human history: be sparing with Occam’s razor (2016) · cites this paper as [30]
In the citing paper
“The Mal’ta boy genome showed that Upper Paleolithic West Eurasians had a more north-easterly distribution and were genetically related to modern-day Native Americans, contributing significantly to their ancestry.”
From Ancient DNA and the rewriting of human history: be sparing with Occam’s razor (2016) · cites this paper as [30]
In the citing paper
“A second regional population with roots in western Eurasia (Ancient North Eurasians (ANE)) expanded into Northeast Asia before 30 ka and contributed to the East Asian genome and—both indirectly and directly—to the Native American genome.”
From Beringia and the peopling of the Western Hemisphere (2023) · cites this paper as [78]
In the citing paper
“The ANE population is present in southern Siberia during middle and late Upper Palaeolithic times at Mal'ta (24 ka) and Afontova Gora (17 ka), and their immediate ancestors (see below) are found in the Arctic and western Beringia as early as 33 ka [39,61,78].”
From Beringia and the peopling of the Western Hemisphere (2023) · cites this paper as [78]
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Citations
Cites
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
Tamura, K., Peterson, D., Peterson, N., Stecher, G., Nei, M., & Kumar, S. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr121 · Cited by 40,166
IntCal13 and Marine13 radiocarbon age calibration curves 0–50,000 years cal BP
Reimer, P. J., Bard, E., Bayliss, A., Beck, J. W., Blackwell, P. G., Ramsey, C. B., Buck, C. E., Cheng, H., Edwards, R. L., Friedrich, M., et al. (2013) · Radiocarbon · doi:10.2458/azu_js_rc.55.16947 · Cited by 14,591
A framework for variation discovery and genotyping using next-generation DNA sequencing data
DePristo, M. A., Banks, E., Poplin, R. E., Garimella, K. V., Maguire, J., Hartl, C., Philippakis, A., del Angel, G., Rivas, M. A., Hanna, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.806 · Cited by 11,457
Bayesian Analysis of Radiocarbon Dates
Bronk Ramsey, C. (2009) · Radiocarbon · doi:10.1017/s0033822200033865 · Cited by 8,725
An integrated map of genetic variation from 1,092 human genomes
The 1000 Genomes Project Consortium (2012) · Nature · doi:10.1038/nature11632 · Cited by 7,711
Population Structure and Eigenanalysis
Patterson, N., Price, A. L., & Reich, D. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020190 · Cited by 5,280
A second generation human haplotype map of over 3.1 million SNPs
The International HapMap Consortium (2007) · Nature · doi:10.1038/nature06258 · Cited by 4,438
A draft sequence of the Neandertal genome
Green, R. E., Krause, J., Briggs, A. W., Maricic, T., Stenzel, U., Kircher, M., Patterson, N., Li, H., Zhai, W., Fritz, M. H.-Y., et al. (2010) · Science · doi:10.1126/science.1188021 · Cited by 4,318
Self-citation
Research works printed but not linked: 3
- Astakhov, S. N. Paleolit Eniseia: Paleoliticheskie Stoianki Afontovoi Gore v G. Krasnoiarske (Evropaiskii Dom, 1999)
- Powell, R. & Gannon, F. Purification of DNA by phenol extraction and ethanol precipitation. Oxford Practical Approach Series. http://fds.oup.com/www.oup.co.uk/pdf/pas/9v1-7-3.pdf (2002)
- International HapMap3 Consortium Integrating common and rare genetic variation in diverse human populations. Nature 467, 52–58 (2010) · DOI · Paper page
Cited by
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Korneliussen, T. S., Albrechtsen, A., & Nielsen, R. (2014) · BMC Bioinformatics · doi:10.1186/s12859-014-0356-4 · Cited by 2,982
Self-citationMassive migration from the steppe was a source for Indo-European languages in Europe
Haak, W., Lazaridis, I., Patterson, N., Rohland, N., Mallick, S., Llamas, B., Brandt, G., Nordenfelt, S., Harney, E., Stewardson, K., et al. (2015) · Nature · doi:10.1038/nature14317 · Cited by 1,940
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Self-citationGenome-wide patterns of selection in 230 ancient Eurasians
Mathieson, I., Lazaridis, I., Rohland, N., Mallick, S., Patterson, N., Roodenberg, S. A., Harney, E., Stewardson, K., Fernandes, D., Novak, M., et al. (2015) · Nature · doi:10.1038/nature16152 · Cited by 1,515
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Lazaridis, I., Patterson, N., Mittnik, A., Renaud, G., Mallick, S., Kirsanow, K., Sudmant, P. H., Schraiber, J. G., Castellano, S., Lipson, M., et al. (2014) · Nature · doi:10.1038/nature13673 · Cited by 1,357
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Fu, Q., Posth, C., Hajdinjak, M., Petr, M., Mallick, S., Fernandes, D., Furtwängler, A., Haak, W., Meyer, M., Mittnik, A., et al. (2016) · Nature · doi:10.1038/nature17993 · Cited by 959
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Partial uracil–DNA–glycosylase treatment for screening of ancient DNA
Rohland, N., Harney, E., Mallick, S., Nordenfelt, S., & Reich, D. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0624 · Cited by 572
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Self-citationThe genomic history of the Iberian Peninsula over the past 8000 years
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Self-citationSouthern African ancient genomes estimate modern human divergence to 350,000 to 260,000 years ago
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Self-citationSchubert, M., Ermini, L., Sarkissian, C. D., Jónsson, H., Ginolhac, A., Schaefer, R., Martin, M. D., Fernández, R., Kircher, M., McCue, M., et al. (2014) · Nature Protocols · doi:10.1038/nprot.2014.063 · Cited by 562
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Self-citationAncient genomes document multiple waves of migration in Southeast Asian prehistory
Lipson, M., Cheronet, O., Mallick, S., Rohland, N., Oxenham, M. F., Pietrusewsky, M., Pryce, T. O., Willis, A., Matsumura, H., Buckley, H. R., et al. (2018) · Science · doi:10.1126/science.aat3188 · Cited by 429
Upper Palaeolithic genomes reveal deep roots of modern Eurasians
Jones, E. R., Gonzalez-Fortes, G., Connell, S., Siska, V., Eriksson, A., Martiniano, R., McLaughlin, R. L., Gallego Llorente, M., Cassidy, L. M., Gamba, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms9912 · Cited by 417
Genomic insights into the peopling of the Southwest Pacific
Skoglund, P., Posth, C., Sirak, K., Spriggs, M., Valentin, F., Bedford, S., Clark, G. R., Reepmeyer, C., Petchey, F., Fernandes, D., et al. (2016) · Nature · doi:10.1038/nature19844 · Cited by 414
Self-citationOrlando, L., Allaby, R., Skoglund, P., Der Sarkissian, C., Stockhammer, P. W., Ávila-Arcos, M. C., Fu, Q., Krause, J., Willerslev, E., Stone, A. C., et al. (2021) · Nature Reviews Methods Primers · doi:10.1038/s43586-020-00011-0 · Cited by 411
Self-citationGenomic Diversity and Admixture Differs for Stone-Age Scandinavian Foragers and Farmers
Skoglund, P., Malmström, H., Omrak, A., Raghavan, M., Valdiosera, C. E., Günther, T., Hall, P. N., Tambets, K., Parik, J., Sjögren, K.-G., et al. (2014) · Science · doi:10.1126/science.1253448 · Cited by 380
Self-citationEarly human dispersals within the Americas
Moreno-Mayar, J. V., Vinner, L., Damgaard, P. D. B., Castro, C. D. L. F., Chan, J., Spence, J. P., Allentoft, M. E., Vimala, T., Racimo, F., Pinotti, T., et al. (2018) · Science · doi:10.1126/science.aav2621 · Cited by 383
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Self-citationEstimating genetic kin relationships in prehistoric populations
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Self-citationThe genetic prehistory of the New World Arctic
Raghavan, M., DeGiorgio, M., Albrechtsen, A., Moltke, I., Skoglund, P., Korneliussen, T. S., Grønnow, B., Appelt, M., Gulløv, H. C., Friesen, T. M., et al. (2014) · Science · doi:10.1126/science.1255832 · Cited by 329
Self-citationThe genetic prehistory of the Baltic Sea region
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Bergström, A., Frantz, L., Schmidt, R., Ersmark, E., Lebrasseur, O., Girdland-Flink, L., Lin, A. T., Storå, J., Sjögren, K.-G., Anthony, D., et al. (2020) · Science · doi:10.1126/science.aba9572 · Cited by 297
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Antonio, M. L., Gao, Z., Moots, H. M., Lucci, M., Candilio, F., Sawyer, S., Oberreiter, V., Calderon, D., Devitofranceschi, K., Aikens, R. C., et al. (2019) · Science · doi:10.1126/science.aay6826 · Cited by 257
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Broushaki, F., Thomas, M. G., Link, V., López, S., van Dorp, L., Kirsanow, K., Hofmanová, Z., Diekmann, Y., Cassidy, L. M., Díez-del-Molino, D., et al. (2016) · Science · doi:10.1126/science.aaf7943 · Cited by 288
Liu, S., Huang, S., Chen, F., Zhao, L., Yuan, Y., Francis, S. S., Fang, L., Li, Z., Lin, L., Liu, R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.016 · Cited by 279
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Orlando, L., Gilbert, M. T. P., & Willerslev, E. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3935 · Cited by 286
Self-citationImproving access to endogenous DNA in ancient bones and teeth
Damgaard, P. B., Margaryan, A., Schroeder, H., Orlando, L., Willerslev, E., & Allentoft, M. E. (2015) · Scientific Reports · doi:10.1038/srep11184 · Cited by 276
Self-citationGenetic origins of the Minoans and Mycenaeans
Lazaridis, I., Mittnik, A., Patterson, N. J., Mallick, S., Rohland, N., Pfrengle, S., Furtwängler, A., Peltzer, A., Posth, C., Vasilakis, A., et al. (2017) · Nature · doi:10.1038/nature23310 · Cited by 286
Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers
Posth, C., He, Y. H., Ghalichi, A., Rougier, H., Crèvecoeur, I., Huang, Y., Ringbauer, H., Rohrlach, A. B., Nägele, K., Villalba‐Mouco, V., et al. (2023) · Nature · doi:10.1038/s41586-023-05726-0 · Cited by 285
On the limits of fitting complex models of population history to f-statistics
Maier, R., Flegontov, P., Flegontova, O., Işıldak, U., Changmai, P., & Reich, D. (2023) · eLife · doi:10.7554/elife.85492 · Cited by 283
Ancestral Origins and Genetic History of Tibetan Highlanders
Lu, D., Lou, H., Yuan, K., Wang, X., Wang, Y., Zhang, C., Lü, Y., Yang, X. W., Deng, L., Zhou, Y., et al. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.07.002 · Cited by 276
Toward a new history and geography of human genes informed by ancient DNA
Pickrell, J. K., & Reich, D. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.07.007 · Cited by 276
Palaeo-Eskimo genetic ancestry and the peopling of Chukotka and North America
Flegontov, P., Altınışık, N. E., Changmai, P., Rohland, N., Mallick, S., Adamski, N., Bolnick, D. A., Broomandkhoshbacht, N., Candilio, F., Culleton, B. J., et al. (2019) · Nature · doi:10.1038/s41586-019-1251-y · Cited by 278
Self-citationPopulation genomics of post-glacial western Eurasia
Allentoft, M. E., Sikora, M., Refoyo-Martínez, A., Irving-Pease, E. K., Fischer, A., Barrie, W., Ingason, A., Stenderup, J. T., Sjögren, K.-G., Pearson, A., et al. (2024) · Nature · doi:10.1038/s41586-023-06865-0 · Cited by 294
Self-citationSpeciation and introgression between Mimulus nasutus and Mimulus guttatus
Brandvain, Y., Kenney, A. M., Flagel, L., Coop, G., & Sweigart, A. L. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004410 · Cited by 259
Admixture, Population Structure, and F -Statistics
Peter, B. M. (2016) · Genetics · doi:10.1534/genetics.115.183913 · Cited by 265
Ancient genomes indicate population replacement in Early Neolithic Britain
Brace, S., Diekmann, Y., Booth, T. J., van Dorp, L., Faltyskova, Z., Rohland, N., Mallick, S., Olalde, Í., Ferry, M., Michel, M., et al. (2019) · Nature Ecology & Evolution · doi:10.1038/s41559-019-0871-9 · Cited by 271
Slatkin, M., & Racimo, F. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524306113 · Cited by 265
Neolithic and Bronze Age migration to Ireland and establishment of the insular Atlantic genome
Cassidy, L. M., Martiniano, R., Murphy, E., Teasdale, M. D., Mallory, J. P., Hartwell, B., & Bradley, D. G. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518445113 · Cited by 256
Günther, T., Malmström, H., Svensson, E., Omrak, A., Sánchez‐Quinto, F., Kılınç, G. M., Krzewińska, M., Eriksson, G., Fraser, M., Edlund, H., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2003703 · Cited by 256
Self-citationAncient Genomics of Modern Humans: The First Decade
Skoglund, P., & Mathieson, I. (2018) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-083117-021749 · Cited by 246
Self-citationThe genetic history of admixture across inner Eurasia
Jeong, C., Balanovsky, O. P., Lukianova, E., Kahbatkyzy, N., Flegontov, P., Владимирович, З. В., Immel, A., Wang, C., Iksan, O., Khussainova, E., et al. (2019) · Nature Ecology & Evolution · doi:10.1038/s41559-019-0878-2 · Cited by 250
Self-citationPleistocene North African genomes link Near Eastern and sub-Saharan African human populations
van de Loosdrecht, M. S., Bouzouggar, A., Humphrey, L., Posth, C., Barton, N., Aximu‐Petri, A., Nickel, B., Nagel, S., Talbi, E. H., Hajraoui, M. A. E., et al. (2018) · Science · doi:10.1126/science.aar8380 · Cited by 247
40,000-Year-Old Individual from Asia Provides Insight into Early Population Structure in Eurasia
Yang, M. A., Gao, X., Theunert, C., Tong, H., Aximu‐Petri, A., Nickel, B., Slatkin, M., Meyer, M., Pääbo, S., Kelso, J. F., et al. (2017) · Current Biology · doi:10.1016/j.cub.2017.09.030 · Cited by 244
Dog domestication and the dual dispersal of people and dogs into the Americas
Perri, A. R., Feuerborn, T. R., Frantz, L., Larson, G., Malhi, R. S., Meltzer, D. J., & Witt, K. E. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2010083118 · Cited by 253
The deep population history of northern East Asia from the Late Pleistocene to the Holocene
Mao, X., Zhang, H., Qiao, S., Liu, Y., Chang, F., Xie, P., Zhang, M., Wang, T., Li, M., Cao, P., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.040 · Cited by 198
Park, S. D. E., Magee, D. A., McGettigan, P., Teasdale, M. D., Edwards, C. J., Lohan, A. J., Murphy, A., Braud, M., Donoghue, M. T. A., Liu, Y., et al. (2015) · Genome biology · doi:10.1186/s13059-015-0790-2 · Cited by 234
Wang, C., Reinhold, S., Kalmykov, A., Wissgott, A., Brandt, G., Jeong, C., Cheronet, O., Ferry, M., Harney, É., Keating, D., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-08220-8 · Cited by 238
Self-citationThe Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity
Abondio, P., Sazzini, M., Garagnani, P., Boattini, A., Monti, D., Franceschi, C., Luiselli, D., & Giuliani, C. (2019) · Genes · doi:10.3390/genes10030222 · Cited by 240
A Paleogenomic Perspective on Evolution and Gene Function: New Insights from Ancient DNA
Shapiro, B., & Hofreiter, M. (2014) · Science · doi:10.1126/science.1236573 · Cited by 192
Paleolithic to Bronze Age Siberians Reveal Connections with First Americans and across Eurasia
He, Y. H., Spyrou, M. A., Karapetian, M. K., Shnaider, S. V., Radzevičiūtė, R., Nägele, K., Neumann, G. U., Penske, S., Zech, J., Lucas, M., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.037 · Cited by 225
Initial Upper Palaeolithic humans in Europe had recent Neanderthal ancestry
Hajdinjak, M., Mafessoni, F., Skov, L., Vernot, B., Hübner, A., Fu, Q., Essel, E., Nagel, S., Nickel, B., Richter, J., et al. (2021) · Nature · doi:10.1038/s41586-021-03335-3 · Cited by 232
Self-citationThe Neolithic Transition in the Baltic Was Not Driven by Admixture with Early European Farmers
Jones, E. R., Zariņa, G., Moiseyev, V. G., Lightfoot, E., Nigst, P. R., Manica, A., Pinhasi, R., & Bradley, D. G. (2017) · Current Biology · doi:10.1016/j.cub.2016.12.060 · Cited by 221
Human population history at the crossroads of East and Southeast Asia since 11,000 years ago
Wang, T., Wang, W., Xie, G., Li, Z., Fan, X., Yang, Q., Wu, X., Cao, P., Liu, Y., Yang, R., et al. (2021) · Cell · doi:10.1016/j.cell.2021.05.018 · Cited by 214
Limits of long-term selection against Neandertal introgression
Petr, M., Pääbo, S., Kelso, J., & Vernot, B. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1814338116 · Cited by 211
Triangulation supports agricultural spread of the Transeurasian languages
Robbeets, M., Bouckaert, R., Conte, M., Savelyev, A., Li, T., An, D.-I., Shinoda, K., Cui, Y., Kawashima, T., Kim, G., et al. (2021) · Nature · doi:10.1038/s41586-021-04108-8 · Cited by 216
Jeong, C., Ozga, A. T., Witonsky, D., Malmström, H., Edlund, H., Hofman, C. A., Hagan, R. W., Jakobsson, M., Lewis, C. M., Aldenderfer, M. S., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520844113 · Cited by 211
Self-citationOlalde, I., Schroeder, H., Sandoval-Velasco, M., Vinner, L., Lobón, I., Ramirez, O., Civit, S., García Borja, P., Salazar-García, D. C., Talamo, S., et al. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv181 · Cited by 207
Ancient Fennoscandian genomes reveal origin and spread of Siberian ancestry in Europe
Lamnidis, T. C., Majander, K., Jeong, C., Salmela, E., Wessman, A., Moiseyev, V. G., Khartanovich, V. I., Balanovsky, O. P., Ongyerth, M., Weihmann, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07483-5 · Cited by 218
Self-citationSchuenemann, V. J., Peltzer, A., Welte, B., van Pelt, W. P., Molak, M., Wang, C.-C., Furtwängler, A., Urban, C., Reiter, E., Nieselt, K., et al. (2017) · Nature Communications · doi:10.1038/ncomms15694 · Cited by 201
Moorjani, P., Sankararaman, S., Fu, Q., Przeworski, M., Patterson, N., & Reich, D. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514696113 · Cited by 174
Bronze Age population dynamics and the rise of dairy pastoralism on the eastern Eurasian steppe
Jeong, C., Wilkin, S., Amgalantugs, T., Bouwman, A. S., Taylor, W. T. T., Hagan, R. W., Bromage, S., Tsolmon, S., Trachsel, C., Grossmann, J., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1813608115 · Cited by 195
The evolutionary history of Neanderthal and Denisovan Y chromosomes
Petr, M., Hajdinjak, M., Fu, Q., Essel, E., Rougier, H., Crèvecoeur, I., Semal, P., Golovanova, L. V., Doronichev, V. B., Lalueza‐Fox, C., et al. (2020) · Science · doi:10.1126/science.abb6460 · Cited by 202
The genetic history of the Southern Arc: A bridge between West Asia and Europe
Lazaridis, I., Alpaslan-Roodenberg, S., Acar, A., Açıkkol, A., Agelarakis, A. P., Aghikyan, L., Akyüz, U., Andreeva, D., Andrijašević, G., Antonović, D., et al. (2022) · Science · doi:10.1126/science.abm4247 · Cited by 219
The genomic origins of the Bronze Age Tarim Basin mummies
Zhang, F., Ning, C., Scott, A., Fu, Q., Bjørn, R., Li, W., Wei, D., Wang, W., Fan, L., Abuduresule, I., et al. (2021) · Nature · doi:10.1038/s41586-021-04052-7 · Cited by 196
The Genetic Legacy of the Expansion of Turkic-Speaking Nomads across Eurasia
Yunusbayev, B., Metspalu, M., Metspalu, E., Valeev, A., Litvinov, S., Valiev, R., Akhmetova, V. R., Balanovska, E. V., Balanovsky, O. P., Тurdikulova, S., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005068 · Cited by 194
Self-citationIlumäE, A.-M., Reidla, M., Chukhryaeva, M., Järve, M., Post, H., Karmin, M., Saag, L., Agdzhoyan, A., Kushniarevich, A., Litvinov, S., et al. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.05.025 · Cited by 192
Self-citationHarnessing ancient genomes to study the history of human adaptation
Marciniak, S., & Perry, G. H. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.65 · Cited by 182
A unified genealogy of modern and ancient genomes
Wohns, A. W., Wong, Y., Jeffery, B., Akbari, A., Mallick, S., Pinhasi, R., Patterson, N. J., Reich, D., Kelleher, J., & McVean, G. (2022) · Science · doi:10.1126/science.abi8264 · Cited by 199
Peopling of the Americas as inferred from ancient genomics
Willerslev, E., & Meltzer, D. J. (2021) · Nature · doi:10.1038/s41586-021-03499-y · Cited by 131
Self-citationTracing the genetic origin of Europe's first farmers reveals insights into their social organization
Szécsényi‐Nagy, A., Brandt, G., Haak, W., Keerl, V., Jakucs, J., Möller-Rieker, S., Köhler, K., Mende, B. G., Oross, K., Marton, T., et al. (2015) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2015.0339 · Cited by 200
Late Pleistocene exploration and settlement of the Americas by modern humans
Waters, M. R. (2019) · Science · doi:10.1126/science.aat5447 · Cited by 176
The evolution and changing ecology of the African hominid oral microbiome
Yates, J. A. F., Velsko, I. M., Aron, F., Posth, C., Hofman, C. A., Austin, R. M., Parker, C., Mann, A. E., Nägele, K., Arthur, K. W., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021655118 · Cited by 180
Genome-wide nucleosome map and cytosine methylation levels of an ancient human genome
Pedersen, J. S., Valen, E., Velazquez, A. M. V., Parker, B. J., Rasmussen, M., Lindgreen, S., Lilje, B., Tobin, D. J., Kelly, T. K., Vang, S., et al. (2014) · Genome Research · doi:10.1101/gr.163592.113 · Cited by 170
Self-citationImpact of climate change on the transition of Neanderthals to modern humans in Europe
Staubwasser, M., Drăgușin, V., Onac, B. P., Assonov, S. S., Ersek, V., Hoffmann, D. L., & Vereş, D. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808647115 · Cited by 169
Metadata
- Authors
- Raghavan, M., Skoglund, P., Graf, K. E., Metspalu, M., Albrechtsen, A., Moltke, I., Rasmussen, S., Stafford Jr, T. W., Orlando, L., Metspalu, E., Karmin, M., Tambets, K., Rootsi, S., Mägi, R., Campos, P. F., Balanovska, E., Balanovsky, O., Khusnutdinova, E., Litvinov, S., Osipova, L. P., Fedorova, S. A., Voevoda, M. I., DeGiorgio, M., Sicheritz-Ponten, T., Brunak, S., Demeshchenko, S., Kivisild, T., Villems, R., Nielsen, R., Jakobsson, M., & Willerslev, E.
- Affiliations
- University of Copenhagen (DK)
- Uppsala University (SE)
- Texas A&M University (US)
- Estonian Biocentre (EE)
- Technical University of Denmark (DK)
- University of Tartu (EE)
- Research Centre for Medical Genetics (RU)
- Russian Academy of Sciences (RU)
- Institute of Cytology and Genetics (RU)
- University of California, Berkeley (US)
- Novo Nordisk Foundation (DK)
- University of Cambridge (GB)
- Estonian Academy of Sciences (EE)
- Corresponding author
- Willerslev, Eske
- ORCID
- Raghavan, Maanasa
- Skoglund, Pontus
- Graf, Kelly E.
- Metspalu, Mait
- Albrechtsen, Anders
- Moltke, Ida
- Rasmussen, Simon
- Orlando, Ludovic
- Metspalu, Ene
- Karmin, Monika
- Tambets, Kristiina
- Mägi, Reedik
- Campos, Paula F.
- Balanovska, Elena
- Balanovsky, Oleg
- Litvinov, Sergey
- Osipova, Ludmila P.
- Voevoda, Mikhail I.
- Brunak, Søren
- Kivisild, Toomas
- Villems, Richard
- Nielsen, Rasmus
- Jakobsson, Mattias
- Willerslev, Eske
- Venue
- Nature
- Published
- 2013-11-20
- Volume
- 505
- Issue
- 7481
- Pages
- 87-91
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4105016
- OpenAlex
- W2050927297
- Cited by
- 963
- References
- 66
- Citations by year
- 2026: 27 · 2025: 97 · 2024: 44 · 2023: 53 · 2022: 80 · 2021: 113 · 2020: 97 · 2019: 81 · 2018: 83 · 2017: 98 · 2016: 64 · 2015: 61 · 2014: 60 · 2013: 3
- FWCI
- 41.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
- Scopus (Elsevier) (submittedVersion)
- Griffith Research Online (submittedVersion)
- Funders
- Villum Fonden (00007171)
- Lundbeckfonden (R109-2012-9995, R70-2010-6286, R155-2013-16338, R38-2008-3048, R24-2008-2527)
- Novo Nordisk Fonden (NNF10CC1016517)
- National Human Genome Research Institute (R01HG003229)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- Upper Palaeolithic, Native American ancestry, East Asian ancestry, gene flow, population divergence time, human migration history, Denisovans, Neanderthals
- MeSH terms
- Animals, Asia, DNA, Mitochondrial, Emigration and Immigration, Haplotypes, Humans, Indians, North American, Male, Phylogeny, Siberia, Skeleton, Genome, Human, Chromosomes, Human, Y, White People, Asian People, Gene Flow, Genome, Mitochondrial, Phylogeography
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